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Items: 1 to 50 of 247

1.

Current challenges and controversies in drug-induced liver injury.

Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, Watkins PB, Albassam M, Liu B, Stancic S, Suter L, Bortolini M.

Drug Saf. 2012 Dec 1;35(12):1099-117. doi: 10.2165/11632970-000000000-00000.

PMID:
23137150
2.

A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis.

Nahon P, Sutton A, Rufat P, Charnaux N, Mansouri A, Moreau R, Ganne-Carrié N, Grando-Lemaire V, N'Kontchou G, Trinchet JC, Pessayre D, Beaugrand M.

J Hepatol. 2012 Feb;56(2):426-32. doi: 10.1016/j.jhep.2011.08.010. Epub 2011 Sep 8.

PMID:
21907168
3.

Central role of mitochondria in drug-induced liver injury.

Pessayre D, Fromenty B, Berson A, Robin MA, Lettéron P, Moreau R, Mansouri A.

Drug Metab Rev. 2012 Feb;44(1):34-87. doi: 10.3109/03602532.2011.604086. Epub 2011 Sep 6. Review.

PMID:
21892896
4.

Lipopolysaccharide-induced mitochondrial DNA depletion.

Choumar A, Tarhuni A, Lettéron P, Reyl-Desmars F, Dauhoo N, Damasse J, Vadrot N, Nahon P, Moreau R, Pessayre D, Mansouri A.

Antioxid Redox Signal. 2011 Dec 1;15(11):2837-54. doi: 10.1089/ars.2010.3713. Epub 2011 Jul 18.

PMID:
21767162
5.

Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?

Nahon P, Sutton A, Pessayre D, Rufat P, Charnaux N, Trinchet JC, Beaugrand M, Deugnier Y.

Antioxid Redox Signal. 2011 Jul 1;15(1):31-8. doi: 10.1089/ars.2010.3529. Epub 2010 Nov 30.

PMID:
20673159
6.

MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.

Mansouri A, Tarhuni A, Larosche I, Reyl-Desmars F, Demeilliers C, Degoul F, Nahon P, Sutton A, Moreau R, Fromenty B, Pessayre D.

Dig Dis. 2010;28(6):756-75. doi: 10.1159/000324284. Epub 2011 Apr 27. Review.

PMID:
21525761
7.

Mitochondrial involvement in drug-induced liver injury.

Pessayre D, Mansouri A, Berson A, Fromenty B.

Handb Exp Pharmacol. 2010;(196):311-65. doi: 10.1007/978-3-642-00663-0_11. Review.

PMID:
20020267
8.

Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase.

Larosche I, Lettéron P, Berson A, Fromenty B, Huang TT, Moreau R, Pessayre D, Mansouri A.

J Pharmacol Exp Ther. 2010 Mar;332(3):886-97. doi: 10.1124/jpet.109.160879. Epub 2009 Dec 16.

PMID:
20016022
9.

Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis.

Nahon P, Sutton A, Rufat P, Ziol M, Akouche H, Laguillier C, Charnaux N, Ganne-Carrié N, Grando-Lemaire V, N'Kontchou G, Trinchet JC, Gattegno L, Pessayre D, Beaugrand M.

Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.

PMID:
19731237
10.

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.

Larosche I, Choumar A, Fromenty B, Lettéron P, Abbey-Toby A, Van Remmen H, Epstein CJ, Richardson A, Feldmann G, Pessayre D, Mansouri A.

Toxicol Appl Pharmacol. 2009 Feb 1;234(3):326-38. doi: 10.1016/j.taap.2008.11.004. Epub 2008 Nov 20.

PMID:
19063909
11.

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

Guichard C, Moreau R, Pessayre D, Epperson TK, Krause KH.

Biochem Soc Trans. 2008 Oct;36(Pt 5):920-9. doi: 10.1042/BST0360920. Review.

PMID:
18793162
12.

The manganese superoxide dismutase Ala16Val dimorphism modulates iron accumulation in human hepatoma cells.

Nahon P, Charnaux N, Friand V, Prost-Squarcioni C, Ziol M, Lièvre N, Trinchet JC, Beaugrand M, Gattegno L, Pessayre D, Sutton A.

Free Radic Biol Med. 2008 Nov 1;45(9):1308-17. doi: 10.1016/j.freeradbiomed.2008.08.011. Epub 2008 Aug 15.

PMID:
18760346
13.

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies.

Labbe G, Pessayre D, Fromenty B.

Fundam Clin Pharmacol. 2008 Aug;22(4):335-53. doi: 10.1111/j.1472-8206.2008.00608.x. Review.

PMID:
18705745
14.

Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.

Robin MA, Descatoire V, Pessayre D, Berson A.

Toxicol In Vitro. 2008 Sep;22(6):1511-9. doi: 10.1016/j.tiv.2008.05.009. Epub 2008 Jul 7.

PMID:
18603402
15.

Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation.

