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Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.

Pedersen DV, Gadeberg TAF, Thomas C, Wang Y, Joram N, Jensen RK, Mazarakis SMM, Revel M, El Sissy C, Petersen SV, Lindorff-Larsen K, Thiel S, Laursen NS, Fremeaux-Bacchi V, Andersen GR.

Front Immunol. 2019 Aug 22;10:2007. doi: 10.3389/fimmu.2019.02007. eCollection 2019.


Grafting phenolics onto milk protein via conjugated polymerization for delivery of multiple functionalities: Synthesis and characterization.

El-Maksoud AAA, Anankanbil S, Zhou Y, El-Ghany IHA, El-Beltagi HS, Banerjee C, Petersen SV, Guo Z.

Food Chem. 2019 Dec 15;301:125298. doi: 10.1016/j.foodchem.2019.125298. Epub 2019 Jul 30.


The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response.

Hu L, Zachariae ED, Larsen UG, Vilhardt F, Petersen SV.

Redox Biol. 2019 Sep;26:101268. doi: 10.1016/j.redox.2019.101268. Epub 2019 Jul 2.


Characterization of extracellular redox enzyme concentrations in response to exercise in humans.

Wadley AJ, Keane G, Cullen T, James L, Vautrinot J, Davies M, Hussey B, Hunter DJ, Mastana S, Holliday A, Petersen SV, Bishop NC, Lindley MR, Coles SJ.

J Appl Physiol (1985). 2019 Sep 1;127(3):858-866. doi: 10.1152/japplphysiol.00340.2019. Epub 2019 Jun 27.


The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.

Nielsen LD, Foged MM, Albert A, Bertelsen AB, Søltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K, Ellgaard L.

J Biol Chem. 2019 May 31;294(22):8745-8759. doi: 10.1074/jbc.RA119.007491. Epub 2019 Apr 11.


Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.

Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE.

Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6.


Insight into the molecular mechanism behind PEG-mediated stabilization of biofluid lipases.

Pérez B, Coletta A, Pedersen JN, Petersen SV, Periole X, Pedersen JS, Sessions RB, Guo Z, Perriman A, Schiøtt B.

Sci Rep. 2018 Aug 16;8(1):12293. doi: 10.1038/s41598-018-29871-z.


CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology.

Olesen MN, Christiansen JR, Petersen SV, Jensen PH, Paslawski W, Romero-Ramos M, Sanchez-Guajardo V.

Heliyon. 2018 Feb 1;4(1):e00513. doi: 10.1016/j.heliyon.2018.e00513. eCollection 2018 Jan.


Folding and assembly defects of pyruvate dehydrogenase deficiency-related variants in the E1α subunit of the pyruvate dehydrogenase complex.

Drakulic S, Rai J, Petersen SV, Golas MM, Sander B.

Cell Mol Life Sci. 2018 Aug;75(16):3009-3026. doi: 10.1007/s00018-018-2775-2. Epub 2018 Feb 14.


Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation.

Hernandez-Saavedra D, Swain K, Tuder R, Petersen SV, Nozik-Grayck E.

Adv Exp Med Biol. 2017;967:57-70. doi: 10.1007/978-3-319-63245-2_5.


Adding functionality to milk-based protein: Preparation, and physico-chemical characterization of β-lactoglobulin-phenolic conjugates.

Abd El-Maksoud AA, Abd El-Ghany IH, El-Beltagi HS, Anankanbil S, Banerjee C, Petersen SV, Pérez B, Guo Z.

Food Chem. 2018 Feb 15;241:281-289. doi: 10.1016/j.foodchem.2017.08.101. Epub 2017 Sep 1.


Hemoglobin polymerization via disulfide bond formation in the hypoxia-tolerant turtle Trachemys scripta: implications for antioxidant defense and O2 transport.

Petersen AG, Petersen SV, Frische S, Drakulic S, Golas MM, Sander B, Fago A.

Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R84-R93. doi: 10.1152/ajpregu.00024.2017. Epub 2017 Sep 6.


