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Items: 40

1.

Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.

Sommer C, Boldajipour B, Kuo TC, Bentley T, Sutton J, Chen A, Geng T, Dong H, Galetto R, Valton J, Pertel T, Juillerat A, Gariboldi A, Pascua E, Brown C, Chin SM, Sai T, Ni Y, Duchateau P, Smith J, Rajpal A, Van Blarcom T, Chaparro-Riggers J, Sasu BJ.

Mol Ther. 2019 Jun 5;27(6):1126-1138. doi: 10.1016/j.ymthe.2019.04.001. Epub 2019 Apr 8.

PMID:
31005597
2.

A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies.

Valton J, Guyot V, Boldajipour B, Sommer C, Pertel T, Juillerat A, Duclert A, Sasu BJ, Duchateau P, Poirot L.

Sci Rep. 2018 Jun 12;8(1):8972. doi: 10.1038/s41598-018-27264-w.

3.

Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.

Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC.

Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018.

4.

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.

Garcia-Beltran WF, Hölzemer A, Martrus G, Chung AW, Pacheco Y, Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M.

Nat Immunol. 2016 Sep;17(9):1067-74. doi: 10.1038/ni.3513. Epub 2016 Jul 25.

5.

ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection.

Metzger TC, Long H, Potluri S, Pertel T, Bailey-Bucktrout SL, Lin JC, Fu T, Sharma P, Allison JP, Feldman RM.

Cancer Res. 2016 Jul 1;76(13):3684-9. doi: 10.1158/0008-5472.CAN-15-3412. Epub 2016 May 4.

6.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

7.

Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation.

Mazzola MA, Raheja R, Murugaiyan G, Rajabi H, Kumar D, Pertel T, Regev K, Griffin R, Aly L, Kivisakk P, Nejad P, Patel B, Gwanyalla N, Hei H, Glanz B, Chitnis T, Weiner HL, Gandhi R.

J Neuroinflammation. 2015 Dec 30;12:245. doi: 10.1186/s12974-015-0460-z.

8.

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.

Hölzemer A, Thobakgale CF, Jimenez Cruz CA, Garcia-Beltran WF, Carlson JM, van Teijlingen NH, Mann JK, Jaggernath M, Kang SG, Körner C, Chung AW, Schafer JL, Evans DT, Alter G, Walker BD, Goulder PJ, Carrington M, Hartmann P, Pertel T, Zhou R, Ndung'u T, Altfeld M.

PLoS Med. 2015 Nov 17;12(11):e1001900; discussion e1001900. doi: 10.1371/journal.pmed.1001900. eCollection 2015 Nov.

9.

Significance of action plans in the development of occupational well-being in the schools of Finland and Estonia.

Laine S, Saaranen T, Pertel T, Hansen S, Lepp K, Tossavainen K.

Eval Program Plann. 2016 Feb;54:74-81. doi: 10.1016/j.evalprogplan.2015.10.004. Epub 2015 Oct 9.

PMID:
26519691
10.

Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration.

Pizzato M, McCauley SM, Neagu MR, Pertel T, Firrito C, Ziglio S, Dauphin A, Zufferey M, Berthoux L, Luban J.

PLoS Pathog. 2015 Jul 16;11(7):e1005050. doi: 10.1371/journal.ppat.1005050. eCollection 2015 Jul.

11.

Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.

Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK.

Nat Commun. 2015 Jul 8;6:7657. doi: 10.1038/ncomms8657. No abstract available.

PMID:
26153760
12.

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity.

Esposito F, Sorosina M, Ottoboni L, Lim ET, Replogle JM, Raj T, Brambilla P, Liberatore G, Guaschino C, Romeo M, Pertel T, Stankiewicz JM, Martinelli V, Rodegher M, Weiner HL, Brassat D, Benoist C, Patsopoulos NA, Comi G, Elyaman W, Martinelli Boneschi F, De Jager PL.

Ann Neurol. 2015 Jul;78(1):115-27. doi: 10.1002/ana.24429. Epub 2015 May 14.

PMID:
25914168
13.

An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.

Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK.

Nat Commun. 2015 Jan 23;6:6072. doi: 10.1038/ncomms7072. Erratum in: Nat Commun. 2015;6:7657.

14.

Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.

Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, Kaufmann DE, Lichterfeld M, Brass AL, Walker BD.

Immunity. 2014 Dec 18;41(6):1001-12. doi: 10.1016/j.immuni.2014.12.011. Epub 2014 Dec 8.

15.

Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL.

Cell Rep. 2014 Oct 23;9(2):752-66. doi: 10.1016/j.celrep.2014.09.031. Epub 2014 Oct 16.

16.

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Erratum in: Nature. 2016 Aug 18;536(7616):359.

17.

The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.

John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL.

J Virol. 2013 Jul;87(14):7837-52. doi: 10.1128/JVI.00481-13. Epub 2013 May 8.

18.

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W.

J Virol. 2013 Jan;87(1):257-72. doi: 10.1128/JVI.01804-12. Epub 2012 Oct 17.

19.

Reactivation of latent HIV-1 by inhibition of BRD4.

Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL.

Cell Rep. 2012 Oct 25;2(4):807-16. doi: 10.1016/j.celrep.2012.09.008. Epub 2012 Oct 4.

