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Items: 1 to 50 of 72

1.

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation.

Austin JW, Buckner CM, Kardava L, Wang W, Zhang X, Melson VA, Swanson RG, Martins AJ, Zhou JQ, Hoehn KB, Fisk JN, Dimopoulos Y, Chassiakos A, O'Dell S, Smelkinson MG, Seamon CA, Kwan RW, Sneller MC, Pittaluga S, Doria-Rose NA, McDermott A, Li Y, Chun TW, Kleinstein SH, Tsang JS, Petrovas C, Moir S.

Sci Transl Med. 2019 Nov 27;11(520). pii: eaax0904. doi: 10.1126/scitranslmed.aax0904.

PMID:
31776286
2.

How to dissect the plasticity of antigen-specific immune response: a tissue perspective.

Amodio D, Santilli V, Zangari P, Cotugno N, Manno EC, Rocca S, Rossi P, Cancrini C, Finocchi A, Chassiakos A, Petrovas C, Palma P.

Clin Exp Immunol. 2019 Oct 18. doi: 10.1111/cei.13386. [Epub ahead of print] Review.

PMID:
31626717
3.

Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.

Pino M, Paganini S, Deleage C, Padhan K, Harper JL, King CT, Micci L, Cervasi B, Mudd JC, Gill KP, Jean SM, Easley K, Silvestri G, Estes JD, Petrovas C, Lederman MM, Paiardini M.

PLoS Pathog. 2019 Oct 18;15(10):e1008081. doi: 10.1371/journal.ppat.1008081. eCollection 2019 Oct.

4.

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates.

Francica JR, Laga R, Lynn GM, Mužíková G, Androvič L, Aussedat B, Walkowicz WE, Padhan K, Ramirez-Valdez RA, Parks R, Schmidt SD, Flynn BJ, Tsybovsky Y, Stewart-Jones GBE, Saunders KO, Baharom F, Petrovas C, Haynes BF, Seder RA.

PLoS Biol. 2019 Jun 17;17(6):e3000328. doi: 10.1371/journal.pbio.3000328. eCollection 2019 Jun.

5.

Editorial: Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure.

Petrovas C, Velu V.

Front Immunol. 2018 Dec 12;9:2950. doi: 10.3389/fimmu.2018.02950. eCollection 2018. No abstract available.

6.

Baseline Circulating Activated TFH and Tissue-Like Exhausted B Cells Negatively Correlate With Meningococcal C Conjugate Vaccine Induced Antibodies in HIV-Infected Individuals.

Milagres L, Silva G, Pereira-Manfro W, Frota AC, Hofer C, Ferreira B, Barreto D, Figueredo M, Coelho B, Villela L, Petrovas C, Koup R.

Front Immunol. 2018 Oct 29;9:2500. doi: 10.3389/fimmu.2018.02500. eCollection 2018.

7.

Bispecific antibodies: Potential immunotherapies for HIV treatment.

Fabozzi G, Pegu A, Koup RA, Petrovas C.

Methods. 2019 Feb 1;154:118-124. doi: 10.1016/j.ymeth.2018.10.010. Epub 2018 Oct 22. Review.

PMID:
30352254
8.

Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?

Poultsidi A, Dimopoulos Y, He TF, Chavakis T, Saloustros E, Lee PP, Petrovas C.

Front Immunol. 2018 Sep 27;9:2233. doi: 10.3389/fimmu.2018.02233. eCollection 2018. Review.

9.

Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells.

Abdi K, Laky K, Padhan K, Petrovas C, Skinner J, Kabat J, Dorward DW, Brzostowski J, Long EO, Trinchieri G, Varma R.

J Immunol. 2018 Nov 15;201(10):2879-2884. doi: 10.4049/jimmunol.1800721. Epub 2018 Oct 12.

10.

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.

Watson DC, Moysi E, Valentin A, Bergamaschi C, Devasundaram S, Fortis SP, Bear J, Chertova E, Bess J Jr, Sowder R, Venzon DJ, Deleage C, Estes JD, Lifson JD, Petrovas C, Felber BK, Pavlakis GN.

PLoS Pathog. 2018 Oct 11;14(10):e1007345. doi: 10.1371/journal.ppat.1007345. eCollection 2018 Oct.

11.

The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses.

Moysi E, Petrovas C, Koup RA.

Retrovirology. 2018 Aug 6;15(1):54. doi: 10.1186/s12977-018-0437-y. Review.

12.

Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective.

Aid M, Dupuy FP, Moysi E, Moir S, Haddad EK, Estes JD, Sekaly RP, Petrovas C, Ribeiro SP.

