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Items: 1 to 50 of 178

1.

Anti-inflammatory effects of estrogen mediate the sexual dimorphic response to Lipid-induced insulin resistance.

Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI.

J Physiol. 2019 Jun 17. doi: 10.1113/JP277270. [Epub ahead of print]

PMID:
31206703
2.

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2019 Mar;25(3):526-528. doi: 10.1038/s41591-018-0220-6.

PMID:
30733621
3.

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23. Erratum in: Nat Med. 2019 Mar;25(3):526-528.

4.

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.

5.

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI.

Cell. 2018 Jan 11;172(1-2):234-248.e17. doi: 10.1016/j.cell.2017.12.001. Epub 2018 Jan 4.

6.

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11285-E11292. doi: 10.1073/pnas.1716990115. Epub 2017 Dec 13.

7.

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. Epub 2017 Nov 9.

8.

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.

9.

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.

Cell Rep. 2017 Jun 6;19(10):1997-2004. doi: 10.1016/j.celrep.2017.05.035.

10.

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI.

FASEB J. 2017 Jul;31(7):2916-2924. doi: 10.1096/fj.201700001R. Epub 2017 Mar 22.

11.

Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis.

Foer D, Zhu M, Cardone RL, Simpson C, Sullivan R, Nemiroff S, Lee G, Kibbey RG, Petersen KF, Insogna KL.

Osteoporos Int. 2017 Jun;28(6):2011-2017. doi: 10.1007/s00198-017-3977-4. Epub 2017 Mar 10.

PMID:
28283687
12.

A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI.

Cell Metab. 2017 Mar 7;25(3):749-756. doi: 10.1016/j.cmet.2016.12.017. Epub 2017 Jan 19.

13.

Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism.

Gilliland T, Dufour S, Shulman GI, Petersen KF, Emre SH.

Pediatr Transplant. 2016 Dec;20(8):1157-1163. doi: 10.1111/petr.12819. Epub 2016 Oct 20.

PMID:
27762491
14.

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI.

Cell Metab. 2016 Jul 12;24(1):167-71. doi: 10.1016/j.cmet.2016.06.005.

15.

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E461-70. doi: 10.1152/ajpendo.00009.2016. Epub 2016 Jul 12.

16.

Hypophosphatemia promotes lower rates of muscle ATP synthesis.

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI.

FASEB J. 2016 Oct;30(10):3378-3387. Epub 2016 Jun 23.

17.

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI.

Nature. 2016 Jun 9;534(7606):213-7. doi: 10.1038/nature18309.

18.

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI.

J Biol Chem. 2016 Jun 3;291(23):12161-70. doi: 10.1074/jbc.M116.720631. Epub 2016 Mar 21.

19.

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis.

Perry RJ, Petersen KF, Shulman GI.

Diabetologia. 2016 May;59(5):933-7. doi: 10.1007/s00125-016-3909-4. Epub 2016 Mar 10. Review.

20.

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.

Camporez JP, Petersen MC, Abudukadier A, Moreira GV, Jurczak MJ, Friedman G, Haqq CM, Petersen KF, Shulman GI.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2212-7. doi: 10.1073/pnas.1525795113. Epub 2016 Feb 8.

21.

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT.

FASEB J. 2016 Mar;30(3):1207-17. doi: 10.1096/fj.15-271999. Epub 2015 Dec 7.

22.

Effect of aging on muscle mitochondrial substrate utilization in humans.

Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11330-4. doi: 10.1073/pnas.1514844112. Epub 2015 Aug 24. Erratum in: Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5762.

23.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI.

Cell. 2015 Feb 12;160(4):745-758. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5.

24.

Response to burgess.

Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI.

Nat Med. 2015 Feb;21(2):109-10. doi: 10.1038/nm.3790. No abstract available.

25.

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

Camporez JP, Kanda S, Petersen MC, Jornayvaz FR, Samuel VT, Bhanot S, Petersen KF, Jurczak MJ, Shulman GI.

J Lipid Res. 2015 Mar;56(3):526-36. doi: 10.1194/jlr.M054080. Epub 2014 Dec 29.

26.

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.

Perry RJ, Samuel VT, Petersen KF, Shulman GI.

Nature. 2014 Jun 5;510(7503):84-91. doi: 10.1038/nature13478. Review.

27.

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy.

Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI.

Nat Med. 2014 Jan;20(1):98-102. doi: 10.1038/nm.3415. Epub 2013 Dec 8.

28.

Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals.

De Feyter HM, Mason GF, Shulman GI, Rothman DL, Petersen KF.

Diabetes. 2013 Sep;62(9):3075-80. doi: 10.2337/db13-0313. Epub 2013 May 28.