20.

IFITM3 restricts the morbidity and mortality associated with influenza.

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P.

Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921.

21.

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome.

Soghoian DZ, Jessen H, Flanders M, Sierra-Davidson K, Cutler S, Pertel T, Ranasinghe S, Lindqvist M, Davis I, Lane K, Rychert J, Rosenberg ES, Piechocka-Trocha A, Brass AL, Brenchley JM, Walker BD, Streeck H.

Sci Transl Med. 2012 Feb 29;4(123):123ra25. doi: 10.1126/scitranslmed.3003165.

22.

IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL.

PLoS Pathog. 2011 Oct;7(10):e1002337. doi: 10.1371/journal.ppat.1002337. Epub 2011 Oct 27.

23.

Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.

Pertel T, Reinhard C, Luban J.

Retrovirology. 2011 Jun 22;8:49. doi: 10.1186/1742-4690-8-49.

24.

TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J.

Nature. 2011 Apr 21;472(7343):361-5. doi: 10.1038/nature09976.

25.

TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.

Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E.

J Virol. 2011 May;85(10):5183-96. doi: 10.1128/JVI.02302-10. Epub 2011 Feb 23.

26.

Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney.

Suñé G, Sarró E, Puigmulé M, López-Hellín J, Zufferey M, Pertel T, Luban J, Meseguer A.

PLoS One. 2010 Nov 10;5(11):e13930. doi: 10.1371/journal.pone.0013930.

27.

Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation.

Bernasconi R, Soldà T, Galli C, Pertel T, Luban J, Molinari M.

PLoS One. 2010 Sep 28;5(9). pii: e13008. doi: 10.1371/journal.pone.0013008.

28.

Polarization of migrating monocytic cells is independent of PI 3-kinase activity.

Volpe S, Thelen S, Pertel T, Lohse MJ, Thelen M.

PLoS One. 2010 Apr 15;5(4):e10159. doi: 10.1371/journal.pone.0010159.

29.

p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.

O'Connor C, Pertel T, Gray S, Robia SL, Bakowska JC, Luban J, Campbell EM.

J Virol. 2010 Jun;84(12):5997-6006. doi: 10.1128/JVI.02412-09. Epub 2010 Mar 31.

30.

Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.

van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17019-24. doi: 10.1073/pnas.0903036106. Epub 2009 Sep 17.

31.

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components.

Neagu MR, Ziegler P, Pertel T, Strambio-De-Castillia C, Grütter C, Martinetti G, Mazzucchelli L, Grütter M, Manz MG, Luban J.

J Clin Invest. 2009 Oct;119(10):3035-47. doi: 10.1172/JCI39354. Epub 2009 Sep 8.

32.

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.

Kaul A, Stauffer S, Berger C, Pertel T, Schmitt J, Kallis S, Zayas M, Lohmann V, Luban J, Bartenschlager R.

PLoS Pathog. 2009 Aug;5(8):e1000546. doi: 10.1371/journal.ppat.1000546. Epub 2009 Aug 14. Erratum in: PLoS Pathog. 2009 Sep;5(9). doi: 10.1371/annotation/29dffb2a-5d37-4196-b166-b0b15bc2f3fd. Lopez, Margarita Zayas [corrected to Zayas, Margarita].

33.

An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding.

Sebastian S, Grütter C, Strambio de Castillia C, Pertel T, Olivari S, Grütter MG, Luban J.

J Virol. 2009 Apr;83(7):3365-73. doi: 10.1128/JVI.00432-08. Epub 2009 Jan 19.

34.

Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.

Goujon C, Arfi V, Pertel T, Luban J, Lienard J, Rigal D, Darlix JL, Cimarelli A.

J Virol. 2008 Dec;82(24):12335-45. doi: 10.1128/JVI.01181-08. Epub 2008 Oct 1.

35.

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal.

Bernasconi R, Pertel T, Luban J, Molinari M.

J Biol Chem. 2008 Jun 13;283(24):16446-54. doi: 10.1074/jbc.M802272200. Epub 2008 Apr 15.

36.

Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.

Takeuchi H, Buckler-White A, Goila-Gaur R, Miyagi E, Khan MA, Opi S, Kao S, Sokolskaja E, Pertel T, Luban J, Strebel K.

J Virol. 2007 Aug;81(15):8080-90. Epub 2007 May 23.

37.

Expression and muscarinic receptor coupling of Lyn kinase in cultured human airway smooth muscle cells.

Pertel T, Zhu D, Panettieri RA, Yamaguchi N, Emala CW, Hirshman CA.

Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L492-500. Epub 2005 Oct 14.

38.

Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS.

Hirshman CA, Zhu D, Pertel T, Panettieri RA, Emala CW.

Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L924-31.

39.

Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells.

Einbond LS, Shimizu M, Xiao D, Nuntanakorn P, Lim JT, Suzui M, Seter C, Pertel T, Kennelly EJ, Kronenberg F, Weinstein IB.

Breast Cancer Res Treat. 2004 Feb;83(3):221-31.

PMID:
14758092
40.

Impairment of NK cell function by NKG2D modulation in NOD mice.

Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL.

Immunity. 2003 Jan;18(1):41-51.

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