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Items: 1 to 50 of 99

1.

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.

Srivastava PK, Eyll JV, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, Mairet-Coello G, Cardenas A, Vanclef F, Laaniste L, Niespodziany I, Keaney J, Gasser J, Gillet G, Shkura K, Chong SA, Behmoaras J, Kadiu I, Petretto E, Kaminski RM, Johnson MR.

Nat Commun. 2018 Sep 3;9(1):3561. doi: 10.1038/s41467-018-06008-4.

2.

Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore.

Min ATL, Langley SR, Tan CF, Fang CJ, Khoo CM, Leow MK, Khoo EYH, Moreno Moral A, Pravenec M, Rotival M, Sadananthan SA, Velan SS, Venkataraman K, Chong YS, Lee YS, Xueling S, Stunkel W, Liu MH, Tai ES, Petretto E.

J Clin Endocrinol Metab. 2018 Aug 21. doi: 10.1210/jc.2018-00309. [Epub ahead of print]

PMID:
30137523
3.

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.

Cuartero S, Weiss FD, Dharmalingam G, Guo Y, Ing-Simmons E, Masella S, Robles-Rebollo I, Xiao X, Wang YF, Barozzi I, Djeghloul D, Amano MT, Niskanen H, Petretto E, Dowell RD, Tachibana K, Kaikkonen MU, Nasmyth KA, Lenhard B, Natoli G, Fisher AG, Merkenschlager M.

Nat Immunol. 2018 Sep;19(9):932-941. doi: 10.1038/s41590-018-0184-1. Epub 2018 Aug 20.

PMID:
30127433
4.

Universal effects of solvent species on the stabilized structure of a protein.

Hayashi T, Inoue M, Yasuda S, Petretto E, Škrbić T, Giacometti A, Kinoshita M.

J Chem Phys. 2018 Jul 28;149(4):045105. doi: 10.1063/1.5042111.

PMID:
30068177
5.

Common signalling pathways in macrophage and osteoclast multinucleation.

Pereira M, Petretto E, Gordon S, Bassett JHD, Williams GR, Behmoaras J.

J Cell Sci. 2018 Jun 5;131(11). pii: jcs216267. doi: 10.1242/jcs.216267. Review.

PMID:
29871956
6.

Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.

Olona A, Terra X, Ko JH, Grau-Bové C, Pinent M, Ardevol A, Diaz AG, Moreno-Moral A, Edin M, Bishop-Bailey D, Zeldin DC, Aitman TJ, Petretto E, Blay M, Behmoaras J.

Mol Metab. 2018 May;11:18-32. doi: 10.1016/j.molmet.2018.03.003. Epub 2018 Mar 9.

7.

Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice.

Sigmundsson K, Ojala JRM, Öhman MK, Österholm AM, Moreno-Moral A, Domogatskaya A, Chong LY, Sun Y, Chai X, Steele JAM, George B, Patarroyo M, Nilsson AS, Rodin S, Ghosh S, Stevens MM, Petretto E, Tryggvason K.

Matrix Biol. 2018 Sep;70:5-19. doi: 10.1016/j.matbio.2018.03.018. Epub 2018 Mar 27.

8.

Cell function in disease: there are more than two parties at play.

Behmoaras J, Petretto E.

Ann Rheum Dis. 2018 Mar 9. pii: annrheumdis-2018-213121. doi: 10.1136/annrheumdis-2018-213121. [Epub ahead of print] No abstract available.

9.

Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk.

Moreno-Moral A, Bagnati M, Koturan S, Ko JH, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, Petretto E.

Ann Rheum Dis. 2018 Apr;77(4):596-601. doi: 10.1136/annrheumdis-2017-212454. Epub 2018 Jan 17.

10.

Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.

Srivastava PK, Roncon P, Lukasiuk K, Gorter JA, Aronica E, Pitkänen A, Petretto E, Johnson MR, Simonato M.

eNeuro. 2017 Dec 28;4(6). pii: ENEURO.0152-17.2017. doi: 10.1523/ENEURO.0152-17.2017. eCollection 2017 Nov-Dec.

11.

Cell Type of Origin Dictates the Route to Pluripotency.

Nefzger CM, Rossello FJ, Chen J, Liu X, Knaupp AS, Firas J, Paynter JM, Pflueger J, Buckberry S, Lim SM, Williams B, Alaei S, Faye-Chauhan K, Petretto E, Nilsson SK, Lister R, Ramialison M, Powell DR, Rackham OJL, Polo JM.