Latency transition of plasminogen activator inhibitor type 1 is evolutionarily conserved.

Jendroszek A, Sønnichsen MS, Muñoz AC, Leyman K, Christensen A, Petersen SV, Wang T, Bendixen C, Panitz F, Andreasen PA, Jensen JK.

Thromb Haemost. 2017 Aug 30;117(9):1688-1699. doi: 10.1160/TH17-02-0102. Epub 2017 Aug 3.


Controlled Gelation of Graphene Towards Unprecedented Superstructures.

Petersen SV, Qiu L, Li D.

Chemistry. 2017 Sep 27;23(54):13264-13269. doi: 10.1002/chem.201703121. Epub 2017 Sep 8.


Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy.

Just J, Lykkemark S, Nielsen CH, Roshenas AR, Drasbek KR, Petersen SV, Bek T, Kristensen P.

Microcirculation. 2017 Aug;24(6). doi: 10.1111/micc.12365.


Heinrich events triggered by ocean forcing and modulated by isostatic adjustment.

Bassis JN, Petersen SV, Mac Cathles L.

Nature. 2017 Feb 15;542(7641):332-334. doi: 10.1038/nature21069.


Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation.

Iversen MB, Gottfredsen RH, Larsen UG, Enghild JJ, Praetorius J, Borregaard N, Petersen SV.

Free Radic Biol Med. 2016 Aug;97:478-488. doi: 10.1016/j.freeradbiomed.2016.07.004. Epub 2016 Jul 6.


End-Cretaceous extinction in Antarctica linked to both Deccan volcanism and meteorite impact via climate change.

Petersen SV, Dutton A, Lohmann KC.

Nat Commun. 2016 Jul 5;7:12079. doi: 10.1038/ncomms12079.


Transglutaminase 2-Catalyzed Intramolecular Cross-Linking of Osteopontin.

Christensen B, Zachariae ED, Scavenius C, Kløverpris S, Oxvig C, Petersen SV, Enghild JJ, Sørensen ES.

Biochemistry. 2016 Jan 19;55(2):294-303. doi: 10.1021/acs.biochem.5b01153. Epub 2016 Jan 4.


The effects of Porapak™ trap temperature on δ(18)O, δ(13)C, and Δ47 values in preparing samples for clumped isotope analysis.

Petersen SV, Winkelstern IZ, Lohmann KC, Meyer KW.

Rapid Commun Mass Spectrom. 2016 Jan 15;30(1):199-208. doi: 10.1002/rcm.7438.


Soluble and immobilized graphene oxide activates complement system differently dependent on surface oxidation state.

Wibroe PP, Petersen SV, Bovet N, Laursen BW, Moghimi SM.

Biomaterials. 2016 Feb;78:20-6. doi: 10.1016/j.biomaterials.2015.11.028. Epub 2015 Nov 19.


An innate antiviral pathway acting before interferons at epithelial surfaces.

Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR.

Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30.


Gold nanoparticles assembled with dithiocarbamate-anchored molecular wires.

Reeler NE, Lerstrup KA, Somerville W, Speder J, Petersen SV, Laursen BW, Arenz M, Qiu X, Vosch T, Nørgaard K.

Sci Rep. 2015 Oct 16;5:15273. doi: 10.1038/srep15273.


Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.

Kløverpris S, Mikkelsen JH, Pedersen JH, Jepsen MR, Laursen LS, Petersen SV, Oxvig C.

J Biol Chem. 2015 Sep 4;290(36):21915-24. doi: 10.1074/jbc.M115.650143. Epub 2015 Jul 20.


Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement.

Mortensen S, Kidmose RT, Petersen SV, Szilágyi Á, Prohászka Z, Andersen GR.

J Immunol. 2015 Jun 1;194(11):5488-96. doi: 10.4049/jimmunol.1500087. Epub 2015 Apr 24.


Fibril Core of Transforming Growth Factor Beta-Induced Protein (TGFBIp) Facilitates Aggregation of Corneal TGFBIp.

