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Items: 1 to 50 of 95

1.

Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks.

Mojumdar A, Sorenson K, Hohl M, Toulouze M, Lees-Miller SP, Dubrana K, Petrini JHJ, Cobb JA.

Cell Rep. 2019 Aug 6;28(6):1564-1573.e3. doi: 10.1016/j.celrep.2019.07.018.

2.

Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.

Kim JH, Penson AV, Taylor BS, Petrini JHJ.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15178-15183. doi: 10.1073/pnas.1905305116. Epub 2019 Jul 8.

PMID:
31285322
3.

Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization.

Huang G, Kaufman AJ, Ryan RJH, Romin Y, Huryn L, Bains S, Manova-Todorova K, Morris PL, Hunnicutt GR, Adelman CA, Petrini JHJ, Ramanathan Y, Singh B.

PLoS One. 2019 Jan 17;14(1):e0209995. doi: 10.1371/journal.pone.0209995. eCollection 2019.

4.

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.

Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaam9078. doi: 10.1126/scitranslmed.aam9078.

5.

Eukaryotic Rad50 functions as a rod-shaped dimer.

Park YB, Hohl M, Padjasek M, Jeong E, Jin KS, Krężel A, Petrini JH, Cho Y.

Nat Struct Mol Biol. 2017 Mar;24(3):248-257. doi: 10.1038/nsmb.3369. Epub 2017 Jan 30.

6.

The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.

Kim JH, Grosbart M, Anand R, Wyman C, Cejka P, Petrini JHJ.

Cell Rep. 2017 Jan 10;18(2):496-507. doi: 10.1016/j.celrep.2016.12.035.

7.

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding.

Sarek G, Vannier JB, Panier S, Petrini JHJ, Boulton SJ.

Mol Cell. 2016 Mar 3;61(5):788-789. doi: 10.1016/j.molcel.2016.02.016. Epub 2016 Mar 3. No abstract available.

8.

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.

Piscuoglio S, Ng CK, Murray M, Burke KA, Edelweiss M, Geyer FC, Macedo GS, Inagaki A, Papanastasiou AD, Martelotto LG, Marchio C, Lim RS, Ioris RA, Nahar PK, Bruijn ID, Smyth L, Akram M, Ross D, Petrini JH, Norton L, Solit DB, Baselga J, Brogi E, Ladanyi M, Weigelt B, Reis-Filho JS.

J Pathol. 2016 Mar;238(4):508-18. doi: 10.1002/path.4672. Epub 2016 Jan 25.

9.

Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model.

Balestrini A, Nicolas L, Yang-Lott K, Guryanova OA, Levine RL, Bassing CH, Chaudhuri J, Petrini JH.

Mol Cancer Res. 2016 Feb;14(2):185-95. doi: 10.1158/1541-7786.MCR-15-0281. Epub 2015 Nov 4.

10.

Functions of the MRE11 complex in the development and maintenance of oocytes.

Inagaki A, Roset R, Petrini JH.

Chromosoma. 2016 Mar;125(1):151-62. doi: 10.1007/s00412-015-0535-8. Epub 2015 Aug 1.

11.

TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.

Sarek G, Vannier JB, Panier S, Petrini JHJ, Boulton SJ.

Mol Cell. 2015 Feb 19;57(4):622-635. doi: 10.1016/j.molcel.2014.12.024. Epub 2015 Jan 22. Erratum in: Mol Cell. 2016 Mar 3;61(5):788-9. Mol Cell. 2016 Mar 3;61(5):788-789.

12.

Interdependence of the rad50 hook and globular domain functions.

Hohl M, Kochańczyk T, Tous C, Aguilera A, Krężel A, Petrini JH.

Mol Cell. 2015 Feb 5;57(3):479-91. doi: 10.1016/j.molcel.2014.12.018. Epub 2015 Jan 15.

13.

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.

Al-Ahmadie H, Iyer G, Hohl M, Asthana S, Inagaki A, Schultz N, Hanrahan AJ, Scott SN, Brannon AR, McDermott GC, Pirun M, Ostrovnaya I, Kim P, Socci ND, Viale A, Schwartz GK, Reuter V, Bochner BH, Rosenberg JE, Bajorin DF, Berger MF, Petrini JH, Solit DB, Taylor BS.

