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D-dimer corrected for thrombin and plasmin generation is a strong predictor of mortality in patients with sepsis.

Semeraro F, Ammollo CT, Caironi P, Masson S, Latini R, Panigada M, Pesenti A, Semeraro N, Gattinoni L, Colucci M.

Blood Transfus. 2019 Nov 19:1-8. doi: 10.2450/2019.0175-19. [Epub ahead of print]


Gastrointestinal colonization with multidrug-resistant Gram-negative bacteria during extracorporeal membrane oxygenation: effect on the risk of subsequent infections and impact on patient outcome.

Grasselli G, Scaravilli V, Alagna L, Bombino M, De Falco S, Bandera A, Abbruzzese C, Patroniti N, Gori A, Pesenti A.

Ann Intensive Care. 2019 Dec 18;9(1):141. doi: 10.1186/s13613-019-0615-7.


Oesophageal balloon calibration during pressure support ventilation: a proof of concept study.

Cammarota G, Verdina F, Santangelo E, Lauro G, Boniolo E, Tarquini R, Spinelli E, Zanoni M, Garofalo E, Bruni A, Pesenti A, Della Corte F, Navalesi P, Vaschetto R, Mauri T.

J Clin Monit Comput. 2019 Dec 2. doi: 10.1007/s10877-019-00436-3. [Epub ahead of print]


Effects of inspiratory flow on lung stress, pendelluft, and ventilation heterogeneity in ARDS: a physiological study.

Santini A, Mauri T, Dalla Corte F, Spinelli E, Pesenti A.

Crit Care. 2019 Nov 21;23(1):369. doi: 10.1186/s13054-019-2641-0.


Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice.

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D; International ECMO Network (ECMONet).

Am J Respir Crit Care Med. 2019 Nov 14. doi: 10.1164/rccm.201907-1283CI. [Epub ahead of print]


Intraoperative extracorporeal membrane oxygenation for lung transplantation in cystic fibrosis patients: Predictors and impact on outcome.

Scaravilli V, Morlacchi LC, Merrino A, Piacentino E, Marasco D, Zanella A, Nosotti M, Rosso L, Polli F, Blasi F, Pesenti A, Grasselli G.

J Cyst Fibros. 2019 Oct 29. pii: S1569-1993(19)30930-0. doi: 10.1016/j.jcf.2019.10.016. [Epub ahead of print]


Extracorporeal Chloride Removal by Electrodialysis (CRe-ED): A Novel Approach to Correct Acidemia.

Zanella A, Caironi P, Castagna L, Rezoagli E, Salerno D, Scotti E, Scaravilli V, Deab SA, Langer T, Mauri T, Ferrari M, Dondossola D, Chiodi M, Zadek F, Magni F, Gatti S, Gattinoni L, Pesenti AM.

Am J Respir Crit Care Med. 2019 Sep 25. doi: 10.1164/rccm.201903-0538OC. [Epub ahead of print]


Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.

Goligher EC, Combes A, Brodie D, Ferguson ND, Pesenti AM, Ranieri VM, Slutsky AS; SUPERNOVA investigators (European Society of Intensive Care Medicine trials group)  and for the International ECMO Network (ECMONet).

Intensive Care Med. 2019 Sep;45(9):1219-1230. doi: 10.1007/s00134-019-05708-9. Epub 2019 Aug 20.


Practical Clinical Application of an Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress Syndrome and Acute on Chronic Respiratory Failure.

Grasselli G, Castagna L, Bottino N, Scaravilli V, Corcione N, Guzzardella A, Bonifazi M, Rossi N, Zanella A, Pesenti A.

ASAIO J. 2019 Aug 6. doi: 10.1097/MAT.0000000000001050. [Epub ahead of print]


Efficacy and safety of lower versus higher CO2 extraction devices to allow ultraprotective ventilation: secondary analysis of the SUPERNOVA study.

Combes A, Tonetti T, Fanelli V, Pham T, Pesenti A, Mancebo J, Brodie D, Ranieri VM.

Thorax. 2019 Dec;74(12):1179-1181. doi: 10.1136/thoraxjnl-2019-213591. Epub 2019 Aug 13.


Driving Pressure Is Associated with Outcome during Assisted Ventilation in Acute Respiratory Distress Syndrome.

Bellani G, Grassi A, Sosio S, Gatti S, Kavanagh BP, Pesenti A, Foti G.

Anesthesiology. 2019 Sep;131(3):594-604. doi: 10.1097/ALN.0000000000002846.


Time-Course of Physiologic Variables During Extracorporeal Membrane Oxygenation and Outcome of Severe Acute Respiratory Distress Syndrome.

