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Items: 1 to 50 of 71

1.

Plasmodium falciparum invasion and intraerythrocytic development are impaired by 2', 3'-dialdehyde adenosine.

Silva LS, Prado GC, Quintana PG, Heise N, Miranda KR, Torres EJL, Persechini PM, de Sá Pinheiro AA, Schachter J.

Microbes Infect. 2018 Mar;20(3):205-211. doi: 10.1016/j.micinf.2017.11.015. Epub 2017 Dec 15.

2.

POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages.

Pimenta-Dos-Reis G, Torres EJL, Quintana PG, Vidal LO, Dos Santos BAF, Lin CS, Heise N, Persechini PM, Schachter J.

Purinergic Signal. 2017 Dec;13(4):611-627. doi: 10.1007/s11302-017-9588-x. Epub 2017 Oct 11.

3.

Neutrophil extracellular traps release induced by Leishmania: role of PI3Kγ, ERK, PI3Kσ, PKC, and [Ca2+].

DeSouza-Vieira T, Guimarães-Costa A, Rochael NC, Lira MN, Nascimento MT, Lima-Gomez PS, Mariante RM, Persechini PM, Saraiva EM.

J Leukoc Biol. 2016 Oct;100(4):801-810. Epub 2016 May 6.

4.

P2×7 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression.

Martinez CG, Zamith-Miranda D, da Silva MG, Ribeiro KC, Brandão IT, Silva CL, Diaz BL, Bellio M, Persechini PM, Kurtenbach E.

Sci Rep. 2015 Nov 23;5:16940. doi: 10.1038/srep16940.

5.

Inhibition of ecto-ATPase activities impairs HIV-1 infection of macrophages.

Schachter J, Delgado KV, Barreto-de-Souza V, Bou-Habib DC, Persechini PM, Meyer-Fernandes JR.

Immunobiology. 2015 May;220(5):589-96. doi: 10.1016/j.imbio.2014.12.004. Epub 2014 Dec 20.

PMID:
25577295
6.

2´,3´-Dialdehyde of ATP, ADP, and adenosine inhibit HIV-1 reverse transcriptase and HIV-1 replication.

Schachter J, Valadao AL, Aguiar RS, Barreto-de-Souza V, Rossi AD, Arantes PR, Verli H, Quintana PG, Heise N, Tanuri A, Bou-Habib DC, Persechini PM.

Curr HIV Res. 2014;12(5):347-58.

PMID:
25174839
7.

Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor.

da Silva-Souza HA, de Lira MN, Patel NK, Spray DC, Persechini PM, Scemes E.

Am J Physiol Cell Physiol. 2014 Sep 15;307(6):C571-9. doi: 10.1152/ajpcell.00087.2014. Epub 2014 Jul 30.

8.

Regulation of extracellular ATP in human erythrocytes infected with Plasmodium falciparum.

Alvarez CL, Schachter J, de Sá Pinheiro AA, Silva Lde S, Verstraeten SV, Persechini PM, Schwarzbaum PJ.

PLoS One. 2014 May 23;9(5):e96216. doi: 10.1371/journal.pone.0096216. eCollection 2014.

9.

Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages.

da Silva-Souza HA, Lira MN, Costa-Junior HM, da Cruz CM, Vasconcellos JS, Mendes AN, Pimenta-Reis G, Alvarez CL, Faccioli LH, Serezani CH, Schachter J, Persechini PM.

Biochim Biophys Acta. 2014 Jul;1838(7):1967-77. doi: 10.1016/j.bbamem.2014.04.006. Epub 2014 Apr 15.

10.

ATP induces the death of developing avian retinal neurons in culture via activation of P2X7 and glutamate receptors.

Anccasi RM, Ornelas IM, Cossenza M, Persechini PM, Ventura AL.

Purinergic Signal. 2013 Mar;9(1):15-29. doi: 10.1007/s11302-012-9324-5. Epub 2012 Jun 26.

11.

Differential modulation of ATP-induced P2X7-associated permeabilities to cations and anions of macrophages by infection with Leishmania amazonensis.

Marques-da-Silva C, Chaves MM, Rodrigues JC, Corte-Real S, Coutinho-Silva R, Persechini PM.

