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Items: 46

1.

Automated profiling of growth cone heterogeneity defines relations between morphology and motility.

Bagonis MM, Fusco L, Pertz O, Danuser G.

J Cell Biol. 2018 Dec 6. pii: jcb.201711023. doi: 10.1083/jcb.201711023. [Epub ahead of print]

PMID:
30523041
2.

Integrated Platform for Monitoring Single-cell MAPK Kinetics in Computer-controlled Temporal Stimulations.

Ryu H, Chung M, Song J, Lee SS, Pertz O, Jeon NL.

Sci Rep. 2018 Jul 24;8(1):11126. doi: 10.1038/s41598-018-28873-1.

3.

Microfluidic platform for single cell analysis under dynamic spatial and temporal stimulation.

Song J, Ryu H, Chung M, Kim Y, Blum Y, Lee SS, Pertz O, Jeon NL.

Biosens Bioelectron. 2018 May 1;104:58-64. doi: 10.1016/j.bios.2017.12.038. Epub 2017 Dec 27.

PMID:
29306762
4.

Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction.

Kempf A, Boda E, Kwok JCF, Fritz R, Grande V, Kaelin AM, Ristic Z, Schmandke A, Schmandke A, Tews B, Fawcett JW, Pertz O, Buffo A, Schwab ME.

Dev Cell. 2017 Oct 9;43(1):24-34.e5. doi: 10.1016/j.devcel.2017.08.014. Epub 2017 Sep 21.

5.

Developmental ERK Signaling Goes Digital.

Dessauges C, Pertz O.

Dev Cell. 2017 Sep 11;42(5):443-444. doi: 10.1016/j.devcel.2017.08.023.

6.

Measuring ERK Activity Dynamics in Single Living Cells Using FRET Biosensors.

Blum Y, Fritz RD, Ryu H, Pertz O.

Methods Mol Biol. 2017;1487:203-221.

PMID:
27924569
7.

Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT).

Nölke T, Schwan C, Lehmann F, Østevold K, Pertz O, Aktories K.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7870-5. doi: 10.1073/pnas.1522717113. Epub 2016 Jun 23.

8.

The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns.

Fritz RD, Pertz O.

F1000Res. 2016 Apr 26;5. pii: F1000 Faculty Rev-749. doi: 10.12688/f1000research.7370.1. eCollection 2016. Review.

9.

Frequency modulation of ERK activation dynamics rewires cell fate.

Ryu H, Chung M, Dobrzyński M, Fey D, Blum Y, Sik Lee S, Peter M, Kholodenko BN, Li Jeon N, Pertz O.

Mol Syst Biol. 2016 Apr 22;12(4):866. doi: 10.15252/msb.20166982. No abstract available.

10.

Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics.

Martin K, Reimann A, Fritz RD, Ryu H, Jeon NL, Pertz O.

Sci Rep. 2016 Feb 25;6:21901. doi: 10.1038/srep21901.

11.

Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling.

Fusco L, Lefort R, Smith K, Benmansour F, Gonzalez G, Barillari C, Rinn B, Fleuret F, Fua P, Pertz O.

J Cell Biol. 2016 Jan 4;212(1):91-111. doi: 10.1083/jcb.201506018.

12.

Frequency modulation of ERK activation dynamics rewires cell fate.

Ryu H, Chung M, Dobrzyński M, Fey D, Blum Y, Lee SS, Peter M, Kholodenko BN, Jeon NL, Pertz O.

Mol Syst Biol. 2015 Nov 27;11(11):838. doi: 10.15252/msb.20156458. Erratum in: Mol Syst Biol. 2016 Apr;12(4):866.

13.

SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion.

Fritz RD, Menshykau D, Martin K, Reimann A, Pontelli V, Pertz O.

Dev Cell. 2015 Oct 12;35(1):78-92. doi: 10.1016/j.devcel.2015.09.002. Epub 2015 Oct 1.