Spinelli E, Mauri T, Carlesso E, Crotti S, Tubiolo D, Lissoni A, Bottino N, Panigada M, Tagliabue P, Rossi N, Scotti E, Conigliaro F, Gattinoni L, Grasselli G, Pesenti A.

ASAIO J. 2019 Jul 12. doi: 10.1097/MAT.0000000000001048. [Epub ahead of print]


Noninvasive assessment of airflows by electrical impedance tomography in intubated hypoxemic patients: an exploratory study.

Mauri T, Spinelli E, Dalla Corte F, Scotti E, Turrini C, Lazzeri M, Alban L, Albanese M, Tortolani D, Wang YM, Spadaro S, Zhou JX, Pesenti A, Grasselli G.

Ann Intensive Care. 2019 Jul 22;9(1):83. doi: 10.1186/s13613-019-0560-5.


Neurological outcome of postanoxic refractory status epilepticus after aggressive treatment.

Beretta S, Coppo A, Bianchi E, Zanchi C, Carone D, Stabile A, Padovano G, Sulmina E, Grassi A, Bogliun G, Foti G, Ferrarese C, Pesenti A, Beghi E, Avalli L.

Epilepsy Behav. 2019 Dec;101(Pt B):106374. doi: 10.1016/j.yebeh.2019.06.018. Epub 2019 Jul 9.


Increasing support by nasal high flow acutely modifies the ROX index in hypoxemic patients: A physiologic study.

Mauri T, Carlesso E, Spinelli E, Turrini C, Corte FD, Russo R, Ricard JD, Pesenti A, Roca O, Grasselli G.

J Crit Care. 2019 Oct;53:183-185. doi: 10.1016/j.jcrc.2019.06.020. Epub 2019 Jun 21.


Nasal high flow: physiology, efficacy and safety in the acute care setting, a narrative review.

Mauri T, Wang YM, Dalla Corte F, Corcione N, Spinelli E, Pesenti A.

Open Access Emerg Med. 2019 May 29;11:109-120. doi: 10.2147/OAEM.S180197. eCollection 2019.


Antithrombin supplementation during extracorporeal membrane oxygenation: study protocol for a pilot randomized clinical trial.

Panigada M, Spinelli E, Cucino A, Cipriani E, De Falco S, Panarello G, Occhipinti G, Arcadipane A, Sales G, Fanelli V, Brazzi L, Novembrino C, Consonni D, Pesenti A, Grasselli G.

Trials. 2019 Jun 11;20(1):349. doi: 10.1186/s13063-019-3386-4.


Veno-venous extracorporeal membrane oxygenation in acute respiratory distress syndrome: should the EOLIA Study results change our clinical approach?

Grasselli G, Zanella A, Pesenti A.

Minerva Anestesiol. 2019 Aug;85(8):909-913. doi: 10.23736/S0375-9393.19.13490-6. Epub 2019 May 21.


Short-term Physiologic Consequences of Regional Pulmonary Vascular Occlusion in Pigs.

Langer T, Castagna V, Brusatori S, Santini A, Mauri T, Zanella A, Pesenti A.

Anesthesiology. 2019 Aug;131(2):336-343. doi: 10.1097/ALN.0000000000002735.


Assessment of Airway Driving Pressure and Respiratory System Mechanics during Neurally Adjusted Ventilatory Assist.

Grasselli G, Castagna L, Abbruzzese C, Corcione N, Colombo SM, Guzzardella A, Mauri T, Scaravilli V, Bottino N, Pesenti A.

Am J Respir Crit Care Med. 2019 Sep 15;200(6):785-788. doi: 10.1164/rccm.201902-0454LE. No abstract available.


Pathophysiology and Management of Acute Respiratory Distress Syndrome in Obese Patients.

Umbrello M, Fumagalli J, Pesenti A, Chiumello D.

Semin Respir Crit Care Med. 2019 Feb;40(1):40-56. doi: 10.1055/s-0039-1685179. Epub 2019 May 6.


Continuous Renal Replacement Therapy in Venovenous Extracorporeal Membrane Oxygenation: A Retrospective Study on Regional Citrate Anticoagulation.

Giani M, Scaravilli V, Stefanini F, Valsecchi G, Rona R, Grasselli G, Bellani G, Pesenti AM, Foti G.

ASAIO J. 2019 Apr 15. doi: 10.1097/MAT.0000000000001003. [Epub ahead of print]


Prevention of Lung Bacterial Colonization With a Leak-Proof Endotracheal Tube Cuff: An Experimental Animal Study.

Rezoagli E, Cressoni M, Bellani G, Grasselli G, Pesenti AM, Kolobow T, Zanella A.

Respir Care. 2019 Sep;64(9):1031-1041. doi: 10.4187/respcare.06573. Epub 2019 Apr 23.


