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Items: 1 to 50 of 83

1.

New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission.

de Macedo CS, Lara FA, Pinheiro RO, Schmitz V, de Berrêdo-Pinho M, Pereira GM, Pessolani MCV.

F1000Res. 2020 Jan 31;9. pii: F1000 Faculty Rev-70. doi: 10.12688/f1000research.21383.1. eCollection 2020. Review.

2.

Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction.

Granato MQ, Sousa IS, Rosa TLSA, Gonçalves DS, Seabra SH, Alviano DS, Pessolani MCV, Santos ALS, Kneipp LF.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):629-638. doi: 10.1080/14756366.2020.1724994.

PMID:
32037904
3.

Intracellular Mycobacterium leprae Utilizes Host Glucose as a Carbon Source in Schwann Cells.

Borah K, Girardi KDCV, Mendum TA, Lery LMS, Beste DJV, Lara FA, Pessolani MCV, McFadden J.

mBio. 2019 Dec 17;10(6). pii: e02351-19. doi: 10.1128/mBio.02351-19.

4.

PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil.

Madureira BP, de Carvalho FM, Pessolani MC, Collin SM, Deps PD.

Immunobiology. 2019 Nov 10:151866. doi: 10.1016/j.imbio.2019.11.001. [Epub ahead of print]

PMID:
31757558
5.

Myelin breakdown favours Mycobacterium leprae survival in Schwann cells.

Mietto BS, de Souza BJ, Rosa PS, Pessolani MCV, Lara FA, Sarno EN.

Cell Microbiol. 2020 Jan;22(1):e13128. doi: 10.1111/cmi.13128. Epub 2019 Nov 13.

PMID:
31652371
6.

Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions.

da Silva CO, Dias AA, da Costa Nery JA, de Miranda Machado A, Ferreira H, Rodrigues TF, Sousa Santos JP, Nadaes NR, Sarno EN, Saraiva EM, Schmitz V, Pessolani MCV.

PLoS Negl Trop Dis. 2019 Sep 10;13(9):e0007368. doi: 10.1371/journal.pntd.0007368. eCollection 2019 Sep.

7.

Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease.

Corrêa RDS, Rodrigues LS, Pereira LHL, Nogueira OC, Leung J, Sousa MDS, Hacker MA, Siqueira HR, Capone D, Alves RLR, Pessolani MCV, Schmitz V, Pereira GMB.

Mem Inst Oswaldo Cruz. 2019;114:e180579. doi: 10.1590/0074-02760180579. Epub 2019 Apr 8.

8.

Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains.

Ferreira JDS, Souza Oliveira DA, Santos JP, Ribeiro CCDU, Baêta BA, Teixeira RC, Neumann ADS, Rosa PS, Pessolani MCV, Moraes MO, Bechara GH, de Oliveira PL, Sorgine MHF, Suffys PN, Fontes ANB, Bell-Sakyi L, Fonseca AH, Lara FA.

PLoS Negl Trop Dis. 2018 Dec 19;12(12):e0007001. doi: 10.1371/journal.pntd.0007001. eCollection 2018 Dec.

9.

Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators.

de Macedo CS, de Carvalho FM, Amaral JJ, de Mendonça Ochs S, Assis EF, Sarno EN, Bozza PT, Pessolani MCV.

Cytokine. 2018 Dec;112:87-94. doi: 10.1016/j.cyto.2018.07.008. Epub 2018 Jul 14. Review.

PMID:
30017389
10.

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

Díaz Acosta CC, Dias AA, Rosa TLSA, Batista-Silva LR, Rosa PS, Toledo-Pinto TG, Costa FDMR, Lara FA, Rodrigues LS, Mattos KA, Sarno EN, Bozza PT, Guilhot C, de Berrêdo-Pinho M, Pessolani MCV.

PLoS Pathog. 2018 Jul 6;14(7):e1007151. doi: 10.1371/journal.ppat.1007151. eCollection 2018 Jul.

11.

Innate Immune Responses in Leprosy.

