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Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis.

de Araujo LS, Pessler K, Sühs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F.

J Transl Med. 2020 Jan 7;18(1):9. doi: 10.1186/s12967-019-02179-w.


Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection.

de Araujo LS, Ribeiro-Alves M, Leal-Calvo T, Leung J, Durán V, Samir M, Talbot S, Tallam A, Mello FCQ, Geffers R, Saad MHF, Pessler F.

mBio. 2019 Dec 3;10(6). pii: e01037-19. doi: 10.1128/mBio.01037-19.


Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia.

Arshad H, Alfonso JCL, Franke R, Michaelis K, Araujo L, Habib A, Zboromyrska Y, Lücke E, Strungaru E, Akmatov MK, Hatzikirou H, Meyer-Hermann M, Petersmann A, Nauck M, Brönstrup M, Bilitewski U, Abel L, Sievers J, Vila J, Illig T, Schreiber J, Pessler F.

J Transl Med. 2019 Nov 11;17(1):365. doi: 10.1186/s12967-019-2112-z.


Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.

Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20644-20654. doi: 10.1073/pnas.1908770116. Epub 2019 Sep 23.


Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1).

Samir M, Vidal RO, Abdallah F, Capece V, Seehusen F, Geffers R, Hussein A, Ali AAH, Bonn S, Pessler F.

RNA Biol. 2020 Jan;17(1):112-124. doi: 10.1080/15476286.2019.1669879. Epub 2019 Oct 4.


Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly.

Akmatov MK, Riese P, Trittel S, May M, Prokein J, Illig T, Schindler C, Guzmán CA, Pessler F.

BMC Infect Dis. 2019 Jul 23;19(1):656. doi: 10.1186/s12879-019-4214-x.


Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study.

Wawro N, Amann U, Butt J, Meisinger C, Akmatov MK, Pessler F, Peters A, Rathmann W, Kääb S, Waterboer T, Linseisen J.

Front Public Health. 2019 Apr 24;7:96. doi: 10.3389/fpubh.2019.00096. eCollection 2019.


Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections.

Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F.

J Infect Dis. 2019 Jun 5;220(1):127-138. doi: 10.1093/infdis/jiz048.


Discovery of Leptospira spp. seroreactive peptides using ORFeome phage display.

Ramli SR, Moreira GMSG, Zantow J, Goris MGA, Nguyen VK, Novoselova N, Pessler F, Hust M.

PLoS Negl Trop Dis. 2019 Jan 24;13(1):e0007131. doi: 10.1371/journal.pntd.0007131. eCollection 2019 Jan.


Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.

Ratuszny D, Sühs KW, Novoselova N, Kuhn M, Kaever V, Skripuletz T, Pessler F, Stangel M.

Int J Mol Sci. 2019 Jan 15;20(2). pii: E337. doi: 10.3390/ijms20020337.


An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia.

Strehlitz A, Goldmann O, Pils MC, Pessler F, Medina E.

Front Immunol. 2018 Jun 25;9:1424. doi: 10.3389/fimmu.2018.01424. eCollection 2018.


Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis.

Chen YL, Jing J, Mo YQ, Ma JD, Yang LJ, Chen LF, Zhang X, Yan T, Zheng DH, Pessler F, Dai L.

Arthritis Res Ther. 2018 Jun 19;20(1):130. doi: 10.1186/s13075-018-1623-y.


Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori.

Filomena A, Pessler F, Akmatov MK, Krause G, Duffy D, Gärtner B, Gerhard M, Albert ML, Joos TO, Schneiderhan-Marra N.

High Throughput. 2017 Oct 30;6(4). pii: E14. doi: 10.3390/ht6040014.


Early Lymphocyte Loss and Increased Granulocyte/Lymphocyte Ratio Predict Systemic Spread of Streptococcus pyogenes in a Mouse Model of Acute Skin Infection.

Loof TG, Sohail A, Bahgat MM, Tallam A, Arshad H, Akmatov MK, Pils MC, Heise U, Beineke A, Pessler F.

Front Cell Infect Microbiol. 2018 Apr 12;8:101. doi: 10.3389/fcimb.2018.00101. eCollection 2018.


Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture.

Olmer R, Engels L, Usman A, Menke S, Malik MNH, Pessler F, Göhring G, Bornhorst D, Bolten S, Abdelilah-Seyfried S, Scheper T, Kempf H, Zweigerdt R, Martin U.

Stem Cell Reports. 2018 May 8;10(5):1657-1672. doi: 10.1016/j.stemcr.2018.03.017. Epub 2018 Apr 19.


NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems.

Petersen H, Mostafa A, Tantawy MA, Iqbal AA, Hoffmann D, Tallam A, Selvakumar B, Pessler F, Beer M, Rautenschlein S, Pleschka S.

Front Microbiol. 2018 Mar 22;9:526. doi: 10.3389/fmicb.2018.00526. eCollection 2018.


An Egyptian HPAI H5N1 isolate from clade is highly pathogenic in an experimentally infected domestic duck breed (Sudani duck).

Samir M, Hamed M, Abdallah F, Kinh Nguyen V, Hernandez-Vargas EA, Seehusen F, Baumgärtner W, Hussein A, Ali AAH, Pessler F.

Transbound Emerg Dis. 2018 Jun;65(3):859-873. doi: 10.1111/tbed.12816. Epub 2018 Jan 24.


Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.

Kuhn M, Sühs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F.

J Neuroinflammation. 2018 Jan 17;15(1):20. doi: 10.1186/s12974-017-1041-0.


15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics.

Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Casadonte R, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Sunitsch S, Tikhilov R, Morawietz L.

Pathol Res Pract. 2017 Aug;213(8):874-881. doi: 10.1016/j.prp.2017.05.005. Epub 2017 May 19. Review.


Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study.

Akmatov MK, Röber N, Ahrens W, Flesch-Janys D, Fricke J, Greiser H, Günther K, Kaaks R, Kemmling Y, Krone B, Linseisen J, Meisinger C, Moebus S, Obi N, Guzman CA, Conrad K, Pessler F.

Arthritis Res Ther. 2017 Jun 6;19(1):127. doi: 10.1186/s13075-017-1338-5.


Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study - findings from Pretest 1 of the German National Cohort.

Akmatov MK, Koch N, Vital M, Ahrens W, Flesch-Janys D, Fricke J, Gatzemeier A, Greiser H, Günther K, Illig T, Kaaks R, Krone B, Kühn A, Linseisen J, Meisinger C, Michels K, Moebus S, Nieters A, Obi N, Schultze A, Six-Merker J, Pieper DH, Pessler F.

Sci Rep. 2017 May 12;7(1):1855. doi: 10.1038/s41598-017-01212-6.


[Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score].

Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Tikhilov R, Morawietz L.

Z Rheumatol. 2017 Aug;76(6):539-546. doi: 10.1007/s00393-017-0308-2. Review. German.


Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.

Akmatov MK, Riese P, May M, Jentsch L, Ahmed MW, Werner D, Rösel A, Tyler M, Pessler K, Prokein J, Bernemann I, Klopp N, Prochnow B, Trittel S, Tallam A, Illig T, Schindler C, Guzmán CA, Pessler F.

Hum Vaccin Immunother. 2017 Jul 3;13(7):1630-1639. doi: 10.1080/21645515.2017.1299300. Epub 2017 Apr 10.


Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection.

Preusse M, Schughart K, Pessler F.

Front Immunol. 2017 Mar 21;8:246. doi: 10.3389/fimmu.2017.00246. eCollection 2017.


Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015).

Karabaev BB, Beisheeva NJ, Satybaldieva AB, Ismailova AD, Pessler F, Akmatov MK.

Infect Dis Poverty. 2017 Feb 21;6(1):45. doi: 10.1186/s40249-017-0255-9.


Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination.

Akmatov MK, Jentsch L, Riese P, May M, Ahmed MW, Werner D, Rösel A, Prokein J, Bernemann I, Klopp N, Prochnow B, Illig T, Schindler C, Guzman CA, Pessler F.

