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Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.

Pham T, Serpa Neto A, Pelosi P, Laffey JG, De Haro C, Lorente JA, Bellani G, Fan E, Brochard LJ, Pesenti A, Schultz MJ, Artigas A; LUNG SAFE Investigators and the European Society of Intensive Care Medicine Trials Group.

Anesthesiology. 2018 Nov 27. doi: 10.1097/ALN.0000000000002508. [Epub ahead of print]


Measurement of Diaphragmatic Electrical Activity by Surface Electromyography in Intubated Subjects and Its Relationship With Inspiratory Effort.

Bellani G, Bronco A, Arrigoni Marocco S, Pozzi M, Sala V, Eronia N, Villa G, Foti G, Tagliabue G, Eger M, Pesenti A.

Respir Care. 2018 Nov;63(11):1341-1349. doi: 10.4187/respcare.06176.


Neurologic outcome of postanoxic refractory status epilepticus after aggressive treatment.

Beretta S, Coppo A, Bianchi E, Zanchi C, Carone D, Stabile A, Padovano G, Sulmina E, Grassi A, Bogliun G, Foti G, Ferrarese C, Pesenti A, Beghi E, Avalli L.

Neurology. 2018 Dec 4;91(23):e2153-e2162. doi: 10.1212/WNL.0000000000006615. Epub 2018 Oct 31.


Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.


Understanding hypoxemia on ECCO2R: back to the alveolar gas equation.

Diehl JL, Mercat A, Pesenti A.

Intensive Care Med. 2018 Oct 15. doi: 10.1007/s00134-018-5409-0. [Epub ahead of print] No abstract available.


Oral Care Protocols With Specialty Training Lead to Safe Oral Care Practices and Reduce Iatrogenic Bleeding in Extracorporeal Membrane Oxygenation Patients.

Lucchini A, Bambi S, de Felippis C, Galazzi A, Addis G, Rona R, Grasselli G, Pesenti A, Fumagalli R, Foti G.

Dimens Crit Care Nurs. 2018 Nov/Dec;37(6):285-293. doi: 10.1097/DCC.0000000000000321.


Septic shock-3 vs 2: an analysis of the ALBIOS study.

Vasques F, Duscio E, Romitti F, Pasticci I, Caironi P, Meessen J, Latini R, Cressoni M, Camporota L, Pesenti A, Fumagalli R, Quintel M, Gattinoni L.

Crit Care. 2018 Sep 27;22(1):237. doi: 10.1186/s13054-018-2169-8.


Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial.

Langer T, Santini A, Zadek F, Chiodi M, Pugni P, Cordolcini V, Bonanomi B, Rosini F, Marcucci M, Valenza F, Marenghi C, Inglese S, Pesenti A, Gattinoni L.

J Clin Anesth. 2019 Feb;52:111-118. doi: 10.1016/j.jclinane.2018.09.021. Epub 2018 Sep 20.


Nasal High Flow Delivered within the Helmet: A New Non-Invasive Respiratory Support.

Mauri T, Spinelli E, Mariani M, Guzzardella A, Del Prete C, Carlesso E, Tortolani D, Tagliabue P, Pesenti A, Grasselli G.

Am J Respir Crit Care Med. 2018 Sep 21. doi: 10.1164/rccm.201806-1124LE. [Epub ahead of print] No abstract available.


Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial.

Mauri T, Foti G, Fornari C, Constantin JM, Guerin C, Pelosi P, Ranieri M, Conti S, Tubiolo D, Rondelli E, Lovisari F, Fossali T, Spadaro S, Grieco DL, Navalesi P, Calamai I, Becher T, Roca O, Wang YM, Knafelj R, Cortegiani A, Mancebo J, Brochard L, Pesenti A; Protection Study Group.

Trials. 2018 Aug 29;19(1):460. doi: 10.1186/s13063-018-2828-8.


Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS.

Intensive Care Med. 2018 Sep;44(9):1388-1399. doi: 10.1007/s00134-018-5327-1. Epub 2018 Jul 26.


Application of prone position in hypoxaemic patients supported by veno-venous ECMO.

Lucchini A, De Felippis C, Pelucchi G, Grasselli G, Patroniti N, Castagna L, Foti G, Pesenti A, Fumagalli R.

Intensive Crit Care Nurs. 2018 Oct;48:61-68. doi: 10.1016/j.iccn.2018.04.002. Epub 2018 Jul 20.


Circulating Proenkephalin, Acute Kidney Injury, and Its Improvement in Patients with Severe Sepsis or Shock.

