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Items: 1 to 50 of 73

1.

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for diabetic foot infections.

Petersen PJ, Ruzin A, Tuckman M, Jones CH.

Diagn Microbiol Infect Dis. 2010 Apr;66(4):407-18. doi: 10.1016/j.diagmicrobio.2009.11.009.

PMID:
20226331
2.

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for hospital acquired pneumonia.

Petersen PJ, Tuckman M, Jones CH.

Infect Dis Rep. 2010 Feb 2;2(1):e1. doi: 10.4081/idr.2010.e1. eCollection 2010 Feb 3. Review.

3.

Resistance development profiling of piperacillin in combination with the novel {beta}-lactamase inhibitor BLI-489.

Ruzin A, Petersen PJ, Jones CH.

J Antimicrob Chemother. 2010 Feb;65(2):252-7. doi: 10.1093/jac/dkp435. Epub 2009 Dec 11.

PMID:
20008048
4.

Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection.

Petersen PJ, Jones CH, Venkatesan AM, Bradford PA.

Antimicrob Agents Chemother. 2009 Apr;53(4):1698-700. doi: 10.1128/AAC.01549-08. Epub 2009 Feb 2.

5.
6.

Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.

Petersen PJ, Jones CH, Venkatesan AM, Mansour TS, Projan SJ, Bradford PA.

Antimicrob Agents Chemother. 2009 Feb;53(2):370-84. doi: 10.1128/AAC.01047-08. Epub 2008 Nov 10.

7.

In vitro activity of tigecycline and occurrence of tetracycline resistance determinants in isolates from patients enrolled in phase 3 clinical trials for community-acquired pneumonia.

Bradford PA, Petersen PJ, Tuckman M, Jones CH.

Clin Microbiol Infect. 2008 Sep;14(9):882-6. doi: 10.1111/j.1469-0691.2008.02063.x.

8.

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.

Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Ado M, Tsuyoshi T, Dos Santos O, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Weiss WJ, Shlaes DM, Mansour TS.

Bioorg Med Chem. 2008 Feb 15;16(4):1890-902. Epub 2007 Nov 5.

PMID:
18061461
9.

In vitro antibacterial activities of tigecycline and comparative agents by time-kill kinetic studies in fresh Mueller-Hinton broth.

Petersen PJ, Jones CH, Bradford PA.

Diagn Microbiol Infect Dis. 2007 Nov;59(3):347-9. Epub 2007 Jul 26.

PMID:
17662552
10.

Occurrence of tetracycline resistance genes among Escherichia coli isolates from the phase 3 clinical trials for tigecycline.

Tuckman M, Petersen PJ, Howe AY, Orlowski M, Mullen S, Chan K, Bradford PA, Jones CH.

Antimicrob Agents Chemother. 2007 Sep;51(9):3205-11. Epub 2007 Jul 9.

11.

Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis.

Mansour TS, Caufield CE, Rasmussen B, Chopra R, Krishnamurthy G, Morris KM, Svenson K, Bard J, Smeltzer C, Naughton S, Antane S, Yang Y, Severin A, Quagliato D, Petersen PJ, Singh G.

ChemMedChem. 2007 Oct;2(10):1414-7. No abstract available.

PMID:
17600795
12.

A novel antibiotic bone assay by liquid chromatography/tandem mass spectrometry for quantitation of tigecycline in rat bone.

Ji AJ, Saunders JP, Wadgaonkar ND, Petersen PJ, O'Leary K, McWilliams WE, Amorusi P, Leal M, Fluhler EN.

J Pharm Biomed Anal. 2007 Aug 15;44(4):970-9. Epub 2007 Apr 20.

PMID:
17537611
13.

Validation and reproducibility assessment of tigecycline MIC determinations by Etest.

Bolmström A, Karlsson A, Engelhardt A, Ho P, Petersen PJ, Bradford PA, Jones CH.

J Clin Microbiol. 2007 Aug;45(8):2474-9. Epub 2007 May 23.

14.

Tigecycline: a case study.

Loh E, Ellis-Grosse E, Petersen PJ, Sum PE, Projan S.

Expert Opin Drug Discov. 2007 Mar;2(3):403-18. doi: 10.1517/17460441.2.3.403.

PMID:
23484649
15.

Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase.

