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Items: 10

1.

Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions.

Kikuchi R, Peterkin VC, Chiou WJ, de Morais SM, Bow DAJ.

Xenobiotica. 2017 Sep;47(9):825-832. doi: 10.1080/00498254.2016.1233372. Epub 2016 Oct 3.

PMID:
27609543
2.

Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.

Qiu Z, Elsayed Z, Peterkin V, Alkatib S, Bennett D, Landry JW.

BMC Biol. 2016 Mar 14;14:18. doi: 10.1186/s12915-016-0238-5.

3.

A High Throughput, 384-Well, Semi-Automated, Hepatocyte Intrinsic Clearance Assay for Screening New Molecular Entities in Drug Discovery.

Heinle L, Peterkin V, de Morais SM, Jenkins GJ, Badagnani I.

Comb Chem High Throughput Screen. 2015;18(5):442-52.

PMID:
25828461
4.

Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease.

Hohlfeld JM, Sharma A, van Noord JA, Cornelissen PJ, Derom E, Towse L, Peterkin V, Disse B.

J Clin Pharmacol. 2014 Apr;54(4):405-14. doi: 10.1002/jcph.215. Epub 2013 Nov 27.

5.

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW, Hall T, Chrencik J, Kraus M, Cronin CN, Saabye M, Highkin MK, Broadus R, Ogawa S, Cukyne K, Zawadzke LE, Peterkin V, Iyanar K, Scholten JA, Wendling J, Fujiwara H, Nemirovskiy O, Wittwer AJ, Nagiec MM.

Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.

PMID:
22397330
6.

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.

Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC.

Drug Metab Dispos. 2010 May;38(5):879-86. doi: 10.1124/dmd.109.030130. Epub 2010 Feb 2.

7.

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.

Peterkin VC, Bauman JN, Goosen TC, Menning L, Man MZ, Paulauskis JD, Williams JA, Myrand SP.

Br J Clin Pharmacol. 2007 Oct;64(4):458-68. Epub 2007 Jun 6.

8.

Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.

Bauman JN, Goosen TC, Tugnait M, Peterkin V, Hurst SI, Menning LC, Milad M, Court MH, Williams JA.

Drug Metab Dispos. 2005 Sep;33(9):1349-54. Epub 2005 Jun 24.

PMID:
15980101
9.

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE.

Drug Metab Dispos. 2004 Nov;32(11):1201-8. Epub 2004 Aug 10. Review.

PMID:
15304429
10.

Effect of growth conditions on the extracellular production of the aspartic proteinase by Candida albicans.

Lam M, Peterkin V, Reiss E, Morrison CJ.

Adv Exp Med Biol. 1991;306:265-7. No abstract available.

PMID:
1812715

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