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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos.

Du Z, Zheng H, Kawamura YK, Zhang K, Gassler J, Powell S, Xu Q, Lin Z, Xu K, Zhou Q, Ozonov EA, Véron N, Huang B, Li L, Yu G, Liu L, Au Yeung WK, Wang P, Chang L, Wang Q, He A, Sun Y, Na J, Sun Q, Sasaki H, Tachibana K, Peters AHFM, Xie W.

Mol Cell. 2019 Dec 4. pii: S1097-2765(19)30840-8. doi: 10.1016/j.molcel.2019.11.011. [Epub ahead of print]


Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne H, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T.

Cancer Discov. 2019 Dec;9(12):1736-1753. doi: 10.1158/2159-8290.CD-18-1463. Epub 2019 Oct 29.


Transforming activities of the NUP98-KMT2A fusion gene associated with myelodysplasia and acute myeloid leukemia.

Fisher JN, Thanasopoulou A, Juge S, Tzankov A, Bagger FO, Mendez MA, Peters AHFM, Schwaller J.

Haematologica. 2019 Sep 26. pii: haematol.2019.219188. doi: 10.3324/haematol.2019.219188. [Epub ahead of print]


Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH.

Mol Cell. 2019 Aug 8;75(3):483-497.e9. doi: 10.1016/j.molcel.2019.06.002. Epub 2019 Jun 25.


Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins.

Welling M, Mohr MA, Ponti A, Rullan Sabater L, Boni A, Kawamura YK, Liberali P, Peters AH, Pelczar P, Pantazis P.

Elife. 2019 Jan 21;8. pii: e44491. doi: 10.7554/eLife.44491.


Kmt2b conveys monovalent and bivalent H3K4me3 in mouse spermatogonial stem cells at germline and embryonic promoters.

Tomizawa SI, Kobayashi Y, Shirakawa T, Watanabe K, Mizoguchi K, Hoshi I, Nakajima K, Nakabayashi J, Singh S, Dahl A, Alexopoulou D, Seki M, Suzuki Y, Royo H, Peters AHFM, Anastassiadis K, Stewart AF, Ohbo K.

Development. 2018 Nov 30;145(23). pii: dev169102. doi: 10.1242/dev.169102.


Toward human egg-like cells in vitro.

Gill ME, Peters AHFM.

Science. 2018 Oct 19;362(6412):291-292. doi: 10.1126/science.aav3479. No abstract available.


Aggressive leukemia driven by MLL-AF9.

Stavropoulou V, Peters AHFM, Schwaller J.

Mol Cell Oncol. 2017 Oct 23;5(3):e1241854. doi: 10.1080/23723556.2016.1241854. eCollection 2018.


A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia.

Stavropoulou V, Almosailleakh M, Royo H, Spetz JF, Juge S, Brault L, Kopp P, Iacovino M, Kyba M, Tzankov A, Stadler MB, Cazzaniga G, Peters AHFM, Schwaller J.

Hemasphere. 2018 Jun 12;2(4):e51. doi: 10.1097/HS9.0000000000000051. eCollection 2018 Aug.


Initiating meiosis in a dish.

Gill ME, Peters AH.

EMBO J. 2017 Nov 2;36(21):3097-3099. doi: 10.15252/embj.201798101. Epub 2017 Oct 4. No abstract available.


Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development.

Magaraki A, van der Heijden G, Sleddens-Linkels E, Magarakis L, van Cappellen WA, Peters AHFM, Gribnau J, Baarends WM, Eijpe M.

Epigenetics Chromatin. 2017 Mar 11;10:11. doi: 10.1186/s13072-017-0119-3. eCollection 2017.


Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline.

Sangrithi MN, Royo H, Mahadevaiah SK, Ojarikre O, Bhaw L, Sesay A, Peters AH, Stadler M, Turner JM.

Dev Cell. 2017 Feb 6;40(3):289-301.e3. doi: 10.1016/j.devcel.2016.12.023. Epub 2017 Jan 26.


MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome.

Stavropoulou V, Kaspar S, Brault L, Sanders MA, Juge S, Morettini S, Tzankov A, Iacovino M, Lau IJ, Milne TA, Royo H, Kyba M, Valk PJM, Peters AHFM, Schwaller J.

Cancer Cell. 2016 Jul 11;30(1):43-58. doi: 10.1016/j.ccell.2016.05.011. Epub 2016 Jun 23.


The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos.

Eymery A, Liu Z, Ozonov EA, Stadler MB, Peters AH.

Development. 2016 Aug 1;143(15):2767-79. doi: 10.1242/dev.132746. Epub 2016 Jun 17.


Alternative Computational Analysis Shows No Evidence for Nucleosome Enrichment at Repetitive Sequences in Mammalian Spermatozoa.

Royo H, Stadler MB, Peters AHFM.

