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Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells.

Stavrou EF, Simantirakis E, Verras M, Barbas C 3rd, Vassilopoulos G, Peterson KR, Athanassiadou A.

Sci Rep. 2019 Dec 24;9(1):19765. doi: 10.1038/s41598-019-56056-z.


An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.

Debrand E, Chakalova L, Miles J, Dai YF, Goyenechea B, Dye S, Osborne CS, Horton A, Harju-Baker S, Pink RC, Caley D, Carter DRF, Peterson KR, Fraser P.

PLoS One. 2019 Aug 14;14(8):e0217532. doi: 10.1371/journal.pone.0217532. eCollection 2019.


Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice.

Oseghale AR, Zhu X, Li B, Peterson KR, Nudelman A, Rephaeli A, Xu H, Pace BS.

Blood Cells Mol Dis. 2019 Nov;79:102345. doi: 10.1016/j.bcmd.2019.102345. Epub 2019 Jul 9.


Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets.

Tang Q, Villar MT, Artigues A, Thyfault JP, Apte U, Zhu H, Peterson KR, Fenton AW.

Sci Rep. 2019 Jun 21;9(1):9031. doi: 10.1038/s41598-019-45202-2.


Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency.

Peterson KR, Gutierrez DA, Kikuchi T, Anderson-Baucum EK, Winn NC, Shuey MM, Bolus WR, McGuinness OP, Hasty AH.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E200-E211. doi: 10.1152/ajpendo.00042.2019. Epub 2019 May 14.


O-GlcNAc homeostasis contributes to cell fate decisions during hematopoiesis.

Zhang Z, Parker MP, Graw S, Novikova LV, Fedosyuk H, Fontes JD, Koestler DC, Peterson KR, Slawson C.

J Biol Chem. 2019 Jan 25;294(4):1363-1379. doi: 10.1074/jbc.RA118.005993. Epub 2018 Dec 6.


A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.

Parnell SC, Magenheimer BS, Maser RL, Pavlov TS, Havens MA, Hastings ML, Jackson SF, Ward CJ, Peterson KR, Staruschenko A, Calvet JP.

Hum Mol Genet. 2018 Oct 1;27(19):3313-3324. doi: 10.1093/hmg/ddy223.


Macrophage-Targeted Therapeutics for Metabolic Disease.

Peterson KR, Cottam MA, Kennedy AJ, Hasty AH.

Trends Pharmacol Sci. 2018 Jun;39(6):536-546. doi: 10.1016/ Epub 2018 Apr 5. Review.


Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments.

Bolus WR, Peterson KR, Hubler MJ, Kennedy AJ, Gruen ML, Hasty AH.

Mol Metab. 2018 Feb;8:86-95. doi: 10.1016/j.molmet.2017.12.004. Epub 2017 Dec 16.


Mouse Models of Erythropoiesis and Associated Diseases.

Parker MP, Peterson KR.

Methods Mol Biol. 2018;1698:37-65. doi: 10.1007/978-1-4939-7428-3_3. Review.


Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue.

Peterson KR, Flaherty DK, Hasty AH.

Obesity (Silver Spring). 2017 Nov;25(11):1881-1884. doi: 10.1002/oby.21982. Epub 2017 Sep 18.


Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism.

Tan EP, McGreal SR, Graw S, Tessman R, Koppel SJ, Dhakal P, Zhang Z, Machacek M, Zachara NE, Koestler DC, Peterson KR, Thyfault JP, Swerdlow RH, Krishnamurthy P, DiTacchio L, Apte U, Slawson C.

J Biol Chem. 2017 Sep 8;292(36):14940-14962. doi: 10.1074/jbc.M117.797944. Epub 2017 Jul 24.


Activation of Fetal γ-globin Gene Expression via Direct Protein Delivery of Synthetic Zinc-finger DNA-Binding Domains.

Hossain MA, Shen Y, Knudson I, Thakur S, Stees JR, Qiu Y, Pace BS, Peterson KR, Bungert J.

Mol Ther Nucleic Acids. 2016 Oct 18;5(10):e378. doi: 10.1038/mtna.2016.85.


O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.

Zhang Z, Costa FC, Tan EP, Bushue N, DiTacchio L, Costello CE, McComb ME, Whelan SA, Peterson KR, Slawson C.

J Biol Chem. 2016 Jul 22;291(30):15628-40. doi: 10.1074/jbc.M116.721928. Epub 2016 May 26.


Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH.

Braghini CA, Costa FC, Fedosyuk H, Neades RY, Novikova LV, Parker MP, Winefield RD, Peterson KR.

Exp Biol Med (Maywood). 2016 Apr;241(7):697-705. doi: 10.1177/1535370216636724. Epub 2016 Mar 4.


The Genomic Basis of Postponed Senescence in Drosophila melanogaster.

Carnes MU, Campbell T, Huang W, Butler DG, Carbone MA, Duncan LH, Harbajan SV, King EM, Peterson KR, Weitzel A, Zhou S, Mackay TF.

PLoS One. 2015 Sep 17;10(9):e0138569. doi: 10.1371/journal.pone.0138569. eCollection 2015.


Quantitative Genetics of Food Intake in Drosophila melanogaster.

Garlapow ME, Huang W, Yarboro MT, Peterson KR, Mackay TF.

PLoS One. 2015 Sep 16;10(9):e0138129. doi: 10.1371/journal.pone.0138129. eCollection 2015.


Iron homeostasis: a new job for macrophages in adipose tissue?

Hubler MJ, Peterson KR, Hasty AH.

Trends Endocrinol Metab. 2015 Feb;26(2):101-9. doi: 10.1016/j.tem.2014.12.005. Epub 2015 Jan 16. Review.


O-GlcNAcase Expression is Sensitive to Changes in O-GlcNAc Homeostasis.

Zhang Z, Tan EP, VandenHull NJ, Peterson KR, Slawson C.

Front Endocrinol (Lausanne). 2014 Dec 1;5:206. doi: 10.3389/fendo.2014.00206. eCollection 2014.


A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies.

Peterson KR, Costa FC, Fedosyuk H, Neades RY, Chazelle AM, Zelenchuk L, Fonteles AH, Dalal P, Roy A, Chaguturu R, Li B, Pace BS.

PLoS One. 2014 Sep 16;9(9):e107006. doi: 10.1371/journal.pone.0107006. eCollection 2014.


Mi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic mice.

Costa FC, Fedosyuk H, Chazelle AM, Neades RY, Peterson KR.

PLoS Genet. 2012;8(12):e1003155. doi: 10.1371/journal.pgen.1003155. Epub 2012 Dec 20.


Creating a movement for active living via a media campaign.

Huberty J, Dodge T, Peterson KR, Balluff M.

Am J Prev Med. 2012 Nov;43(5 Suppl 4):S390-1. doi: 10.1016/j.amepre.2012.07.004.


LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.

Peterson KR, Fedosyuk H, Harju-Baker S.

Nucleic Acids Res. 2012 Dec;40(22):11256-69. doi: 10.1093/nar/gks900. Epub 2012 Oct 4.


Sickle cell disease: genetics, cellular and molecular mechanisms, and therapies.

Pace BS, Ofori-Acquah SF, Peterson KR.

Anemia. 2012;2012:143594. doi: 10.1155/2012/143594. Epub 2012 Aug 22. No abstract available.


Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator.

Costa FC, Fedosyuk H, Neades R, de Los Rios JB, Barbas CF 3rd, Peterson KR.

Anemia. 2012;2012:507894. doi: 10.1155/2012/507894. Epub 2012 Jun 15.


The key to reducing EHS risks.

Peterson KR.

Occup Health Saf. 2012 Jan;81(1):26-7. No abstract available.


Transgenic expression of human LAMA5 suppresses murine Lama5 mRNA and laminin α5 protein deposition.

Steenhard BM, Zelenchuk A, Stroganova L, Isom K, St John PL, Andrews GK, Peterson KR, Abrahamson DR.

PLoS One. 2011;6(9):e23926. doi: 10.1371/journal.pone.0023926. Epub 2011 Sep 7.


Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.

Giardine B, Borg J, Higgs DR, Peterson KR, Philipsen S, Maglott D, Singleton BK, Anstee DJ, Basak AN, Clark B, Costa FC, Faustino P, Fedosyuk H, Felice AE, Francina A, Galanello R, Gallivan MV, Georgitsi M, Gibbons RJ, Giordano PC, Harteveld CL, Hoyer JD, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis MN, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye JS, Wiemann C, Zukic B, Chui DH, Wajcman H, Hardison RC, Patrinos GP.

Nat Genet. 2011 Mar 20;43(4):295-301. doi: 10.1038/ng.785.


Phylogeny of Cyttaria inferred from nuclear and mitochondrial sequence and morphological data.

