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Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury.

Bhattacharjee S, Jun B, Belayev L, Heap J, Kautzmann MA, Obenaus A, Menghani H, Marcell SJ, Khoutorova L, Yang R, Petasis NA, Bazan NG.

Sci Adv. 2017 Sep 27;3(9):e1700735. doi: 10.1126/sciadv.1700735. eCollection 2017 Sep.


Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity.

Jun B, Mukherjee PK, Asatryan A, Kautzmann MA, Heap J, Gordon WC, Bhattacharjee S, Yang R, Petasis NA, Bazan NG.

Sci Rep. 2017 Jul 13;7(1):5279. doi: 10.1038/s41598-017-05433-7.


Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12232-12237. Epub 2016 Oct 6.


Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BD.

Am J Pathol. 2016 Jul;186(7):1801-1813. doi: 10.1016/j.ajpath.2016.03.011. Epub 2016 May 10.


Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance.

Winkler JW, Orr SK, Dalli J, Cheng CY, Sanger JM, Chiang N, Petasis NA, Serhan CN.

Sci Rep. 2016 Jan 8;6:18972. doi: 10.1038/srep18972.


Component-selective and stereocontrolled one-step three-component reaction among aldehydes, amines, and allenyl boronic acids or allenyl pinacolboronates.

Liepouri F, Bernasconi G, Petasis NA.

Org Lett. 2015 Apr 3;17(7):1628-31. doi: 10.1021/acs.orglett.5b00024. Epub 2015 Mar 19.


Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

Glynn SJ, Gaffney KJ, Sainz MA, Louie SG, Petasis NA.

Org Biomol Chem. 2015 Apr 7;13(13):3887-99. doi: 10.1039/c4ob02512a.


Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1.

Musto AE, Walker CP, Petasis NA, Bazan NG.

PLoS One. 2015 Jan 24;10(1):e0116543. doi: 10.1371/journal.pone.0116543. eCollection 2015.


Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.

Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BD.

J Immunol. 2015 Feb 1;194(3):863-7. doi: 10.4049/jimmunol.1402534. Epub 2014 Dec 24.


Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective.

Abdulnour RE, Dalli J, Colby JK, Krishnamoorthy N, Timmons JY, Tan SH, Colas RA, Petasis NA, Serhan CN, Levy BD.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16526-31. doi: 10.1073/pnas.1407123111. Epub 2014 Nov 4.


The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation.

Hua J, Jin Y, Chen Y, Inomata T, Lee H, Chauhan SK, Petasis NA, Serhan CN, Dana R.

Invest Ophthalmol Vis Sci. 2014 Aug 21;55(9):5944-51. doi: 10.1167/iovs.14-14356.


Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.

Asatryan L, Yardley MM, Khoja S, Trudell JR, Hyunh N, Louie SG, Petasis NA, Alkana RL, Davies DL.

Int J Neuropsychopharmacol. 2014 Jun;17(6):907-16. doi: 10.1017/S1461145713001703. Epub 2014 Jan 22.


Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1.

Sheets KG, Jun B, Zhou Y, Zhu M, Petasis NA, Gordon WC, Bazan NG.

Mol Vis. 2013 Aug 4;19:1747-59. Print 2013.


Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer.

Winkler JW, Uddin J, Serhan CN, Petasis NA.

Org Lett. 2013 Apr 5;15(7):1424-7. doi: 10.1021/ol400484u. Epub 2013 Mar 19.


The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.

Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN.

FASEB J. 2013 Jul;27(7):2573-83. doi: 10.1096/fj.13-227728. Epub 2013 Mar 15.


Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.

Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CN.

Chem Biol. 2013 Feb 21;20(2):188-201. doi: 10.1016/j.chembiol.2012.11.010.


Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.

Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53. doi: 10.1073/pnas.1205226109. Epub 2012 Sep 17.


Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration.