Cell Rep. 2017 Dec 5;21(10):2649-2660. doi: 10.1016/j.celrep.2017.11.029.

12.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

13.

IL-11 is a crucial determinant of cardiovascular fibrosis.

Schafer S, Viswanathan S, Widjaja AA, Lim WW, Moreno-Moral A, DeLaughter DM, Ng B, Patone G, Chow K, Khin E, Tan J, Chothani SP, Ye L, Rackham OJL, Ko NSJ, Sahib NE, Pua CJ, Zhen NTG, Xie C, Wang M, Maatz H, Lim S, Saar K, Blachut S, Petretto E, Schmidt S, Putoczki T, Guimarães-Camboa N, Wakimoto H, van Heesch S, Sigmundsson K, Lim SL, Soon JL, Chao VTT, Chua YL, Tan TE, Evans SM, Loh YJ, Jamal MH, Ong KK, Chua KC, Ong BH, Chakaramakkil MJ, Seidman JG, Seidman CE, Hubner N, Sin KYK, Cook SA.

Nature. 2017 Dec 7;552(7683):110-115. doi: 10.1038/nature24676. Epub 2017 Nov 13.

14.

MWASTools: an R/bioconductor package for metabolome-wide association studies.

Rodriguez-Martinez A, Posma JM, Ayala R, Neves AL, Anwar M, Petretto E, Emanueli C, Gauguier D, Nicholson JK, Dumas ME.

Bioinformatics. 2018 Mar 1;34(5):890-892. doi: 10.1093/bioinformatics/btx477.

15.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N.

Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.

16.

An embryonic system to assess direct and indirect Wnt transcriptional targets.

Suresh J, Harmston N, Lim KK, Kaur P, Jin HJ, Lusk JB, Petretto E, Tolwinski NS.

Sci Rep. 2017 Sep 11;7(1):11092. doi: 10.1038/s41598-017-11519-z.

17.

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.

Krishnan ML, Van Steenwinckel J, Schang AL, Yan J, Arnadottir J, Le Charpentier T, Csaba Z, Dournaud P, Cipriani S, Auvynet C, Titomanlio L, Pansiot J, Ball G, Boardman JP, Walley AJ, Saxena A, Mirza G, Fleiss B, Edwards AD, Petretto E, Gressens P.

Nat Commun. 2017 Sep 5;8(1):428. doi: 10.1038/s41467-017-00422-w.

18.

Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.

Chen TD, Rotival M, Chiu LY, Bagnati M, Ko JH, Srivastava PK, Petretto E, Pusey CD, Lai PC, Aitman TJ, Cook HT, Behmoaras J.

Genetics. 2017 Jun;206(2):1139-1151. doi: 10.1534/genetics.116.197376. Epub 2017 Apr 26.

19.

Genome-wide analysis of differential RNA editing in epilepsy.

Srivastava PK, Bagnati M, Delahaye-Duriez A, Ko JH, Rotival M, Langley SR, Shkura K, Mazzuferi M, Danis B, van Eyll J, Foerch P, Behmoaras J, Kaminski RM, Petretto E, Johnson MR.

Genome Res. 2017 Mar;27(3):440-450. doi: 10.1101/gr.210740.116.

20.

A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation.

Rackham OJ, Langley SR, Oates T, Vradi E, Harmston N, Srivastava PK, Behmoaras J, Dellaportas P, Bottolo L, Petretto E.

Genetics. 2017 Apr;205(4):1443-1458. doi: 10.1534/genetics.116.195008. Epub 2017 Feb 17.

21.

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.

Beltrami C, Besnier M, Shantikumar S, Shearn AI, Rajakaruna C, Laftah A, Sessa F, Spinetti G, Petretto E, Angelini GD, Emanueli C.

Mol Ther. 2017 Mar 1;25(3):679-693. doi: 10.1016/j.ymthe.2016.12.022. Epub 2017 Feb 1.

22.

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.

McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM.

PLoS One. 2017 Feb 3;12(2):e0170458. doi: 10.1371/journal.pone.0170458. eCollection 2017.

23.

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat.

Coan PM, Hummel O, Garcia Diaz A, Barrier M, Alfazema N, Norsworthy PJ, Pravenec M, Petretto E, Hübner N, Aitman TJ.