Caironi P, Latini R, Struck J, Hartmann O, Bergmann A, Bellato V, Ferraris S, Tognoni G, Pesenti A, Gattinoni L, Masson S; ALBIOS Study Investigators.

Clin Chem. 2018 Sep;64(9):1361-1369. doi: 10.1373/clinchem.2018.288068. Epub 2018 Jul 16.


Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No.

Vincent JL, Marini JJ, Pesenti A.

Intensive Care Med. 2018 Nov;44(11):1989-1991. doi: 10.1007/s00134-018-5220-y. Epub 2018 Jun 11. No abstract available.


Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.

Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group.

Crit Care. 2018 Jun 12;22(1):157. doi: 10.1186/s13054-018-2079-9.


The first five years of neonatal and pediatric transports on extracorporeal membrane oxygenation in the center and south of Italy: The pediatric branch of the Italian "Rete Respira" network.

Di Nardo M, Lonero M, Pasotti E, Cancani F, Perrotta D, Cecchetti C, Stoppa F, Pirozzi N, La Salvia O, Nicolini A, Amodeo A, Patroniti N, Pesenti A.

Perfusion. 2018 May;33(1_suppl):24-30. doi: 10.1177/0267659118766829.


Persistence of Central Venous Oxygen Desaturation During Early Sepsis Is Associated With Higher Mortality: A Retrospective Analysis of the ALBIOS Trial.

Protti A, Masson S, Latini R, Fumagalli R, Romero M, Pessina C, Pasetti G, Tognoni G, Pesenti A, Gattinoni L, Caironi P.

Chest. 2018 Dec;154(6):1291-1300. doi: 10.1016/j.chest.2018.04.043. Epub 2018 May 19.


Effects of sodium citrate, citric acid and lactic acid on human blood coagulation.

Scaravilli V, Di Girolamo L, Scotti E, Busana M, Biancolilli O, Leonardi P, Carlin A, Lonati C, Panigada M, Pesenti A, Zanella A.

Perfusion. 2018 Oct;33(7):577-583. doi: 10.1177/0267659118777441. Epub 2018 May 22.


Antithrombin During Extracorporeal Membrane Oxygenation in Adults: National Survey and Retrospective Analysis.

Iapichino GE, Protti A, Andreis DT, Panigada M, Artoni A, Novembrino C, Pesenti A, Gattinoni L.

ASAIO J. 2018 May 8. doi: 10.1097/MAT.0000000000000806. [Epub ahead of print]


Impact of flow and temperature on patient comfort during respiratory support by high-flow nasal cannula.

Mauri T, Galazzi A, Binda F, Masciopinto L, Corcione N, Carlesso E, Lazzeri M, Spinelli E, Tubiolo D, Volta CA, Adamini I, Pesenti A, Grasselli G.

Crit Care. 2018 May 9;22(1):120. doi: 10.1186/s13054-018-2039-4.


Safety of anesthesia for children with mucopolysaccharidoses: A retrospective analysis of 54 patients.

Scaravilli V, Zanella A, Ciceri V, Bosatra M, Flandoli C, La Bruna A, Sosio S, Parini R, Gasperini S, Pesenti A, Moretto A.

Paediatr Anaesth. 2018 May;28(5):436-442. doi: 10.1111/pan.13379. Epub 2018 Apr 23.


Induction Dosage of Propofol for Repeated Sedations in Children With Hematological Disorders.

Moretto A, Zanella A, Ciceri V, Rota M, Scaravilli V, Beltrama V, Bosatra M, Pesenti A.

J Pediatr Hematol Oncol. 2018 Jul;40(5):e295-e298. doi: 10.1097/MPH.0000000000001145.


Ted Kolobow.

Gattinoni L, Pesenti A, Berra L, Bartlett R.

Intensive Care Med. 2018 May;44(5):551-552. doi: 10.1007/s00134-018-5162-4. Epub 2018 Apr 16. No abstract available.


Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.

Røsjø H, Masson S, Caironi P, Stridsberg M, Magnoli M, Christensen G, Moise G, Urbano MC, Gattinoni L, Pesenti A, Latini R, Omland T; ALBIOS Biomarkers Study Investigators.

Crit Care Med. 2018 May;46(5):e404-e410. doi: 10.1097/CCM.0000000000003050.


Variation of poorly ventilated lung units (silent spaces) measured by electrical impedance tomography to dynamically assess recruitment.

Spadaro S, Mauri T, Böhm SH, Scaramuzzo G, Turrini C, Waldmann AD, Ragazzi R, Pesenti A, Volta CA.