29.

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.

Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT.

Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19.

30.

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.

Camporez JP, Jornayvaz FR, Lee HY, Kanda S, Guigni BA, Kahn M, Samuel VT, Carvalho CR, Petersen KF, Jurczak MJ, Shulman GI.

Endocrinology. 2013 Mar;154(3):1021-8. doi: 10.1210/en.2012-1989. Epub 2013 Jan 30.

31.

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.

Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, Petersen KF, Cline GW, Samuel VT, Shulman GI.

Hepatology. 2013 May;57(5):1763-72. doi: 10.1002/hep.26170. Epub 2013 Jan 25.

32.

³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism.

Befroy DE, Rothman DL, Petersen KF, Shulman GI.

Diabetes. 2012 Nov;61(11):2669-78. doi: 10.2337/db12-0558. Review.

33.

Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly.

Flannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF.

Diabetes. 2012 Nov;61(11):2711-7. doi: 10.2337/db12-0206. Epub 2012 Jul 24.

34.

In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET.

Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW.

J Nucl Med. 2012 Jun;53(6):908-16. doi: 10.2967/jnumed.111.100545. Epub 2012 May 9.

35.

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes.

Petersen KF, Dufour S, Morino K, Yoo PS, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8236-40. doi: 10.1073/pnas.1205675109. Epub 2012 Apr 30.

36.

Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes.

Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI.

Diabetes. 2012 Apr;61(4):877-87. doi: 10.2337/db11-1391. Epub 2012 Feb 24.

37.

Disassociation of liver and muscle insulin resistance from ectopic lipid accumulation in low-birth-weight individuals.

Dufour S, Petersen KF.

J Clin Endocrinol Metab. 2011 Dec;96(12):3873-80. doi: 10.1210/jc.2011-1747. Epub 2011 Oct 12.

38.

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.

Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16381-5. doi: 10.1073/pnas.1113359108. Epub 2011 Sep 19.

39.

Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals.

Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13705-9. doi: 10.1073/pnas.1110105108. Epub 2011 Aug 1.

40.

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.

Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, Shulman GI.

Hepatology. 2011 Nov;54(5):1650-60. doi: 10.1002/hep.24571. Epub 2011 Aug 19.

41.

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI.

Cell Metab. 2010 Dec 1;12(6):668-74. doi: 10.1016/j.cmet.2010.11.004.

42.

The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy.

Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL.

J Neurosci. 2010 Oct 20;30(42):13983-91. doi: 10.1523/JNEUROSCI.2040-10.2010.

43.

Lipid-induced insulin resistance: unravelling the mechanism.

Samuel VT, Petersen KF, Shulman GI.

Lancet. 2010 Jun 26;375(9733):2267-77. doi: 10.1016/S0140-6736(10)60408-4. Review.

44.

High prevalence of diabetes and pre-diabetes in adults with Williams syndrome.

Pober BR, Wang E, Caprio S, Petersen KF, Brandt C, Stanley T, Osborne LR, Dzuria J, Gulanski B.

Am J Med Genet C Semin Med Genet. 2010 May 15;154C(2):291-8. doi: 10.1002/ajmg.c.30261.

45.

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.

Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI.

N Engl J Med. 2010 Mar 25;362(12):1082-9. doi: 10.1056/NEJMoa0907295.

46.

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.

Mitchell CS, Savage DB, Dufour S, Schoenmakers N, Murgatroyd P, Befroy D, Halsall D, Northcott S, Raymond-Barker P, Curran S, Henning E, Keogh J, Owen P, Lazarus J, Rothman DL, Farooqi IS, Shulman GI, Chatterjee K, Petersen KF.

J Clin Invest. 2010 Apr;120(4):1345-54. doi: 10.1172/JCI38793. Epub 2010 Mar 8.

47.

Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats.

Buhl ES, Jensen TK, Jessen N, Elfving B, Buhl CS, Kristiansen SB, Pold R, Solskov L, Schmitz O, Wegener G, Lund S, Petersen KF.

Am J Physiol Endocrinol Metab. 2010 May;298(5):E920-9. doi: 10.1152/ajpendo.00606.2009. Epub 2010 Jan 26.

48.

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.

Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF.

J Cereb Blood Flow Metab. 2010 Jan;30(1):211-21. doi: 10.1038/jcbfm.2009.197. Epub 2009 Sep 30.

49.

Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans.

Dufour S, Lebon V, Shulman GI, Petersen KF.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E231-5. doi: 10.1152/ajpendo.00222.2009. Epub 2009 May 19.

50.

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. doi: 10.1073/pnas.0810339105. Epub 2008 Dec 9.

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