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Items: 43

1.

Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.

Engelhardt H, Böse D, Petronczki M, Scharn D, Bader G, Baum A, Bergner A, Chong E, Döbel S, Egger G, Engelhardt C, Ettmayer P, Fuchs JE, Gerstberger T, Gonnella N, Grimm A, Grondal E, Haddad N, Hopfgartner B, Kousek R, Krawiec M, Kriz M, Lamarre L, Leung J, Mayer M, Patel ND, Simov BP, Reeves JT, Schnitzer R, Schrenk A, Sharps B, Solca F, Stadtmüller H, Tan Z, Wunberg T, Zoephel A, McConnell DB.

J Med Chem. 2019 Nov 13. doi: 10.1021/acs.jmedchem.9b01169. [Epub ahead of print]

PMID:
31689114
2.

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers.

Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Májek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Müller AC, Bock C, Kubicek S.

Nat Genet. 2019 Sep;51(9):1399-1410. doi: 10.1038/s41588-019-0477-9. Epub 2019 Aug 19.

PMID:
31427792
3.

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

Ehrenhöfer-Wölfer K, Puchner T, Schwarz C, Rippka J, Blaha-Ostermann S, Strobl U, Hörmann A, Bader G, Kornigg S, Zahn S, Sommergruber W, Schweifer N, Zichner T, Schlattl A, Neumüller RA, Shi J, Vakoc CR, Kögl M, Petronczki M, Kraut N, Pearson MA, Wöhrle S.

Sci Rep. 2019 Aug 12;9(1):11661. doi: 10.1038/s41598-019-48152-x.

4.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, Huber KVM, Rogers CM, Wells CI, Fedorov O, Rumpel K, Zoephel A, Mayer M, Wunberg T, Böse D, Zahn S, Arnhof H, Berger H, Reiser C, Hörmann A, Krammer T, Corcokovic M, Sharps B, Winkler S, Häring D, Cockcroft XL, Fuchs JE, Müllauer B, Weiss-Puxbaum A, Gerstberger T, Boehmelt G, Vakoc CR, Arrowsmith CH, Pearson M, McConnell DB.

Nat Chem Biol. 2019 Aug;15(8):822-829. doi: 10.1038/s41589-019-0310-x. Epub 2019 Jul 8.

PMID:
31285596
5.

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.

Lieb S, Blaha-Ostermann S, Kamper E, Rippka J, Schwarz C, Ehrenhöfer-Wölfer K, Schlattl A, Wernitznig A, Lipp JJ, Nagasaka K, van der Lelij P, Bader G, Koi M, Goel A, Neumüller RA, Peters JM, Kraut N, Pearson MA, Petronczki M, Wöhrle S.

Elife. 2019 Mar 25;8. pii: e43333. doi: 10.7554/eLife.43333.

6.

Tumor clonality and resistance mechanisms in EGFR mutation-positive non-small-cell lung cancer: implications for therapeutic sequencing.

Kohsaka S, Petronczki M, Solca F, Maemondo M.

Future Oncol. 2019 Feb;15(6):637-652. doi: 10.2217/fon-2018-0736. Epub 2018 Nov 8. Review.

7.

RIOK1 kinase activity is required for cell survival irrespective of MTAP status.

Hörmann A, Hopfgartner B, Köcher T, Corcokovic M, Krammer T, Reiser C, Bader G, Shi J, Ehrenhöfer K, Wöhrle S, Schweifer N, Vakoc CR, Kraut N, Pearson M, Petronczki M, Neumüller RA.

Oncotarget. 2018 Jun 19;9(47):28625-28637. doi: 10.18632/oncotarget.25586. eCollection 2018 Jun 19.

8.

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.

Takaki T, Montagner M, Serres MP, Le Berre M, Russell M, Collinson L, Szuhai K, Howell M, Boulton SJ, Sahai E, Petronczki M.

Nat Commun. 2017 Jul 24;8:16013. doi: 10.1038/ncomms16013.

9.