Choi I, Lee YS, Chung HK, Choi D, Ecoiffier T, Lee HN, Kim KE, Lee S, Park EK, Maeng YS, Kim NY, Ladner RD, Petasis NA, Koh CJ, Chen L, Lenz HJ, Hong YK.

Angiogenesis. 2013 Jan;16(1):29-44. doi: 10.1007/s10456-012-9297-6. Epub 2012 Sep 4.


Perillyl alcohol for the treatment of temozolomide-resistant gliomas.

Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis NA, Louie SG, Schönthal AH, Hofman FM, Chen TC.

Mol Cancer Ther. 2012 Nov;11(11):2462-72. doi: 10.1158/1535-7163.MCT-12-0321. Epub 2012 Aug 28.


Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent.

Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, Schönthal AH, Louie SG.

Cancer Lett. 2012 Dec 30;326(2):143-54. doi: 10.1016/j.canlet.2012.07.029. Epub 2012 Aug 1.


Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer.

Petasis NA, Yang R, Winkler JW, Zhu M, Uddin J, Bazan NG, Serhan CN.

Tetrahedron Lett. 2012 Apr 4;53(14):1695-1698. Epub 2012 Jan 14.


Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.

Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman FM, Louie SG, Schönthal AH.

Cancer Lett. 2012 Dec 1;325(1):63-71. doi: 10.1016/j.canlet.2012.05.030. Epub 2012 Jun 1.


Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis.

Lee YS, Choi I, Ning Y, Kim NY, Khatchadourian V, Yang D, Chung HK, Choi D, LaBonte MJ, Ladner RD, Nagulapalli Venkata KC, Rosenberg DO, Petasis NA, Lenz HJ, Hong YK.

Br J Cancer. 2012 May 22;106(11):1833-41. doi: 10.1038/bjc.2012.177.


Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke.

Bazan NG, Eady TN, Khoutorova L, Atkins KD, Hong S, Lu Y, Zhang C, Jun B, Obenaus A, Fredman G, Zhu M, Winkler JW, Petasis NA, Serhan CN, Belayev L.

Exp Neurol. 2012 Jul;236(1):122-30. doi: 10.1016/j.expneurol.2012.04.007. Epub 2012 Apr 19.


Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1.

Calandria JM, Mukherjee PK, de Rivero Vaccari JC, Zhu M, Petasis NA, Bazan NG.

J Biol Chem. 2012 Jul 6;287(28):23726-39. doi: 10.1074/jbc.M111.287078. Epub 2012 Apr 16.


Ivermectin reduces alcohol intake and preference in mice.

Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL.

Neuropharmacology. 2012 Aug;63(2):190-201. doi: 10.1016/j.neuropharm.2012.03.014. Epub 2012 Mar 23.


Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.

Jayathilaka N, Han A, Gaffney KJ, Dey R, Jarusiewicz JA, Noridomi K, Philips MA, Lei X, He J, Ye J, Gao T, Petasis NA, Chen L.

Nucleic Acids Res. 2012 Jul;40(12):5378-88. doi: 10.1093/nar/gks189. Epub 2012 Mar 6.


The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models.

Ning Y, Labonte MJ, Zhang W, Bohanes PO, Gerger A, Yang D, Benhaim L, Paez D, Rosenberg DO, Nagulapalli Venkata KC, Louie SG, Petasis NA, Ladner RD, Lenz HJ.

Mol Cancer Ther. 2012 Jun;11(6):1353-64. doi: 10.1158/1535-7163.MCT-11-0915. Epub 2012 Mar 5.


Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.

Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA.

FASEB J. 2012 Apr;26(4):1755-65. doi: 10.1096/fj.11-201442. Epub 2012 Jan 17.


Noscapine inhibits tumor growth in TMZ-resistant gliomas.

Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, Louie SG, Hofman FM, Chen TC.

Cancer Lett. 2011 Dec 22;312(2):245-52. doi: 10.1016/j.canlet.2011.08.015. Epub 2011 Aug 28.


