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Items: 37


Histone methyltransferase PRDM9 is not essential for meiosis in male mice.

Mihola O, Pratto F, Brick K, Linhartova E, Kobets T, Flachs P, Baker CL, Sedlacek R, Paigen K, Petkov PM, Camerini-Otero RD, Trachtulec Z.

Genome Res. 2019 Jun 11. pii: gr.244426.118. doi: 10.1101/gr.244426.118. [Epub ahead of print]


Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.

Bhattacharyya T, Walker M, Powers NR, Brunton C, Fine AD, Petkov PM, Handel MA.

Curr Biol. 2019 Mar 18;29(6):1002-1018.e7. doi: 10.1016/j.cub.2019.02.007. Epub 2019 Mar 7.


Tissue-Specific Trans Regulation of the Mouse Epigenome.

Baker CL, Walker M, Arat S, Ananda G, Petkova P, Powers NR, Tian H, Spruce C, Ji B, Rausch D, Choi K, Petkov PM, Carter GW, Paigen K.

Genetics. 2019 Mar;211(3):831-845. doi: 10.1534/genetics.118.301697. Epub 2018 Dec 28.


CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse.

Tian H, Billings T, Petkov PM.

PLoS Genet. 2018 Oct 26;14(10):e1007657. doi: 10.1371/journal.pgen.1007657. eCollection 2018 Oct.


PRDM9 and Its Role in Genetic Recombination.

Paigen K, Petkov PM.

Trends Genet. 2018 Apr;34(4):291-300. doi: 10.1016/j.tig.2017.12.017. Epub 2018 Jan 21. Review.


PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.

Parvanov ED, Tian H, Billings T, Saxl RL, Spruce C, Aithal R, Krejci L, Paigen K, Petkov PM.

Mol Biol Cell. 2017 Feb 1;28(3):488-499. doi: 10.1091/mbc.E16-09-0686. Epub 2016 Dec 8.


The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo.

Powers NR, Parvanov ED, Baker CL, Walker M, Petkov PM, Paigen K.

PLoS Genet. 2016 Jun 30;12(6):e1006146. doi: 10.1371/journal.pgen.1006146. eCollection 2016 Jun.


Health and population effects of rare gene knockouts in adult humans with related parents.

Narasimhan VM, Hunt KA, Mason D, Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C, Bellary S, Bockett NA, Giorda K, Griffiths CJ, Hemingway H, Jia Z, Kelly MA, Khawaja HA, Lek M, McCarthy S, McEachan R, O'Donnell-Luria A, Paigen K, Parisinos CA, Sheridan E, Southgate L, Tee L, Thomas M, Xue Y, Schnall-Levin M, Petkov PM, Tyler-Smith C, Maher ER, Trembath RC, MacArthur DG, Wright J, Durbin R, van Heel DA.

Science. 2016 Apr 22;352(6284):474-7. doi: 10.1126/science.aac8624. Epub 2016 Mar 3.


Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.

Baker CL, Petkova P, Walker M, Flachs P, Mihola O, Trachtulec Z, Petkov PM, Paigen K.

PLoS Genet. 2015 Sep 14;11(9):e1005512. doi: 10.1371/journal.pgen.1005512. eCollection 2015 Sep.


Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage.

Walker M, Billings T, Baker CL, Powers N, Tian H, Saxl RL, Choi K, Hibbs MA, Carter GW, Handel MA, Paigen K, Petkov PM.

Epigenetics Chromatin. 2015 Sep 7;8:31. doi: 10.1186/s13072-015-0024-6. eCollection 2015.


Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis.

Sun F, Fujiwara Y, Reinholdt LG, Hu J, Saxl RL, Baker CL, Petkov PM, Paigen K, Handel MA.

Chromosoma. 2015 Sep;124(3):397-415. doi: 10.1007/s00412-015-0511-3. Epub 2015 Apr 18.


A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.


PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination.

Baker CL, Kajita S, Walker M, Saxl RL, Raghupathy N, Choi K, Petkov PM, Paigen K.

PLoS Genet. 2015 Jan 8;11(1):e1004916. doi: 10.1371/journal.pgen.1004916. eCollection 2015 Jan.


PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration.

Baker CL, Walker M, Kajita S, Petkov PM, Paigen K.

Genome Res. 2014 May;24(5):724-32. doi: 10.1101/gr.170167.113. Epub 2014 Mar 6.


DNA binding specificities of the long zinc-finger recombination protein PRDM9.

Billings T, Parvanov ED, Baker CL, Walker M, Paigen K, Petkov PM.

Genome Biol. 2013 Apr 24;14(4):R35. doi: 10.1186/gb-2013-14-4-r35.


Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.

Billings T, Sargent EE, Szatkiewicz JP, Leahy N, Kwak IY, Bektassova N, Walker M, Hassold T, Graber JH, Broman KW, Petkov PM.

PLoS One. 2010 Dec 8;5(12):e15340. doi: 10.1371/journal.pone.0015340.


Prdm9 controls activation of mammalian recombination hotspots.

Parvanov ED, Petkov PM, Paigen K.