Gilbert AM, Failli A, Shumsky J, Yang Y, Severin A, Singh G, Hu W, Keeney D, Petersen PJ, Katz AH.

J Med Chem. 2006 Oct 5;49(20):6027-36.

PMID:
17004716
16.

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Ado M, Tsuyoshi T, Dos Santos O, Gu Y, Sum FW, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Kumagai T, Weiss WJ, Shlaes DM, Knox JR, Mansour TS.

J Med Chem. 2006 Jul 27;49(15):4623-37.

PMID:
16854068
17.

3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.

Yang Y, Severin A, Chopra R, Krishnamurthy G, Singh G, Hu W, Keeney D, Svenson K, Petersen PJ, Labthavikul P, Shlaes DM, Rasmussen BA, Failli AA, Shumsky JS, Kutterer KM, Gilbert A, Mansour TS.

Antimicrob Agents Chemother. 2006 Feb;50(2):556-64.

18.

In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis.

Petersen PJ, Labthavikul P, Jones CH, Bradford PA.

J Antimicrob Chemother. 2006 Mar;57(3):573-6. Epub 2006 Jan 23.

PMID:
16431863
19.

Tigecycline: a review of preclinical and clinical studies of the first-in-class glycylcycline antibiotic.

Jones CH, Petersen PJ.

Drugs Today (Barc). 2005 Oct;41(10):637-59. Review.

PMID:
16389407
20.

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM.

J Med Chem. 2005 Dec 15;48(25):7960-9.

PMID:
16335920
21.

Synthesis and antibacterial activity of 9-substituted minocycline derivatives.

Sum PE, Ross AT, Petersen PJ, Testa RT.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):400-3. Epub 2005 Oct 21.

PMID:
16246559
22.

Pulvinones as bacterial cell wall biosynthesis inhibitors.

Antane S, Caufield CE, Hu W, Keeney D, Labthavikul P, Morris K, Naughton SM, Petersen PJ, Rasmussen BA, Singh G, Yang Y.

Bioorg Med Chem Lett. 2006 Jan 1;16(1):176-80. Epub 2005 Oct 10.

PMID:
16216496
24.

Tigecycline MIC testing by broth dilution requires use of fresh medium or addition of the biocatalytic oxygen-reducing reagent oxyrase to standardize the test method.

Bradford PA, Petersen PJ, Young M, Jones CH, Tischler M, O'Connell J.

Antimicrob Agents Chemother. 2005 Sep;49(9):3903-9.

26.

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

Venkatesan AM, Gu Y, Dos Santos O, Abe T, Agarwal A, Yang Y, Petersen PJ, Weiss WJ, Mansour TS, Nukaga M, Hujer AM, Bonomo RA, Knox JR.

J Med Chem. 2004 Dec 16;47(26):6556-68.

PMID:
15588091
27.

In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.

Weiss WJ, Petersen PJ, Murphy TM, Tardio L, Yang Y, Bradford PA, Venkatesan AM, Abe T, Isoda T, Mihira A, Ushirogochi H, Takasake T, Projan S, O'Connell J, Mansour TS.

Antimicrob Agents Chemother. 2004 Dec;48(12):4589-96.

28.

Novel imidazole substituted 6-methylidene-penems as broad-spectrum beta-lactamase inhibitors.

Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Kumagai T, Petersen PJ, Weiss WJ, Lenoy E, Yang Y, Shlaes DM, Ryan JL, Mansour TS.

Bioorg Med Chem. 2004 Nov 15;12(22):5807-17.

PMID:
15498657
29.

Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis.

Dunman PM, Mounts W, McAleese F, Immermann F, Macapagal D, Marsilio E, McDougal L, Tenover FC, Bradford PA, Petersen PJ, Projan SJ, Murphy E.

J Clin Microbiol. 2004 Sep;42(9):4275-83.

30.

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.

Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Kincaid SL, Sukhdeo MN, Sutherland AG, Ding W, Kenny CH, Sabus CL, Liu H, Dushin EG, Moghazeh SL, Labthavikul P, Petersen PJ, Tuckman M, Haney SA, Ruzin AV.

Bioorg Med Chem. 2004 Oct 1;12(19):5115-31. Erratum in: Bioorg Med Chem. 2005 Oct 15;13(20):5884. Haney, Steven A [added].

PMID:
15351395
31.