Front Immunol. 2018 Jun 18;9:895. doi: 10.3389/fimmu.2018.00895. eCollection 2018. Review.

13.

Altered immune cell follicular dynamics in HIV infection following influenza vaccination.

Moysi E, Pallikkuth S, De Armas LR, Gonzalez LE, Ambrozak D, George V, Huddleston D, Pahwa R, Koup RA, Petrovas C, Pahwa S.

J Clin Invest. 2018 Jul 2;128(7):3171-3185. doi: 10.1172/JCI99884. Epub 2018 Jun 18.

14.

Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.

Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.

Sci Immunol. 2018 Jun 1;3(24). pii: eaar4526. doi: 10.1126/sciimmunol.aar4526.

15.

Lymphoid tissue fibrosis is associated with impaired vaccine responses.

Kityo C, Makamdop KN, Rothenberger M, Chipman JG, Hoskuldsson T, Beilman GJ, Grzywacz B, Mugyenyi P, Ssali F, Akondy RS, Anderson J, Schmidt TE, Reimann T, Callisto SP, Schoephoerster J, Schuster J, Muloma P, Ssengendo P, Moysi E, Petrovas C, Lanciotti R, Zhang L, Arévalo MT, Rodriguez B, Ross TM, Trautmann L, Sekaly RP, Lederman MM, Koup RA, Ahmed R, Reilly C, Douek DC, Schacker TW.

J Clin Invest. 2018 Jul 2;128(7):2763-2773. doi: 10.1172/JCI97377. Epub 2018 May 21.

16.

Accumulation of follicular CD8+ T cells in pathogenic SIV infection.

Ferrando-Martinez S, Moysi E, Pegu A, Andrews S, Nganou Makamdop K, Ambrozak D, McDermott AB, Palesch D, Paiardini M, Pavlakis GN, Brenchley JM, Douek D, Mascola JR, Petrovas C, Koup RA.

J Clin Invest. 2018 May 1;128(5):2089-2103. doi: 10.1172/JCI96207. Epub 2018 Apr 16.

17.

Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections.

Estes JD, LeGrand R, Petrovas C.

Front Immunol. 2018 Mar 2;9:423. doi: 10.3389/fimmu.2018.00423. eCollection 2018. Review.

18.

Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients.

Hsu DC, Breglio KF, Pei L, Wong CS, Andrade BB, Sheikh V, Smelkinson M, Petrovas C, Rupert A, Gil-Santana L, Zelazny A, Holland SM, Olivier K, Barber D, Sereti I.

Clin Infect Dis. 2018 Jul 18;67(3):437-446. doi: 10.1093/cid/ciy016.

19.

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.

Watson DC, Moysi E, Valentin A, Bergamaschi C, Devasundaram S, Fortis SP, Bear J, Chertova E, Bess J Jr, Sowder R, Venzon DJ, Deleage C, Estes JD, Lifson JD, Petrovas C, Felber BK, Pavlakis GN.

PLoS Pathog. 2018 Feb 23;14(2):e1006902. doi: 10.1371/journal.ppat.1006902. eCollection 2018 Feb. Erratum in: PLoS Pathog. 2018 Oct 11;14(10):e1007345.

20.

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.

Reuter MA, Del Rio Estrada PM, Buggert M, Petrovas C, Ferrando-Martinez S, Nguyen S, Sada Japp A, Ablanedo-Terrazas Y, Rivero-Arrieta A, Kuri-Cervantes L, Gunzelman HM, Gostick E, Price DA, Koup RA, Naji A, Canaday DH, Reyes-Terán G, Betts MR.

Cell Rep. 2017 Dec 19;21(12):3458-3470. doi: 10.1016/j.celrep.2017.11.075.

21.

Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination.

Amodio D, Cotugno N, Macchiarulo G, Rocca S, Dimopoulos Y, Castrucci MR, De Vito R, Tucci FM, McDermott AB, Narpala S, Rossi P, Koup RA, Palma P, Petrovas C.

J Immunol. 2018 Jan 15;200(2):538-550. doi: 10.4049/jimmunol.1701312. Epub 2017 Dec 13.

22.

Novel advances on tissue immune dynamics in HIV/simian immunodeficiency virus: lessons from imaging studies.

Moysi E, Padhan K, Fabozzi G, Petrovas C.

Curr Opin HIV AIDS. 2018 Mar;13(2):112-118. doi: 10.1097/COH.0000000000000437. Review.

PMID:
29227356
23.

The Lymph Node in HIV Pathogenesis.

Dimopoulos Y, Moysi E, Petrovas C.

Curr HIV/AIDS Rep. 2017 Aug;14(4):133-140. doi: 10.1007/s11904-017-0359-7. Review.