14.

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

Moretti F, Rolando C, Winker M, Ivanek R, Rodriguez J, Von Kriegsheim A, Taylor V, Bustin M, Pertz O.

Mol Cell Biol. 2015 Jun 1;35(11):2035-50. doi: 10.1128/MCB.00133-15. Epub 2015 Mar 30.

15.

Network-based identification of feedback modules that control RhoA activity and cell migration.

Kim TH, Monsefi N, Song JH, von Kriegsheim A, Vandamme D, Pertz O, Kholodenko BN, Kolch W, Cho KH.

J Mol Cell Biol. 2015 Jun;7(3):242-52. doi: 10.1093/jmcb/mjv017. Epub 2015 Mar 16.

PMID:
25780058
16.

A growth factor-induced, spatially organizing cytoskeletal module enables rapid and persistent fibroblast migration.

Martin K, Vilela M, Jeon NL, Danuser G, Pertz O.

Dev Cell. 2014 Sep 29;30(6):701-16. doi: 10.1016/j.devcel.2014.07.022.

17.

Spatial proteomic and phospho-proteomic organization in three prototypical cell migration modes.

Fengos G, Schmidt A, Martin K, Fluri E, Aebersold R, Iber D, Pertz O.

Proteome Sci. 2014 May 1;12:23. doi: 10.1186/1477-5956-12-23. eCollection 2014.

18.

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

Viaud J, Lagarrigue F, Ramel D, Allart S, Chicanne G, Ceccato L, Courilleau D, Xuereb JM, Pertz O, Payrastre B, Gaits-Iacovoni F.

Nat Commun. 2014 Jun 6;5:4080. doi: 10.1038/ncomms5080.

PMID:
24905281
19.

A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space.

Fritz RD, Letzelter M, Reimann A, Martin K, Fusco L, Ritsma L, Ponsioen B, Fluri E, Schulte-Merker S, van Rheenen J, Pertz O.

Sci Signal. 2013 Jul 23;6(285):rs12. doi: 10.1126/scisignal.2004135.

PMID:
23882122
20.

Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation.

Feltrin D, Fusco L, Witte H, Moretti F, Martin K, Letzelter M, Fluri E, Scheiffele P, Pertz O.

PLoS Biol. 2012;10(12):e1001439. doi: 10.1371/journal.pbio.1001439. Epub 2012 Dec 4.

21.

Assessment of Rho GTPase signaling during neurite outgrowth.

Feltrin D, Pertz O.

Methods Mol Biol. 2012;827:181-94. doi: 10.1007/978-1-61779-442-1_13.

PMID:
22144276
22.

Filopodia: Nanodevices that sense nanotopographic ECM cues to orient neurite outgrowth.

Pertz O.

Commun Integr Biol. 2011 Jul;4(4):436-9. doi: 10.4161/cib.4.4.15325. Epub 2011 Jul 1.

23.

Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.

Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH.

Nat Cell Biol. 2011 Jun;13(6):660-7. doi: 10.1038/ncb2231. Epub 2011 May 15.

24.

Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction.

Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG 2nd, Smith RD, Klemke RL.

J Biol Chem. 2011 May 20;286(20):18190-201. doi: 10.1074/jbc.M111.236133. Epub 2011 Mar 28.

25.

Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth.

Jang KJ, Kim MS, Feltrin D, Jeon NL, Suh KY, Pertz O.

PLoS One. 2010 Dec 30;5(12):e15966. doi: 10.1371/journal.pone.0015966.

26.

Spatio-temporal Rho GTPase signaling - where are we now?

Pertz O.

J Cell Sci. 2010 Jun 1;123(Pt 11):1841-50. doi: 10.1242/jcs.064345. Review.

27.

Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC.

Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R.

Oncogene. 2010 Apr 22;29(16):2441-8. doi: 10.1038/onc.2009.515. Epub 2010 Jan 25.