Pinheiro RO, Schmitz V, Silva BJA, Dias AA, de Souza BJ, de Mattos Barbosa MG, de Almeida Esquenazi D, Pessolani MCV, Sarno EN.

Front Immunol. 2018 Mar 28;9:518. doi: 10.3389/fimmu.2018.00518. eCollection 2018. Review.

12.

Blood coagulation abnormalities in multibacillary leprosy patients.

Silva DSD, Teixeira LAC, Beghini DG, Ferreira ATDS, Pinho MBM, Rosa PS, Ribeiro MR, Freire MDC, Hacker MA, Nery JADC, Pessolani MCV, Tovar AMF, Sarno EN, Perales J, Bozza FA, Esquenazi D, Monteiro RQ, Lara FA.

PLoS Negl Trop Dis. 2018 Mar 22;12(3):e0006214. doi: 10.1371/journal.pntd.0006214. eCollection 2018 Mar.

13.

Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens.

de Carvalho FM, Rodrigues LS, Duppre NC, Alvim IMP, Ribeiro-Alves M, Pinheiro RO, Sarno EN, Pessolani MCV, Pereira GMB.

PLoS Negl Trop Dis. 2017 May 3;11(5):e0005560. doi: 10.1371/journal.pntd.0005560. eCollection 2017 May.

14.

Type 1 Reaction in Patients With Leprosy Corresponds to a Decrease in Proresolving Lipid Mediators and an Increase in Proinflammatory Lipid Mediators.

Silva CA, Webb K, Andre BG, Marques MA, Carvalho FM, de Macedo CS, Pinheiro RO, Sarno EN, Pessolani MC, Belisle JT.

J Infect Dis. 2017 Feb 1;215(3):431-439. doi: 10.1093/infdis/jiw541.

PMID:
27932613
15.

Response to Comment on "DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum".

Pereira GM, Pessolani MC, Sarno EN.

J Immunol. 2016 Dec 1;197(11):4184-4185. No abstract available.

16.

Subversion of Schwann cell glucose metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, de Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Nov 18;291(47):24803. No abstract available.

17.

Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Oct 7;291(41):21375-21387. Epub 2016 Aug 23. Erratum in: J Biol Chem. 2016 Nov 18;291(47):24803.

18.

DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum.

Dias AA, Silva CO, Santos JP, Batista-Silva LR, Acosta CC, Fontes AN, Pinheiro RO, Lara FA, Machado AM, Nery JA, Sarno EN, Pereira GM, Pessolani MC.

J Immunol. 2016 Sep 1;197(5):1905-13. doi: 10.4049/jimmunol.1600042. Epub 2016 Jul 29.

19.

Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages.

Batista-Silva LR, Rodrigues LS, Vivarini Ade C, Costa Fda M, Mattos KA, Costa MR, Rosa PS, Toledo-Pinto TG, Dias AA, Moura DF, Sarno EN, Lopes UG, Pessolani MC.

Sci Rep. 2016 Jun 10;6:27632. doi: 10.1038/srep27632.

20.

Experimental Infection of Rhodnius prolixus (Hemiptera, Triatominae) with Mycobacterium leprae Indicates Potential for Leprosy Transmission.

Neumann Ada S, Dias Fde A, Ferreira Jda S, Fontes AN, Rosa PS, Macedo RE, Oliveira JH, Teixeira RL, Pessolani MC, Moraes MO, Suffys PN, Oliveira PL, Sorgine MH, Lara FA.

PLoS One. 2016 May 20;11(5):e0156037. doi: 10.1371/journal.pone.0156037. eCollection 2016.

21.

STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.

de Toledo-Pinto TG, Ferreira AB, Ribeiro-Alves M, Rodrigues LS, Batista-Silva LR, Silva BJ, Lemes RM, Martinez AN, Sandoval FG, Alvarado-Arnez LE, Rosa PS, Shannon EJ, Pessolani MC, Pinheiro RO, Antunes SL, Sarno EN, Lara FA, Williams DL, Ozório Moraes M.

J Infect Dis. 2016 Jul 15;214(2):311-20. doi: 10.1093/infdis/jiw144. Epub 2016 May 14.

