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Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model.

Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Taracido IC, Johns DG, Beerens M, MacRae CA, Caldwell J, Sorota S, Asnani A, Peterson RT.

Chembiochem. 2020 Jan 30. doi: 10.1002/cbic.201900741. [Epub ahead of print]


Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish.

Nath AK, Ma J, Chen ZZ, Li Z, Vitery MDC, Kelley ML, Peterson RT, Gerszten RE, Yeh JJ.

FASEB J. 2020 Jan;34(1):1546-1557. doi: 10.1096/fj.201901466R. Epub 2019 Dec 2.


Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish.

Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT.

Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z.


Use of Zebrafish in Drug Discovery Toxicology.

Cassar S, Adatto I, Freeman JL, Gamse JT, Iturria I, Lawrence C, Muriana A, Peterson RT, Van Cruchten S, Zon LI.

Chem Res Toxicol. 2020 Jan 21;33(1):95-118. doi: 10.1021/acs.chemrestox.9b00335. Epub 2019 Nov 16.


Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.

McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D.

Nat Commun. 2019 Sep 9;10(1):4078. doi: 10.1038/s41467-019-11936-w.


The zebrafish subcortical social brain as a model for studying social behavior disorders.

Geng Y, Peterson RT.

Dis Model Mech. 2019 Aug 6;12(8). pii: dmm039446. doi: 10.1242/dmm.039446. Review.


Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.

Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK.

FASEB Bioadv. 2019 Feb;1(2):81-92. doi: 10.1096/fba.1024. Epub 2018 Oct 8.


Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles.

Tu J, Svatunek D, Parvez S, Liu AC, Levandowski BJ, Eckvahl HJ, Peterson RT, Houk KN, Franzini RM.

Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9043-9048. doi: 10.1002/anie.201903877. Epub 2019 Jun 6.


Developing zebrafish disease models for in vivo small molecule screens.

Lam PY, Peterson RT.

Curr Opin Chem Biol. 2019 Jun;50:37-44. doi: 10.1016/j.cbpa.2019.02.005. Epub 2019 Mar 28. Review.


5-Nitrofurans and Cancer: Teaching an Old Drug New Tricks.

Peterson RT.

Cell Chem Biol. 2018 Dec 20;25(12):1439-1440. doi: 10.1016/j.chembiol.2018.12.005.


High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy.

Jordi J, Guggiana-Nilo D, Bolton AD, Prabha S, Ballotti K, Herrera K, Rennekamp AJ, Peterson RT, Lutz TA, Engert F.

Sci Adv. 2018 Oct 31;4(10):eaav1966. doi: 10.1126/sciadv.aav1966. eCollection 2018 Oct.


Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells.

Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT.

Nat Chem Biol. 2018 Sep;14(9):844-852. doi: 10.1038/s41589-018-0098-0. Epub 2018 Jul 9.


Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo.

Tu J, Xu M, Parvez S, Peterson RT, Franzini RM.

J Am Chem Soc. 2018 Jul 11;140(27):8410-8414. doi: 10.1021/jacs.8b05093. Epub 2018 Jun 27.


Small Molecule Inhibitors of NFkB Reverse Iron Overload and Hepcidin Deregulation in a Zebrafish Model for Hereditary Hemochromatosis Type 3.

Basu S, Jalodia K, Ranjan S, Yeh JJ, Peterson RT, Sachidanandan C.

ACS Chem Biol. 2018 Aug 17;13(8):2143-2152. doi: 10.1021/acschembio.8b00317. Epub 2018 Jun 28.


Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA.

PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018.


Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.

Asnani A, Zheng B, Liu Y, Wang Y, Chen HH, Vohra A, Chi A, Cornella-Taracido I, Wang H, Johns DG, Sosnovik DE, Peterson RT.

JCI Insight. 2018 Jan 11;3(1). pii: 96753. doi: 10.1172/jci.insight.96753. eCollection 2018 Jan 11.


Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.

O'Sullivan JF, Morningstar JE, Yang Q, Zheng B, Gao Y, Jeanfavre S, Scott J, Fernandez C, Zheng H, O'Connor S, Cohen P, Vasan RS, Long MT, Wilson JG, Melander O, Wang TJ, Fox C, Peterson RT, Clish CB, Corey KE, Gerszten RE.

J Clin Invest. 2017 Dec 1;127(12):4394-4402. doi: 10.1172/JCI95995. Epub 2017 Oct 30.


A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.

Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT.

Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z.


Development of an opioid self-administration assay to study drug seeking in zebrafish.

Bossé GD, Peterson RT.

Behav Brain Res. 2017 Sep 29;335:158-166. doi: 10.1016/j.bbr.2017.08.001. Epub 2017 Aug 12.


Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp.

Wu G, Nielson JR, Peterson RT, Winter JM.

Mar Drugs. 2017 Jun 24;15(7). pii: E195. doi: 10.3390/md15070195.


Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis.

Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE.

JCI Insight. 2017 May 4;2(9). pii: 92989. doi: 10.1172/jci.insight.92989. eCollection 2017 May 4.


Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT.

Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13.


A countermeasure development pipeline.

MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT.

Ann N Y Acad Sci. 2016 Aug;1378(1):58-67. doi: 10.1111/nyas.13224. Review.


Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.

Noonan HR, Metelo AM, Kamei CN, Peterson RT, Drummond IA, Iliopoulos O.

Dis Model Mech. 2016 Aug 1;9(8):873-84. doi: 10.1242/dmm.024380.


Chemical Screening in Zebrafish.

Brady CA, Rennekamp AJ, Peterson RT.