PMID:
20101212
28.

Coordination of Rho GTPase activities during cell protrusion.

Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G.

Nature. 2009 Sep 3;461(7260):99-103. doi: 10.1038/nature08242. Epub 2009 Aug 19.

29.

p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells.

Su L, Pertz O, Mikawa M, Hahn K, Parsons SJ.

Exp Cell Res. 2009 May 1;315(8):1347-59. doi: 10.1016/j.yexcr.2009.02.014. Epub 2009 Feb 27.

30.

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM.

Exp Cell Res. 2008 Apr 15;314(7):1540-52. doi: 10.1016/j.yexcr.2008.01.016. Epub 2008 Feb 2.

31.

Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network.

Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG 2nd, Smith RD, Klemke RL.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1931-6. doi: 10.1073/pnas.0706545105. Epub 2008 Feb 1.

32.

Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors.

Hodgson L, Pertz O, Hahn KM.

Methods Cell Biol. 2008;85:63-81.

PMID:
18155459
33.

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.

Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM.

Dev Cell. 2007 May;12(5):699-712. Erratum in: Dev Cell. 2007 Jun;12(6):1007.

34.

Functional proteometrics for cell migration.

Shen F, Hodgson L, Rabinovich A, Pertz O, Hahn K, Price JH.

Cytometry A. 2006 Jul;69(7):563-72.

35.

Spatiotemporal dynamics of RhoA activity in migrating cells.

Pertz O, Hodgson L, Klemke RL, Hahn KM.

Nature. 2006 Apr 20;440(7087):1069-72. Epub 2006 Mar 19.

PMID:
16547516
36.

Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism.

Wong K, Pertz O, Hahn K, Bourne H.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3639-44. Epub 2006 Feb 28.

37.

Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.

Subauste MC, Pertz O, Adamson ED, Turner CE, Junger S, Hahn KM.

J Cell Biol. 2004 May 10;165(3):371-81.

38.
39.

Homoassociation of VE-cadherin follows a mechanism common to "classical" cadherins.

Ahrens T, Lambert M, Pertz O, Sasaki T, Schulthess T, Mège RM, Timpl R, Engel J.

J Mol Biol. 2003 Jan 24;325(4):733-42.

PMID:
12507476
40.

Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: changes in mobility, conformation and mapping of contact regions.

Häussinger D, Ahrens T, Sass HJ, Pertz O, Engel J, Grzesiek S.

J Mol Biol. 2002 Dec 6;324(4):823-39.

PMID:
12460580
41.

E-cadherin is a ligand for integrin alpha2beta1.

Whittard JD, Craig SE, Mould AP, Koch A, Pertz O, Engel J, Humphries MJ.

Matrix Biol. 2002 Oct;21(6):525-32.

PMID:
12392763
42.

Structure/function relationships in the minicollagen of Hydra nematocysts.

Ozbek S, Pertz O, Schwager M, Lustig A, Holstein T, Engel J.

J Biol Chem. 2002 Dec 20;277(51):49200-4. Epub 2002 Oct 3.

43.

Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains.

Ahrens T, Pertz O, Haussinger D, Fauser C, Schulthess T, Engel J.

J Biol Chem. 2002 May 31;277(22):19455-60. Epub 2002 Mar 21.

44.

A switch in disulfide linkage during minicollagen assembly in Hydra nematocysts.

Engel U, Pertz O, Fauser C, Engel J, David CN, Holstein TW.

EMBO J. 2001 Jun 15;20(12):3063-73.

45.

Homophilic adhesion by cadherins.

Koch AW, Bozic D, Pertz O, Engel J.

Curr Opin Struct Biol. 1999 Apr;9(2):275-81. Review.

PMID:
10322209
46.

A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation.

Pertz O, Bozic D, Koch AW, Fauser C, Brancaccio A, Engel J.

EMBO J. 1999 Apr 1;18(7):1738-47.

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