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.

van der Lelij P, Lieb S, Jude J, Wutz G, Santos CP, Falkenberg K, Schlattl A, Ban J, Schwentner R, Hoffmann T, Kovar H, Real FX, Waldman T, Pearson MA, Kraut N, Peters JM, Zuber J, Petronczki M.

Elife. 2017 Jul 10;6. pii: e26980. doi: 10.7554/eLife.26980.

10.

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.

Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C.

Cancer Discov. 2017 Feb;7(2):218-233. doi: 10.1158/2159-8290.CD-16-0645. Epub 2017 Jan 9.

11.

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis.

Kotýnková K, Su KC, West SC, Petronczki M.

Cell Rep. 2016 Dec 6;17(10):2672-2686. doi: 10.1016/j.celrep.2016.11.029.

12.

Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.

Basant A, Lekomtsev S, Tse YC, Zhang D, Longhini KM, Petronczki M, Glotzer M.

Dev Cell. 2015 Apr 20;33(2):204-15. doi: 10.1016/j.devcel.2015.03.015.

13.

Cytokinesis in animal cells.

D'Avino PP, Giansanti MG, Petronczki M.

Cold Spring Harb Perspect Biol. 2015 Feb 13;7(4):a015834. doi: 10.1101/cshperspect.a015834. Review.

14.

An astral simulacrum of the central spindle accounts for normal, spindle-less, and anucleate cytokinesis in echinoderm embryos.

Su KC, Bement WM, Petronczki M, von Dassow G.

Mol Biol Cell. 2014 Dec 15;25(25):4049-62. doi: 10.1091/mbc.E14-04-0859. Epub 2014 Oct 8.

15.

Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion.

Sundaramoorthy S, Vázquez-Novelle MD, Lekomtsev S, Howell M, Petronczki M.

EMBO J. 2014 Nov 18;33(22):2623-42. doi: 10.15252/embj.201488244. Epub 2014 Sep 25.

16.

Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase.

Vázquez-Novelle MD, Sansregret L, Dick AE, Smith CA, McAinsh AD, Gerlich DW, Petronczki M.

Curr Biol. 2014 Mar 17;24(6):638-45. doi: 10.1016/j.cub.2014.01.034. Epub 2014 Feb 27.

17.

Born equal: dual safeguards for daughter cell size symmetry.

Sansregret L, Petronczki M.

Cell. 2013 Jul 18;154(2):269-71. doi: 10.1016/j.cell.2013.06.035.

18.

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.

Lekomtsev S, Su KC, Pye VE, Blight K, Sundaramoorthy S, Takaki T, Collinson LM, Cherepanov P, Divecha N, Petronczki M.

Nature. 2012 Dec 13;492(7428):276-9. doi: 10.1038/nature11773.

PMID:
23235882
19.

Cell biology. ESCRTing DNA at the cleavage site during cytokinesis.

Petronczki M, Uhlmann F.

Science. 2012 Apr 13;336(6078):166-7. doi: 10.1126/science.1221832. No abstract available.

PMID:
22499931
20.

Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.

Su KC, Takaki T, Petronczki M.

Dev Cell. 2011 Dec 13;21(6):1104-15. doi: 10.1016/j.devcel.2011.11.003.

21.

Meiotic nuclear divisions in budding yeast require PP2A(Cdc55)-mediated antagonism of Net1 phosphorylation by Cdk.

Kerr GW, Sarkar S, Tibbles KL, Petronczki M, Millar JB, Arumugam P.

J Cell Biol. 2011 Jun 27;193(7):1157-66. doi: 10.1083/jcb.201103019. Epub 2011 Jun 20.

22.

The 'anaphase problem': how to disable the mitotic checkpoint when sisters split.

Vázquez-Novelle MD, Mirchenko L, Uhlmann F, Petronczki M.

Biochem Soc Trans. 2010 Dec;38(6):1660-6. doi: 10.1042/BST0381660. Review.

PMID:
21118144
23.

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M, Griffith JD, West SC.

