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Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.

Shearn CT, Fennimore B, Orlicky DJ, Gao YR, Saba LM, Battista KD, Aivazidis S, Assiri M, Harris PS, Michel C, Merrill GF, Schmidt EE, Colgan SP, Petersen DR.

Free Radic Biol Med. 2019 Nov 1;143:101-114. doi: 10.1016/j.freeradbiomed.2019.07.036. Epub 2019 Aug 1.


Cognitive and attentional vulnerability to depression in youth: A review.

Kertz SJ, Petersen DR, Stevens KT.

Clin Psychol Rev. 2019 Jul;71:63-77. doi: 10.1016/j.cpr.2019.01.004. Epub 2019 Jan 24. Review.


Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.

Petersen DR, Orlicky DJ, Roede JR, Shearn CT.

Exp Mol Pathol. 2018 Aug;105(1):32-36. doi: 10.1016/j.yexmp.2018.05.012. Epub 2018 May 29.


Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.

Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT.

PLoS One. 2018 May 25;13(5):e0198139. doi: 10.1371/journal.pone.0198139. eCollection 2018.


Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.

Shearn CT, Pulliam CF, Pedersen K, Meredith K, Mercer KE, Saba LM, Orlicky DJ, Ronis MJ, Petersen DR.

Alcohol Clin Exp Res. 2018 Jul;42(7):1192-1205. doi: 10.1111/acer.13766. Epub 2018 May 30.


Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA.

Biomolecules. 2018 Mar 26;8(2). pii: E16. doi: 10.3390/biom8020016.


Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.

Shearn CT, Orlicky DJ, Petersen DR.

Exp Mol Pathol. 2018 Feb;104(1):1-8. doi: 10.1016/j.yexmp.2017.11.012. Epub 2017 Nov 24.


Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.

Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR.

FASEB J. 2018 Mar;32(3):1265-1280. doi: 10.1096/fj.201700586R. Epub 2018 Jan 3.


Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.

Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR.

Free Radic Biol Med. 2017 Dec;113:280-290. doi: 10.1016/j.freeradbiomed.2017.10.004. Epub 2017 Oct 6.


Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Osna NA, Carter WG, Ganesan M, Kirpich IA, McClain CJ, Petersen DR, Shearn CT, Tomasi ML, Kharbanda KK.

World J Gastroenterol. 2016 Jul 21;22(27):6192-200. doi: 10.3748/wjg.v22.i27.6192. Review.


Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.

Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR.

PLoS One. 2016 Apr 28;11(4):e0154152. doi: 10.1371/journal.pone.0154152. eCollection 2016.


Collagen Type I Improves the Differentiation of Human Embryonic Stem Cells towards Definitive Endoderm.

Rasmussen CH, Petersen DR, Moeller JB, Hansson M, Dufva M.

PLoS One. 2015 Dec 29;10(12):e0145389. doi: 10.1371/journal.pone.0145389. eCollection 2015.


Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.

Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR.

Redox Biol. 2016 Apr;7:68-77. doi: 10.1016/j.redox.2015.11.013. Epub 2015 Nov 27.


Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.

Shearn CT, Orlicky DJ, Saba LM, Shearn AH, Petersen DR.

Free Radic Biol Med. 2015 Dec;89:1144-53. doi: 10.1016/j.freeradbiomed.2015.10.420. Epub 2015 Oct 27.


N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically.

Caro AA, Bell M, Ejiofor S, Zurcher G, Petersen DR, Ronis MJ.

Alcohol Clin Exp Res. 2014 Dec;38(12):2896-906. doi: 10.1111/acer.12576.


Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease.

Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G403-15. doi: 10.1152/ajpgi.00154.2014. Epub 2014 Dec 11.


Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.

Shearn CT, Petersen DR.

Adv Exp Med Biol. 2015;815:173-84. doi: 10.1007/978-3-319-09614-8_10. Review.


Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR.

Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9.


Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.

Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR.

PLoS One. 2014 May 12;9(5):e96553. doi: 10.1371/journal.pone.0096553. eCollection 2014.


Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.

Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR.

J Biol Chem. 2014 May 30;289(22):15449-62. doi: 10.1074/jbc.M113.543942. Epub 2014 Apr 10.


Ethanol metabolism modifies hepatic protein acylation in mice.

Fritz KS, Green MF, Petersen DR, Hirschey MD.

PLoS One. 2013 Sep 20;8(9):e75868. doi: 10.1371/journal.pone.0075868. eCollection 2013.


Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR.

Free Radic Biol Med. 2013 Dec;65:680-692. doi: 10.1016/j.freeradbiomed.2013.07.011. Epub 2013 Jul 17.


Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.

Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P.

Neurochem Res. 2013 Sep;38(9):1838-49. doi: 10.1007/s11064-013-1090-4. Epub 2013 Jun 7.


Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.

Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR.

J Nutr Biochem. 2013 Aug;24(8):1436-45. doi: 10.1016/j.jnutbio.2012.12.002. Epub 2013 Mar 1.


Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.

Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR.

J Lipid Res. 2013 May;54(5):1335-45. doi: 10.1194/jlr.M034892. Epub 2013 Jan 28.


The human protein disulfide isomerase gene family.

Galligan JJ, Petersen DR.

Hum Genomics. 2012 Jul 5;6:6. doi: 10.1186/1479-7364-6-6.


Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.

Serup P, Gustavsen C, Klein T, Potter LA, Lin R, Mullapudi N, Wandzioch E, Hines A, Davis A, Bruun C, Engberg N, Petersen DR, Peterslund JM, Macdonald RJ, Grapin-Botton A, Magnuson MA, Zaret KS.

Dis Model Mech. 2012 Nov;5(6):956-66. doi: 10.1242/dmm.009696. Epub 2012 Aug 10.


Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR.

J Toxicol. 2012;2012:207594. doi: 10.1155/2012/207594. Epub 2012 Jul 5.


An overview of the chemistry and biology of reactive aldehydes.

Fritz KS, Petersen DR.

Free Radic Biol Med. 2013 Jun;59:85-91. doi: 10.1016/j.freeradbiomed.2012.06.025. Epub 2012 Jun 28. Review.


Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.

Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR.

PLoS One. 2012;7(6):e38459. doi: 10.1371/journal.pone.0038459. Epub 2012 Jun 6.


Protein carbonylation in a murine model for early alcoholic liver disease.

Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR.

Chem Res Toxicol. 2012 May 21;25(5):1012-21. doi: 10.1021/tx300002q. Epub 2012 May 1.


4-HNE adduct stability characterized by collision-induced dissociation and electron transfer dissociation mass spectrometry.

Fritz KS, Kellersberger KA, Gomez JD, Petersen DR.

Chem Res Toxicol. 2012 Apr 16;25(4):965-70. doi: 10.1021/tx300100w. Epub 2012 Mar 28.


Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.

Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.

J Proteome Res. 2012 Mar 2;11(3):1633-43. doi: 10.1021/pr2008384. Epub 2012 Feb 21.


Engineering artificial signaling centers to polarize embryoid body differentiation.

Petersen DR, Gustavsen C, Lindskog SR, Magnuson MA, Zaret KS, Serup P.

Stem Cells Dev. 2012 Mar 1;21(4):647-53. doi: 10.1089/scd.2011.0344. Epub 2011 Sep 29.


Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease.

Gentile CL, Nivala AM, Gonzales JC, Pfaffenbach KT, Wang D, Wei Y, Jiang H, Orlicky DJ, Petersen DR, Pagliassotti MJ, Maclean KN.

Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1710-22. doi: 10.1152/ajpregu.00677.2010. Epub 2011 Sep 28.


Exploring the biology of lipid peroxidation-derived protein carbonylation.

Fritz KS, Petersen DR.

Chem Res Toxicol. 2011 Sep 19;24(9):1411-9. doi: 10.1021/tx200169n. Epub 2011 Aug 18. Review.


The human sirtuin family: evolutionary divergences and functions.

Vassilopoulos A, Fritz KS, Petersen DR, Gius D.

Hum Genomics. 2011 Jul;5(5):485-96.


Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis.

Setshedi M, Longato L, Petersen DR, Ronis M, Chen WC, Wands JR, de la Monte SM.

Alcohol Clin Exp Res. 2011 Dec;35(12):2139-51. doi: 10.1111/j.1530-0277.2011.01569.x. Epub 2011 Jul 25.


The human fatty acid-binding protein family: evolutionary divergences and functions.

Smathers RL, Petersen DR.

Hum Genomics. 2011 Mar;5(3):170-91. Review.


4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR.

Chem Res Toxicol. 2011 May 16;24(5):651-62. doi: 10.1021/tx100355a. Epub 2011 Apr 14.


Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

Shearn CT, Fritz KS, Reigan P, Petersen DR.

Biochemistry. 2011 May 17;50(19):3984-96. doi: 10.1021/bi200029w. Epub 2011 Apr 20.


Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534. Epub 2011 Mar 17.


Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease.

Smathers RL, Galligan JJ, Stewart BJ, Petersen DR.

Chem Biol Interact. 2011 Jun 30;192(1-2):107-12. doi: 10.1016/j.cbi.2011.02.021. Epub 2011 Feb 24. Review.


Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion.

Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR.

J Proteome Res. 2011 Apr 1;10(4):1837-47. doi: 10.1021/pr101101s. Epub 2011 Mar 7.


Effects of long-term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease.

Ronis MJ, Hennings L, Stewart B, Basnakian AG, Apostolov EO, Albano E, Badger TM, Petersen DR.

Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G109-19. doi: 10.1152/ajpgi.00145.2010. Epub 2010 Nov 4.


Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal.

Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC.

Free Radic Biol Med. 2011 Jan 1;50(1):14-26. doi: 10.1016/j.freeradbiomed.2010.10.694. Epub 2010 Oct 21.


Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling.

Engberg N, Kahn M, Petersen DR, Hansson M, Serup P.

Stem Cells. 2010 Sep;28(9):1498-509. doi: 10.1002/stem.479.


Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.

LoPachin RM, Gavin T, Petersen DR, Barber DS.

Chem Res Toxicol. 2009 Sep;22(9):1499-508. doi: 10.1021/tx900147g. Review.


In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal.

Roede JR, Carbone DL, Doorn JA, Kirichenko OV, Reigan P, Petersen DR.

Chem Res Toxicol. 2008 Dec;21(12):2289-99. doi: 10.1021/tx800244u.


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