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ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.

Bertran MT, Mouilleron S, Zhou Y, Bajaj R, Uliana F, Kumar GS, van Drogen A, Lee R, Banerjee JJ, Hauri S, O'Reilly N, Gstaiger M, Page R, Peti W, Tapon N.

Nat Commun. 2019 Feb 15;10(1):771. doi: 10.1038/s41467-019-08686-0.


Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.

Heroes E, Van der Hoeven G, Choy MS, Garcia JDP, Ferreira M, Nys M, Derua R, Beullens M, Ulens C, Peti W, Van Meervelt L, Page R, Bollen M.

Structure. 2019 Mar 5;27(3):507-518.e5. doi: 10.1016/j.str.2018.12.002. Epub 2019 Jan 17.


Preparation of Phosphorylated Proteins for NMR Spectroscopy.

Kumar GS, Page R, Peti W.

Methods Enzymol. 2019;614:187-205. doi: 10.1016/bs.mie.2018.07.004. Epub 2018 Sep 5.


The structure of SDS22 provides insights into the mechanism of heterodimer formation with PP1.

Choy MS, Bolik-Coulon N, Archuleta TL, Peti W, Page R.

Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):817-824. doi: 10.1107/S2053230X18016503. Epub 2018 Nov 30.


Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.

Kumar GS, Choy MS, Koveal DM, Lorinsky MK, Lyons SP, Kettenbach AN, Page R, Peti W.

Sci Adv. 2018 Nov 14;4(11):eaau6044. doi: 10.1126/sciadv.aau6044. eCollection 2018 Nov.


The structures of penicillin-binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance.

Moon TM, D'Andréa ÉD, Lee CW, Soares A, Jakoncic J, Desbonnet C, Garcia-Solache M, Rice LB, Page R, Peti W.

J Biol Chem. 2018 Nov 30;293(48):18574-18584. doi: 10.1074/jbc.RA118.006052. Epub 2018 Oct 24.


A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.

Lyons SP, Jenkins NP, Nasa I, Choy MS, Adamo ME, Page R, Peti W, Moorhead GB, Kettenbach AN.

Mol Cell Proteomics. 2018 Dec;17(12):2448-2461. doi: 10.1074/mcp.RA118.000822. Epub 2018 Sep 18.


KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.

Bajaj R, Bollen M, Peti W, Page R.

Structure. 2018 Oct 2;26(10):1327-1336.e4. doi: 10.1016/j.str.2018.06.013. Epub 2018 Aug 9.


Dynamic activation and regulation of the mitogen-activated protein kinase p38.

Kumar GS, Clarkson MW, Kunze MBA, Granata D, Wand AJ, Lindorff-Larsen K, Page R, Peti W.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4655-4660. doi: 10.1073/pnas.1721441115. Epub 2018 Apr 16.


A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.

Crespillo-Casado A, Claes Z, Choy MS, Peti W, Bollen M, Ron D.

J Biol Chem. 2018 May 18;293(20):7766-7776. doi: 10.1074/jbc.RA118.002325. Epub 2018 Apr 4.


Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in Enterococcus faecalis.

Rice LB, Desbonnet C, Tait-Kamradt A, Garcia-Solache M, Lonks J, Moon TM, D'Andréa ÉD, Page R, Peti W.

MBio. 2018 Apr 3;9(2). pii: e00361-18. doi: 10.1128/mBio.00361-18.


A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor.

Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK.

Nucleic Acids Res. 2018 Feb 16;46(3):1501-1512. doi: 10.1093/nar/gkx1234.


Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome.

Machado LESF, Critton DA, Page R, Peti W.

ACS Omega. 2017 Nov 30;2(11):8313-8318. doi: 10.1021/acsomega.7b01318. Epub 2017 Nov 27.


PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.

Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W.

J Am Chem Soc. 2017 Dec 13;139(49):17703-17706. doi: 10.1021/jacs.7b09368. Epub 2017 Nov 28.


Structures of Dynamic Protein Complexes: Hybrid Techniques to Study MAP Kinase Complexes and the ESCRT System.

Peti W, Page R, Boura E, Różycki B.

Methods Mol Biol. 2018;1688:375-389. doi: 10.1007/978-1-4939-7386-6_17.


