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Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation.

Tian W, Jiang X, Sung YK, Shuffle E, Wu TH, Kao PN, Tu AB, Dorfmüller P, Cao A, Wang L, Peng G, Kim Y, Zhang P, Chappell J, Pasupneti S, Dahms P, Maguire P, Chaib H, Zamanian R, Peters-Golden M, Snyder MP, Voelkel NF, Humbert M, Rabinovitch M, Nicolls MR.

Circulation. 2019 Aug 29. doi: 10.1161/CIRCULATIONAHA.119.040629. [Epub ahead of print]


Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations.

Draijer C, Penke LRK, Peters-Golden M.

J Immunol. 2019 May 1;202(9):2700-2709. doi: 10.4049/jimmunol.1801387. Epub 2019 Mar 13.


Special Delivery: A New Package for an Old Antifibrotic Mediator.

Penke LR, Peters-Golden M.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):249-250. doi: 10.1165/rcmb.2018-0312ED. No abstract available.


Microenvironmental Influences on Extracellular Vesicle-Mediated Communication in the Lung.

Haggadone MD, Peters-Golden M.

Trends Mol Med. 2018 Nov;24(11):963-975. doi: 10.1016/j.molmed.2018.08.006. Epub 2018 Sep 21. Review.


FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis.

Penke LR, Speth JM, Dommeti VL, White ES, Bergin IL, Peters-Golden M.

J Clin Invest. 2018 Jun 1;128(6):2389-2405. doi: 10.1172/JCI87631. Epub 2018 May 7.


Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.

Mancuso P, Curtis JL, Freeman CM, Peters-Golden M, Weinberg JB, Myers MG Jr.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L78-L86. doi: 10.1152/ajplung.00447.2017. Epub 2018 Mar 22.


The Chemical Elucidation of Slow-Reacting Substance: Bronchospasm and Beyond.

Peters-Golden M.

J Immunol. 2018 Mar 1;200(5):1535-1537. doi: 10.4049/jimmunol.1800037. No abstract available.


Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2.

Aoyagi T, Newstead MW, Zeng X, Nanjo Y, Peters-Golden M, Kaku M, Standiford TJ.

PLoS Pathog. 2017 Nov 22;13(11):e1006737. doi: 10.1371/journal.ppat.1006737. eCollection 2017 Nov.


Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs.

Kim LH, Plaza K, Thomas SR, Draijer C, Radford K, Peters-Golden M, Mukherjee M, Nair P.

J Immunol Methods. 2018 Mar;454:76-79. doi: 10.1016/j.jim.2017.11.005. Epub 2017 Nov 14.


Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication.

Schneider DJ, Speth JM, Penke LR, Wettlaufer SH, Swanson JA, Peters-Golden M.

J Biol Chem. 2017 Dec 22;292(51):20897-20910. doi: 10.1074/jbc.M117.792416. Epub 2017 Nov 3.


Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products.

Pinheiro CDS, Monteiro APT, Dutra FF, Bozza MT, Peters-Golden M, Benjamim CF, Canetti C.

Mediators Inflamm. 2017;2017:2086840. doi: 10.1155/2017/2086840. Epub 2017 Aug 15.


Distinct PKA regulatory subunits mediate PGE2 inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation.

Wettlaufer SH, Penke LR, Okunishi K, Peters-Golden M.

Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L722-L731. doi: 10.1152/ajplung.00131.2017. Epub 2017 Jul 20.


Leukotriene B4 antagonism ameliorates experimental lymphedema.

Tian W, Rockson SG, Jiang X, Kim J, Begaye A, Shuffle EM, Tu AB, Cribb M, Nepiyushchikh Z, Feroze AH, Zamanian RT, Dhillon GS, Voelkel NF, Peters-Golden M, Kitajewski J, Dixon JB, Nicolls MR.

Sci Transl Med. 2017 May 10;9(389). pii: eaal3920. doi: 10.1126/scitranslmed.aal3920.


The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.

Zasłona Z, Pålsson-McDermott EM, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran SE, Peters-Golden M, O'Neill LAJ.

J Immunol. 2017 May 1;198(9):3558-3564. doi: 10.4049/jimmunol.1602072. Epub 2017 Mar 15.


Alveolar Macrophages in Allergic Asthma: the Forgotten Cell Awakes.

Draijer C, Peters-Golden M.

Curr Allergy Asthma Rep. 2017 Feb;17(2):12. doi: 10.1007/s11882-017-0681-6. Review.


IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.

Kovach MA, Singer B, Martinez-Colon G, Newstead MW, Zeng X, Mancuso P, Moore TA, Kunkel SL, Peters-Golden M, Moore BB, Standiford TJ.

Mucosal Immunol. 2017 Sep;10(5):1320-1334. doi: 10.1038/mi.2016.130. Epub 2017 Feb 8.


Simultaneously Targeting Myofibroblast Contractility and Extracellular Matrix Cross-Linking as a Therapeutic Concept in Airway Fibrosis.

Lin YC, Sung YK, Jiang X, Peters-Golden M, Nicolls MR.