PLoS One. 2011;6(9):e25356. doi: 10.1371/journal.pone.0025356. Epub 2011 Sep 23.

12.

Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination.

de Alencar BC, Persechini PM, Haolla FA, de Oliveira G, Silverio JC, Lannes-Vieira J, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM.

Infect Immun. 2009 Oct;77(10):4383-95. doi: 10.1128/IAI.01459-08. Epub 2009 Aug 3.

13.

Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination.

Chaves SP, Torres-Santos EC, Marques C, Figliuolo VR, Persechini PM, Coutinho-Silva R, Rossi-Bergmann B.

Microbes Infect. 2009 Sep;11(10-11):842-9. doi: 10.1016/j.micinf.2009.05.001. Epub 2009 May 9.

PMID:
19439191
14.

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells.

Welter-Stahl L, da Silva CM, Schachter J, Persechini PM, Souza HS, Ojcius DM, Coutinho-Silva R.

Biochim Biophys Acta. 2009 May;1788(5):1176-87. doi: 10.1016/j.bbamem.2009.03.006. Epub 2009 Mar 21.

15.

ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages.

Costa-Junior HM, Mendes AN, Davis GH, da Cruz CM, Ventura AL, Serezani CH, Faccioli LH, Nomizo A, Freire-de-Lima CG, Bisaggio Rda C, Persechini PM.

Prostaglandins Other Lipid Mediat. 2009 Jan;88(1-2):51-61. doi: 10.1016/j.prostaglandins.2008.09.004. Epub 2008 Oct 15.

PMID:
18984060
16.

ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages.

Schachter J, Motta AP, de Souza Zamorano A, da Silva-Souza HA, Guimarães MZ, Persechini PM.

J Cell Sci. 2008 Oct 1;121(Pt 19):3261-70. doi: 10.1242/jcs.029991. Epub 2008 Sep 9.

17.

P2X7 modulatory web in Trypanosoma cruzi infection.

Cascabulho CM, Menna-Barreto RF, Coutinho-Silva R, Persechini PM, Henriques-Pons A.

Parasitol Res. 2008 Sep;103(4):829-38. doi: 10.1007/s00436-008-1063-8. Epub 2008 Jul 8.

PMID:
18604654
18.

Modulation of P2X7 receptor expression in macrophages from mineral oil-injected mice.

Marques da Silva C, Miranda Rodrigues L, Passos da Silva Gomes A, Mantuano Barradas M, Sarmento Vieira F, Persechini PM, Coutinho-Silva R.

Immunobiology. 2008;213(6):481-92. doi: 10.1016/j.imbio.2007.11.006. Epub 2008 Jan 4.

PMID:
18514750
19.

The role of P2 receptors in controlling infections by intracellular pathogens.

Coutinho-Silva R, Monteiro da Cruz C, Persechini PM, Ojcius DM.

Purinergic Signal. 2007 Mar;3(1-2):83-90. doi: 10.1007/s11302-006-9039-6. Epub 2007 Jan 12.

21.

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages.

Cruz CM, Rinna A, Forman HJ, Ventura AL, Persechini PM, Ojcius DM.

J Biol Chem. 2007 Feb 2;282(5):2871-9. Epub 2006 Nov 27.

22.

Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve.

Gantus MA, Nasciutti LE, Cruz CM, Persechini PM, Martinez AM.

Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.

PMID:
17027671
23.

The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice.

Gonçalves RG, Gabrich L, Rosário A Jr, Takiya CM, Ferreira ML, Chiarini LB, Persechini PM, Coutinho-Silva R, Leite M Jr.

Kidney Int. 2006 Nov;70(9):1599-606. Epub 2006 Sep 13.

24.

Effect of extracellular ATP on the human leukaemic cell line K562 and its multidrug counterpart.

Bernardo AA, Pinto-Silva FE, Persechini PM, Coutinho-Silva R, Meyer-Fernandes JR, de Souza AL, Rumjanek VM.

Mol Cell Biochem. 2006 Sep;289(1-2):111-24. Epub 2006 Jul 6.

PMID:
16823516
25.