1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase.

Machado LESF, Page R, Peti W.

Biomol NMR Assign. 2018 Apr;12(1):5-9. doi: 10.1007/s12104-017-9770-7. Epub 2017 Aug 30.


The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation.

Machado LESF, Shen TL, Page R, Peti W.

J Biol Chem. 2017 May 26;292(21):8786-8796. doi: 10.1074/jbc.M116.774174. Epub 2017 Apr 7.


Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.

Choy MS, Li Y, Machado LESF, Kunze MBA, Connors CR, Wei X, Lindorff-Larsen K, Page R, Peti W.

Mol Cell. 2017 Feb 16;65(4):644-658.e5. doi: 10.1016/j.molcel.2017.01.014.


Expanding the PP2A Interactome by Defining a B56-Specific SLiM.

Wang X, Bajaj R, Bollen M, Peti W, Page R.

Structure. 2016 Dec 6;24(12):2174-2181. doi: 10.1016/j.str.2016.09.010. Epub 2016 Oct 27.


Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.

Sheftic SR, Page R, Peti W.

Sci Rep. 2016 Dec 15;6:38920. doi: 10.1038/srep38920.


Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.

Chen E, Choy MS, Petrényi K, Kónya Z, Erdődi F, Dombrádi V, Peti W, Page R.

MBio. 2016 Aug 30;7(4). pii: e00872-16. doi: 10.1128/mBio.00872-16.


The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.

Kumar GS, Gokhan E, De Munter S, Bollen M, Vagnarelli P, Peti W, Page R.

Elife. 2016 Aug 30;5. pii: e16539. doi: 10.7554/eLife.16539.


NMR Spectroscopy to Study MAP Kinase Binding to MAP Kinase Phosphatases.

Peti W, Page R.

Methods Mol Biol. 2016;1447:181-96. doi: 10.1007/978-1-4939-3746-2_11.


Toxin-antitoxin systems in bacterial growth arrest and persistence.

Page R, Peti W.

Nat Chem Biol. 2016 Apr;12(4):208-14. doi: 10.1038/nchembio.2044. Review.


PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, Van Aelst L, Shea SD, Tonks NK.

J Clin Invest. 2015 Aug 3;125(8):3163-77. doi: 10.1172/JCI80323. Epub 2015 Jul 27.


Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

Choy MS, Yusoff P, Lee IC, Newton JC, Goh CW, Page R, Shenolikar S, Peti W.

Cell Rep. 2015 Jun 30;11(12):1885-91. doi: 10.1016/j.celrep.2015.05.043. Epub 2015 Jun 18.


The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress.

Kwan BW, Lord DM, Peti W, Page R, Benedik MJ, Wood TK.

Environ Microbiol. 2015 Sep;17(9):3168-81. doi: 10.1111/1462-2920.12749. Epub 2015 Feb 14.


McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation.

Lord DM, Uzgoren Baran A, Soo VW, Wood TK, Peti W, Page R.

Biochemistry. 2014 Nov 25;53(46):7223-31. doi: 10.1021/bi500871a. Epub 2014 Nov 7.


BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH.

Lord DM, Baran AU, Wood TK, Peti W, Page R.

PLoS One. 2014 Sep 22;9(9):e105751. doi: 10.1371/journal.pone.0105751. eCollection 2014.


Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.

Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK.

Nat Chem Biol. 2014 Jul;10(7):558-66. doi: 10.1038/nchembio.1528. Epub 2014 May 20.


Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2.

Francis DM, Koveal D, Tortajada A, Page R, Peti W.

PLoS One. 2014 Mar 17;9(3):e91934. doi: 10.1371/journal.pone.0091934. eCollection 2014.


Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.

Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4097-102. doi: 10.1073/pnas.1317395111. Epub 2014 Mar 3.


Enzyme mechanisms: What's up 'Doc'?

Peti W, Page R.

Nat Chem Biol. 2013 Dec;9(12):756-7. doi: 10.1038/nchembio.1379. Epub 2013 Oct 20. No abstract available. Erratum in: Nat Chem Biol. 2014 Feb;10(2):164.


Molecular basis of MAP kinase regulation.

Peti W, Page R.