Sørensen CS, Runager K, Scavenius C, Jensen MM, Nielsen NS, Christiansen G, Petersen SV, Karring H, Sanggaard KW, Enghild JJ.

Biochemistry. 2015 May 19;54(19):2943-56. doi: 10.1021/acs.biochem.5b00292. Epub 2015 May 6.


The effects of hypochlorous acid and neutrophil proteases on the structure and function of extracellular superoxide dismutase.

Morales K, Olesen MN, Poulsen ET, Larsen UG, Enghild JJ, Petersen SV.

Free Radic Biol Med. 2015 Apr;81:38-46. doi: 10.1016/j.freeradbiomed.2014.12.027. Epub 2015 Jan 9.


The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold.

Hong Z, Nowakowski M, Spronk C, Petersen SV, Andreasen PA, Koźmiński W, Mulder FA, Jensen JK.

Biochem J. 2015 Mar 1;466(2):299-309. doi: 10.1042/BJ20141236.


Clumped isotope measurements of small carbonate samples using a high-efficiency dual-reservoir technique.

Petersen SV, Schrag DP.

Rapid Commun Mass Spectrom. 2014 Nov 15;28(21):2371-81. doi: 10.1002/rcm.7022.


Structural and functional characterization of human and murine C5a anaphylatoxins.

Schatz-Jakobsen JA, Yatime L, Larsen C, Petersen SV, Klos A, Andersen GR.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1704-17. doi: 10.1107/S139900471400844X. Epub 2014 May 30.


The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the naturally occurring R213G substitution.

Gottfredsen RH, Goldstrohm DA, Hartney JM, Larsen UG, Bowler RP, Petersen SV.

Free Radic Biol Med. 2014 Apr;69:348-56. doi: 10.1016/j.freeradbiomed.2014.01.038. Epub 2014 Feb 7.


Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae.

Jørgensen ML, Friis NA, Just J, Madsen P, Petersen SV, Kristensen P.

Microb Cell Fact. 2014 Jan 15;13:9. doi: 10.1186/1475-2859-13-9.


Three monoclonal antibodies against the serpin protease nexin-1 prevent protease translocation.

Kousted TM, Skjoedt K, Petersen SV, Koch C, Vitved L, Sochalska M, Lacroix C, Andersen LM, Wind T, Andreasen PA, Jensen JK.

Thromb Haemost. 2014 Jan;111(1):29-40. doi: 10.1160/TH13-04-0340. Epub 2013 Oct 2.


Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition.

Gottfredsen RH, Larsen UG, Enghild JJ, Petersen SV.

Redox Biol. 2013 Jan 11;1:24-31. doi: 10.1016/j.redox.2012.12.004. eCollection 2013.


Murine extracellular superoxide dismutase is converted into the inactive fold by the Ser195Cys mutation.

Scavenius C, Petersen JS, Thomsen LR, Poulsen ET, Valnickova-Hansen Z, Bowler RP, Oury TD, Petersen SV, Enghild JJ.

Biochemistry. 2013 May 14;52(19):3369-75. doi: 10.1021/bi400171b. Epub 2013 May 1.


Off-pathway aggregation can inhibit fibrillation at high protein concentrations.

Deva T, Lorenzen N, Vad BS, Petersen SV, Thørgersen I, Enghild JJ, Kristensen T, Otzen DE.

Biochim Biophys Acta. 2013 Mar;1834(3):677-87. doi: 10.1016/j.bbapap.2012.12.020. Epub 2013 Jan 8.


Renal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosis.

Weyer K, Nielsen R, Petersen SV, Christensen EI, Rehling M, Birn H.

J Nucl Med. 2013 Jan;54(1):159-65. doi: 10.2967/jnumed.112.110528. Epub 2012 Dec 11.


Structure, function and control of complement C5 and its proteolytic fragments.

Laursen NS, Magnani F, Gottfredsen RH, Petersen SV, Andersen GR.

Curr Mol Med. 2012 Sep;12(8):1083-97. Review.


