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Items: 15

1.

Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.

Javanbakht H, Mueller H, Walther J, Zhou X, Lopez A, Pattupara T, Blaising J, Pedersen L, Albæk N, Jackerott M, Shi T, Ploix C, Driessen W, Persson R, Ravn J, Young JAT, Ottosen S.

Mol Ther Nucleic Acids. 2018 Jun 1;11:441-454. doi: 10.1016/j.omtn.2018.02.005. Epub 2018 Feb 23.

2.

Locked nucleic acid: modality, diversity, and drug discovery.

Hagedorn PH, Persson R, Funder ED, Albæk N, Diemer SL, Hansen DJ, Møller MR, Papargyri N, Christiansen H, Hansen BR, Hansen HF, Jensen MA, Koch T.

Drug Discov Today. 2018 Jan;23(1):101-114. doi: 10.1016/j.drudis.2017.09.018. Epub 2017 Oct 6. Review.

3.

From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.

Braendli-Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch MJ, Fisker N, Funk J, Mohr S, Constien R, Ploix C, Brady K, Berrera M, Altmann B, Lenz B, Albassam M, Schmitt G, Weiser T, Schuler F, Singer T, Tessier Y.

Toxicol Sci. 2017 May 1;157(1):112-128. doi: 10.1093/toxsci/kfx025.

4.

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.

van Poelgeest EP, Hodges MR, Moerland M, Tessier Y, Levin AA, Persson R, Lindholm MW, Dumong Erichsen K, Ørum H, Cohen AF, Burggraaf J.

Br J Clin Pharmacol. 2015 Dec;80(6):1350-61. doi: 10.1111/bcp.12738. Epub 2015 Oct 24.

5.

The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection.

Persson R, Wensaas KA, Hanevik K, Eide GE, Langeland N, Rortveit G.

BMC Gastroenterol. 2015 Jun 10;15:66. doi: 10.1186/s12876-015-0296-0.

6.

Biological activity and biotechnological aspects of locked nucleic acids.

Lundin KE, Højland T, Hansen BR, Persson R, Bramsen JB, Kjems J, Koch T, Wengel J, Smith CI.

Adv Genet. 2013;82:47-107. doi: 10.1016/B978-0-12-407676-1.00002-0. Review.

PMID:
23721720
7.

Treatment of HCV infection by targeting microRNA.

Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR.

N Engl J Med. 2013 May 2;368(18):1685-94. doi: 10.1056/NEJMoa1209026. Epub 2013 Mar 27.

8.

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys.

Hildebrandt-Eriksen ES, Aarup V, Persson R, Hansen HF, Munk ME, Ørum H.

Nucleic Acid Ther. 2012 Jun;22(3):152-61. doi: 10.1089/nat.2011.0332. Epub 2012 Apr 30.

PMID:
22545703
9.

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T.

Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22.

10.

Open access publishing. And now, e-publication bias.

Jakobsen AK, Christensen R, Persson R, Bartels EM, Kristensen LE.

BMJ. 2010 Apr 28;340:c2243. doi: 10.1136/bmj.c2243. No abstract available.

PMID:
20427450
11.

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.

Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, Ørum H.

Science. 2010 Jan 8;327(5962):198-201. doi: 10.1126/science.1178178. Epub 2009 Dec 3.

12.

High blood pressure despite treatment: results from a cross-sectional primary healthcare-based study in southern Sweden.

Hedblad B, Nerbrand C, Ekesbo R, Johansson L, Midlöv P, Brunkstedt I, Svensson P, Gyllerup S, Sträng B, Persson R, Janzon L.

Scand J Prim Health Care. 2006 Dec;24(4):224-30.

PMID:
17118862
13.

Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator.

Tuvesson H, Hallin I, Persson R, Sparre B, Gunnarsson PO, Seidegård J.

Drug Metab Dispos. 2005 Jun;33(6):866-72. Epub 2005 Mar 11.

14.

A new screening model for safety evaluation of superantigen-antibody recombinant fusion proteins (mAb Fab-SEA/E) using telemetric monitoring in conscious rabbits.

Ilbäck NG, Persson R, Gunnarsson K, Stålhandske T.

J Pharmacol Toxicol Methods. 2002 Jul-Aug;48(1):31-9.

PMID:
12750039
15.

Effects of a superantigen-antibody recombinant fusion protein (r-C242 Fab-SEA) on toxicological responses in the anaesthetised rabbit.

Ilbäck NG, Gunnarsson K, Persson R, Lindh U, Stålhandske T.

Toxicology. 2003 Mar 14;185(1-2):161-74.

PMID:
12505454

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