Dev Cell. 2016 Apr 4;37(1):98-104. doi: 10.1016/j.devcel.2016.03.010.


Sperm is epigenetically programmed to regulate gene transcription in embryos.

Teperek M, Simeone A, Gaggioli V, Miyamoto K, Allen GE, Erkek S, Kwon T, Marcotte EM, Zegerman P, Bradshaw CR, Peters AH, Gurdon JB, Jullien J.

Genome Res. 2016 Aug;26(8):1034-46. doi: 10.1101/gr.201541.115. Epub 2016 Mar 31.


Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation.

Royo H, Seitz H, ElInati E, Peters AH, Stadler MB, Turner JM.

PLoS Genet. 2015 Oct 28;11(10):e1005461. doi: 10.1371/journal.pgen.1005461. eCollection 2015 Oct.


Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.

Siklenka K, Erkek S, Godmann M, Lambrot R, McGraw S, Lafleur C, Cohen T, Xia J, Suderman M, Hallett M, Trasler J, Peters AH, Kimmins S.

Science. 2015 Nov 6;350(6261):aab2006. doi: 10.1126/science.aab2006. Epub 2015 Oct 8.


Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos.

Nestorov P, Hotz HR, Liu Z, Peters AH.

Sci Rep. 2015 Sep 25;5:14347. doi: 10.1038/srep14347.


Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner.

Tardat M, Albert M, Kunzmann R, Liu Z, Kaustov L, Thierry R, Duan S, Brykczynska U, Arrowsmith CH, Peters AH.

Mol Cell. 2015 Apr 2;58(1):157-71. doi: 10.1016/j.molcel.2015.02.013. Epub 2015 Mar 19.


Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications.

van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends WM, Laven JS, Peters AH, Baart EB.

Nat Commun. 2014 Dec 18;5:5868. doi: 10.1038/ncomms6868.


Absolute quantification of histone PTM marks by MRM-based LC-MS/MS.

Gao J, Liao R, Yu Y, Zhai H, Wang Y, Sack R, Peters AH, Chen J, Wu H, Huang Z, Hu M, Qi W, Lu C, Atadja P, Oyang C, Li E, Yi W, Zhou S.

Anal Chem. 2014 Oct 7;86(19):9679-86. doi: 10.1021/ac502333a. Epub 2014 Sep 8.


In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism.

Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AHFM, Patti ME, Ferguson-Smith AC.

Science. 2014 Aug 15;345(6198):1255903. doi: 10.1126/science.1255903. Epub 2014 Jul 10.


Genome-wide chromatin analysis in mature mouse and human spermatozoa.

Hisano M, Erkek S, Dessus-Babus S, Ramos L, Stadler MB, Peters AH.

Nat Protoc. 2013 Dec;8(12):2449-70. doi: 10.1038/nprot.2013.145. Epub 2013 Nov 14. Erratum in: Nat Protoc. 2014 Mar;9(3):741.


Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa.

Erkek S, Hisano M, Liang CY, Gill M, Murr R, Dieker J, Schübeler D, van der Vlag J, Stadler MB, Peters AH.

Nat Struct Mol Biol. 2013 Jul;20(7):868-75. doi: 10.1038/nsmb.2599. Epub 2013 Jun 16. Erratum in: Nat Struct Mol Biol. 2013 Oct;20(10):1236.


H3K9/HP1 and Polycomb: two key epigenetic silencing pathways for gene regulation and embryo development.

Nestorov P, Tardat M, Peters AH.

Curr Top Dev Biol. 2013;104:243-91. doi: 10.1016/B978-0-12-416027-9.00008-5. Review.


PRC1 coordinates timing of sexual differentiation of female primordial germ cells.

Yokobayashi S, Liang CY, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AH.

Nature. 2013 Mar 14;495(7440):236-40. doi: 10.1038/nature11918.


Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.

Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AH, Eichmann A, Wellik D, Ducret S, Rijli FM.

Science. 2013 Jan 11;339(6116):204-7. doi: 10.1126/science.1229326.


[Crucial role of Polycomb proteins from maternal origin in mouse early embryonic development].

Salvaing J, Posfai E, Peters AH, Beaujean N.

Med Sci (Paris). 2012 Dec;28(12):1047-9. doi: 10.1051/medsci/20122812009. Epub 2012 Dec 21. French. No abstract available.


Polycomb function during oogenesis is required for mouse embryonic development.

Posfai E, Kunzmann R, Brochard V, Salvaing J, Cabuy E, Roloff TC, Liu Z, Tardat M, van Lohuizen M, Vidal M, Beaujean N, Peters AH.

Genes Dev. 2012 May 1;26(9):920-32. doi: 10.1101/gad.188094.112. Epub 2012 Apr 12.


Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.