Protein Sci. 2013 Dec;22(12):1698-710. doi: 10.1002/pro.2374. Epub 2013 Oct 19. Review.


The differential regulation of p38α by the neuronal kinase interaction motif protein tyrosine phosphatases, a detailed molecular study.

Francis DM, Kumar GS, Koveal D, Tortajada A, Page R, Peti W.

Structure. 2013 Sep 3;21(9):1612-23. doi: 10.1016/j.str.2013.07.003. Epub 2013 Aug 8.


Structural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solution.

Kumar GS, Zettl H, Page R, Peti W.

J Biol Chem. 2013 Sep 27;288(39):28347-56. doi: 10.1074/jbc.M113.499178. Epub 2013 Aug 7.


Sequence-specific backbone ¹H, ¹³C and ¹⁵N assignments of the 34 kDa catalytic domain of PTPN5 (STEP).

Francis DM, Page R, Peti W.

Biomol NMR Assign. 2014 Apr;8(1):185-8. doi: 10.1007/s12104-013-9480-8. Epub 2013 May 3.


Ligand binding reduces conformational flexibility in the active site of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonasaeruginosa.

Koveal D, Clarkson MW, Wood TK, Page R, Peti W.

J Mol Biol. 2013 Jun 26;425(12):2219-31. doi: 10.1016/j.jmb.2013.03.023. Epub 2013 Mar 21.


The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

Grigoriu S, Bond R, Cossio P, Chen JA, Ly N, Hummer G, Page R, Cyert MS, Peti W.

PLoS Biol. 2013;11(2):e1001492. doi: 10.1371/journal.pbio.1001492. Epub 2013 Feb 26.


Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS.

Wang X, Lord DM, Hong SH, Peti W, Benedik MJ, Page R, Wood TK.

Environ Microbiol. 2013 Jun;15(6):1734-44. doi: 10.1111/1462-2920.12063. Epub 2013 Jan 4.


A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane.

Koveal D, Schuh-Nuhfer N, Ritt D, Page R, Morrison DK, Peti W.

Sci Signal. 2012 Dec 18;5(255):ra94. doi: 10.1126/scisignal.2003289.


NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes.

Minnebo N, Görnemann J, O'Connell N, Van Dessel N, Derua R, Vermunt MW, Page R, Beullens M, Peti W, Van Eynde A, Bollen M.

Nucleic Acids Res. 2013 Jan;41(2):842-54. doi: 10.1093/nar/gks1255. Epub 2012 Dec 13.


The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter.

Brown BL, Lord DM, Grigoriu S, Peti W, Page R.

J Biol Chem. 2013 Jan 11;288(2):1286-94. doi: 10.1074/jbc.M112.421008. Epub 2012 Nov 21.


Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38α.

Piserchio A, Francis DM, Koveal D, Dalby KN, Page R, Peti W, Ghose R.

Biochemistry. 2012 Oct 16;51(41):8047-9. doi: 10.1021/bi3012725. Epub 2012 Oct 5.


Regulation of protein phosphatase 1 by intrinsically disordered proteins.

Choy MS, Page R, Peti W.

Biochem Soc Trans. 2012 Oct;40(5):969-74. Review.


A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS.

Wang X, Lord DM, Cheng HY, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R, Wood TK.

Nat Chem Biol. 2012 Oct;8(10):855-61.


The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.

O'Connell N, Nichols SR, Heroes E, Beullens M, Bollen M, Peti W, Page R.

Structure. 2012 Oct 10;20(10):1746-56. doi: 10.1016/j.str.2012.08.003. Epub 2012 Aug 30.


Structural and functional analysis of the NLRP4 pyrin domain.

Eibl C, Grigoriu S, Hessenberger M, Wenger J, Puehringer S, Pinheiro AS, Wagner RN, Proell M, Reed JC, Page R, Diederichs K, Peti W.

Biochemistry. 2012 Sep 18;51(37):7330-41. doi: 10.1021/bi3007059. Epub 2012 Sep 6.


Folding of Intrinsically Disordered Protein Phosphatase 1 Regulatory Proteins.

Peti W, Nairn AC, Page R.

Curr Phys Chem. 2012 Jan;2(1):107-114.

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