Dis Model Mech. 2017 Mar 1;10(3):297-306. doi: 10.1242/dmm.026716. Epub 2017 Jan 26.

24.

The State of Systems Genetics in 2017.

Baliga NS, Björkegren JL, Boeke JD, Boutros M, Crawford NP, Dudley AM, Farber CR, Jones A, Levey AI, Lusis AJ, Mak HC, Nadeau JH, Noyes MB, Petretto E, Seyfried NT, Steinmetz LM, Vonesch SC.

Cell Syst. 2017 Jan 25;4(1):7-15. doi: 10.1016/j.cels.2017.01.005.

25.

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.

Delahaye-Duriez A, Srivastava P, Shkura K, Langley SR, Laaniste L, Moreno-Moral A, Danis B, Mazzuferi M, Foerch P, Gazina EV, Richards K, Petrou S, Kaminski RM, Petretto E, Johnson MR.

Genome Biol. 2016 Dec 13;17(1):245.

26.

Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.

Moreno-Moral A, Pesce F, Behmoaras J, Petretto E.

Methods Mol Biol. 2017;1488:337-362.

PMID:
27933533
27.

Expression QTLs Mapping and Analysis: A Bayesian Perspective.

Imprialou M, Petretto E, Bottolo L.

Methods Mol Biol. 2017;1488:189-215. Review.

PMID:
27933525
28.

Influence of shear stress magnitude and direction on atherosclerotic plaque composition.

Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E, Krams R.

R Soc Open Sci. 2016 Oct 19;3(10):160588. eCollection 2016 Oct.

29.

Computational methods for direct cell conversion.

Kamaraj US, Gough J, Polo JM, Petretto E, Rackham OJ.

Cell Cycle. 2016 Dec 16;15(24):3343-3354. doi: 10.1080/15384101.2016.1238119. Epub 2016 Oct 13. Review.

30.

From integrative genomics to systems genetics in the rat to link genotypes to phenotypes.

Moreno-Moral A, Petretto E.

Dis Model Mech. 2016 Oct 1;9(10):1097-1110. Review.

31.

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet.

Martínez-Micaelo N, González-Abuín N, Terra X, Ardévol A, Pinent M, Petretto E, Behmoaras J, Blay M.

Dis Model Mech. 2016 Oct 1;9(10):1231-1239. Epub 2016 Jul 13.

32.

Wars2 is a determinant of angiogenesis.

Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, Widjaja AA, Schafer S, Yusoff P, Choksi PK, Ko NS, Singh MK, Epstein D, Guan Y, Houštěk J, Mracek T, Nuskova H, Mikell B, Tan J, Pesce F, Kolar F, Bottolo L, Mancini M, Hubner N, Pravenec M, Petretto E, MacRae C, Cook SA.

Nat Commun. 2016 Jul 8;7:12061. doi: 10.1038/ncomms12061.

33.

A predictive computational framework for direct reprogramming between human cell types.

Rackham OJ, Firas J, Fang H, Oates ME, Holmes ML, Knaupp AS; FANTOM Consortium, Suzuki H, Nefzger CM, Daub CO, Shin JW, Petretto E, Forrest AR, Hayashizaki Y, Polo JM, Gough J.

Nat Genet. 2016 Mar;48(3):331-5. doi: 10.1038/ng.3487. Epub 2016 Jan 18.

PMID:
26780608
34.

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.

Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E.

Nat Neurosci. 2016 Feb;19(2):223-32. doi: 10.1038/nn.4205. Epub 2015 Dec 21.

35.

MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues.

Lewin A, Saadi H, Peters JE, Moreno-Moral A, Lee JC, Smith KG, Petretto E, Bottolo L, Richardson S.

Bioinformatics. 2016 Feb 15;32(4):523-32. doi: 10.1093/bioinformatics/btv568. Epub 2015 Oct 26.

36.

Web-based Gene Pathogenicity Analysis (WGPA): a web platform to interpret gene pathogenicity from personal genome data.

Diaz-Montana JJ, Rackham OJ, Diaz-Diaz N, Petretto E.

Bioinformatics. 2016 Feb 15;32(4):635-7. doi: 10.1093/bioinformatics/btv598. Epub 2015 Oct 21.

37.

Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet.

Martínez-Micaelo N, González-Abuín N, Ardévol A, Pinent M, Petretto E, Behmoaras J, Blay M.

