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Items: 1 to 50 of 414

1.

Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms.

Bose A, Petsko GA, Eliezer D.

J Parkinsons Dis. 2018;8(3):385-398. doi: 10.3233/JPD-171263.

2.

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.

Intlekofer AM, Shih AH, Wang B, Nazir A, Rustenburg AS, Albanese SK, Patel M, Famulare C, Correa FM, Takemoto N, Durani V, Liu H, Taylor J, Farnoud N, Papaemmanuil E, Cross JR, Tallman MS, Arcila ME, Roshal M, Petsko GA, Wu B, Choe S, Konteatis ZD, Biller SA, Chodera JD, Thompson CB, Levine RL, Stein EM.

Nature. 2018 Jul;559(7712):125-129. doi: 10.1038/s41586-018-0251-7. Epub 2018 Jun 27.

PMID:
29950729
3.

Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.

Tu Y, Kreinbring CA, Hill M, Liu C, Petsko GA, McCune CD, Berkowitz DB, Liu D, Ringe D.

Biochemistry. 2018 Jun 5;57(22):3134-3145. doi: 10.1021/acs.biochem.8b00092. Epub 2018 Apr 13.

PMID:
29630349
4.

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB.

Stem Cell Reports. 2018 Mar 13;10(3):1046-1058. doi: 10.1016/j.stemcr.2018.01.031. Epub 2018 Mar 1.

5.

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease.

Rosenberg JB, Kaplitt MG, De BP, Chen A, Flagiello T, Salami C, Pey E, Zhao L, Ricart Arbona RJ, Monette S, Dyke JP, Ballon DJ, Kaminsky SM, Sondhi D, Petsko GA, Paul SM, Crystal RG.

Hum Gene Ther Clin Dev. 2018 Mar;29(1):24-47. doi: 10.1089/humc.2017.231. Epub 2018 Mar 13.

PMID:
29409358
6.

Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors.

Campbell BC, Petsko GA, Liu CF.

Structure. 2018 Feb 6;26(2):225-237.e3. doi: 10.1016/j.str.2017.12.006. Epub 2018 Jan 4.

PMID:
29307487
7.

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.

Small SA, Simoes-Spassov S, Mayeux R, Petsko GA.

Trends Neurosci. 2017 Oct;40(10):592-602. doi: 10.1016/j.tins.2017.08.003. Review.

PMID:
28962801
8.

PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.

Wu R, Sanishvili R, Belitsky BR, Juncosa JI, Le HV, Lehrer HJ, Farley M, Silverman RB, Petsko GA, Ringe D, Liu D.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3891-3896. doi: 10.1073/pnas.1703019114. Epub 2017 Mar 27.

9.

Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).

Naffin-Olivos JL, Daab A, White A, Goldfarb NE, Milne AC, Liu D, Baikovitz J, Dunn BM, Rengarajan J, Petsko GA, Ringe D.

Biochemistry. 2017 May 2;56(17):2304-2314. doi: 10.1021/acs.biochem.6b01066. Epub 2017 Apr 7.

10.

Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily.

Zahniser MPD, Prasad S, Kneen MM, Kreinbring CA, Petsko GA, Ringe D, McLeish MJ.

Protein Eng Des Sel. 2017 Mar 1;30(3):271-278. doi: 10.1093/protein/gzx015.

11.

Dual chemistry catalyzed by human acireductone dioxygenase.

Deshpande AR, Pochapsky TC, Petsko GA, Ringe D.

Protein Eng Des Sel. 2017 Mar 1;30(3):197-204. doi: 10.1093/protein/gzw078.

12.

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Liu CF, Brandt GS, Hoang QQ, Naumova N, Lazarevic V, Hwang ES, Dekker J, Glimcher LH, Ringe D, Petsko GA.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6572-E6581. Epub 2016 Oct 10.

13.

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.

Bassil F, Fernagut PO, Bezard E, Pruvost A, Leste-Lasserre T, Hoang QQ, Ringe D, Petsko GA, Meissner WG.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9593-8. doi: 10.1073/pnas.1609291113. Epub 2016 Aug 1.

14.

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9587-92. doi: 10.1073/pnas.1610099113. Epub 2016 Aug 1.

15.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

16.

Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.

Deshpande AR, Wagenpfeil K, Pochapsky TC, Petsko GA, Ringe D.

Biochemistry. 2016 Mar 8;55(9):1398-407. doi: 10.1021/acs.biochem.5b01319. Epub 2016 Feb 24.

17.

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.

Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, Nguyen QT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, Tu Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, Kim KS.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. doi: 10.1073/pnas.1509742112. Epub 2015 Jun 29.

18.

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.

Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7821-6. doi: 10.1073/pnas.1509744112. Epub 2015 Jun 8.

19.

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.

Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG.

Lancet Neurol. 2015 Aug;14(8):855-866. doi: 10.1016/S1474-4422(15)00006-X. Epub 2015 Jun 3. Review.

20.

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders.

Small SA, Petsko GA.

Nat Rev Neurosci. 2015 Mar;16(3):126-32. doi: 10.1038/nrn3896. Epub 2015 Feb 11. Review.

PMID:
25669742
21.

The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.

Berman DE, Ringe D, Petsko GA, Small SA.

Neurotherapeutics. 2015 Jan;12(1):12-8. doi: 10.1007/s13311-014-0321-y. Review.

22.

Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.

Choi MS, Nakamura T, Cho SJ, Han X, Holland EA, Qu J, Petsko GA, Yates JR 3rd, Liddington RC, Lipton SA.