Tiwari VK, Burger L, Nikoletopoulou V, Deogracias R, Thakurela S, Wirbelauer C, Kaut J, Terranova R, Hoerner L, Mielke C, Boege F, Murr R, Peters AH, Barde YA, Schübeler D.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E934-43. doi: 10.1073/pnas.1119798109. Epub 2012 Apr 2.


Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?

Gill ME, Erkek S, Peters AH.

Curr Opin Cell Biol. 2012 Jun;24(3):387-96. doi: 10.1016/ Epub 2012 Mar 23. Review.


HP1γ links histone methylation marks to meiotic synapsis in mice.

Takada Y, Naruse C, Costa Y, Shirakawa T, Tachibana M, Sharif J, Kezuka-Shiotani F, Kakiuchi D, Masumoto H, Shinkai Y, Ohbo K, Peters AH, Turner JM, Asano M, Koseki H.

Development. 2011 Oct;138(19):4207-17. doi: 10.1242/dev.064444.


Epigenetics: Tet proteins in the limelight.

Véron N, Peters AH.

Nature. 2011 May 19;473(7347):293-4. doi: 10.1038/473293a. No abstract available.


Integrating care for people with depression: developments in the Netherlands.

Peters AH, de Leeuw RJ, Schrijvers GJ.

Int J Integr Care. 2010 Nov 23;10:e62.


Epigenetic mechanisms in acute myeloid leukemia.

Peters AH, Schwaller J.

Prog Drug Res. 2011;67:197-219. Review.


Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa.

Brykczynska U, Hisano M, Erkek S, Ramos L, Oakeley EJ, Roloff TC, Beisel C, Schübeler D, Stadler MB, Peters AH.

Nat Struct Mol Biol. 2010 Jun;17(6):679-87. doi: 10.1038/nsmb.1821. Epub 2010 May 16.


Genetic vasectomy-overexpression of Prm1-EGFP fusion protein in elongating spermatids causes dominant male sterility in mice.

Haueter S, Kawasumi M, Asner I, Brykczynska U, Cinelli P, Moisyadi S, Bürki K, Peters AH, Pelczar P.

Genesis. 2010 Mar;48(3):151-60. doi: 10.1002/dvg.20598.


Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.

Kudo NR, Anger M, Peters AH, Stemmann O, Theussl HC, Helmhart W, Kudo H, Heyting C, Nasmyth K.

J Cell Sci. 2009 Aug 1;122(Pt 15):2686-98. doi: 10.1242/jcs.035287.


Mechanisms of transcriptional repression by histone lysine methylation.

Hublitz P, Albert M, Peters AH.

Int J Dev Biol. 2009;53(2-3):335-54. doi: 10.1387/ijdb.082717ph. Review.


Genetic and epigenetic control of early mouse development.

Albert M, Peters AH.

Curr Opin Genet Dev. 2009 Apr;19(2):113-21. doi: 10.1016/j.gde.2009.03.004. Epub 2009 Apr 7. Review.


Protein demethylation required for DNA methylation.

Hotz HR, Peters AH.

Nat Genet. 2009 Jan;41(1):10-1. doi: 10.1038/ng0109-10. No abstract available.


Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Döhner K, Döhner H, Weber O, Blum C, Rodewald HR, Sassone-Corsi P, Peters AH, Fehling HJ.

Blood. 2009 Feb 12;113(7):1444-54. doi: 10.1182/blood-2008-02-142638. Epub 2008 Oct 24.


TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.

Daher A, Laraki G, Singh M, Melendez-Peña CE, Bannwarth S, Peters AH, Meurs EF, Braun RE, Patel RC, Gatignol A.

Mol Cell Biol. 2009 Jan;29(1):254-65. doi: 10.1128/MCB.01030-08. Epub 2008 Oct 20.


Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.

Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH.

Dev Cell. 2008 Nov;15(5):668-79. doi: 10.1016/j.devcel.2008.08.015. Epub 2008 Oct 9.


PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.

Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH.

Nat Genet. 2008 Apr;40(4):411-20. doi: 10.1038/ng.99. Epub 2008 Mar 2.


Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.

Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D.

EMBO J. 2007 Dec 12;26(24):4974-84. Epub 2007 Nov 15.


Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation.

van der Heijden GW, Derijck AA, Pósfai E, Giele M, Pelczar P, Ramos L, Wansink DG, van der Vlag J, Peters AH, de Boer P.

Nat Genet. 2007 Feb;39(2):251-8. Epub 2007 Jan 21.


A Bruno-like gene is required for stem cell maintenance in planarians.

Guo T, Peters AH, Newmark PA.

Dev Cell. 2006 Aug;11(2):159-69.


The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

Bradley SP, Kaminski DA, Peters AH, Jenuwein T, Stavnezer J.

J Immunol. 2006 Jul 15;177(2):1179-88.

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