The C-terminal proteolytic processing of extracellular superoxide dismutase is redox regulated.

Gottfredsen RH, Tran SM, Larsen UG, Madsen P, Nielsen MS, Enghild JJ, Petersen SV.

Free Radic Biol Med. 2012 Jan 1;52(1):191-7. doi: 10.1016/j.freeradbiomed.2011.10.443. Epub 2011 Oct 20.


The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein.

Gjelstrup LC, Andersen SH, Petersen SV, Enghild JJ, Blom AM, Vorup-Jensen T, Thiel S.

Mol Immunol. 2011 Oct;49(1-2):38-47. doi: 10.1016/j.molimm.2011.07.018.


Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates.

Valnickova Z, Sanglas L, Arolas JL, Petersen SV, Schar C, Otzen D, Aviles FX, Gomis-Rüth FX, Enghild JJ.

J Biol Chem. 2010 Dec 3;285(49):38243-50. doi: 10.1074/jbc.M110.150342. Epub 2010 Sep 29.


The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis.

Petersen SV, Thøgersen IB, Valnickova Z, Nielsen MS, Petersen JS, Poulsen ET, Jacobsen C, Oury TD, Moestrup SK, Crapo JD, Nielsen NC, Kristensen T, Enghild JJ.

Free Radic Biol Med. 2010 Sep 1;49(5):894-9. doi: 10.1016/j.freeradbiomed.2010.06.019. Epub 2010 Jun 27.


Functional amyloid in Pseudomonas.

Dueholm MS, Petersen SV, Sønderkær M, Larsen P, Christiansen G, Hein KL, Enghild JJ, Nielsen JL, Nielsen KL, Nielsen PH, Otzen DE.

Mol Microbiol. 2010 Aug;77(4):1009-20. doi: 10.1111/j.1365-2958.2010.07269.x. Epub 2010 Jun 21.


Widespread abundance of functional bacterial amyloid in mycolata and other gram-positive bacteria.

Jordal PB, Dueholm MS, Larsen P, Petersen SV, Enghild JJ, Christiansen G, Højrup P, Nielsen PH, Otzen DE.

Appl Environ Microbiol. 2009 Jun;75(12):4101-10. doi: 10.1128/AEM.02107-08. Epub 2009 Apr 24.


Stable intermediates determine proteins' primary unfolding sites in the presence of surfactants.

Hansen JH, Petersen SV, Andersen KK, Enghild JJ, Damhus T, Otzen D.

Biopolymers. 2009 Mar;91(3):221-31. doi: 10.1002/bip.21125.


The folding of human active and inactive extracellular superoxide dismutases is an intracellular event.

Petersen SV, Kristensen T, Petersen JS, Ramsgaard L, Oury TD, Crapo JD, Nielsen NC, Enghild JJ.

J Biol Chem. 2008 May 30;283(22):15031-6. doi: 10.1074/jbc.M801548200. Epub 2008 Apr 2.


The subunit composition of human extracellular superoxide dismutase (EC-SOD) regulates enzymatic activity.

Petersen SV, Valnickova Z, Oury TD, Crapo JD, Chr Nielsen N, Enghild JJ.

BMC Biochem. 2007 Oct 15;8:19.


The major allergen from birch tree pollen, Bet v 1, binds and permeabilizes membranes.

Mogensen JE, Ferreras M, Wimmer R, Petersen SV, Enghild JJ, Otzen DE.

Biochemistry. 2007 Mar 20;46(11):3356-65. Epub 2007 Feb 21.


Heparin binding induces a conformational change in pigment epithelium-derived factor.

Valnickova Z, Petersen SV, Nielsen SB, Otzen DE, Enghild JJ.

J Biol Chem. 2007 Mar 2;282(9):6661-7. Epub 2007 Jan 2.


A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.

Nielsen MJ, Petersen SV, Jacobsen C, Thirup S, Enghild JJ, Graversen JH, Moestrup SK.

J Biol Chem. 2007 Jan 12;282(2):1072-9. Epub 2006 Nov 13.

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