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

Dushin RG, Wang TZ, Sum PE, He H, Sutherland AG, Ashcroft JS, Graziani EI, Koehn FE, Bradford PA, Petersen PJ, Wheless KL, How D, Torres N, Lenoy EB, Weiss WJ, Lang SA, Projan SJ, Shlaes DM, Mansour TS.

J Med Chem. 2004 Jul 1;47(14):3487-90.

PMID:
15214775
32.

Novel alpha-pyrones produced by a marine Pseudomonas sp. F92S91: taxonomy and biological activities.

Singh MP, Kong F, Janso JE, Arias DA, Suarez PA, Bernan VS, Petersen PJ, Weiss WJ, Carter G, Greenstein M.

J Antibiot (Tokyo). 2003 Dec;56(12):1033-44.

33.

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.

Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31.

PMID:
15006376
35.

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

Sutherland AG, Alvarez J, Ding W, Foreman KW, Kenny CH, Labthavikul P, Mosyak L, Petersen PJ, Rush TS 3rd, Ruzin A, Tsao DH, Wheless KL.

Org Biomol Chem. 2003 Dec 7;1(23):4138-40. Epub 2003 Oct 29.

PMID:
14685315
36.

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria.

He H, Shen B, Petersen PJ, Weiss WJ, Yang HY, Wang TZ, Dushin RG, Koehn FE, Carter GT.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):279-82.

PMID:
14684343
37.

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis.

Francisco GD, Li Z, Albright JD, Eudy NH, Katz AH, Petersen PJ, Labthavikul P, Singh G, Yang Y, Rasmussen BA, Lin YI, Mansour TS.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):235-8.

PMID:
14684334
38.

Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.

Gilbert AM, Kirisits M, Toy P, Nunn DS, Failli A, Dushin EG, Novikova E, Petersen PJ, Joseph-McCarthy D, McFadyen I, Fritz CC.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):37-41.

PMID:
14684293
39.

In vitro activity of tigecycline against Staphylococcus epidermidis growing in an adherent-cell biofilm model.

Labthavikul P, Petersen PJ, Bradford PA.

Antimicrob Agents Chemother. 2003 Dec;47(12):3967-9.

40.

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.

Yamashita A, Norton E, Petersen PJ, Rasmussen BA, Singh G, Yang Y, Mansour TS, Ho DM.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3345-50.

PMID:
12951123
41.

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.

Sum PE, How D, Torres N, Petersen PJ, Ashcroft J, Graziani EI, Koehn FE, Mansour TS.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2805-8.

PMID:
12873519
42.

Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics.

Sum PE, How D, Torres N, Newman H, Petersen PJ, Mansour TS.

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2607-10.

PMID:
12852976
43.

2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis.

Li Z, Francisco GD, Hu W, Labthavikul P, Petersen PJ, Severin A, Singh G, Yang Y, Rasmussen BA, Lin YI, Skotnicki JS, Mansour TS.

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2591-4.

PMID:
12852973
44.

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic.

Sum PE, How D, Torres N, Petersen PJ, Lenoy EB, Weiss WJ, Mansour TS.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1151-5.

PMID:
12643932
45.

Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: antibacterial and mechanistic activities.

Singh MP, Petersen PJ, Weiss WJ, Janso JE, Luckman SW, Lenoy EB, Bradford PA, Testa RT, Greenstein M.

Antimicrob Agents Chemother. 2003 Jan;47(1):62-9.

46.

Structures of the muraymycins, novel peptidoglycan biosynthesis inhibitors.

McDonald LA, Barbieri LR, Carter GT, Lenoy E, Lotvin J, Petersen PJ, Siegel MM, Singh G, Williamson RT.

J Am Chem Soc. 2002 Sep 4;124(35):10260-1.

PMID:
12197711
47.

Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98.

He H, Williamson RT, Shen B, Graziani EI, Yang HY, Sakya SM, Petersen PJ, Carter GT.

J Am Chem Soc. 2002 Aug 21;124(33):9729-36.

PMID:
12175230
49.

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.

Sandanayaka VP, Feigelson GB, Prashad AS, Yang Y, Petersen PJ.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):997-1000. Erratum in: Bioorg Med Chem Lett 2001 Jul 23;11(14):1963.

PMID:
11327608
50.

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