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Two classes of EF1-family translational GTPases encoded by giant viruses.

Zinoviev A, Kuroha K, Pestova TV, Hellen CUT.

Nucleic Acids Res. 2019 Jun 20;47(11):5761-5776. doi: 10.1093/nar/gkz296.


Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.

Kuroha K, Zinoviev A, Hellen CUT, Pestova TV.

Mol Cell. 2018 Oct 18;72(2):286-302.e8. doi: 10.1016/j.molcel.2018.08.022. Epub 2018 Sep 20.


Human eIF5 and eIF1A Compete for Binding to eIF5B.

Lin KY, Nag N, Pestova TV, Marintchev A.

Biochemistry. 2018 Oct 9;57(40):5910-5920. doi: 10.1021/acs.biochem.8b00839. Epub 2018 Sep 26.


Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2.

Zinoviev A, Goyal A, Jindal S, LaCava J, Komar AA, Rodnina MV, Hellen CUT, Pestova TV.

Genes Dev. 2018 Sep 1;32(17-18):1226-1241. doi: 10.1101/gad.314724.118. Epub 2018 Aug 14.


Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs.

Kumar P, Hellen CU, Pestova TV.

Genes Dev. 2016 Jul 1;30(13):1573-88. doi: 10.1101/gad.282418.116.


Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus.

Asnani M, Pestova TV, Hellen CU.

Nucleic Acids Res. 2016 Apr 20;44(7):3390-407. doi: 10.1093/nar/gkw074. Epub 2016 Feb 11.


Attachment of ribosomal complexes and retrograde scanning during initiation on the Halastavi árva virus IRES.

Abaeva IS, Pestova TV, Hellen CU.

Nucleic Acids Res. 2016 Mar 18;44(5):2362-77. doi: 10.1093/nar/gkw016. Epub 2016 Jan 17.


5' UTR m(6)A Promotes Cap-Independent Translation.

Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB, Jaffrey SR.

Cell. 2015 Nov 5;163(4):999-1010. doi: 10.1016/j.cell.2015.10.012. Epub 2015 Oct 22.


Structure of mammalian eIF3 in the context of the 43S preinitiation complex.

des Georges A, Dhote V, Kuhn L, Hellen CU, Pestova TV, Frank J, Hashem Y.

Nature. 2015 Sep 24;525(7570):491-5. doi: 10.1038/nature14891. Epub 2015 Sep 7.


Multiple mechanisms of reinitiation on bicistronic calicivirus mRNAs.

Zinoviev A, Hellen CUT, Pestova TV.

Mol Cell. 2015 Mar 19;57(6):1059-1073. doi: 10.1016/j.molcel.2015.01.039.


Cryo-EM of ribosomal 80S complexes with termination factors reveals the translocated cricket paralysis virus IRES.

Muhs M, Hilal T, Mielke T, Skabkin MA, Sanbonmatsu KY, Pestova TV, Spahn CM.

Mol Cell. 2015 Feb 5;57(3):422-32. doi: 10.1016/j.molcel.2014.12.016. Epub 2015 Jan 15.


Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.

Kumar P, Sweeney TR, Skabkin MA, Skabkina OV, Hellen CU, Pestova TV.

Nucleic Acids Res. 2014 Mar;42(5):3228-45. doi: 10.1093/nar/gkt1321. Epub 2013 Dec 25.


The mechanism of translation initiation on Type 1 picornavirus IRESs.

Sweeney TR, Abaeva IS, Pestova TV, Hellen CU.

EMBO J. 2014 Jan 7;33(1):76-92. doi: 10.1002/embj.201386124. Epub 2013 Dec 15.


Structure of the mammalian ribosomal pre-termination complex associated with eRF1.eRF3.GDPNP.

des Georges A, Hashem Y, Unbehaun A, Grassucci RA, Taylor D, Hellen CU, Pestova TV, Frank J.

Nucleic Acids Res. 2014 Mar;42(5):3409-18. doi: 10.1093/nar/gkt1279. Epub 2013 Dec 11.


Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit.

Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Pestova TV, Hellen CU, Frank J.

Nature. 2013 Nov 28;503(7477):539-43. doi: 10.1038/nature12658. Epub 2013 Nov 3.


Reinitiation and other unconventional posttermination events during eukaryotic translation.