Cancer Discov. 2014 Sep;4(9):1014-21. doi: 10.1158/2159-8290.CD-14-0380. Epub 2014 Jun 16.

14.

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.

Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ.

Nat Neurosci. 2014 Jun;17(6):813-21. doi: 10.1038/nn.3715. Epub 2014 May 4.

15.

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J.

Nat Immunol. 2014 Jun;15(6):538-45. doi: 10.1038/ni.2888. Epub 2014 Apr 28.

16.

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.

Roset R, Inagaki A, Hohl M, Brenet F, Lafrance-Vanasse J, Lange J, Scandura JM, Tainer JA, Keeney S, Petrini JH.

Genes Dev. 2014 Mar 1;28(5):451-62. doi: 10.1101/gad.236745.113. Epub 2014 Feb 14.

17.

The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.

Gupta GP, Vanness K, Barlas A, Manova-Todorova KO, Wen YH, Petrini JH.

Mol Cell. 2013 Nov 7;52(3):353-65. doi: 10.1016/j.molcel.2013.09.001. Epub 2013 Oct 10.

18.

A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.

Ballew BJ, Joseph V, De S, Sarek G, Vannier JB, Stracker T, Schrader KA, Small TN, O'Reilly R, Manschreck C, Harlan Fleischut MM, Zhang L, Sullivan J, Stratton K, Yeager M, Jacobs K, Giri N, Alter BP, Boland J, Burdett L, Offit K, Boulton SJ, Savage SA, Petrini JH.

PLoS Genet. 2013 Aug;9(8):e1003695. doi: 10.1371/journal.pgen.1003695. Epub 2013 Aug 29.

19.

The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks.

Balestrini A, Ristic D, Dionne I, Liu XZ, Wyman C, Wellinger RJ, Petrini JH.

Cell Rep. 2013 Jun 27;3(6):2033-45. doi: 10.1016/j.celrep.2013.05.026. Epub 2013 Jun 13.

20.

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.

Kannan K, Inagaki A, Silber J, Gorovets D, Zhang J, Kastenhuber ER, Heguy A, Petrini JH, Chan TA, Huse JT.

Oncotarget. 2012 Oct;3(10):1194-203.

21.

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.

Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP.

PLoS Genet. 2012 Aug;8(8):e1002935. doi: 10.1371/journal.pgen.1002935. Epub 2012 Aug 23.

22.

Cohesin association to replication sites depends on rad50 and promotes fork restart.

Tittel-Elmer M, Lengronne A, Davidson MB, Bacal J, François P, Hohl M, Petrini JHJ, Pasero P, Cobb JA.

Mol Cell. 2012 Oct 12;48(1):98-108. doi: 10.1016/j.molcel.2012.07.004. Epub 2012 Aug 9.

23.

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.

Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK; ALT Starr Cancer Consortium.

PLoS Genet. 2012;8(7):e1002772. Epub 2012 Jul 19.

24.

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.

Foster SS, De S, Johnson LK, Petrini JH, Stracker TH.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9953-8. doi: 10.1073/pnas.1120476109. Epub 2012 Jun 5.

25.

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Hohl M, Kwon Y, Galván SM, Xue X, Tous C, Aguilera A, Sung P, Petrini JH.

Nat Struct Mol Biol. 2011 Sep 4;18(10):1124-31. doi: 10.1038/nsmb.2116.

26.

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.

Foster SS, Balestrini A, Petrini JH.

Mol Cell Biol. 2011 Nov;31(21):4379-89. doi: 10.1128/MCB.05854-11. Epub 2011 Aug 29.

27.

The MRE11 complex: starting from the ends.

Stracker TH, Petrini JH.

Nat Rev Mol Cell Biol. 2011 Feb;12(2):90-103. doi: 10.1038/nrm3047. Review.

28.

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.

Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC.

Cancer Cell. 2010 Dec 14;18(6):619-29. doi: 10.1016/j.ccr.2010.10.034.

29.

NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.

Brugmans L, Verkaik NS, Kunen M, van Drunen E, Williams BR, Petrini JH, Kanaar R, Essers J, van Gent DC.