BMC Med Res Methodol. 2017 Feb 2;17(1):18. doi: 10.1186/s12874-017-0302-z.


Transcriptomic Biomarkers for Tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA Expression in Peripheral Blood.

de Araujo LS, Vaas LA, Ribeiro-Alves M, Geffers R, Mello FC, de Almeida AS, Moreira AD, Kritski AL, Lapa E Silva JR, Moraes MO, Pessler F, Saad MH.

Front Microbiol. 2016 Oct 25;7:1586. eCollection 2016.


MicroRNAs in the Host Response to Viral Infections of Veterinary Importance.

Samir M, Vaas LA, Pessler F.

Front Vet Sci. 2016 Oct 17;3:86. eCollection 2016. Review.


Erratum: Cell culture-derived HCV cannot infect synovial fibroblasts.

Abd-Elshafy DN, Pietschmann T, Müller-Ladner U, Neumann E, Anggakusuma, Bahgat MM, Pessler F, Behrendt P.

Sci Rep. 2016 Aug 26;6:21441. doi: 10.1038/srep21441. No abstract available.


Exhaled breath analysis in childhood rheumatic disorders--a longitudinal study.

Hendel N, Akmatov MK, Hamel J, Vogelberg C, Pessler F.

J Breath Res. 2016 Apr 19;10(2):021001. doi: 10.1088/1752-7155/10/2/021001.


Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications.

Samir M, Pessler F.

Front Vet Sci. 2016 Apr 4;3:22. doi: 10.3389/fvets.2016.00022. eCollection 2016. Review.


Sonographic Findings in Gouty Arthritis: Diagnostic Value and Association with Disease Duration.

Elsaman AM, Muhammad EM, Pessler F.

Ultrasound Med Biol. 2016 Jun;42(6):1330-6. doi: 10.1016/j.ultrasmedbio.2016.01.014. Epub 2016 Mar 16.


Impact of rotavirus vaccination on coverage and timing of pentavalent vaccination - Experience from 2 Latin American countries.

Schweitzer A, Pessler F, Akmatov MK.

Hum Vaccin Immunother. 2016 May 3;12(5):1250-6. doi: 10.1080/21645515.2015.1127486. Epub 2016 Feb 1.


Quantitative, Organ-Specific Interscanner and Intrascanner Variability for 3 T Whole-Body Magnetic Resonance Imaging in a Multicenter, Multivendor Study.

Schlett CL, Hendel T, Hirsch J, Weckbach S, Caspers S, Schulz-Menger J, Ittermann T, von Knobelsdorff-Brenkenhoff F, Ladd SC, Moebus S, Stroszczynski C, Fischer B, Leitzmann M, Kuhl C, Pessler F, Hartung D, Kemmling Y, Hetterich H, Amunts K, Günther M, Wacker F, Rummeny E, Kauczor HU, Forsting M, Völzke H, Hosten N, Reiser MF, Bamberg F.

Invest Radiol. 2016 Apr;51(4):255-65. doi: 10.1097/RLI.0000000000000237.


Diverse recruitment strategies result in different participation percentages in a web-based study, but in similar compliance.

Akmatov MK, Rübsamen N, Schultze A, Kemmling Y, Obi N, Günther K, Ahrens W, Pessler F, Krause G, Mikolajczyk RT.

Int J Public Health. 2015 Dec;60(8):937-43. doi: 10.1007/s00038-015-0737-0. Epub 2015 Sep 14.


The impact of distance and duration of travel on participation rates and participants' satisfaction: results from a pilot study at one study centre in Pretest 2 of the German National Cohort.

Schweitzer A, Akmatov MK, Kindler F, Kemmling Y, Kreienbrock L, Krause G, Pessler F.

BMJ Open. 2015 Aug 21;5(8):e007461. doi: 10.1136/bmjopen-2014-007461.


Improved coverage and timing of childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan.

Schweitzer A, Krause G, Pessler F, Akmatov MK.

BMC Public Health. 2015 Aug 19;15:798. doi: 10.1186/s12889-015-2091-9.


Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains.

Preusse M, Schughart K, Wilk E, Klawonn F, Pessler F.