PMID:
28685417
24.

Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection.

Paris RM, Milagres LG, Moysi E, Okulicz JF, Agan BK, Ganesan A, Petrovas C, Koup RA.

Pathog Immun. 2017;2(1):66-88. doi: 10.20411/pai.v2i1.175. Epub 2017 Mar 14.

25.

CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?

Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J.

Front Immunol. 2017 Feb 20;8:135. doi: 10.3389/fimmu.2017.00135. eCollection 2017. Review.

26.

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.

Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, Ruiz-Mateos E, Vagios I, Leal M, Ablanedo-Terrazas Y, Rivero A, Gonzalez-Hernandez LA, McDermott AB, Moir S, Reyes-Terán G, Docobo F, Pantaleo G, Douek DC, Betts MR, Estes JD, Germain RN, Mascola JR, Koup RA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaag2285. doi: 10.1126/scitranslmed.aag2285.

27.

Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.

Saharia KK, Petrovas C, Ferrando-Martinez S, Leal M, Luque R, Ive P, Luetkemeyer A, Havlir D, Koup RA.

PLoS One. 2016 Jul 1;11(7):e0158262. doi: 10.1371/journal.pone.0158262. eCollection 2016.

28.

Novel Imaging Methods for Analysis of Tissue Resident Cells in HIV/SIV.

Moysi E, Estes JD, Petrovas C.

Curr HIV/AIDS Rep. 2016 Feb;13(1):38-43. doi: 10.1007/s11904-016-0300-5. Review.

PMID:
26830285
29.

Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression.

Paris RM, Petrovas C, Ferrando-Martinez S, Moysi E, Boswell KL, Archer E, Yamamoto T, Ambrozak D, Casazza JP, Haubrich R, Connors M, Ake J, Kim JH, Koup RA.

PLoS One. 2015 Dec 17;10(12):e0144767. doi: 10.1371/journal.pone.0144767. eCollection 2015.

30.

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.

Cubas R, van Grevenynghe J, Wills S, Kardava L, Santich BH, Buckner CM, Muir R, Tardif V, Nichols C, Procopio F, He Z, Metcalf T, Ghneim K, Locci M, Ancuta P, Routy JP, Trautmann L, Li Y, McDermott AB, Koup RA, Petrovas C, Migueles SA, Connors M, Tomaras GD, Moir S, Crotty S, Haddad EK.

J Immunol. 2015 Dec 15;195(12):5625-36. doi: 10.4049/jimmunol.1501524. Epub 2015 Nov 6.

31.

Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection.

Yamamoto T, Lynch RM, Gautam R, Matus-Nicodemos R, Schmidt SD, Boswell KL, Darko S, Wong P, Sheng Z, Petrovas C, McDermott AB, Seder RA, Keele BF, Shapiro L, Douek DC, Nishimura Y, Mascola JR, Martin MA, Koup RA.

Sci Transl Med. 2015 Jul 29;7(298):298ra120. doi: 10.1126/scitranslmed.aab3964.

PMID:
26223303
32.

Coinhibitory receptors and CD8 T cell exhaustion in chronic infections.

Kuchroo VK, Anderson AC, Petrovas C.

Curr Opin HIV AIDS. 2014 Sep;9(5):439-45. doi: 10.1097/COH.0000000000000088. Review.

PMID:
25010894
33.

Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.

Bhadra R, Moretto MM, Castillo JC, Petrovas C, Ferrando-Martinez S, Shokal U, Leal M, Koup RA, Eleftherianos I, Khan IA.

J Clin Invest. 2014 Jun;124(6):2441-55. doi: 10.1172/JCI70522. Epub 2014 Apr 24.

34.

T follicular helper cells and HIV/SIV-specific antibody responses.

Petrovas C, Koup RA.

Curr Opin HIV AIDS. 2014 May;9(3):235-41. doi: 10.1097/COH.0000000000000053. Review.

PMID:
24670319
35.

Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection.

Boswell KL, Paris R, Boritz E, Ambrozak D, Yamamoto T, Darko S, Wloka K, Wheatley A, Narpala S, McDermott A, Roederer M, Haubrich R, Connors M, Ake J, Douek DC, Kim J, Petrovas C, Koup RA.

PLoS Pathog. 2014 Jan 30;10(1):e1003853. doi: 10.1371/journal.ppat.1003853. eCollection 2014 Jan.

36.

Modeling Bone Marrow Progenitor Cell Differentiation and Susceptibility to HIV-1 Infection.

Alexaki A, Quiterio SJ, Nonnemacher MR, Shah S, Liu Y, Banerjee A, Li L, Passic S, Pirrone V, Kilareski E, Petrovas C, Wigdahl B.