Crit Care. 2018 Jan 31;22(1):26. doi: 10.1186/s13054-017-1931-7.


Research in Extracorporeal Life Support: A Call to Action.

Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet).

Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024. Epub 2018 Jan 31. No abstract available.


Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study.

Panigada M, E Iapichino G, Brioni M, Panarello G, Protti A, Grasselli G, Occhipinti G, Novembrino C, Consonni D, Arcadipane A, Gattinoni L, Pesenti A.

Ann Intensive Care. 2018 Jan 16;8(1):7. doi: 10.1186/s13613-017-0352-8.


The authors reply.

Grasselli G, Scaravilli V, Alagna L, Gori A, Pesenti A.

Crit Care Med. 2018 Feb;46(2):e172-e173. doi: 10.1097/CCM.0000000000002852. No abstract available.


Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis.

Semeraro F, Colucci M, Caironi P, Masson S, Ammollo CT, Teli R, Semeraro N, Magnoli M, Salati G, Isetta M, Panigada M, Tonetti T, Tognoni G, Latini R, Pesenti A, Gattinoni L.

Crit Care Med. 2018 Mar;46(3):e221-e228. doi: 10.1097/CCM.0000000000002919.


Quality of Life of Adult Survivors After Extra Corporeal Membrane Oxygenation (ECMO): A Quantitative Study.

Galazzi A, Brambilla A, Grasselli G, Pesenti A, Fumagalli R, Lucchini A.

Dimens Crit Care Nurs. 2018 Jan/Feb;37(1):12-17. doi: 10.1097/DCC.0000000000000278.


Ventilation during extracorporeal support : Why and how.

Pesenti A, Carlesso E, Langer T, Mauri T.

Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):26-30. doi: 10.1007/s00063-017-0384-8. Epub 2017 Nov 28. Review.


Intravenous fluid therapy for hospitalized and critically ill children: rationale, available drugs and possible side effects.

Langer T, Limuti R, Tommasino C, van Regenmortel N, Duval ELIM, Caironi P, Malbrain MLNG, Pesenti A.

Anaesthesiol Intensive Ther. 2018;50(1):49-58. doi: 10.5603/AIT.a2017.0058. Epub 2017 Nov 18.


Randomized, multicenter trial of lateral Trendelenburg versus semirecumbent body position for the prevention of ventilator-associated pneumonia.

Li Bassi G, Panigada M, Ranzani OT, Zanella A, Berra L, Cressoni M, Parrini V, Kandil H, Salati G, Selvaggi P, Amatu A, Sanz-Moncosi M, Biagioni E, Tagliaferri F, Furia M, Mercurio G, Costa A, Manca T, Lindau S, Babel J, Cavana M, Chiurazzi C, Marti JD, Consonni D, Gattinoni L, Pesenti A, Wiener-Kronish J, Bruschi C, Ballotta A, Salsi P, Livigni S, Iotti G, Fernandez J, Girardis M, Barbagallo M, Moise G, Antonelli M, Caspani ML, Vezzani A, Meybohm P, Gasparovic V, Geat E, Amato M, Niederman M, Kolobow T, Torres A; Gravity-VAP Network.

Intensive Care Med. 2017 Nov;43(11):1572-1584. doi: 10.1007/s00134-017-4858-1. Epub 2017 Jun 20.


Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Intensive Care Med. 2018 Jan;44(1):157-165. doi: 10.1007/s00134-017-4981-z.


Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.

Munshi L, Del Sorbo L, Adhikari NKJ, Hodgson CL, Wunsch H, Meade MO, Uleryk E, Mancebo J, Pesenti A, Ranieri VM, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S280-S288. doi: 10.1513/AnnalsATS.201704-343OT. Review.


A novel risk score for severe ARDS patients undergoing ECMO after retrieval from peripheral hospitals.

Lazzeri C, Cianchi G, Mauri T, Pesenti A, Bonizzoli M, Batacchi S, Chiostri M, Socci F, Peris A.

Acta Anaesthesiol Scand. 2018 Jan;62(1):38-48. doi: 10.1111/aas.13022. Epub 2017 Oct 23.


Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study.

Lanini S, Portella G, Vairo F, Kobinger GP, Pesenti A, Langer M, Kabia S, Brogiato G, Amone J, Castilletti C, Miccio R, Capobianchi MR, Strada G, Zumla A, Di Caro A, Ippolito G; INMI-EMERGENCY EBOV Sierra Leone Study Group .

Clin Infect Dis. 2018 Jan 6;66(1):36-44. doi: 10.1093/cid/cix704.


Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?