Cazanave S, Vadrot N, Tinel M, Berson A, Lettéron P, Larosche I, Descatoire V, Feldmann G, Robin MA, Pessayre D.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):336-43. doi: 10.1016/j.taap.2008.05.010. Epub 2008 May 20.

PMID:
18572215
16.

Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice.

Begriche K, Lettéron P, Abbey-Toby A, Vadrot N, Robin MA, Bado A, Pessayre D, Fromenty B.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E939-51. doi: 10.1152/ajpendo.00379.2007. Epub 2008 Mar 18.

17.

Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran.

Kenne K, Skanberg I, Glinghammar B, Berson A, Pessayre D, Flinois JP, Beaune P, Edebert I, Pohl CD, Carlsson S, Andersson TB.

Toxicol In Vitro. 2008 Apr;22(3):730-46. doi: 10.1016/j.tiv.2007.11.014. Epub 2007 Dec 3.

PMID:
18191936
18.

Role of mitochondria in non-alcoholic fatty liver disease.

Pessayre D.

J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S20-7. Review. Erratum in: J Gastroenterol Hepatol. 2008 Mar;23(3):501-2.

PMID:
17567459
19.

Beclin 1 mRNA strongly correlates with Bcl-XLmRNA expression in human hepatocellular carcinoma.

Daniel F, Legrand A, Pessayre D, Borrega-Pires F, Mbida L, Lardeux B, Degott C, van Nhieu JT, Bernuau D.

Cancer Invest. 2007 Jun;25(4):226-31.

PMID:
17612932
20.

High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice.

Igoudjil A, Abbey-Toby A, Begriche K, Grodet A, Chataigner K, Peytavin G, Maachi M, Colin M, Robin MA, Lettéron P, Feldmann G, Pessayre D, Fromenty B.

Antivir Ther. 2007;12(3):389-400.

PMID:
17591029
21.

Manganese superoxide dismutase dimorphism and iron overload, hepatocellular carcinoma, and death in hepatitis C virus-infected patients.

Nahon P, Sutton A, Pessayre D, Rufat P, Ziol M, Ganne-Carrie N, Charnaux N, Trinchet JC, Gattegno L, Beaugrand M.

Clin Gastroenterol Hepatol. 2007 May;5(5):630-5. Epub 2007 Mar 2.

PMID:
17336594
22.

Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver.

Larosche I, Lettéron P, Fromenty B, Vadrot N, Abbey-Toby A, Feldmann G, Pessayre D, Mansouri A.

J Pharmacol Exp Ther. 2007 May;321(2):526-35. Epub 2007 Feb 2.

PMID:
17277197
23.

High hepatic glutathione stores alleviate Fas-induced apoptosis in mice.

Cazanave S, Berson A, Haouzi D, Vadrot N, Fau D, Grodet A, Lettéron P, Feldmann G, El-Benna J, Fromenty B, Robin MA, Pessayre D.

J Hepatol. 2007 May;46(5):858-68. Epub 2006 Dec 18.

PMID:
17275124
24.

Dexamethasone hepatic induction in rats subsequently treated with high dose buprenorphine does not lead to respiratory depression.

Hreiche R, Mégarbane B, Pirnay S, Borron SW, Monier C, Risède P, Milan N, Descatoire V, Pessayre D, Baud FJ.

Toxicol Appl Pharmacol. 2006 Dec 15;217(3):352-62. Epub 2006 Sep 30.

PMID:
17084876
25.

Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells.

Daniel F, Legrand A, Pessayre D, Vadrot N, Descatoire V, Bernuau D.

World J Gastroenterol. 2006 May 14;12(18):2895-900.

26.

Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor.

Lasfer M, Davenne L, Vadrot N, Alexia C, Sadji-Ouatas Z, Bringuier AF, Feldmann G, Pessayre D, Reyl-Desmars F.

FEBS Lett. 2006 May 15;580(11):2547-52. Epub 2006 Apr 12.

27.

The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin.

Berson A, Cazanave S, Descatoire V, Tinel M, Grodet A, Wolf C, Feldmann G, Pessayre D.

J Pharmacol Exp Ther. 2006 Jul;318(1):444-54. Epub 2006 Apr 14.

PMID:
16617166
28.

Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis.

Sutton A, Nahon P, Pessayre D, Rufat P, Poiré A, Ziol M, Vidaud D, Barget N, Ganne-Carrié N, Charnaux N, Trinchet JC, Gattegno L, Beaugrand M.

Cancer Res. 2006 Mar 1;66(5):2844-52.

29.

Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.

Begriche K, Igoudjil A, Pessayre D, Fromenty B.

Mitochondrion. 2006 Feb;6(1):1-28. Epub 2006 Jan 5. Review.

PMID:
16406828
30.

Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.

Robin MA, Sauvage I, Grandperret T, Descatoire V, Pessayre D, Fromenty B.