PMID:
27190175
22.

MALDI imaging reveals lipid changes in the skin of leprosy patients before and after multidrug therapy (MDT).

de Macedo CS, Anderson DM, Pascarelli BM, Spraggins JM, Sarno EN, Schey KL, Pessolani MC.

J Mass Spectrom. 2015 Dec;50(12):1374-85. doi: 10.1002/jms.3708.

PMID:
26634971
23.

The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production.

Marques MA, Berrêdo-Pinho M, Rosa TL, Pujari V, Lemes RM, Lery LM, Silva CA, Guimarães AC, Atella GC, Wheat WH, Brennan PJ, Crick DC, Belisle JT, Pessolani MC.

J Bacteriol. 2015 Dec;197(23):3698-707. doi: 10.1128/JB.00625-15. Epub 2015 Sep 21.

24.

Downregulation of PHEX in multibacillary leprosy patients: observational cross-sectional study.

Silva SR, Illarramendi X, Tempone AJ, Silva PH, Nery JA, Monteiro AM, Pessolani MC, Boasquevisque E, Sarno EN, Pereira GM, Esquenazi D.

J Transl Med. 2015 Sep 11;13:296. doi: 10.1186/s12967-015-0651-5.

25.

Skin imprinting in silica plates: a potential diagnostic methodology for leprosy using high-resolution mass spectrometry.

Lima Ede O, de Macedo CS, Esteves CZ, de Oliveira DN, Pessolani MC, Nery JA, Sarno EN, Catharino RR.

Anal Chem. 2015 Apr 7;87(7):3585-92. doi: 10.1021/acs.analchem.5b00097. Epub 2015 Mar 25.

PMID:
25785304
26.

Statins increase rifampin mycobactericidal effect.

Lobato LS, Rosa PS, Ferreira Jda S, Neumann Ada S, da Silva MG, do Nascimento DC, Soares CT, Pedrini SC, Oliveira DS, Monteiro CP, Pereira GM, Ribeiro-Alves M, Hacker MA, Moraes MO, Pessolani MC, Duarte RS, Lara FA.

Antimicrob Agents Chemother. 2014 Oct;58(10):5766-74. doi: 10.1128/AAC.01826-13. Epub 2014 Jul 21.

27.

Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment.

Mattos KA, Oliveira VC, Berrêdo-Pinho M, Amaral JJ, Antunes LC, Melo RC, Acosta CC, Moura DF, Olmo R, Han J, Rosa PS, Almeida PE, Finlay BB, Borchers CH, Sarno EN, Bozza PT, Atella GC, Pessolani MC.

Cell Microbiol. 2014 Jun;16(6):797-815. doi: 10.1111/cmi.12279. Epub 2014 Mar 21.

28.

Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease.

Amaral JJ, Antunes LC, de Macedo CS, Mattos KA, Han J, Pan J, Candéa AL, Henriques Md, Ribeiro-Alves M, Borchers CH, Sarno EN, Bozza PT, Finlay BB, Pessolani MC.

PLoS Negl Trop Dis. 2013 Aug 15;7(8):e2381. doi: 10.1371/journal.pntd.0002381. eCollection 2013.

29.

Gene expression profiling specifies chemokine, mitochondrial and lipid metabolism signatures in leprosy.

Guerreiro LT, Robottom-Ferreira AB, Ribeiro-Alves M, Toledo-Pinto TG, Rosa Brito T, Rosa PS, Sandoval FG, Jardim MR, Antunes SG, Shannon EJ, Sarno EN, Pessolani MC, Williams DL, Moraes MO.

PLoS One. 2013 Jun 14;8(6):e64748. doi: 10.1371/journal.pone.0064748. Print 2013.

30.

Interaction of Mycobacterium leprae with human airway epithelial cells: adherence, entry, survival, and identification of potential adhesins by surface proteome analysis.

Silva CA, Danelishvili L, McNamara M, Berredo-Pinho M, Bildfell R, Biet F, Rodrigues LS, Oliveira AV, Bermudez LE, Pessolani MC.