Nat Struct Mol Biol. 2010 Oct;17(10):1263-5. doi: 10.1038/nsmb.1905. Epub 2010 Aug 22.

24.

Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase.

Vázquez-Novelle MD, Petronczki M.

Curr Biol. 2010 Aug 10;20(15):1402-7. doi: 10.1016/j.cub.2010.06.036. Epub 2010 Jul 8.

25.

Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells.

Lekomtsev S, Guizetti J, Pozniakovsky A, Gerlich DW, Petronczki M.

J Cell Sci. 2010 May 1;123(Pt 9):1395-400. doi: 10.1242/jcs.068015. Epub 2010 Mar 31.

26.

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.

Wolfe BA, Takaki T, Petronczki M, Glotzer M.

PLoS Biol. 2009 May 5;7(5):e1000110. doi: 10.1371/journal.pbio.1000110. Epub 2009 May 26.

27.

Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.

Takaki T, Trenz K, Costanzo V, Petronczki M.

Curr Opin Cell Biol. 2008 Dec;20(6):650-60. doi: 10.1016/j.ceb.2008.10.005. Epub 2008 Nov 27. Review.

PMID:
19000759
28.

Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

Petronczki M, Lénárt P, Peters JM.

Dev Cell. 2008 May;14(5):646-59. doi: 10.1016/j.devcel.2008.04.014. Review.

29.

Tandem affinity purification of functional TAP-tagged proteins from human cells.

Gregan J, Riedel CG, Petronczki M, Cipak L, Rumpf C, Poser I, Buchholz F, Mechtler K, Nasmyth K.

Nat Protoc. 2007;2(5):1145-51.

30.
31.

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM.

Curr Biol. 2007 Feb 20;17(4):304-15. Epub 2007 Feb 8.

32.

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

Steegmaier M, Hoffmann M, Baum A, Lénárt P, Petronczki M, Krssák M, Gürtler U, Garin-Chesa P, Lieb S, Quant J, Grauert M, Adolf GR, Kraut N, Peters JM, Rettig WJ.

Curr Biol. 2007 Feb 20;17(4):316-22. Epub 2007 Feb 8.

33.

Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.

Petronczki M, Matos J, Mori S, Gregan J, Bogdanova A, Schwickart M, Mechtler K, Shirahige K, Zachariae W, Nasmyth K.

Cell. 2006 Sep 22;126(6):1049-64.

34.

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K.

Nature. 2006 May 4;441(7089):53-61. Epub 2006 Mar 15.

PMID:
16541024
35.

Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II.

Petronczki M, Chwalla B, Siomos MF, Yokobayashi S, Helmhart W, Deutschbauer AM, Davis RW, Watanabe Y, Nasmyth K.

J Cell Sci. 2004 Jul 15;117(Pt 16):3547-59. Epub 2004 Jun 29.

36.
37.

Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.

Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Tóth A, Nasmyth K.

Dev Cell. 2003 May;4(5):727-39.

38.

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I.

Rabitsch KP, Petronczki M, Javerzat JP, Genier S, Chwalla B, Schleiffer A, Tanaka TU, Nasmyth K.

Dev Cell. 2003 Apr;4(4):535-48. Erratum in: Dev Cell. 2003 Sep;5(3):523.

39.

Un ménage à quatre: the molecular biology of chromosome segregation in meiosis.

Petronczki M, Siomos MF, Nasmyth K.

Cell. 2003 Feb 21;112(4):423-40. Review.

40.

Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system.

Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich JA.

Cell. 2001 Oct 19;107(2):183-94.

41.

Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila.

Huynh JR, Petronczki M, Knoblich JA, St Johnston D.

Curr Biol. 2001 Jun 5;11(11):901-6.

42.

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole.

van Eeden FJ, Palacios IM, Petronczki M, Weston MJ, St Johnston D.

J Cell Biol. 2001 Aug 6;154(3):511-23. Epub 2001 Jul 30.

43.

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila.

Petronczki M, Knoblich JA.

Nat Cell Biol. 2001 Jan;3(1):43-9.

PMID:
11146625

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