BMC Res Notes. 2015 Jun 6;8:225. doi: 10.1186/s13104-015-1195-8.


Primary osteomyelitis of the sternum in the pediatric age group: report of a new case and comprehensive analysis of seventy-four cases.

Schweitzer A, Della Beffa C, Akmatov MK, Narchi H, Abaev YK, Sherry DD, Pessler F.

Pediatr Infect Dis J. 2015 Apr;34(4):e92-e101. doi: 10.1097/INF.0000000000000597. Review.


Evaluation of invalid vaccine doses in 31 countries of the WHO African Region.

Akmatov MK, Kimani-Murage E, Pessler F, Guzman CA, Krause G, Kreienbrock L, Mikolajczyk RT.

Vaccine. 2015 Feb 11;33(7):892-901. doi: 10.1016/j.vaccine.2014.10.089. Epub 2014 Dec 15.


Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study.

Sievers C, Akmatov MK, Kreienbrock L, Hille K, Ahrens W, Günther K, Flesch-Janys D, Obi N, Michels KB, Fricke J, Greiser KH, Kaaks R, Peter HH, Pessler F, Nieters A, Krause G.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1283-91. doi: 10.1007/s00103-014-2052-y.


Comparison of stool collection on site versus at home in a population-based study : feasibility and participants' preference in Pretest 2 of the German National Cohort.

Schultze A, Akmatov MK, Andrzejak M, Karras N, Kemmling Y, Maulhardt A, Wieghold S, Ahrens W, Günther K, Schlenz H, Krause G, Pessler F.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1264-9. doi: 10.1007/s00103-014-2051-z.


Collection of vaccination data in the German National Cohort : Findings of a feasibility study in three study centers.

Schultze A, Akmatov MK, Castell S, Karch A, Ahrens W, Günther K, Schlenz H, Flesch-Janys D, Obi N, Pessler F, Krause G.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1292-9. doi: 10.1007/s00103-014-2050-0.


Web-based questionnaires to capture acute infections in long-term cohorts : findings of a feasibility study.

Mall S, Akmatov MK, Schultze A, Ahrens W, Obi N, Pessler F, Krause G.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1308-14. doi: 10.1007/s00103-014-2049-6.


Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort.

Kühn A, Nieters A, Köttgen A, Goek ON, Michels K, Nöthlings U, Jacobs G, Meisinger C, Pessler F, Akmatov MF, Kühnisch J, Moebus S, Glocker E, Naus S, Keimling M, Leitzmann M, Linseisen J, Sarioglu H, von Toerne C, Hauck SM, Wallaschofski H, Wichmann HE, Illig T.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1255-63. doi: 10.1007/s00103-014-2048-7.


Test-retest reliability of an infectious disease questionnaire and evaluation of self-assessed vulnerability to infections : findings of Pretest 2 of the German National Cohort.

Castell S, Akmatov MK, Obi N, Flesh-Janys D, Nieters A, Kemmling Y, Pessler F, Krause G.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1300-7. doi: 10.1007/s00103-014-2045-x.


Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in northern Germany.

Mehraj J, Akmatov MK, Strömpl J, Gatzemeier A, Layer F, Werner G, Pieper DH, Medina E, Witte W, Pessler F, Krause G.

PLoS One. 2014 Sep 24;9(9):e107937. doi: 10.1371/journal.pone.0107937. eCollection 2014.


Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany.

Akmatov MK, Mehraj J, Gatzemeier A, Strömpl J, Witte W, Krause G, Pessler F.

Int J Infect Dis. 2014 Aug;25:4-10. doi: 10.1016/j.ijid.2014.01.021. Epub 2014 May 9. Erratum in: Int J Infect Dis. 2015 Jan;30:166.


HUM calculator and HUM package for R: easy-to-use software tools for multicategory receiver operating characteristic analysis.

Novoselova N, Della Beffa C, Wang J, Li J, Pessler F, Klawonn F.

Bioinformatics. 2014 Jun 1;30(11):1635-6. doi: 10.1093/bioinformatics/btu086. Epub 2014 Feb 10.


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