Respiratory Physiology for the Anesthesiologist.

Bigatello L, Pesenti A.

Anesthesiology. 2019 Jun;130(6):1064-1077. doi: 10.1097/ALN.0000000000002666.


High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis.

Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, Demoule A, Lemiale V, Pesenti A, Riviello ED, Mauri T, Mancebo J, Brochard L, Burns K.

Intensive Care Med. 2019 May;45(5):563-572. doi: 10.1007/s00134-019-05590-5. Epub 2019 Mar 19. Review.


Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome.

Grasselli G, Scaravilli V, Tubiolo D, Russo R, Crimella F, Bichi F, Corinna Morlacchi L, Scotti E, Patrini L, Gattinoni L, Pesenti A, Chiumello D.

Anesthesiology. 2019 Apr;130(4):572-580. doi: 10.1097/ALN.0000000000002624.


Effects of a physiotherapic program in patients on veno-venous extracorporeal membrane oxygenation: an 8-year single-center experience.

Bonizzoli M, Lazzeri C, Drago A, Tadini Boninsegni L, Donati M, Di Valvasone S, Pesenti A, Peris A.

Minerva Anestesiol. 2019 Sep;85(9):989-994. doi: 10.23736/S0375-9393.19.13287-7. Epub 2019 Mar 12.


Microbiological colonization of healthcare workers' mobile phones in a tertiary-level Italian intensive care unit.

Galazzi A, Panigada M, Broggi E, Grancini A, Adamini I, Binda F, Mauri T, Pesenti A, Laquintana D, Grasselli G.

Intensive Crit Care Nurs. 2019 Jun;52:17-21. doi: 10.1016/j.iccn.2019.01.005. Epub 2019 Feb 5.


Oxygenation during general anesthesia and thoracic surgery in a patient with Titusville low-oxygen affinity hemoglobin.

Scaravilli V, Polli F, Mendogni P, Zanella A, Graziadei G, Pesenti A, Taccone P.

J Appl Physiol (1985). 2019 Apr 1;126(4):810-814. doi: 10.1152/japplphysiol.00860.2018. Epub 2019 Feb 7.


An Artificial Cough Maneuver to Remove Secretions From Below the Endotracheal Tube Cuff.

Zanella A, Florio G, Rezoagli E, Pastore M, Cadringer P, Biancolilli O, Carlesso E, Scaravilli V, Ristagno G, Pesenti AM.

Respir Care. 2019 Apr;64(4):372-383. doi: 10.4187/respcare.06076. Epub 2019 Jan 8.


Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.

Pham T, Serpa Neto A, Pelosi P, Laffey JG, De Haro C, Lorente JA, Bellani G, Fan E, Brochard LJ, Pesenti A, Schultz MJ, Artigas A; LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group.

Anesthesiology. 2019 Feb;130(2):263-283. doi: 10.1097/ALN.0000000000002508.


Measurement of Diaphragmatic Electrical Activity by Surface Electromyography in Intubated Subjects and Its Relationship With Inspiratory Effort.

Bellani G, Bronco A, Arrigoni Marocco S, Pozzi M, Sala V, Eronia N, Villa G, Foti G, Tagliabue G, Eger M, Pesenti A.

Respir Care. 2018 Nov;63(11):1341-1349. doi: 10.4187/respcare.06176.


Neurologic outcome of postanoxic refractory status epilepticus after aggressive treatment.

Beretta S, Coppo A, Bianchi E, Zanchi C, Carone D, Stabile A, Padovano G, Sulmina E, Grassi A, Bogliun G, Foti G, Ferrarese C, Pesenti A, Beghi E, Avalli L.

Neurology. 2018 Dec 4;91(23):e2153-e2162. doi: 10.1212/WNL.0000000000006615. Epub 2018 Oct 31.


Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.


Understanding hypoxemia on ECCO2R: back to the alveolar gas equation.

Diehl JL, Mercat A, Pesenti A.

Intensive Care Med. 2019 Feb;45(2):255-256. doi: 10.1007/s00134-018-5409-0. Epub 2018 Oct 15. No abstract available.


Oral Care Protocols With Specialty Training Lead to Safe Oral Care Practices and Reduce Iatrogenic Bleeding in Extracorporeal Membrane Oxygenation Patients.

Lucchini A, Bambi S, de Felippis C, Galazzi A, Addis G, Rona R, Grasselli G, Pesenti A, Fumagalli R, Foti G.

Dimens Crit Care Nurs. 2018 Nov/Dec;37(6):285-293. doi: 10.1097/DCC.0000000000000321.


Septic shock-3 vs 2: an analysis of the ALBIOS study.