Infect Immun. 2013 Jul;81(7):2645-59. doi: 10.1128/IAI.00147-13. Epub 2013 May 13.

31.

Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence.

Dias AA, Raze D, de Lima CS, Marques MA, Drobecq H, Debrie AS, Ribeiro-Guimarães ML, Biet F, Pessolani MC.

Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:174-82.

32.

Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis.

de Mattos KA, Sarno EN, Pessolani MC, Bozza PT.

Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:156-66. Review.

33.

Genotyping of Mycobacterium leprae present on Ziehl-Neelsen-stained microscopic slides and in skin biopsy samples from leprosy patients in different geographic regions of Brazil.

Fontes AN, Gomes HM, Araujo MI, Albuquerque EC, Baptista IM, Moura MM, Rezende DS, Pessolani MC, Lara FA, Pontes MA, Gonçalves Hde S, Lucena-Silva N, Sarno EN, Vissa VD, Brennan PJ, Suffys PN.

Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:143-9.

34.

Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal.

Bobosha K, Tang ST, van der Ploeg-van Schip JJ, Bekele Y, Martins MV, Lund O, Franken KL, Khadge S, Pontes MA, Gonçalves Hde S, Hussien J, Thapa P, Kunwar CB, Hagge DA, Aseffa A, Pessolani MC, Pereira GM, Ottenhoff TH, Geluk A.

Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:112-23.

35.

Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy.

Martins MV, Guimarães MM, Spencer JS, Hacker MA, Costa LS, Carvalho FM, Geluk A, van der Ploeg-van Schip JJ, Pontes MA, Gonçalves HS, de Morais JP, Bandeira TJ, Pessolani MC, Brennan PJ, Pereira GM.

PLoS Negl Trop Dis. 2012;6(4):e1616. doi: 10.1371/journal.pntd.0001616. Epub 2012 Apr 24.

36.

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.

Geluk A, Bobosha K, van der Ploeg-van Schip JJ, Spencer JS, Banu S, Martins MV, Cho SN, Franken KL, Kim HJ, Bekele Y, Uddin MK, Hadi SA, Aseffa A, Pessolani MC, Pereira GM, Dockrell HM, Ottenhoff TH.

J Immunol. 2012 May 15;188(10):4782-91. doi: 10.4049/jimmunol.1103452. Epub 2012 Apr 13.

37.

Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls.

Bobosha K, van der Ploeg-van Schip JJ, Esquenazi DA, Guimarães MM, Martins MV, Bekele Y, Fantahun Y, Aseffa A, Franken KL, Gismondi RC, Pessolani MC, Ottenhoff TH, Pereira GM, Geluk A.

J Trop Med. 2012;2012:132049. doi: 10.1155/2012/132049. Epub 2012 Jan 29.

38.

Circulating levels of insulin-like growth factor-I (IGF-I) correlate with disease status in leprosy.

Rodrigues LS, Hacker MA, Illarramendi X, Pinheiro MF, Nery JA, Sarno EN, Pessolani MC.

BMC Infect Dis. 2011 Dec 13;11:339. doi: 10.1186/1471-2334-11-339.

39.

TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence.

Mattos KA, Oliveira VG, D'Avila H, Rodrigues LS, Pinheiro RO, Sarno EN, Pessolani MC, Bozza PT.

J Immunol. 2011 Sep 1;187(5):2548-58. doi: 10.4049/jimmunol.1101344. Epub 2011 Aug 3.

40.

ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria.

Geluk A, van den Eeden SJ, Dijkman K, Wilson L, Kim HJ, Franken KL, Spencer JS, Pessolani MC, Pereira GM, Ottenhoff TH.

J Immunol. 2011 Aug 1;187(3):1393-402. doi: 10.4049/jimmunol.1100980. Epub 2011 Jun 24.

41.

Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes.

Mattos KA, Lara FA, Oliveira VG, Rodrigues LS, D'Avila H, Melo RC, Manso PP, Sarno EN, Bozza PT, Pessolani MC.