Science. 2010 Feb 12;327(5967):835. doi: 10.1126/science.1181495. Epub 2009 Dec 31.


Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15.

Ng SH, Maas SA, Petkov PM, Mills KD, Paigen K.

Genes Chromosomes Cancer. 2009 Oct;48(10):925-30. doi: 10.1002/gcc.20693.


Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus.

Ng SH, Madeira R, Parvanov ED, Petros LM, Petkov PM, Paigen K.

BMC Mol Biol. 2009 May 13;10:43. doi: 10.1186/1471-2199-10-43.


Trans-regulation of mouse meiotic recombination hotspots by Rcr1.

Parvanov ED, Ng SH, Petkov PM, Paigen K.

PLoS Biol. 2009 Feb 17;7(2):e36. doi: 10.1371/journal.pbio.1000036.


A quantitative assay for crossover and noncrossover molecular events at individual recombination hotspots in both male and female gametes.

Ng SH, Parvanov E, Petkov PM, Paigen K.

Genomics. 2008 Oct;92(4):204-9. doi: 10.1016/j.ygeno.2008.06.008. Epub 2008 Aug 12.


The recombinational anatomy of a mouse chromosome.

Paigen K, Szatkiewicz JP, Sawyer K, Leahy N, Parvanov ED, Ng SH, Graber JH, Broman KW, Petkov PM.

PLoS Genet. 2008 Jul 11;4(7):e1000119. doi: 10.1371/journal.pgen.1000119.


Crossover interference underlies sex differences in recombination rates.

Petkov PM, Broman KW, Szatkiewicz JP, Paigen K.

Trends Genet. 2007 Nov;23(11):539-42. Epub 2007 Oct 26.


Evidence of a large-scale functional organization of Mammalian chromosomes.

Petkov PM, Graber JH, Churchill GA, DiPetrillo K, King BL, Paigen K.

PLoS Biol. 2007 May;5(5):e127; author reply e128. No abstract available.


Patterns and mechanisms of genome organization in the mouse.

Graber JH, Churchill GA, Dipetrillo KJ, King BL, Petkov PM, Paigen K.

J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):683-8. Review.


Expression and localization of PCSK9 in rat hepatic cells.

Grozdanov PN, Petkov PM, Karagyozov LK, Dabeva MD.

Biochem Cell Biol. 2006 Feb;84(1):80-92.


Evidence of a large-scale functional organization of mammalian chromosomes.

Petkov PM, Graber JH, Churchill GA, DiPetrillo K, King BL, Paigen K.

PLoS Genet. 2005 Sep;1(3):e33.


An efficient SNP system for mouse genome scanning and elucidating strain relationships.

Petkov PM, Ding Y, Cassell MA, Zhang W, Wagner G, Sargent EE, Asquith S, Crew V, Johnson KA, Robinson P, Scott VE, Wiles MV.

Genome Res. 2004 Sep;14(9):1806-11.


Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.

Petkov PM, Cassell MA, Sargent EE, Donnelly CJ, Robinson P, Crew V, Asquith S, Haar RV, Wiles MV.

Genomics. 2004 May;83(5):902-11.


Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays.

Petkov PM, Zavadil J, Goetz D, Chu T, Carver R, Rogler CE, Bottinger EP, Shafritz DA, Dabeva MD.

Hepatology. 2004 Mar;39(3):617-27.


Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells.

Sandhu JS, Petkov PM, Dabeva MD, Shafritz DA.

Am J Pathol. 2001 Oct;159(4):1323-34.


Identification of differentially expressed genes in epithelial stem/progenitor cells of fetal rat liver.

Petkov PM, Kim K, Sandhu J, Shafritz DA, Dabeva MD.

Genomics. 2000 Sep 1;68(2):197-209.


Proliferation and differentiation of fetal liver epithelial progenitor cells after transplantation into adult rat liver.

Dabeva MD, Petkov PM, Sandhu J, Oren R, Laconi E, Hurston E, Shafritz DA.

Am J Pathol. 2000 Jun;156(6):2017-31.


Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes.

Oren R, Dabeva MD, Karnezis AN, Petkov PM, Rosencrantz R, Sandhu JP, Moss SF, Wang S, Hurston E, Laconi E, Holt PR, Thung SN, Zhu L, Shafritz DA.

Hepatology. 1999 Oct;30(4):903-13.


Liver regeneration and alpha-fetoprotein messenger RNA expression in the retrorsine model for hepatocyte transplantation.

Dabeva MD, Laconi E, Oren R, Petkov PM, Hurston E, Shafritz DA.

Cancer Res. 1998 Dec 15;58(24):5825-34.


Restoration of serum albumin levels in nagase analbuminemic rats by hepatocyte transplantation.

Oren R, Dabeva MD, Petkov PM, Hurston E, Laconi E, Shafritz DA.

Hepatology. 1999 Jan;29(1):75-81.


Purification and characterization of diaphorases from some Drosophila species.

Ralchev KH, Petkov PM, Dunkov BH.

Biochem Genet. 1992 Jun;30(5-6):305-15.


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