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Items: 1 to 50 of 208

1.

HIV Transcription Is Independent of Mediator Kinases.

Cary DC, Rheinberger M, Rojc A, Peterlin BM.

AIDS Res Hum Retroviruses. 2019 Aug;35(8):710-717. doi: 10.1089/AID.2019.0039. Epub 2019 May 29.

PMID:
31044597
2.

Procyanidin trimer C1 reactivates latent HIV as a triple combination therapy with kansui and JQ1.

Cary DC, Peterlin BM.

PLoS One. 2018 Nov 26;13(11):e0208055. doi: 10.1371/journal.pone.0208055. eCollection 2018.

3.

HEXIM1-Tat chimera inhibits HIV-1 replication.

Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K.

PLoS Pathog. 2018 Nov 5;14(11):e1007402. doi: 10.1371/journal.ppat.1007402. eCollection 2018 Nov.

4.

Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.

Huang F, Shao W, Fujinaga K, Peterlin BM.

J Biol Chem. 2018 Apr 6;293(14):4993-5004. doi: 10.1074/jbc.RA117.001518. Epub 2018 Feb 20.

5.

Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA.

Ferdin J, Goričar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M.

PLoS One. 2018 Jan 24;13(1):e0191613. doi: 10.1371/journal.pone.0191613. eCollection 2018.

6.

Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.

Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD.

PLoS Pathog. 2018 Jan 5;14(1):e1006830. doi: 10.1371/journal.ppat.1006830. eCollection 2018 Jan.

7.

Natural Products and HIV/AIDS.

Cary DC, Peterlin BM.

AIDS Res Hum Retroviruses. 2018 Jan;34(1):31-38. doi: 10.1089/AID.2017.0232. Epub 2018 Jan 10. Review.

8.

Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes.

Pužar Dominkuš P, Ferdin J, Plemenitaš A, Peterlin BM, Lenassi M.

J Neurovirol. 2017 Oct;23(5):713-724. doi: 10.1007/s13365-017-0552-x. Epub 2017 Jul 31.

9.

Hili Inhibits HIV Replication in Activated T Cells.

Peterlin BM, Liu P, Wang X, Cary D, Shao W, Leoz M, Hong T, Pan T, Fujinaga K.

J Virol. 2017 May 12;91(11). pii: e00237-17. doi: 10.1128/JVI.00237-17. Print 2017 Jun 1.

10.

Euphorbia Kansui Reactivates Latent HIV.

Cary DC, Fujinaga K, Peterlin BM.

PLoS One. 2016 Dec 15;11(12):e0168027. doi: 10.1371/journal.pone.0168027. eCollection 2016.

11.

A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny.

Sabino Cunha M, Lima Sampaio T, Peterlin BM, Jesus da Costa L.

Viruses. 2016 Jul 7;8(7). pii: E189. doi: 10.3390/v8070189.

12.

FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).

Shao W, Zumer K, Fujinaga K, Peterlin BM.

J Biol Chem. 2016 Aug 19;291(34):17953-63. doi: 10.1074/jbc.M116.724401. Epub 2016 Jun 30.

13.

Targeting the latent reservoir to achieve functional HIV cure.

Cary DC, Peterlin BM.

F1000Res. 2016 May 26;5. pii: F1000 Faculty Rev-1009. doi: 10.12688/f1000research.8109.1. eCollection 2016. Review.

14.

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI.

Mol Cell. 2016 Apr 7;62(1):34-46. doi: 10.1016/j.molcel.2016.03.013.

15.

Molecular mechanisms of HIV latency.

Cary DC, Fujinaga K, Peterlin BM.

J Clin Invest. 2016 Feb;126(2):448-54. doi: 10.1172/JCI80565. Epub 2016 Jan 5. Review.

16.

CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.

Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM.

Cell Host Microbe. 2015 Nov 11;18(5):560-70. doi: 10.1016/j.chom.2015.10.012.

17.

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression.

Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, Schwartz C, Vila J, Burny A, Clumeck N, Moutschen M, De Wit S, Peterlin BM, Rouzioux C, Rohr O, Van Lint C.

PLoS Pathog. 2015 Jul 30;11(7):e1005063. doi: 10.1371/journal.ppat.1005063. eCollection 2015 Jul.

18.

Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells.

Fujinaga K, Luo Z, Schaufele F, Peterlin BM.

J Biol Chem. 2015 Jan 16;290(3):1829-36. doi: 10.1074/jbc.M114.605816. Epub 2014 Dec 9.

19.

Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.

Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM.

Mol Cell Biol. 2015 Jan;35(2):468-78. doi: 10.1128/MCB.01157-14. Epub 2014 Nov 10.

20.

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters.

Pandeló José D, Bartholomeeusen K, da Cunha RD, Abreu CM, Glinski J, da Costa TB, Bacchi Rabay AF, Pianowski Filho LF, Dudycz LW, Ranga U, Peterlin BM, Pianowski LF, Tanuri A, Aguiar RS.

Virology. 2014 Aug;462-463:328-39. doi: 10.1016/j.virol.2014.05.033. Epub 2014 Jul 9.

21.
22.

Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015. Epub 2014 Feb 10.

23.

Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription.

Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM.

J Biol Chem. 2013 May 17;288(20):14400-7. doi: 10.1074/jbc.M113.464834. Epub 2013 Mar 28.

24.

The mechanism of tissue-restricted antigen gene expression by AIRE.

Zumer K, Saksela K, Peterlin BM.

J Immunol. 2013 Mar 15;190(6):2479-82. doi: 10.4049/jimmunol.1203210. Review.

25.

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.

Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD.

PLoS Pathog. 2012 Dec;8(12):e1003085. doi: 10.1371/journal.ppat.1003085. Epub 2012 Dec 27.