Grasselli G, Vergnano B, Pozzi MR, Sala V, D'Andrea G, Scaravilli V, Mantero M, Pesci A, Pesenti A.

Ann Intensive Care. 2017 Sep 18;7(1):98. doi: 10.1186/s13613-017-0320-3.


Do we need randomized clinical trials in extracorporeal respiratory support? Yes.

Combes A, Pesenti A, Brodie D.

Intensive Care Med. 2017 Dec;43(12):1862-1865. doi: 10.1007/s00134-017-4933-7. Epub 2017 Sep 15.


Respiratory support in patients with acute respiratory distress syndrome: an expert opinion.

Chiumello D, Brochard L, Marini JJ, Slutsky AS, Mancebo J, Ranieri VM, Thompson BT, Papazian L, Schultz MJ, Amato M, Gattinoni L, Mercat A, Pesenti A, Talmor D, Vincent JL.

Crit Care. 2017 Sep 12;21(1):240. doi: 10.1186/s13054-017-1820-0. Review.


Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impact on Patients' Outcome.

Grasselli G, Scaravilli V, Di Bella S, Biffi S, Bombino M, Patroniti N, Bisi L, Peri AM, Pesenti A, Gori A, Alagna L.

Crit Care Med. 2017 Oct;45(10):1726-1733. doi: 10.1097/CCM.0000000000002652.


Optimum support by high-flow nasal cannula in acute hypoxemic respiratory failure: effects of increasing flow rates.

Mauri T, Alban L, Turrini C, Cambiaghi B, Carlesso E, Taccone P, Bottino N, Lissoni A, Spadaro S, Volta CA, Gattinoni L, Pesenti A, Grasselli G.

Intensive Care Med. 2017 Oct;43(10):1453-1463. doi: 10.1007/s00134-017-4890-1. Epub 2017 Jul 31.


Bedside selection of positive end-expiratory pressure by electrical impedance tomography in hypoxemic patients: a feasibility study.

Eronia N, Mauri T, Maffezzini E, Gatti S, Bronco A, Alban L, Binda F, Sasso T, Marenghi C, Grasselli G, Foti G, Pesenti A, Bellani G.

Ann Intensive Care. 2017 Dec;7(1):76. doi: 10.1186/s13613-017-0299-9. Epub 2017 Jul 20.


Extracorporeal CO2 removal: a powerful tool to be handled with care.

Grasselli G, Pesenti A.

Minerva Anestesiol. 2017 Jul;83(7):682-684. doi: 10.23736/S0375-9393.17.12165-6. No abstract available.


Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F, Ranieri M, Rubenfeld G, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Lancet Respir Med. 2017 Aug;5(8):627-638. doi: 10.1016/S2213-2600(17)30213-8. Epub 2017 Jun 15.


Systematic assessment of advanced respiratory physiology: precision medicine entering real-life ICU?

Mauri T, Grasselli G, Pesenti A.

Crit Care. 2017 Jun 16;21(1):143. doi: 10.1186/s13054-017-1720-3. No abstract available.


Neurologic Injury in Adults Supported With Veno-Venous Extracorporeal Membrane Oxygenation for Respiratory Failure: Findings From the Extracorporeal Life Support Organization Database.

Lorusso R, Gelsomino S, Parise O, Di Mauro M, Barili F, Geskes G, Vizzardi E, Rycus PT, Muellenbach R, Mueller T, Pesenti A, Combes A, Peek G, Frenckner B, Di Nardo M, Swol J, Maessen J, Thiagarajan RR.

Crit Care Med. 2017 Aug;45(8):1389-1397. doi: 10.1097/CCM.0000000000002502.


Infections during extracorporeal membrane oxygenation: epidemiology, risk factors, pathogenesis and prevention.

Biffi S, Di Bella S, Scaravilli V, Peri AM, Grasselli G, Alagna L, Pesenti A, Gori A.

Int J Antimicrob Agents. 2017 Jul;50(1):9-16. doi: 10.1016/j.ijantimicag.2017.02.025. Epub 2017 May 18. Review.


Understanding blood gas analysis.

Gattinoni L, Pesenti A, Matthay M.

Intensive Care Med. 2018 Jan;44(1):91-93. doi: 10.1007/s00134-017-4824-y. Epub 2017 May 11. No abstract available.


Reply: "A Word of Caution Regarding Patient Self-inflicted Lung Injury and Prophylactic Intubation" and "Hyperventilation (Not Ventilator)-induced Lung Injury".

Brochard L, Slutsky AS, Pesenti A.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):937-938. doi: 10.1164/rccm.201704-0780LE. No abstract available.


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