Am J Transplant. 2017 May;17(5):1229-1241. doi: 10.1111/ajt.14103. Epub 2016 Dec 5.


Signed, Sealed, Delivered: Microenvironmental Modulation of Extracellular Vesicle-Dependent Immunoregulation in the Lung.

Schneider DJ, Speth JM, Peters-Golden M.

Front Cell Dev Biol. 2016 Aug 30;4:94. doi: 10.3389/fcell.2016.00094. eCollection 2016. Review.


Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain.

Zhu L, Maruvada R, Sapirstein A, Peters-Golden M, Kim KS.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12661. Epub 2016 Sep 25.


Protein kinase A inhibition of macrophage maturation is accompanied by an increase in DNA methylation of the colony-stimulating factor 1 receptor gene.

Zasłona Z, Scruggs AM, Peters-Golden M, Huang SK.

Immunology. 2016 Oct;149(2):225-37. doi: 10.1111/imm.12641. Epub 2016 Aug 16.


Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.

Speth JM, Bourdonnay E, Penke LR, Mancuso P, Moore BB, Weinberg JB, Peters-Golden M.

J Immunol. 2016 Jun 15;196(12):5112-20. doi: 10.4049/jimmunol.1502153. Epub 2016 May 13.


Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.

Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1111-20. doi: 10.1152/ajplung.00220.2015. Epub 2016 Apr 8.


Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis.

Gu H, Fisher AJ, Mickler EA, Duerson F 3rd, Cummings OW, Peters-Golden M, Twigg HL 3rd, Woodruff TM, Wilkes DS, Vittal R.

FASEB J. 2016 Jun;30(6):2336-50. doi: 10.1096/fj.201500044. Epub 2016 Mar 8.


IL-36γ is secreted in microparticles and exosomes by lung macrophages in response to bacteria and bacterial components.

Kovach MA, Singer BH, Newstead MW, Zeng X, Moore TA, White ES, Kunkel SL, Peters-Golden M, Standiford TJ.

J Leukoc Biol. 2016 Aug;100(2):413-21. doi: 10.1189/jlb.4A0315-087R. Epub 2016 Feb 10.


Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension.

Qian J, Tian W, Jiang X, Tamosiuniene R, Sung YK, Shuffle EM, Tu AB, Valenzuela A, Jiang S, Zamanian RT, Fiorentino DF, Voelkel NF, Peters-Golden M, Stenmark KR, Chung L, Rabinovitch M, Nicolls MR.

Hypertension. 2015 Dec;66(6):1227-1239. doi: 10.1161/HYPERTENSIONAHA.115.06370. Epub 2015 Oct 5.


Prostanoids in Asthma and COPD: Actions, Dysregulation, and Therapeutic Opportunities.

Zaslona Z, Peters-Golden M.

Chest. 2015 Nov;148(5):1300-1306. doi: 10.1378/chest.15-1029. Review.


Reversal of the Transcriptome by Prostaglandin E2 during Myofibroblast Dedifferentiation.

Wettlaufer SH, Scott JP, McEachin RC, Peters-Golden M, Huang SK.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):114-27. doi: 10.1165/rcmb.2014-0468OC.


Prostaglandin E₂ and polyenylphosphatidylcholine: stiff competition for the fibrotic complications of inflammatory bowel disease?

Huang SK, Peters-Golden M.

Dig Dis Sci. 2015 Jun;60(6):1514-6. doi: 10.1007/s10620-015-3668-y. Epub 2015 Apr 24. No abstract available.


Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.

Bourdonnay E, Zasłona Z, Penke LR, Speth JM, Schneider DJ, Przybranowski S, Swanson JA, Mancuso P, Freeman CM, Curtis JL, Peters-Golden M.

J Exp Med. 2015 May 4;212(5):729-42. doi: 10.1084/jem.20141675. Epub 2015 Apr 6.


Clostridium difficile-induced colitis in mice is independent of leukotrienes.

Trindade BC, Theriot CM, Leslie JL, Carlson PE Jr, Bergin IL, Peters-Golden M, Young VB, Aronoff DM.

Anaerobe. 2014 Dec;30:90-8. doi: 10.1016/j.anaerobe.2014.09.006. Epub 2014 Sep 16.


Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.

Zasłona Z, Przybranowski S, Wilke C, van Rooijen N, Teitz-Tennenbaum S, Osterholzer JJ, Wilkinson JE, Moore BB, Peters-Golden M.

J Immunol. 2014 Oct 15;193(8):4245-53. doi: 10.4049/jimmunol.1400580. Epub 2014 Sep 15.


Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung.

Huang SK, Scruggs AM, McEachin RC, White ES, Peters-Golden M.

PLoS One. 2014 Sep 12;9(9):e107055. doi: 10.1371/journal.pone.0107055. eCollection 2014.


Perinatal bisphenol A exposure beginning before gestation enhances allergen sensitization, but not pulmonary inflammation, in adult mice.