J Neurosci. 2014 Nov 5;34(45):15123-31. doi: 10.1523/JNEUROSCI.4751-13.2014.

23.

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Erratum in: Nature. 2016 Aug 18;536(7616):359.

24.

Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.

Jackson KL, Dayton RD, Orchard EA, Ju S, Ringe D, Petsko GA, Maquat LE, Klein RL.

Gene Ther. 2015 Jan;22(1):20-8. doi: 10.1038/gt.2014.101. Epub 2014 Nov 6.

25.

Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR.

Keedy DA, van den Bedem H, Sivak DA, Petsko GA, Ringe D, Wilson MA, Fraser JS.

Structure. 2014 Jun 10;22(6):899-910. doi: 10.1016/j.str.2014.04.016. Epub 2014 May 29.

26.

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Naffin-Olivos JL, Georgieva M, Goldfarb N, Madan-Lala R, Dong L, Bizzell E, Valinetz E, Brandt GS, Yu S, Shabashvili DE, Ringe D, Dunn BM, Petsko GA, Rengarajan J.

PLoS Pathog. 2014 May 15;10(5):e1004132. doi: 10.1371/journal.ppat.1004132. eCollection 2014 May.

27.

Pharmacological chaperones stabilize retromer to limit APP processing.

Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.

Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20.

28.

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.

Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NY, Santagata S, Durham HD, Agar JN.

Proteomics. 2014 May;14(10):1152-7. doi: 10.1002/pmic.201300450. Epub 2014 Apr 17.

29.

Structure of a eukaryotic thiaminase I.

Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110. Epub 2013 Dec 18.

30.

Open questions: Zombie projects, translational research, and the real secret of the inside of the cell.

Petsko GA.

BMC Biol. 2013 Sep 2;11:97. doi: 10.1186/1741-7007-11-97. No abstract available.

31.

Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.

Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC, Hoang QQ, Belitsky BR, Petsko GA, Ringe D, Liu D.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17820-5. doi: 10.1073/pnas.1315887110. Epub 2013 Oct 14.

32.

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.

Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC.

J Clin Invest. 2013 Sep;123(9):4010-22. doi: 10.1172/JCI69443. Epub 2013 Aug 15.

33.

Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.

Auclair JR, Johnson JL, Liu Q, Salisbury JP, Rotunno MS, Petsko GA, Ringe D, Brown RH Jr, Bosco DA, Agar JN.

Biochemistry. 2013 Sep 10;52(36):6137-44. doi: 10.1021/bi4006122. Epub 2013 Aug 26.

34.

Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase.

Auclair JR, Brodkin HR, D'Aquino JA, Petsko GA, Ringe D, Agar JN.

Biochemistry. 2013 Sep 10;52(36):6145-50. doi: 10.1021/bi400613h. Epub 2013 Aug 26.

35.

Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.

Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JM, Pybus B, Ringe D, Petsko GA, Boxer SG, Herschlag D.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2552-61. doi: 10.1073/pnas.1302191110. Epub 2013 Jun 24.

36.

A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.

Liu CF, Liu D, Momb J, Thomas PW, Lajoie A, Petsko GA, Fast W, Ringe D.

Biochemistry. 2013 Mar 5;52(9):1603-10. doi: 10.1021/bi400050j. Epub 2013 Feb 20.

37.

Hypothesis-driven genomics pays off.

Petsko GA.

Genome Biol. 2012 Oct 30;13(10):176. doi: 10.1186/gb4057. No abstract available.

38.

Behind the movement.

Ringe D, Petsko GA.

Cell. 2012 Sep 14;150(6):1093-5. doi: 10.1016/j.cell.2012.08.031.

39.

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S.

Mol Psychiatry. 2013 Aug;18(8):882-8. doi: 10.1038/mp.2012.115. Epub 2012 Aug 7.

40.

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S.

Mol Psychiatry. 2013 Aug;18(8):889-97. doi: 10.1038/mp.2012.106. Epub 2012 Jul 31.

41.

Mass spectrometry tools for analysis of intermolecular interactions.

Auclair JR, Somasundaran M, Green KM, Evans JE, Schiffer CA, Ringe D, Petsko GA, Agar JN.

Methods Mol Biol. 2012;896:387-98. doi: 10.1007/978-1-4614-3704-8_26.

42.

Out of Africa.

Petsko GA.

Genome Biol. 2012 Jun 29;13(6):162. doi: 10.1186/gb-2012-13-6-162. No abstract available.

43.

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).

Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. doi: 10.1016/j.bmcl.2012.04.124. Epub 2012 May 4.

44.

Goodbye, Columbus.

Petsko GA.

Genome Biol. 2012;13(5):155. No abstract available.

45.

Mending walls.

Petsko GA.

BMC Biol. 2012 May 11;10:41. doi: 10.1186/1741-7007-10-41. No abstract available.

46.

Economies of scale.

Petsko GA.

Genome Biol. 2012;13(4):154. No abstract available.

47.

Apocalypse now?

Petsko GA.

Genome Biol. 2012;13(3):151. doi: 10.1186/gb-2012-13-3-151. No abstract available.

48.

A case of the flu.

Petsko GA.

Genome Biol. 2012 Feb 24;13(2):146. doi: 10.1186/gb-2012-13-2-146. No abstract available.

49.

The dog particle.

Petsko GA.

Genome Biol. 2012 Jan 30;13(1):142. doi: 10.1186/gb-2012-13-1-142. No abstract available.

50.

The columnist manifesto.

Petsko GA.

Genome Biol. 2011 Dec 28;12(12):136. doi: 10.1186/gb-2011-12-12-136. No abstract available.

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