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Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome.

Ma L, Herren AW, Espinal G, Randol J, McLaughlin B, Martinez-Cerdeño V, Pessah IN, Hagerman RJ, Hagerman PJ.

Acta Neuropathol Commun. 2019 Sep 3;7(1):143. doi: 10.1186/s40478-019-0796-1.


Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice.

Rude KM, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EN, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG.

Environ Pollut. 2019 Oct;253:708-721. doi: 10.1016/j.envpol.2019.07.066. Epub 2019 Jul 14.


Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors.

Zheng J, Yu Y, Feng W, Li J, Liu J, Zhang C, Dong Y, Pessah IN, Cao Z.

Environ Health Perspect. 2019 Jun;127(6):67003. doi: 10.1289/EHP4583. Epub 2019 Jun 5.


Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1.

Truong KM, Cherednichenko G, Pessah IN.

Toxicol Sci. 2019 Aug 1;170(2):509-524. doi: 10.1093/toxsci/kfz120.


Neurotoxicity of polychlorinated biphenyls and related organohalogens.

Pessah IN, Lein PJ, Seegal RF, Sagiv SK.

Acta Neuropathol. 2019 Sep;138(3):363-387. doi: 10.1007/s00401-019-01978-1. Epub 2019 Apr 11. Review.


Additional Safety Assessments Needed for Diamide Insecticides.

Pessah IN, Truong K.

Toxicol Sci. 2019 Mar 4. pii: kfz062. doi: 10.1093/toxsci/kfz062. [Epub ahead of print] No abstract available.


Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor.

Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ.

Environ Sci Technol. 2019 Apr 2;53(7):3948-3958. doi: 10.1021/acs.est.9b00535. Epub 2019 Mar 19.


A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study.

Hertz-Picciotto I, Schmidt RJ, Walker CK, Bennett DH, Oliver M, Shedd-Wise KM, LaSalle JM, Giulivi C, Puschner B, Thomas J, Roa DL, Pessah IN, Van de Water J, Tancredi DJ, Ozonoff S.

Environ Health Perspect. 2018 Nov;126(11):117004. doi: 10.1289/EHP535.


Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca2+ concentration.

Zheng J, Chen J, Zou X, Zhao F, Guo M, Wang H, Zhang T, Zhang C, Feng W, Pessah IN, Cao Z.

Neurotoxicology. 2019 Jan;70:112-121. doi: 10.1016/j.neuro.2018.11.006. Epub 2018 Nov 17.


Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice.

Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ.

Genes Brain Behav. 2019 Jan;18(1):e12526. doi: 10.1111/gbb.12526. Epub 2018 Nov 6.


Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 Jul 3;52(13):7594. doi: 10.1021/acs.est.8b03174. Epub 2018 Jun 19. No abstract available.


Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 May 1;52(9):5469-5478. doi: 10.1021/acs.est.8b00512. Epub 2018 Apr 20. Erratum in: Environ Sci Technol. 2018 Jul 3;52(13):7594.


Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example.

Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler HJ.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16508-16521. doi: 10.1007/s11356-017-1162-0. Epub 2018 Jan 10.


Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks.

Feng W, Zheng J, Robin G, Dong Y, Ichikawa M, Inoue Y, Mori T, Nakano T, Pessah IN.

Environ Sci Technol. 2017 Dec 19;51(24):14406-14416. doi: 10.1021/acs.est.7b04446. Epub 2017 Nov 28.


Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ.

Aquat Toxicol. 2017 Nov;192:105-115. doi: 10.1016/j.aquatox.2017.09.002. Epub 2017 Sep 4.


Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome.

Robin G, López JR, Espinal GM, Hulsizer S, Hagerman PJ, Pessah IN.

Hum Mol Genet. 2017 Jul 15;26(14):2649-2666. doi: 10.1093/hmg/ddx148.


Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye.

Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN.

Mol Pharmacol. 2017 Jul;92(1):88-99. doi: 10.1124/mol.117.108563. Epub 2017 Apr 20.


Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A.

Zhang R, Pessah IN.

Mol Pharmacol. 2017 Apr;91(4):428-436. doi: 10.1124/mol.116.107342. Epub 2017 Jan 31.


Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures.

Cao Z, Xu J, Hulsizer S, Cui Y, Dong Y, Pessah IN.

Neurotoxicology. 2017 Jan;58:11-22. doi: 10.1016/j.neuro.2016.10.015. Epub 2016 Oct 29.


Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.

Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM.

Cell Rep. 2016 Dec 13;17(11):3035-3048. doi: 10.1016/j.celrep.2016.11.058.


An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors.

Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler HJ, Pessah IN.

Toxicol Sci. 2017 Jan;155(1):170-181. doi: 10.1093/toxsci/kfw189. Epub 2016 Sep 21.


Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.

Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.


In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide.

Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2460-8. doi: 10.1073/pnas.1517342113. Epub 2016 Apr 11.


Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay.

Ahn KC, Ranganathan A, Bever CS, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ.

Environ Sci Technol. 2016 Apr 5;50(7):3754-61. doi: 10.1021/acs.est.5b05357. Epub 2016 Mar 18.


Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.

Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ.

Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14.


Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.

Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN.

Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12.


Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA.

Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN.

Aquat Toxicol. 2015 Feb;159:156-66. doi: 10.1016/j.aquatox.2014.12.017. Epub 2014 Dec 19.


The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.

Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H.

Neurotherapeutics. 2015 Jan;12(1):234-49. doi: 10.1007/s13311-014-0305-y.


Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome.

Berman RF, Buijsen RA, Usdin K, Pintado E, Kooy F, Pretto D, Pessah IN, Nelson DL, Zalewski Z, Charlet-Bergeurand N, Willemsen R, Hukema RK.

J Neurodev Disord. 2014;6(1):25. doi: 10.1186/1866-1955-6-25. Epub 2014 Jul 30. Review.


Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle.

Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD, López JR.

J Biol Chem. 2014 Jul 4;289(27):19180-90. doi: 10.1074/jbc.M114.550764. Epub 2014 May 20.


Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity.

Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN.

Mol Pharmacol. 2014 Apr;85(4):630-9. doi: 10.1124/mol.113.090076. Epub 2014 Jan 30.


PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms.

Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ.

Toxicol Sci. 2014 Apr;138(2):379-92. doi: 10.1093/toxsci/kft334. Epub 2014 Jan 2.


Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.

Pretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone F.

Neurobiol Aging. 2014 May;35(5):1189-97. doi: 10.1016/j.neurobiolaging.2013.11.009. Epub 2013 Nov 16.


Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction.

Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler HJ, Pessah IN.

Toxicol Sci. 2013 Dec;136(2):500-13. doi: 10.1093/toxsci/kft202. Epub 2013 Sep 7.


Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation.

Vogel CF, Wu D, Goth SR, Baek J, Lollies A, Domhardt R, Grindel A, Pessah IN.

Immunol Cell Biol. 2013 Oct;91(9):568-75. doi: 10.1038/icb.2013.43. Epub 2013 Sep 3.


Autism-specific maternal autoantibodies recognize critical proteins in developing brain.

Braunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J.

Transl Psychiatry. 2013 Jul 9;3:e277. doi: 10.1038/tp.2013.50.


Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss).

Fritsch EB, Pessah IN.

Aquat Toxicol. 2013 Sep 15;140-141:204-12. doi: 10.1016/j.aquatox.2013.06.003. Epub 2013 Jun 14.


Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.

Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ.

Biol Psychiatry. 2013 Aug 1;74(3):204-11. doi: 10.1016/j.biopsych.2013.03.006. Epub 2013 Apr 25.


Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion.

Cao Z, Hulsizer S, Cui Y, Pretto DL, Kim KH, Hagerman PJ, Tassone F, Pessah IN.

J Biol Chem. 2013 May 10;288(19):13831-41. doi: 10.1074/jbc.M112.441055. Epub 2013 Apr 3.


Global increases in both common and rare copy number load associated with autism.

Girirajan S, Johnson RL, Tassone F, Balciuniene J, Katiyar N, Fox K, Baker C, Srikanth A, Yeoh KH, Khoo SJ, Nauth TB, Hansen R, Ritchie M, Hertz-Picciotto I, Eichler EE, Pessah IN, Selleck SB.

Hum Mol Genet. 2013 Jul 15;22(14):2870-80. doi: 10.1093/hmg/ddt136. Epub 2013 Mar 27.


Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas).

Fritsch EB, Connon RE, Werner I, Davies RE, Beggel S, Feng W, Pessah IN.

Environ Sci Technol. 2013 Feb 19;47(4):2008-17. doi: 10.1021/es303790b. Epub 2013 Jan 28.


Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia.

Eltit JM, Ding X, Pessah IN, Allen PD, Lopez JR.

FASEB J. 2013 Mar;27(3):991-1000. doi: 10.1096/fj.12-218354. Epub 2012 Nov 16.


Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice.

Koenig CM, Lango J, Pessah IN, Berman RF.

Neurotoxicol Teratol. 2012 Nov-Dec;34(6):571-80. doi: 10.1016/ Epub 2012 Sep 28.


Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.

Braunschweig D, Golub MS, Koenig CM, Qi L, Pessah IN, Van de Water J, Berman RF.

J Neuroimmunol. 2012 Nov 15;252(1-2):56-65. doi: 10.1016/j.jneuroim.2012.08.002. Epub 2012 Aug 27.


Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder.

Mitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM.

Environ Mol Mutagen. 2012 Oct;53(8):589-98. doi: 10.1002/em.21722. Epub 2012 Aug 29.


Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model.

Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN.

J Neurochem. 2012 Nov;123(4):613-21. doi: 10.1111/j.1471-4159.2012.07936.x. Epub 2012 Sep 28.


Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin.

Feng W, Hwang HS, Kryshtal DO, Yang T, Padilla IT, Tiwary AK, Puschner B, Pessah IN, Knollmann BC.

Mol Pharmacol. 2012 Nov;82(5):993-1000. doi: 10.1124/mol.112.079707. Epub 2012 Aug 23.


Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14158-63. doi: 10.1073/pnas.1211314109. Epub 2012 Aug 13. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16393.

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