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Items: 12

1.

A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton.

Kostrhunova H, Zajac J, Novohradsky V, Kasparkova J, Malina J, Aldrich-Wright JR, Petruzzella E, Sirota R, Gibson D, Brabec V.

J Med Chem. 2019 May 23;62(10):5176-5190. doi: 10.1021/acs.jmedchem.9b00489. Epub 2019 May 9.

PMID:
31030506
2.

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.

Kostrhunova H, Petruzzella E, Gibson D, Kasparkova J, Brabec V.

Chemistry. 2019 Apr 5;25(20):5235-5245. doi: 10.1002/chem.201805626. Epub 2019 Mar 18.

PMID:
30740808
3.

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance.

Petruzzella E, Sirota R, Solazzo I, Gandin V, Gibson D.

Chem Sci. 2018 Apr 24;9(18):4299-4307. doi: 10.1039/c8sc00428e. eCollection 2018 May 14.

4.

A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines.

Petruzzella E, Braude JP, Aldrich-Wright JR, Gandin V, Gibson D.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11539-11544. doi: 10.1002/anie.201706739. Epub 2017 Aug 11.

PMID:
28759160
5.

Synthesis, characterization and in vitro and in vivo anticancer activity of Pt(iv) derivatives of [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)].

Harper BWJ, Petruzzella E, Sirota R, Faccioli FF, Aldrich-Wright JR, Gandin V, Gibson D.

Dalton Trans. 2017 May 30;46(21):7005-7019. doi: 10.1039/c7dt01054k.

PMID:
28513693
6.

Probing the Interactions of Cytotoxic [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)] and Its PtIV Derivatives with Human Serum.

Harper BW, Friedman-Ezra A, Sirota R, Petruzzella E, Aldrich-Wright JR, Gibson D.

ChemMedChem. 2017 Apr 6;12(7):510-519. doi: 10.1002/cmdc.201700092. Epub 2017 Mar 21.

PMID:
28206707
7.

Microwave-assisted synthesis of the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2].

Petruzzella E, Chirosca CV, Heidenga CS, Hoeschele JD.

Dalton Trans. 2015 Feb 21;44(7):3384-92. doi: 10.1039/c4dt03617d.

PMID:
25600831
8.

DNA fragment conformations in adducts with Kiteplatin.

Margiotta N, Petruzzella E, Platts JA, Mutter ST, Deeth RJ, Ranaldo R, Papadia P, Marzilli PA, Marzilli LG, Hoeschele JD, Natile G.

Dalton Trans. 2015 Feb 28;44(8):3544-56. doi: 10.1039/c4dt01796j.

PMID:
25144401
9.

Reactivity of kiteplatin with S-donor biomolecules and nucleotides.

Petruzzella E, Margiotta N, Natile G, Hoeschele JD.

Dalton Trans. 2014 Sep 14;43(34):12851-9. doi: 10.1039/c4dt01474j.

PMID:
25051186
10.

Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy.

Assi HH, Paran C, VanderVeen N, Savakus J, Doherty R, Petruzzella E, Hoeschele JD, Appelman H, Raptis L, Mikkelsen T, Lowenstein PR, Castro MG.

J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. doi: 10.1124/jpet.114.214619. Epub 2014 Apr 2.

11.

NMR investigation of the spontaneous thermal- and/or photoinduced reduction of trans dihydroxido Pt(IV) derivatives.

Petruzzella E, Margiotta N, Ravera M, Natile G.

Inorg Chem. 2013 Mar 4;52(5):2393-403. doi: 10.1021/ic302100x. Epub 2013 Feb 18.

PMID:
23414056
12.

Revisiting [PtClâ‚‚(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

Margiotta N, Marzano C, Gandin V, Osella D, Ravera M, Gabano E, Platts JA, Petruzzella E, Hoeschele JD, Natile G.

J Med Chem. 2012 Aug 23;55(16):7182-92. doi: 10.1021/jm3006838. Epub 2012 Aug 10.

PMID:
22788918

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