Vasques F, Duscio E, Romitti F, Pasticci I, Caironi P, Meessen J, Latini R, Cressoni M, Camporota L, Pesenti A, Fumagalli R, Quintel M, Gattinoni L.

Crit Care. 2018 Sep 27;22(1):237. doi: 10.1186/s13054-018-2169-8.


Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial.

Langer T, Santini A, Zadek F, Chiodi M, Pugni P, Cordolcini V, Bonanomi B, Rosini F, Marcucci M, Valenza F, Marenghi C, Inglese S, Pesenti A, Gattinoni L.

J Clin Anesth. 2019 Feb;52:111-118. doi: 10.1016/j.jclinane.2018.09.021. Epub 2018 Sep 20.


Nasal High Flow Delivered within the Helmet: A New Noninvasive Respiratory Support.

Mauri T, Spinelli E, Mariani M, Guzzardella A, Del Prete C, Carlesso E, Tortolani D, Tagliabue P, Pesenti A, Grasselli G.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):115-117. doi: 10.1164/rccm.201806-1124LE. No abstract available.


Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial.

Mauri T, Foti G, Fornari C, Constantin JM, Guerin C, Pelosi P, Ranieri M, Conti S, Tubiolo D, Rondelli E, Lovisari F, Fossali T, Spadaro S, Grieco DL, Navalesi P, Calamai I, Becher T, Roca O, Wang YM, Knafelj R, Cortegiani A, Mancebo J, Brochard L, Pesenti A; Protection Study Group.

Trials. 2018 Aug 29;19(1):460. doi: 10.1186/s13063-018-2828-8.


Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS.

Intensive Care Med. 2018 Sep;44(9):1388-1399. doi: 10.1007/s00134-018-5327-1. Epub 2018 Jul 26.


Application of prone position in hypoxaemic patients supported by veno-venous ECMO.

Lucchini A, De Felippis C, Pelucchi G, Grasselli G, Patroniti N, Castagna L, Foti G, Pesenti A, Fumagalli R.

Intensive Crit Care Nurs. 2018 Oct;48:61-68. doi: 10.1016/j.iccn.2018.04.002. Epub 2018 Jul 20.


Circulating Proenkephalin, Acute Kidney Injury, and Its Improvement in Patients with Severe Sepsis or Shock.

Caironi P, Latini R, Struck J, Hartmann O, Bergmann A, Bellato V, Ferraris S, Tognoni G, Pesenti A, Gattinoni L, Masson S; ALBIOS Study Investigators.

Clin Chem. 2018 Sep;64(9):1361-1369. doi: 10.1373/clinchem.2018.288068. Epub 2018 Jul 16.


Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No.

Vincent JL, Marini JJ, Pesenti A.

Intensive Care Med. 2018 Nov;44(11):1989-1991. doi: 10.1007/s00134-018-5220-y. Epub 2018 Jun 11. No abstract available.


Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.

Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group.

Crit Care. 2018 Jun 12;22(1):157. doi: 10.1186/s13054-018-2079-9.


The first five years of neonatal and pediatric transports on extracorporeal membrane oxygenation in the center and south of Italy: The pediatric branch of the Italian "Rete Respira" network.

Di Nardo M, Lonero M, Pasotti E, Cancani F, Perrotta D, Cecchetti C, Stoppa F, Pirozzi N, La Salvia O, Nicolini A, Amodeo A, Patroniti N, Pesenti A.

Perfusion. 2018 May;33(1_suppl):24-30. doi: 10.1177/0267659118766829.


Persistence of Central Venous Oxygen Desaturation During Early Sepsis Is Associated With Higher Mortality: A Retrospective Analysis of the ALBIOS Trial.

Protti A, Masson S, Latini R, Fumagalli R, Romero M, Pessina C, Pasetti G, Tognoni G, Pesenti A, Gattinoni L, Caironi P.

Chest. 2018 Dec;154(6):1291-1300. doi: 10.1016/j.chest.2018.04.043. Epub 2018 May 19.


Effects of sodium citrate, citric acid and lactic acid on human blood coagulation.

Scaravilli V, Di Girolamo L, Scotti E, Busana M, Biancolilli O, Leonardi P, Carlin A, Lonati C, Panigada M, Pesenti A, Zanella A.

Perfusion. 2018 Oct;33(7):577-583. doi: 10.1177/0267659118777441. Epub 2018 May 22.


Antithrombin During Extracorporeal Membrane Oxygenation in Adults: National Survey and Retrospective Analysis.

Iapichino GE, Protti A, Andreis DT, Panigada M, Artoni A, Novembrino C, Pesenti A, Gattinoni L.

ASAIO J. 2019 Mar/Apr;65(3):257-263. doi: 10.1097/MAT.0000000000000806.


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