MOJ Immunol. 2014;1(2):00009-9.

37.

Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression.

Johnson MJ, Björkström NK, Petrovas C, Liang F, Gall JG, Loré K, Koup RA.

Vaccine. 2014 Feb 3;32(6):717-24. doi: 10.1016/j.vaccine.2013.11.055. Epub 2013 Dec 8.

38.

HIV integration and T cell death: additional commentary.

Cooper A, García M, Petrovas C, Yamamoto T, Koup RA, Nabel GJ.

Retrovirology. 2013 Dec 9;10:150. doi: 10.1186/1742-4690-10-150.

39.

High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance.

Petrovas C, Yamamoto T, Price DA, Rao SS, Klatt NR, Brenchley JM, Douek DC, Gostick E, Angermann BR, Grossman Z, Macallan DC, Meier-Schellersheim M, Koup RA.

J Virol. 2013 Sep;87(17):9836-44. doi: 10.1128/JVI.01001-13. Epub 2013 Jul 3.

40.

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.

Cooper A, García M, Petrovas C, Yamamoto T, Koup RA, Nabel GJ.

Nature. 2013 Jun 20;498(7454):376-9. doi: 10.1038/nature12274. Epub 2013 Jun 5.

PMID:
23739328
41.

CD4 T follicular helper cell dynamics during SIV infection.

Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, Tomaras GD, Roederer M, Douek DC, Seder RA, Germain RN, Haddad EK, Koup RA.

J Clin Invest. 2012 Sep;122(9):3281-94. doi: 10.1172/JCI63039. Epub 2012 Aug 27.

42.

Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity.

Johnson MJ, Petrovas C, Yamamoto T, Lindsay RW, Loré K, Gall JG, Gostick E, Lefebvre F, Cameron MJ, Price DA, Haddad E, Sekaly RP, Seder RA, Koup RA.

J Immunol. 2012 Jun 15;188(12):6109-18. doi: 10.4049/jimmunol.1103717. Epub 2012 May 14.

43.

Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection.

Yamamoto T, Johnson MJ, Price DA, Wolinsky DI, Almeida JR, Petrovas C, Nason M, Yeh WW, Shen L, Roederer M, Rao SS, McDermott AB, Lefebvre F, Nabel GJ, Haddad EK, Letvin NL, Douek DC, Koup RA.

J Virol. 2012 May;86(10):5877-84. doi: 10.1128/JVI.00315-12. Epub 2012 Mar 14.

44.

Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation.

Adams WC, Gujer C, McInerney G, Gall JG, Petrovas C, Karlsson Hedestam GB, Koup RA, Loré K.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7499-504. doi: 10.1073/pnas.1017146108. Epub 2011 Apr 18.

45.

Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.

Yamamoto T, Price DA, Casazza JP, Ferrari G, Nason M, Chattopadhyay PK, Roederer M, Gostick E, Katsikis PD, Douek DC, Haubrich R, Petrovas C, Koup RA.

Blood. 2011 May 5;117(18):4805-15. doi: 10.1182/blood-2010-11-317297. Epub 2011 Mar 11.

46.

Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.

Geldmacher C, Ngwenyama N, Schuetz A, Petrovas C, Reither K, Heeregrave EJ, Casazza JP, Ambrozak DR, Louder M, Ampofo W, Pollakis G, Hill B, Sanga E, Saathoff E, Maboko L, Roederer M, Paxton WA, Hoelscher M, Koup RA.

J Exp Med. 2010 Dec 20;207(13):2869-81. doi: 10.1084/jem.20100090. Epub 2010 Nov 29.

47.

Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.

Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ, Kaberlein JJ, Petrovas C, Koup RA, Longo D, Ozato K, Gardner K.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19286-91. doi: 10.1073/pnas.0905469106. Epub 2009 Oct 30.

48.

Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.

Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA.

J Immunol. 2009 Jul 15;183(2):1120-32. doi: 10.4049/jimmunol.0900182. Epub 2009 Jun 29.

49.

Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response.

Geldmacher C, Metzler IS, Tovanabutra S, Asher TE, Gostick E, Ambrozak DR, Petrovas C, Schuetz A, Ngwenyama N, Kijak G, Maboko L, Hoelscher M, McCutchan F, Price DA, Douek DC, Koup RA.

Blood. 2009 Aug 20;114(8):1553-62. doi: 10.1182/blood-2009-02-206193. Epub 2009 Jun 19.

50.

Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells.

Vassilopoulos A, Wang RH, Petrovas C, Ambrozak D, Koup R, Deng CX.

Int J Biol Sci. 2008 May 4;4(3):133-42.

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