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PRDM9 and Its Role in Genetic Recombination.

Paigen K, Petkov PM.

Trends Genet. 2018 Apr;34(4):291-300. doi: 10.1016/j.tig.2017.12.017. Epub 2018 Jan 21. Review.


PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.

Parvanov ED, Tian H, Billings T, Saxl RL, Spruce C, Aithal R, Krejci L, Paigen K, Petkov PM.

Mol Biol Cell. 2017 Feb 1;28(3):488-499. doi: 10.1091/mbc.E16-09-0686. Epub 2016 Dec 8.


The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo.

Powers NR, Parvanov ED, Baker CL, Walker M, Petkov PM, Paigen K.

PLoS Genet. 2016 Jun 30;12(6):e1006146. doi: 10.1371/journal.pgen.1006146. eCollection 2016 Jun.


Health and population effects of rare gene knockouts in adult humans with related parents.

Narasimhan VM, Hunt KA, Mason D, Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C, Bellary S, Bockett NA, Giorda K, Griffiths CJ, Hemingway H, Jia Z, Kelly MA, Khawaja HA, Lek M, McCarthy S, McEachan R, O'Donnell-Luria A, Paigen K, Parisinos CA, Sheridan E, Southgate L, Tee L, Thomas M, Xue Y, Schnall-Levin M, Petkov PM, Tyler-Smith C, Maher ER, Trembath RC, MacArthur DG, Wright J, Durbin R, van Heel DA.

Science. 2016 Apr 22;352(6284):474-7. doi: 10.1126/science.aac8624. Epub 2016 Mar 3.


Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.

Baker CL, Petkova P, Walker M, Flachs P, Mihola O, Trachtulec Z, Petkov PM, Paigen K.

PLoS Genet. 2015 Sep 14;11(9):e1005512. doi: 10.1371/journal.pgen.1005512. eCollection 2015 Sep.


Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage.

Walker M, Billings T, Baker CL, Powers N, Tian H, Saxl RL, Choi K, Hibbs MA, Carter GW, Handel MA, Paigen K, Petkov PM.

Epigenetics Chromatin. 2015 Sep 7;8:31. doi: 10.1186/s13072-015-0024-6. eCollection 2015.


Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis.

Sun F, Fujiwara Y, Reinholdt LG, Hu J, Saxl RL, Baker CL, Petkov PM, Paigen K, Handel MA.

Chromosoma. 2015 Sep;124(3):397-415. doi: 10.1007/s00412-015-0511-3. Epub 2015 Apr 18.


A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.


PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination.

Baker CL, Kajita S, Walker M, Saxl RL, Raghupathy N, Choi K, Petkov PM, Paigen K.

PLoS Genet. 2015 Jan 8;11(1):e1004916. doi: 10.1371/journal.pgen.1004916. eCollection 2015 Jan.


PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration.

Baker CL, Walker M, Kajita S, Petkov PM, Paigen K.

Genome Res. 2014 May;24(5):724-32. doi: 10.1101/gr.170167.113. Epub 2014 Mar 6.


DNA binding specificities of the long zinc-finger recombination protein PRDM9.

Billings T, Parvanov ED, Baker CL, Walker M, Paigen K, Petkov PM.

Genome Biol. 2013 Apr 24;14(4):R35. doi: 10.1186/gb-2013-14-4-r35.


Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.

Billings T, Sargent EE, Szatkiewicz JP, Leahy N, Kwak IY, Bektassova N, Walker M, Hassold T, Graber JH, Broman KW, Petkov PM.

PLoS One. 2010 Dec 8;5(12):e15340. doi: 10.1371/journal.pone.0015340.


Prdm9 controls activation of mammalian recombination hotspots.

Parvanov ED, Petkov PM, Paigen K.

Science. 2010 Feb 12;327(5967):835. doi: 10.1126/science.1181495. Epub 2009 Dec 31.


Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15.

Ng SH, Maas SA, Petkov PM, Mills KD, Paigen K.

Genes Chromosomes Cancer. 2009 Oct;48(10):925-30. doi: 10.1002/gcc.20693.


Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus.

Ng SH, Madeira R, Parvanov ED, Petros LM, Petkov PM, Paigen K.

BMC Mol Biol. 2009 May 13;10:43. doi: 10.1186/1471-2199-10-43.


Trans-regulation of mouse meiotic recombination hotspots by Rcr1.

Parvanov ED, Ng SH, Petkov PM, Paigen K.

PLoS Biol. 2009 Feb 17;7(2):e36. doi: 10.1371/journal.pbio.1000036.


A quantitative assay for crossover and noncrossover molecular events at individual recombination hotspots in both male and female gametes.

Ng SH, Parvanov E, Petkov PM, Paigen K.

Genomics. 2008 Oct;92(4):204-9. doi: 10.1016/j.ygeno.2008.06.008. Epub 2008 Aug 12.


The recombinational anatomy of a mouse chromosome.

Paigen K, Szatkiewicz JP, Sawyer K, Leahy N, Parvanov ED, Ng SH, Graber JH, Broman KW, Petkov PM.

PLoS Genet. 2008 Jul 11;4(7):e1000119. doi: 10.1371/journal.pgen.1000119.


Crossover interference underlies sex differences in recombination rates.

Petkov PM, Broman KW, Szatkiewicz JP, Paigen K.

Trends Genet. 2007 Nov;23(11):539-42. Epub 2007 Oct 26.


Evidence of a large-scale functional organization of Mammalian chromosomes.

Petkov PM, Graber JH, Churchill GA, DiPetrillo K, King BL, Paigen K.

PLoS Biol. 2007 May;5(5):e127; author reply e128. No abstract available.

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