26.

Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.

J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746. Epub 2012 Sep 5. Erratum in: J Biol Chem. 2013 Apr 26;288(17):12214.

27.

PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM.

Nucleic Acids Res. 2012 Oct;40(18):9160-70. doi: 10.1093/nar/gks682. Epub 2012 Jul 20.

28.

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Lu C, Luo Z, Jäger S, Krogan NJ, Peterlin BM.

J Virol. 2012 Oct;86(19):10517-23. doi: 10.1128/JVI.00868-12. Epub 2012 Jul 18.

29.

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.

Žumer K, Low AK, Jiang H, Saksela K, Peterlin BM.

Mol Cell Biol. 2012 Apr;32(8):1354-62. doi: 10.1128/MCB.06359-11. Epub 2012 Feb 6.

30.

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM.

Genes Dev. 2011 Oct 15;25(20):2158-72. doi: 10.1101/gad.16962311.

31.

7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription.

Peterlin BM, Brogie JE, Price DH.

Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):92-103. doi: 10.1002/wrna.106. Epub 2011 Aug 18.

32.

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.

Žumer K, Plemenitaš A, Saksela K, Peterlin BM.

Nucleic Acids Res. 2011 Oct;39(18):7908-19. doi: 10.1093/nar/gkr527. Epub 2011 Jun 30.

33.

Cap-binding protein complex links pre-mRNA capping to transcription elongation and alternative splicing through positive transcription elongation factor b (P-TEFb).

Lenasi T, Peterlin BM, Barboric M.

J Biol Chem. 2011 Jul 1;286(26):22758-68. doi: 10.1074/jbc.M111.235077. Epub 2011 May 2.

34.

P bodies inhibit retrotransposition of endogenous intracisternal a particles.

Lu C, Contreras X, Peterlin BM.

J Virol. 2011 Jul;85(13):6244-51. doi: 10.1128/JVI.02517-10. Epub 2011 Apr 27.

35.

Transcription elongation takes central stage: the P-TEFb connection.

Peterlin BM.

Cell Cycle. 2010 Aug 1;9(15):2933-4. doi: 10.4161/cc.9.15.12698. Epub 2010 Aug 1. No abstract available.

PMID:
20703074
36.

HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells.

Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM.

Traffic. 2010 Jan;11(1):110-22. doi: 10.1111/j.1600-0854.2009.01006.x.

37.

APOBEC3 proteins inhibit LINE-1 retrotransposition in the absence of ORF1p binding.

Lovsin N, Peterlin BM.

Ann N Y Acad Sci. 2009 Oct;1178:268-75. doi: 10.1111/j.1749-6632.2009.05006.x.

38.

Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques.

Jesus da Costa L, Lopes Dos Santos A, Mandic R, Shaw K, Santana de Aguiar R, Tanuri A, Luciw PA, Peterlin BM.

Virology. 2009 Nov 10;394(1):47-56. doi: 10.1016/j.virol.2009.08.024. Epub 2009 Sep 11.

39.

Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5.

Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S.

PLoS One. 2009 Sep 9;4(9):e6918. doi: 10.1371/journal.pone.0006918.

40.

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.

Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7798-803. doi: 10.1073/pnas.0903188106. Epub 2009 Apr 27.

41.

Genetic analysis of P-TEFb function via heterologous nucleic acid tethering systems.

Li Q, Peterlin BM.

Methods. 2009 Aug;48(4):375-80. doi: 10.1016/j.ymeth.2009.04.006. Epub 2009 May 3.

42.

Cyclin T2 is essential for mouse embryogenesis.

Kohoutek J, Li Q, Blazek D, Luo Z, Jiang H, Peterlin BM.

Mol Cell Biol. 2009 Jun;29(12):3280-5. doi: 10.1128/MCB.00172-09. Epub 2009 Apr 13.

43.

Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.

Okeoma CM, Low A, Bailis W, Fan HY, Peterlin BM, Ross SR.

J Virol. 2009 Apr;83(8):3486-95. doi: 10.1128/JVI.02347-08. Epub 2009 Jan 19.

44.

Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.

Low A, Okeoma CM, Lovsin N, de las Heras M, Taylor TH, Peterlin BM, Ross SR, Fan H.

Virology. 2009 Mar 15;385(2):455-63. doi: 10.1016/j.virol.2008.11.051. Epub 2009 Jan 15.

45.

Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells.

Contreras X, Schweneker M, Chen CS, McCune JM, Deeks SG, Martin J, Peterlin BM.

J Biol Chem. 2009 Mar 13;284(11):6782-9. doi: 10.1074/jbc.M807898200. Epub 2009 Jan 9.

46.

Transcriptional interference antagonizes proviral gene expression to promote HIV latency.

Lenasi T, Contreras X, Peterlin BM.

Cell Host Microbe. 2008 Aug 14;4(2):123-33. doi: 10.1016/j.chom.2008.05.016.

47.

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.

Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS.

J Clin Invest. 2008 May;118(5):1712-26. doi: 10.1172/JCI34523.

48.

Tat-SIRT1 tango.

Blazek D, Peterlin BM.

Mol Cell. 2008 Mar 14;29(5):539-40. doi: 10.1016/j.molcel.2008.02.007.

49.

APOBEC3 proteins and reverse transcription.

Aguiar RS, Peterlin BM.

Virus Res. 2008 Jun;134(1-2):74-85. doi: 10.1016/j.virusres.2007.12.022. Epub 2008 Feb 11. Review.

PMID:
18262674
50.

Vpr.A3A chimera inhibits HIV replication.

Aguiar RS, Lovsin N, Tanuri A, Peterlin BM.

J Biol Chem. 2008 Feb 1;283(5):2518-25. Epub 2007 Dec 5.

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