FEBS Lett. 2005 Dec 19;579(30):6895-902. Epub 2005 Dec 1.

31.

Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice.

Robin MA, Demeilliers C, Sutton A, Paradis V, Maisonneuve C, Dubois S, Poirel O, Lettéron P, Pessayre D, Fromenty B.

Hepatology. 2005 Dec;42(6):1280-90.

PMID:
16317704
32.

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.

Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D, Jaeschke H.

J Pharmacol Exp Ther. 2005 Nov;315(2):879-87. Epub 2005 Aug 4.

PMID:
16081675
33.

NASH: a mitochondrial disease.

Pessayre D, Fromenty B.

J Hepatol. 2005 Jun;42(6):928-40. Epub 2005 Mar 26. Review. No abstract available.

PMID:
15885365
34.

The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability.

Sutton A, Imbert A, Igoudjil A, Descatoire V, Cazanave S, Pessayre D, Degoul F.

Pharmacogenet Genomics. 2005 May;15(5):311-9.

PMID:
15864132
35.

Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death.

Nahon P, Sutton A, Pessayre D, Rufat P, Degoul F, Ganne-Carrie N, Ziol M, Charnaux N, N'kontchou G, Trinchet JC, Gattegno L, Beaugrand M.

Clin Gastroenterol Hepatol. 2005 Mar;3(3):292-8.

PMID:
15765450
36.

Potent induction of apoptosis in human hepatoma cell lines by targeted cytotoxic somatostatin analogue AN-238.

Lasfer M, Vadrot N, Schally AV, Nagy A, Halmos G, Pessayre D, Feldmann G, Reyl-Desmars FJ.

J Hepatol. 2005 Feb;42(2):230-7.

PMID:
15664249
37.

Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting.

Maisonneuve C, Igoudjil A, Begriche K, Lettéron P, Guimont MC, Bastin J, Laigneau JP, Pessayre D, Fromenty B.

Antivir Ther. 2004 Oct;9(5):801-10.

PMID:
15535418
38.

Mitochondrial injury in steatohepatitis.

Pessayre D, Fromenty B, Mansouri A.

Eur J Gastroenterol Hepatol. 2004 Nov;16(11):1095-105. Review.

PMID:
15489566
39.

The ins and outs of mitochondrial dysfunction in NASH.

Fromenty B, Robin MA, Igoudjil A, Mansouri A, Pessayre D.

Diabetes Metab. 2004 Apr;30(2):121-38. Review.

PMID:
15223984
40.

Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice.

Tinel M, Berson A, Vadrot N, Descatoire V, Grodet A, Feldmann G, Thénot JP, Pessayre D.

Hepatology. 2004 Mar;39(3):655-66.

PMID:
14999684
41.

Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model.

Perlemuter G, Lettéron P, Carnot F, Zavala F, Pessayre D, Nalpas B, Bréchot C.

J Hepatol. 2003 Dec;39(6):1020-7.

PMID:
14642621
42.

Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments.

Note R, Maisonneuve C, Lettéron P, Peytavin G, Djouadi F, Igoudjil A, Guimont MC, Biour M, Pessayre D, Fromenty B.

Antimicrob Agents Chemother. 2003 Nov;47(11):3384-92.

43.

Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver.

Mansouri A, Haouzi D, Descatoire V, Demeilliers C, Sutton A, Vadrot N, Fromenty B, Feldmann G, Pessayre D, Berson A.

Hepatology. 2003 Sep;38(3):715-25.

PMID:
12939598
44.

Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA.

Tinel M, Berson A, Elkahwaji J, Cresteil T, Beaune P, Pessayre D.

J Hepatol. 2003 Aug;39(2):171-8.

PMID:
12873812
45.

Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.

Lettéron P, Sutton A, Mansouri A, Fromenty B, Pessayre D.

Hepatology. 2003 Jul;38(1):133-40.

PMID:
12829995
46.

The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria.

Sutton A, Khoury H, Prip-Buus C, Cepanec C, Pessayre D, Degoul F.

Pharmacogenetics. 2003 Mar;13(3):145-57.

PMID:
12618592
47.

Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice.

Demeilliers C, Maisonneuve C, Grodet A, Mansouri A, Nguyen R, Tinel M, Lettéron P, Degott C, Feldmann G, Pessayre D, Fromenty B.

Gastroenterology. 2002 Oct;123(4):1278-90.

PMID:
12360488
48.

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis.

Perlemuter G, Sabile A, Letteron P, Vona G, Topilco A, Chrétien Y, Koike K, Pessayre D, Chapman J, Barba G, Bréchot C.

FASEB J. 2002 Feb;16(2):185-94.

PMID:
11818366
49.

Mechanisms of hepatotoxicity.

Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ.

Toxicol Sci. 2002 Feb;65(2):166-76. Review.

PMID:
11812920
50.

Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis.

Pessayre D, Mansouri A, Fromenty B.

Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G193-9. Review.

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