Peterson KR, Pfister DH.

Mycologia. 2010 Nov-Dec;102(6):1398-416. doi: 10.3852/10-046. Epub 2010 Jun 1.


Cophylogeny and biogeography of the fungal parasite Cyttaria and its host Nothofagus, southern beech.

Peterson KR, Pfister DH, Bell CD.

Mycologia. 2010 Nov-Dec;102(6):1417-25. doi: 10.3852/10-048. Epub 2010 Jun 1.


Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo.

Chen J, Peterson KR, Iancu-Rubin C, Bieker JJ.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16846-51. doi: 10.1073/pnas.0912896107. Epub 2010 Sep 13.


Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.

Heruth DP, Hawkins T, Logsdon DP, Gibson MI, Sokolovsky IV, Nsumu NN, Major SL, Fegley B, Woods GM, Lewing KB, Neville KA, Cornetta K, Peterson KR, White RA.

Genomics. 2010 Nov;96(5):303-7. doi: 10.1016/j.ygeno.2010.07.009. Epub 2010 Aug 5.


Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production.

Tschulena U, Peterson KR, Gonzalez B, Fedosyuk H, Barbas CF 3rd.

Nat Struct Mol Biol. 2009 Nov;16(11):1195-9. doi: 10.1038/nsmb.1677. Epub 2009 Oct 18.


Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model.

Desmarets M, Cadwell CM, Peterson KR, Neades R, Zimring JC.

Blood. 2009 Sep 10;114(11):2315-22. doi: 10.1182/blood-2009-04-214387. Epub 2009 Jun 12.


Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids.

Chin JY, Kuan JY, Lonkar PS, Krause DS, Seidman MM, Peterson KR, Nielsen PE, Kole R, Glazer PM.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13514-9. doi: 10.1073/pnas.0711793105. Epub 2008 Aug 29.


Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.

Harju-Baker S, Costa FC, Fedosyuk H, Neades R, Peterson KR.

Mol Cell Biol. 2008 May;28(10):3101-13. doi: 10.1128/MCB.01858-07. Epub 2008 Mar 17.


Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster.

de Andrade TG, Peterson KR, Cunha AF, Moreira LS, Fattori A, Saad ST, Costa FF.

Blood Cells Mol Dis. 2006 Sep-Oct;37(2):82-90. Epub 2006 Sep 6.


Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.

Navas PA, Li Q, Peterson KR, Stamatoyannopoulos G.

Exp Biol Med (Maywood). 2006 Mar;231(3):328-34.


Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.

Harju S, Navas PA, Stamatoyannopoulos G, Peterson KR.

Mol Cell Biol. 2005 Oct;25(20):8765-78.


Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.

Fang X, Sun J, Xiang P, Yu M, Navas PA, Peterson KR, Stamatoyannopoulos G, Li Q.

Mol Cell Biol. 2005 Aug;25(16):7033-41.


A FTZ-F1-containing yeast artificial chromosome recapitulates expression of steroidogenic factor 1 in vivo.

Karpova T, Presley J, Manimaran RR, Scherrer SP, Tejada L, Peterson KR, Heckert LL.

Mol Endocrinol. 2005 Oct;19(10):2549-63. Epub 2005 Jun 16.


Transgenic Cre expression mice for generation of erythroid-specific gene alterations.

Peterson KR, Fedosyuk H, Zelenchuk L, Nakamoto B, Yannaki E, Stamatoyannopoulos G, Ciciotte S, Peters LL, Scott LM, Papayannopoulou T.

Genesis. 2004 May;39(1):1-9.


Rapid isolation of yeast genomic DNA: Bust n' Grab.

Harju S, Fedosyuk H, Peterson KR.

BMC Biotechnol. 2004 Apr 21;4:8.


Transgenic mice carrying yeast artificial chromosomes.

Peterson KR.

Expert Rev Mol Med. 2003 Apr 7;5(13):1-25. doi: 10.1017/S1462399403006082. Review.


Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.

Navas PA, Swank RA, Yu M, Peterson KR, Stamatoyannopoulos G.

Hum Mol Genet. 2003 Nov 15;12(22):2941-8. Epub 2003 Sep 23.


Remarkable sequence conservation of the last intron in the PKD1 gene.

Rodova M, Islam MR, Peterson KR, Calvet JP.

Mol Biol Evol. 2003 Oct;20(10):1669-74. Epub 2003 Jun 27.


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