Skabkin MA, Skabkina OV, Hellen CU, Pestova TV.

Mol Cell. 2013 Jul 25;51(2):249-64. doi: 10.1016/j.molcel.2013.05.026. Epub 2013 Jun 27.


Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29.

Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Hellen CU, Pestova TV, Frank J.

Cell. 2013 May 23;153(5):1108-19. doi: 10.1016/j.cell.2013.04.036.


Cryo-EM structure of the mammalian eukaryotic release factor eRF1-eRF3-associated termination complex.

Taylor D, Unbehaun A, Li W, Das S, Lei J, Liao HY, Grassucci RA, Pestova TV, Frank J.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18413-8. doi: 10.1073/pnas.1216730109. Epub 2012 Oct 22.


Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs.

Dhote V, Sweeney TR, Kim N, Hellen CU, Pestova TV.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3150-9. doi: 10.1073/pnas.1208014109. Epub 2012 Oct 9.


Termination and post-termination events in eukaryotic translation.

Jackson RJ, Hellen CU, Pestova TV.

Adv Protein Chem Struct Biol. 2012;86:45-93. doi: 10.1016/B978-0-12-386497-0.00002-5. Review.


The mechanism of translation initiation on Aichivirus RNA mediated by a novel type of picornavirus IRES.

Yu Y, Sweeney TR, Kafasla P, Jackson RJ, Pestova TV, Hellen CU.

EMBO J. 2011 Aug 26;30(21):4423-36. doi: 10.1038/emboj.2011.306.


Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.

Pisareva VP, Skabkin MA, Hellen CU, Pestova TV, Pisarev AV.

EMBO J. 2011 May 4;30(9):1804-17. doi: 10.1038/emboj.2011.93. Epub 2011 Mar 29.


Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors.

Yu Y, Abaeva IS, Marintchev A, Pestova TV, Hellen CU.

Nucleic Acids Res. 2011 Jun;39(11):4851-65. doi: 10.1093/nar/gkr045. Epub 2011 Feb 8.


Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning.

Abaeva IS, Marintchev A, Pisareva VP, Hellen CU, Pestova TV.

EMBO J. 2011 Jan 5;30(1):115-29. doi: 10.1038/emboj.2010.302. Epub 2010 Nov 26.


Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

Skabkin MA, Skabkina OV, Dhote V, Komar AA, Hellen CU, Pestova TV.

Genes Dev. 2010 Aug 15;24(16):1787-801. doi: 10.1101/gad.1957510.


The role of ABCE1 in eukaryotic posttermination ribosomal recycling.

Pisarev AV, Skabkin MA, Pisareva VP, Skabkina OV, Rakotondrafara AM, Hentze MW, Hellen CU, Pestova TV.

Mol Cell. 2010 Jan 29;37(2):196-210. doi: 10.1016/j.molcel.2009.12.034.


The mechanism of eukaryotic translation initiation and principles of its regulation.

Jackson RJ, Hellen CU, Pestova TV.

Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27. doi: 10.1038/nrm2838. Review.


The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.

Parsyan A, Shahbazian D, Martineau Y, Petroulakis E, Alain T, Larsson O, Mathonnet G, Tettweiler G, Hellen CU, Pestova TV, Svitkin YV, Sonenberg N.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22217-22. doi: 10.1073/pnas.0909773106. Epub 2009 Dec 11.


Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing.

Yu Y, Marintchev A, Kolupaeva VG, Unbehaun A, Veryasova T, Lai SC, Hong P, Wagner G, Hellen CU, Pestova TV.

Nucleic Acids Res. 2009 Aug;37(15):5167-82. doi: 10.1093/nar/gkp519. Epub 2009 Jun 26.


Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites.

de Breyne S, Yu Y, Unbehaun A, Pestova TV, Hellen CU.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9197-202. doi: 10.1073/pnas.0900153106. Epub 2009 May 22.


Structural insights into eRF3 and stop codon recognition by eRF1.

Cheng Z, Saito K, Pisarev AV, Wada M, Pisareva VP, Pestova TV, Gajda M, Round A, Kong C, Lim M, Nakamura Y, Svergun DI, Ito K, Song H.

Genes Dev. 2009 May 1;23(9):1106-18. doi: 10.1101/gad.1770109.


Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29.

Pisareva VP, Pisarev AV, Komar AA, Hellen CU, Pestova TV.

Cell. 2008 Dec 26;135(7):1237-50. doi: 10.1016/j.cell.2008.10.037.


General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation.

Svitkin YV, Evdokimova VM, Brasey A, Pestova TV, Fantus D, Yanagiya A, Imataka H, Skabkin MA, Ovchinnikov LP, Merrick WC, Sonenberg N.

EMBO J. 2009 Jan 7;28(1):58-68. doi: 10.1038/emboj.2008.259. Epub 2008 Dec 11.


Distinct eRF3 requirements suggest alternate eRF1 conformations mediate peptide release during eukaryotic translation termination.

Fan-Minogue H, Du M, Pisarev AV, Kallmeyer AK, Salas-Marco J, Keeling KM, Thompson SR, Pestova TV, Bedwell DM.

Mol Cell. 2008 Jun 6;30(5):599-609. doi: 10.1016/j.molcel.2008.03.020.


Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes.

Pisarev AV, Kolupaeva VG, Yusupov MM, Hellen CU, Pestova TV.

EMBO J. 2008 Jun 4;27(11):1609-21. doi: 10.1038/emboj.2008.90. Epub 2008 May 8.


eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II.

Pestova TV, de Breyne S, Pisarev AV, Abaeva IS, Hellen CU.

EMBO J. 2008 Apr 9;27(7):1060-72. doi: 10.1038/emboj.2008.49. Epub 2008 Mar 13.


Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism.

Lin D, Pestova TV, Hellen CU, Tiedge H.

Mol Cell Biol. 2008 May;28(9):3008-19. doi: 10.1128/MCB.01800-07. Epub 2008 Mar 3.


Factor requirements for translation initiation on the Simian picornavirus internal ribosomal entry site.

de Breyne S, Yu Y, Pestova TV, Hellen CU.

RNA. 2008 Feb;14(2):367-80. Epub 2007 Dec 19.


Recycling of eukaryotic posttermination ribosomal complexes.

Pisarev AV, Hellen CU, Pestova TV.

Cell. 2007 Oct 19;131(2):286-99.


In vitro reconstitution and biochemical characterization of translation initiation by internal ribosomal entry.

Kolupaeva VG, de Breyne S, Pestova TV, Hellen CU.

Methods Enzymol. 2007;430:409-39.


Assembly and analysis of eukaryotic translation initiation complexes.

Pisarev AV, Unbehaun A, Hellen CU, Pestova TV.

Methods Enzymol. 2007;430:147-77.


Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5.

Galkin O, Bentley AA, Gupta S, Compton BA, Mazumder B, Kinzy TG, Merrick WC, Hatzoglou M, Pestova TV, Hellen CU, Komar AA.

RNA. 2007 Dec;13(12):2116-28. Epub 2007 Sep 27.


Translation mechanism and regulation: old players, new concepts. Meeting on translational control and non-coding RNA.

Holcik M, Pestova TV.

EMBO Rep. 2007 Jul;8(7):639-43. Epub 2007 Jun 15. No abstract available.


Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing.

Unbehaun A, Marintchev A, Lomakin IB, Didenko T, Wagner G, Hellen CU, Pestova TV.

EMBO J. 2007 Jul 11;26(13):3109-23. Epub 2007 Jun 14.


Kinetic analysis of the interaction of guanine nucleotides with eukaryotic translation initiation factor eIF5B.

Pisareva VP, Hellen CU, Pestova TV.

Biochemistry. 2007 Mar 13;46(10):2622-9. Epub 2007 Feb 13.


Kinetic analysis of interaction of eukaryotic release factor 3 with guanine nucleotides.

Pisareva VP, Pisarev AV, Hellen CU, Rodnina MV, Pestova TV.

J Biol Chem. 2006 Dec 29;281(52):40224-35. Epub 2006 Oct 24.


In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.

Alkalaeva EZ, Pisarev AV, Frolova LY, Kisselev LL, Pestova TV.

Cell. 2006 Jun 16;125(6):1125-36.


Small molecule derails translation initiation.

Pestova TV, Hellen CU.

Nat Chem Biol. 2006 Apr;2(4):176-7. No abstract available.


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