DNA Repair (Amst). 2009 Dec 3;8(12):1363-70. doi: 10.1016/j.dnarep.2009.09.002. Epub 2009 Sep 25.

30.

The mre11 complex and the response to dysfunctional telomeres.

Attwooll CL, Akpinar M, Petrini JH.

Mol Cell Biol. 2009 Oct;29(20):5540-51. doi: 10.1128/MCB.00479-09. Epub 2009 Aug 10.

31.

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.

Halberg RB, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JH, Albertson DG, Dove WF.

Cancer Res. 2009 Jul 15;69(14):5768-75. doi: 10.1158/0008-5472.CAN-09-0446. Epub 2009 Jul 7.

32.

Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.

Stracker TH, Usui T, Petrini JH.

DNA Repair (Amst). 2009 Sep 2;8(9):1047-54. doi: 10.1016/j.dnarep.2009.04.012. Epub 2009 May 26. Review.

33.

Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.

Adelman CA, Petrini JH.

Cell Cycle. 2009 May 15;8(10):1510-4. Epub 2009 May 10.

34.

DNA replication reaches the breaking point.

Petrini JH.

Cell. 2009 Apr 17;137(2):211-2. doi: 10.1016/j.cell.2009.04.003.

35.

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

Deriano L, Stracker TH, Baker A, Petrini JH, Roth DB.

Mol Cell. 2009 Apr 10;34(1):13-25. doi: 10.1016/j.molcel.2009.03.009.

36.

Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.

Usui T, Foster SS, Petrini JH.

Mol Cell. 2009 Jan 30;33(2):147-59. doi: 10.1016/j.molcel.2008.12.022.

37.

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ.

Genes Dev. 2009 Jan 15;23(2):171-80. doi: 10.1101/gad.1746609.

38.
39.

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):503-14. doi: 10.1128/MCB.01354-08. Epub 2008 Nov 17.

40.

Rad50 is dispensable for the maintenance and viability of postmitotic tissues.

Adelman CA, De S, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):483-92. doi: 10.1128/MCB.01525-08. Epub 2008 Nov 10.

41.

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH.

Mol Cell. 2008 Jul 11;31(1):21-32. doi: 10.1016/j.molcel.2008.04.028. Erratum in: Mol Cell. 2008 Dec 26;32(6):889.

42.

DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.

Morales M, Liu Y, Laiakis EC, Morgan WF, Nimer SD, Petrini JH.

Cancer Res. 2008 Apr 1;68(7):2186-93. doi: 10.1158/0008-5472.CAN-07-2355.

43.

ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.

Adelman CA, Petrini JH.

PLoS Genet. 2008 Mar 28;4(3):e1000042. doi: 10.1371/journal.pgen.1000042.

44.

Functional interactions between Sae2 and the Mre11 complex.

Kim HS, Vijayakumar S, Reger M, Harrison JC, Haber JE, Weil C, Petrini JH.

Genetics. 2008 Feb;178(2):711-23. doi: 10.1534/genetics.107.081331. Epub 2008 Feb 1.

45.

Cell signaling. A touching response to damage.

Petrini JH.

Science. 2007 May 25;316(5828):1138-9. No abstract available.

PMID:
17525326
46.

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.

Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.

Nature. 2007 May 10;447(7141):218-21. Epub 2007 Apr 11.

47.

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.

Krishna S, Wagener BM, Liu HP, Lo YC, Sterk R, Petrini JH, Nickoloff JA.

DNA Repair (Amst). 2007 Jun 1;6(6):797-808. Epub 2007 Feb 26.

48.

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.

Usui T, Petrini JH.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2797-802. Epub 2007 Feb 13.

49.

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.

Cherry SM, Adelman CA, Theunissen JW, Hassold TJ, Hunt PA, Petrini JH.

Curr Biol. 2007 Feb 20;17(4):373-8. Epub 2007 Feb 8.

50.

Rad50S alleles of the Mre11 complex: questions answered and questions raised.

Usui T, Petrini JH, Morales M.

Exp Cell Res. 2006 Aug 15;312(14):2694-9. Epub 2006 Jun 20. Review.

PMID:
16857186

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