Cell Microbiol. 2011 Feb;13(2):259-73. doi: 10.1111/j.1462-5822.2010.01533.x. Epub 2010 Nov 2.

PMID:
20955239
42.

Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts.

Silva SR, Tempone AJ, Silva TP, Costa MR, Pereira GM, Lara FA, Pessolani MC, Esquenazi D.

Mem Inst Oswaldo Cruz. 2010 Aug;105(5):627-32.

43.

Involvement of 9-O-Acetyl GD3 ganglioside in Mycobacterium leprae infection of Schwann cells.

Ribeiro-Resende VT, Ribeiro-Guimarães ML, Lemes RM, Nascimento IC, Alves L, Mendez-Otero R, Pessolani MC, Lara FA.

J Biol Chem. 2010 Oct 29;285(44):34086-96. doi: 10.1074/jbc.M110.147272. Epub 2010 Aug 25.

44.

Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae.

Ribeiro-Guimarães ML, Marengo EB, Tempone AJ, Amaral JJ, Klitzke CF, Silveira EK, Portaro FC, Pessolani MC.

Mem Inst Oswaldo Cruz. 2009 Dec;104(8):1132-8.

45.

Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis.

Mattos KA, D'Avila H, Rodrigues LS, Oliveira VG, Sarno EN, Atella GC, Pereira GM, Bozza PT, Pessolani MC.

J Leukoc Biol. 2010 Mar;87(3):371-84. doi: 10.1189/jlb.0609433. Epub 2009 Dec 1. Erratum in: J Leukoc Biol. 2010 Nov;88(5):1061. Erratum in: J Leukoc Biol. 2010 Nov;88(5):1061.

PMID:
19952355
46.

Mycobacterium leprae induces insulin-like growth factor and promotes survival of Schwann cells upon serum withdrawal.

Rodrigues LS, da Silva Maeda E, Moreira ME, Tempone AJ, Lobato LS, Ribeiro-Resende VT, Alves L, Rossle S, Lopes UG, Pessolani MC.

Cell Microbiol. 2010 Jan;12(1):42-54. doi: 10.1111/j.1462-5822.2009.01377.x. Epub 2009 Sep 2.

PMID:
19732058
47.

Schwann cells express the macrophage mannose receptor and MHC class II. Do they have a role in antigen presentation?

Baetas-da-Cruz W, Alves L, Pessolani MC, Barbosa HS, Régnier-Vigouroux A, Corte-Real S, Cavalcante LA.

J Peripher Nerv Syst. 2009 Jun;14(2):84-92. doi: 10.1111/j.1529-8027.2009.00217.x.

PMID:
19691530
48.

Efficient uptake of mannosylated proteins by a human Schwann cell line.

Baetas-da-Cruz W, Alves L, Guimarães EV, Santos-Silva A, Pessolani MC, Barbosa HS, Corte-Real S, Cavalcante LA.

Histol Histopathol. 2009 Aug;24(8):1029-34. doi: 10.14670/HH-24.1029.

PMID:
19554510
49.

Heparin-binding hemagglutinin (HBHA) of Mycobacterium leprae is expressed during infection and enhances bacterial adherence to epithelial cells.

de Lima CS, Marques MA, Debrie AS, Almeida EC, Silva CA, Brennan PJ, Sarno EN, Menozzi FD, Pessolani MC.

FEMS Microbiol Lett. 2009 Mar;292(2):162-9. doi: 10.1111/j.1574-6968.2009.01488.x. Epub 2009 Feb 6.

50.

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis.

Geluk A, Spencer JS, Bobosha K, Pessolani MC, Pereira GM, Banu S, Honoré N, Reece ST, MacDonald M, Sapkota BR, Ranjit C, Franken KL, Zewdie M, Aseffa A, Hussain R, Stefani MM, Cho SN, Oskam L, Brennan PJ, Dockrell HM; IDEAL Consortium.

Clin Vaccine Immunol. 2009 Mar;16(3):352-9. doi: 10.1128/CVI.00414-08. Epub 2009 Jan 28.

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