J Mol Endocrinol. 2016 Jan;56(1):1-10. doi: 10.1530/JME-15-0089. Epub 2015 Oct 8.

PMID:
26450996
38.

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.

Roncon P, Soukupovà M, Binaschi A, Falcicchia C, Zucchini S, Ferracin M, Langley SR, Petretto E, Johnson MR, Marucci G, Michelucci R, Rubboli G, Simonato M.

Sci Rep. 2015 Sep 18;5:14143. doi: 10.1038/srep14143.

39.

Wnt addiction of genetically defined cancers reversed by PORCN inhibition.

Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, Keller TH, Lee MA, Matter A, Virshup DM.

Oncogene. 2016 Apr 28;35(17):2197-207. doi: 10.1038/onc.2015.280. Epub 2015 Aug 10.

40.

Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs.

Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WA, Dall'Ara G, Mattesini A, Bjørklund MM, Andersen NP, Grøndal AK, Petretto E, Foin N, Davies JE, Di Mario C, Fog Bentzon J, Erik Bøtker H, Falk E, Krams R, de Silva R.

Circulation. 2015 Sep 15;132(11):1003-12. doi: 10.1161/CIRCULATIONAHA.115.016270. Epub 2015 Jul 15.

41.

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.

Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knöll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, López-Olañeta MM, Gómez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schäfer S, Hübner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knöll R.

Circ Cardiovasc Genet. 2015 Oct;8(5):643-52. doi: 10.1161/CIRCGENETICS.113.000690. Epub 2015 Jul 14.

42.

Macrophage epoxygenase determines a profibrotic transcriptome signature.

Behmoaras J, Diaz AG, Venda L, Ko JH, Srivastava P, Montoya A, Faull P, Webster Z, Moyon B, Pusey CD, Abraham DJ, Petretto E, Cook TH, Aitman TJ.

J Immunol. 2015 May 15;194(10):4705-4716. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.

43.

WGBSSuite: simulating whole-genome bisulphite sequencing data and benchmarking differential DNA methylation analysis tools.

Rackham OJ, Dellaportas P, Petretto E, Bottolo L.

Bioinformatics. 2015 Jul 15;31(14):2371-3. doi: 10.1093/bioinformatics/btv114. Epub 2015 Mar 15.

44.

Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants.

Dominy KM, Roufosse C, de Kort H, Willicombe M, Brookes P, Behmoaras JV, Petretto EG, Galliford J, Choi P, Taube D, Cook HT, Mclean AG.

Transplantation. 2015 Sep;99(9):1981-8. doi: 10.1097/TP.0000000000000621.

45.

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.

Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O'Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E.

Nat Commun. 2015 Jan 23;6:6031. doi: 10.1038/ncomms7031.

46.

EvoTol: a protein-sequence based evolutionary intolerance framework for disease-gene prioritization.

Rackham OJ, Shihab HA, Johnson MR, Petretto E.

Nucleic Acids Res. 2015 Mar 11;43(5):e33. doi: 10.1093/nar/gku1322. Epub 2014 Dec 29.

47.

Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.

Rotival M, Ko JH, Srivastava PK, Kerloc'h A, Montoya A, Mauro C, Faull P, Cutillas PR, Petretto E, Behmoaras J.

Mol Cell Proteomics. 2015 Mar;14(3):484-98. doi: 10.1074/mcp.M114.043836. Epub 2014 Dec 22.

48.

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.

Johnson MD, Mueller M, Adamowicz-Brice M, Collins MJ, Gellert P, Maratou K, Srivastava PK, Rotival M, Butt S, Game L, Atanur SS, Silver N, Norsworthy PJ, Langley SR, Petretto E, Pravenec M, Aitman TJ.

PLoS Genet. 2014 Dec 4;10(12):e1004813. doi: 10.1371/journal.pgen.1004813. eCollection 2014 Dec.

49.

Unique regulatory properties of mesangial cells are genetically determined in the rat.

Lai PC, Chiu LY, Srivastava P, Trento C, Dazzi F, Petretto E, Cook HT, Behmoaras J.

PLoS One. 2014 Oct 24;9(10):e111452. doi: 10.1371/journal.pone.0111452. eCollection 2014.

50.

Genetic influences on brain gene expression in rats selected for tameness and aggression.

Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW.

Genetics. 2014 Nov;198(3):1277-90. doi: 10.1534/genetics.114.168948. Epub 2014 Sep 3.

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