Methods Mol Biol. 2016;1451:3-16. doi: 10.1007/978-1-4939-3771-4_1.


σ1 receptor ligands control a switch between passive and active threat responses.

Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT.

Nat Chem Biol. 2016 Jul;12(7):552-8. doi: 10.1038/nchembio.2089. Epub 2016 May 30.


Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D.

Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30.


Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.

Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, Bloch KD, Bloch DB, Peterson RT.

J Clin Invest. 2016 Jan;126(1):389-401. doi: 10.1172/JCI83831. Epub 2015 Dec 14.


A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.

Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ.

Cell Rep. 2015 Dec 1;13(9):2027-36. doi: 10.1016/j.celrep.2015.10.042. Epub 2015 Nov 19.


Zebrafish as tools for drug discovery.

MacRae CA, Peterson RT.

Nat Rev Drug Discov. 2015 Oct;14(10):721-31. doi: 10.1038/nrd4627. Epub 2015 Sep 11. Review.


Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK.

Nature. 2015 Jul 23;523(7561):481-5. doi: 10.1038/nature14592. Epub 2015 Jun 22.


Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.

Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL.

Chem Biol. 2015 Jun 18;22(6):764-75. doi: 10.1016/j.chembiol.2015.05.012.


Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model.

Metelo AM, Noonan HR, Li X, Jin Y, Baker R, Kamentsky L, Zhang Y, van Rooijen E, Shin J, Carpenter AE, Yeh JR, Peterson RT, Iliopoulos O.

J Clin Invest. 2015 May;125(5):1987-97. doi: 10.1172/JCI73665. Epub 2015 Apr 13.


PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.

Nath AK, Ryu JH, Jin YN, Roberts LD, Dejam A, Gerszten RE, Peterson RT.

Cell Rep. 2015 Feb 10;10(5):694-701. doi: 10.1016/j.celrep.2015.01.010. Epub 2015 Feb 5.


Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.

Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT.

Sci Transl Med. 2014 Dec 10;6(266):266ra170. doi: 10.1126/scitranslmed.3010189.


15 years of zebrafish chemical screening.

Rennekamp AJ, Peterson RT.

Curr Opin Chem Biol. 2015 Feb;24:58-70. doi: 10.1016/j.cbpa.2014.10.025. Epub 2014 Nov 15.


Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation.

van Ham TJ, Brady CA, Kalicharan RD, Oosterhof N, Kuipers J, Veenstra-Algra A, Sjollema KA, Peterson RT, Kampinga HH, Giepmans BN.

Dis Model Mech. 2014 Jul;7(7):857-69. doi: 10.1242/dmm.014886.


The zebrafish as a tool to identify novel therapies for human cardiovascular disease.

Asnani A, Peterson RT.

Dis Model Mech. 2014 Jul;7(7):763-7. doi: 10.1242/dmm.016170. Review.


Methods for targeted mutagenesis in zebrafish using TALENs.

Hwang WY, Peterson RT, Yeh JR.

Methods. 2014 Aug 15;69(1):76-84. doi: 10.1016/j.ymeth.2014.04.009. Epub 2014 Apr 18.


Zebrafish models of cerebrovascular disease.

Walcott BP, Peterson RT.

J Cereb Blood Flow Metab. 2014 Apr;34(4):571-7. doi: 10.1038/jcbfm.2014.27. Epub 2014 Feb 12. Review.


The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.

Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AU.

Blood. 2014 Apr 3;123(14):2261-8. doi: 10.1182/blood-2013-02-480095. Epub 2014 Feb 5.



Ishaq O, Negri J, Bray MA, Pacureanu A, Peterson RT, Wählby C.

Proc IEEE Int Symp Biomed Imaging. 2013:902-905.


A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.

Burger A, Vasilyev A, Tomar R, Selig MK, Nielsen GP, Peterson RT, Drummond IA, Haber DA.

Dis Model Mech. 2014 Jul;7(7):907-13. doi: 10.1242/dmm.013128. Epub 2013 Dec 5.


Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.

Peterson RT, Macrae CA.

Drug Discov Today Dis Models. 2013 Spring;10(1). doi: 10.1016/j.ddmod.2013.05.001.


Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions.

Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2258. No abstract available.


Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.

Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK.

J Natl Cancer Inst. 2013 Aug 21;105(16):1188-201. doi: 10.1093/jnci/djt164. Epub 2013 Jul 30. Erratum in: J Natl Cancer Inst. 2013 Nov 20;105(22):1762.


Heritable and precise zebrafish genome editing using a CRISPR-Cas system.

Hwang WY, Fu Y, Reyon D, Maeder ML, Kaini P, Sander JD, Joung JK, Peterson RT, Yeh JR.

PLoS One. 2013 Jul 9;8(7):e68708. doi: 10.1371/journal.pone.0068708. Print 2013.


AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway.

Zhang Y, Wang J, Wheat J, Chen X, Jin S, Sadrzadeh H, Fathi AT, Peterson RT, Kung AL, Sweetser DA, Yeh JR.

Blood. 2013 Jun 13;121(24):4906-16. doi: 10.1182/blood-2012-08-447763. Epub 2013 May 3.


From phenotype to mechanism after zebrafish small molecule screens.

Rennekamp AJ, Peterson RT.

Drug Discov Today Dis Models. 2013 Spring;10(1):e51-e55.


Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury.

Ryu JH, Walcott BP, Kahle KT, Sheth SA, Peterson RT, Nahed BV, Coumans JV, Simard JM.

Neurocrit Care. 2013 Oct;19(2):222-31. doi: 10.1007/s12028-013-9824-3. Review.


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