Novel proresolving aspirin-triggered DHA pathway.

Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA.

Chem Biol. 2011 Aug 26;18(8):976-87. doi: 10.1016/j.chembiol.2011.06.008.


Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response.

Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA.

Curr Pharm Des. 2011;17(23):2428-38. Review.


Resolvins and protectins in inflammation resolution.

Serhan CN, Petasis NA.

Chem Rev. 2011 Oct 12;111(10):5922-43. doi: 10.1021/cr100396c. Epub 2011 Jul 18. Review. No abstract available.


Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.

Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z, Kam W, Hsu YT, Winkler JW, Chen JC, Petasis NA, Baudry M, Sioutas C, Finch CE.

Environ Health Perspect. 2011 Jul;119(7):1003-9. doi: 10.1289/ehp.1002973.


Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).

Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N.

J Med Chem. 2011 Apr 28;54(8):2902-14. doi: 10.1021/jm101655d. Epub 2011 Mar 28.


Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib.

Ferrario A, Lim S, Xu F, Luna M, Gaffney KJ, Petasis NA, Schönthal AH, Gomer CJ.

Cancer Lett. 2011 May 1;304(1):33-40. doi: 10.1016/j.canlet.2011.01.023. Epub 2011 Feb 19.


Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models.

Zhao Y, Calon F, Julien C, Winkler JW, Petasis NA, Lukiw WJ, Bazan NG.

PLoS One. 2011 Jan 5;6(1):e15816. doi: 10.1371/journal.pone.0015816.


Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature.

Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schönthal AH, Chen TC, Hofman FM.

Mol Cancer Ther. 2010 Mar;9(3):631-41. doi: 10.1158/1535-7163.MCT-09-0652. Epub 2010 Mar 2.


Resolvin D1 binds human phagocytes with evidence for proresolving receptors.

Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. doi: 10.1073/pnas.0907342107. Epub 2010 Jan 4.


Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils.

Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Winkler JW, Petasis NA, Serhan CN, Bazan NG.

Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):27-34. doi: 10.1016/j.plefa.2009.10.010.


Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN.

Nature. 2009 Oct 29;461(7268):1287-91. doi: 10.1038/nature08541.


Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs.

Sun YP, Tjonahen E, Keledjian R, Zhu M, Yang R, Recchiuti A, Pillai PS, Petasis NA, Serhan CN.

Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec;81(5-6):357-66. doi: 10.1016/j.plefa.2009.09.004. Epub 2009 Oct 22.


Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2.

Chen ST, Thomas S, Gaffney KJ, Louie SG, Petasis NA, Schönthal AH.

Leuk Res. 2010 Feb;34(2):250-3. doi: 10.1016/j.leukres.2009.09.028.


15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury.

El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JG.

Am J Respir Crit Care Med. 2009 Aug 15;180(4):311-9. doi: 10.1164/rccm.200810-1601OC. Epub 2009 May 29.


Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1.

Calandria JM, Marcheselli VL, Mukherjee PK, Uddin J, Winkler JW, Petasis NA, Bazan NG.

J Biol Chem. 2009 Jun 26;284(26):17877-82. doi: 10.1074/jbc.M109.003988. Epub 2009 Apr 29.


Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress.

Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH.

Cancer Lett. 2009 Sep 8;282(1):87-97. doi: 10.1016/j.canlet.2009.03.007. Epub 2009 Apr 3.


Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate.

Carlo T, Petasis NA, Levy BD.

Biochemistry. 2009 Apr 7;48(13):2997-3004. doi: 10.1021/bi8020636.


Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.

Golden EB, Lam PY, Kardosh A, Gaffney KJ, Cadenas E, Louie SG, Petasis NA, Chen TC, Schönthal AH.

Blood. 2009 Jun 4;113(23):5927-37. doi: 10.1182/blood-2008-07-171389. Epub 2009 Feb 3.

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