O'Brien E, Bergin IL, Dolinoy DC, Zaslona Z, Little RJ, Tao Y, Peters-Golden M, Mancuso P.

J Dev Orig Health Dis. 2014 Apr;5(2):121-31. doi: 10.1017/S204017441400004X.


Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation.

Degraaf AJ, Zasłona Z, Bourdonnay E, Peters-Golden M.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):242-50. doi: 10.1165/rcmb.2013-0495OC.


Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation.

Wang Z, Filgueiras LR, Wang S, Serezani AP, Peters-Golden M, Jancar S, Serezani CH.

J Immunol. 2014 Mar 1;192(5):2349-56. doi: 10.4049/jimmunol.1302982. Epub 2014 Jan 29.


Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing.

Brogliato AR, Moor AN, Kesl SL, Guilherme RF, Georgii JL, Peters-Golden M, Canetti C, Gould LJ, Benjamim CF.

J Invest Dermatol. 2014 May;134(5):1436-1445. doi: 10.1038/jid.2013.493. Epub 2013 Nov 13.


Prostaglandin E₂ suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells.

Zasłona Z, Okunishi K, Bourdonnay E, Domingo-Gonzalez R, Moore BB, Lukacs NW, Aronoff DM, Peters-Golden M.

J Allergy Clin Immunol. 2014 Feb;133(2):379-87. doi: 10.1016/j.jaci.2013.07.037. Epub 2013 Sep 24.


Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions.

Okunishi K, DeGraaf AJ, Zasłona Z, Peters-Golden M.

FASEB J. 2014 Jan;28(1):56-66. doi: 10.1096/fj.13-231720. Epub 2013 Sep 26.


Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.

Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, Gera L, Farkas L, Rabinovitch M, Zamanian RT, Inayathullah M, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR.

Sci Transl Med. 2013 Aug 28;5(200):200ra117. doi: 10.1126/scitranslmed.3006674.


Pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis.

Monteiro AP, Soledade E, Pinheiro CS, Dellatorre-Teixeira L, Oliveira GP, Oliveira MG, Peters-Golden M, Rocco PR, Benjamim CF, Canetti C.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):87-95. doi: 10.1165/rcmb.2012-0525OC.


Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2.

Mason KL, Rogers LM, Soares EM, Bani-Hashemi T, Erb Downward J, Agnew D, Peters-Golden M, Weinberg JB, Crofford LJ, Aronoff DM.

J Immunol. 2013 Sep 1;191(5):2457-65. doi: 10.4049/jimmunol.1300786. Epub 2013 Aug 2.


EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii.

Rogers LM, Thelen T, Fordyce K, Bourdonnay E, Lewis C, Yu H, Zhang J, Xie J, Serezani CH, Peters-Golden M, Aronoff DM.

Am J Reprod Immunol. 2014 Jan;71(1):34-43. doi: 10.1111/aji.12153. Epub 2013 Aug 1.


Antileukotriene agents for the treatment of lung disease.

Scott JP, Peters-Golden M.

Am J Respir Crit Care Med. 2013 Sep 1;188(5):538-44. doi: 10.1164/rccm.201301-0023PP. Review.


Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts.

Huang SK, Scruggs AM, Donaghy J, Horowitz JC, Zaslona Z, Przybranowski S, White ES, Peters-Golden M.

Cell Death Dis. 2013 May 2;4:e621. doi: 10.1038/cddis.2013.146.


Reversal of myofibroblast differentiation by prostaglandin E(2).

Garrison G, Huang SK, Okunishi K, Scott JP, Kumar Penke LR, Scruggs AM, Peters-Golden M.

Am J Respir Cell Mol Biol. 2013 May;48(5):550-8. doi: 10.1165/rcmb.2012-0262OC.


Murine colitis is mediated by vimentin.

Mor-Vaknin N, Legendre M, Yu Y, Serezani CH, Garg SK, Jatzek A, Swanson MD, Gonzalez-Hernandez MJ, Teitz-Tennenbaum S, Punturieri A, Engleberg NC, Banerjee R, Peters-Golden M, Kao JY, Markovitz DM.

Sci Rep. 2013;3:1045. doi: 10.1038/srep01045. Epub 2013 Jan 9.


Ketoprofen impairs immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2.

Brogliato AR, Antunes CA, Carvalho RS, Monteiro AP, Tinoco RF, Bozza MT, Canetti C, Peters-Golden M, Kunkel SL, Vianna-Jorge R, Benjamim CF.

Shock. 2012 Dec;38(6):620-9. doi: 10.1097/SHK.0b013e318272ff8a.


A lipid mediator controls neutrophil recruitment in acute lung injury--should we really be surprised?

Zasłona Z, Peters-Golden M.

Crit Care. 2012 Oct 25;16(5):161. doi: 10.1186/cc11519.


An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice.

Kaul V, Bhattacharya D, Singh Y, Van Kaer L, Peters-Golden M, Bishai WR, Das G.

J Infect Dis. 2012 Dec 15;206(12):1816-25. doi: 10.1093/infdis/jis609. Epub 2012 Oct 2.

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