Apoptosis-inducing factor of a cytotoxic T cell line: involvement of a secretory phospholipase A2.

Costa-Junior HM, Hamaty FC, da Silva Farias R, Einicker-Lamas M, da Silva MH, Persechini PM.

Cell Tissue Res. 2006 May;324(2):255-66. Epub 2006 Jan 27.

PMID:
16609916
26.

Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice.

Tzelepis F, de Alencar BC, Penido ML, Gazzinelli RT, Persechini PM, Rodrigues MM.

Infect Immun. 2006 Apr;74(4):2477-81.

27.

Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation.

da Cruz CM, Ventura AL, Schachter J, Costa-Junior HM, da Silva Souza HA, Gomes FR, Coutinho-Silva R, Ojcius DM, Persechini PM.

Br J Pharmacol. 2006 Feb;147(3):324-34.

28.

Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages.

Coutinho-Silva R, Ojcius DM, Górecki DC, Persechini PM, Bisaggio RC, Mendes AN, Marks J, Burnstock G, Dunn PM.

Biochem Pharmacol. 2005 Feb 15;69(4):641-55. Epub 2005 Jan 12.

PMID:
15670583
29.

Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors.

Fortes FS, Pecora IL, Persechini PM, Hurtado S, Costa V, Coutinho-Silva R, Braga MB, Silva-Filho FC, Bisaggio RC, De Farias FP, Scemes E, De Carvalho AC, Goldenberg RC.

J Cell Sci. 2004 Sep 15;117(Pt 20):4717-26. Epub 2004 Aug 25.

30.

What is going on with natural killer cells in HIV infection?

Dines I, Rumjanek VM, Persechini PM.

Int Arch Allergy Immunol. 2004 Apr;133(4):330-9. Epub 2004 Mar 17. Review.

PMID:
15031606
31.

Extracellular ATP induces cell death in CD4+/CD8+ double-positive thymocytes in mice infected with Trypanosoma cruzi.

Mantuano-Barradas M, Henriques-Pons A, Araújo-Jorge TC, Di Virgilio F, Coutinho-Silva R, Persechini PM.

Microbes Infect. 2003 Dec;5(15):1363-71.

PMID:
14670449
32.

Evidence for a perforin-mediated mechanism controlling cardiac inflammation in Trypanosoma cruzi infection.

Henriques-Pons A, Oliveira GM, Paiva MM, Correa AF, Batista MM, Bisaggio RC, Liu CC, Cotta-De-Almeida V, Coutinho CM, Persechini PM, Araujo-Jorge TC.

Int J Exp Pathol. 2002 Apr;83(2):67-79.

33.

Characterization of P2 receptors in thymic epithelial cells.

Bisaggio RD, Nihei OK, Persechini PM, Savino W, Alves LA.

Cell Mol Biol (Noisy-le-grand). 2001 Feb;47(1):19-31.

PMID:
11292255
34.

Modulation of P2Z/P2X(7) receptor activity in macrophages infected with Chlamydia psittaci.

Coutinho-Silva R, Perfettini JL, Persechini PM, Dautry-Varsat A, Ojcius DM.

Am J Physiol Cell Physiol. 2001 Jan;280(1):C81-9.

35.

P2Z/P2X7 receptor-dependent apoptosis of dendritic cells.

Coutinho-Silva R, Persechini PM, Bisaggio RD, Perfettini JL, Neto AC, Kanellopoulos JM, Motta-Ly I, Dautry-Varsat A, Ojcius DM.

Am J Physiol. 1999 May;276(5):C1139-47. doi: 10.1152/ajpcell.1999.276.5.C1139.

PMID:
10329963
36.

Extracellular ATP in the lymphohematopoietic system: P2Z purinoceptors off membrane permeabilization.

Persechini PM, Bisaggio RC, Alves-Neto JL, Coutinho-Silva R.

Braz J Med Biol Res. 1998 Jan;31(1):25-34. Review.

PMID:
9686176
37.

P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells.

Coutinho-Silva R, Persechini PM.

Am J Physiol. 1997 Dec;273(6):C1793-800. doi: 10.1152/ajpcell.1997.273.6.C1793.

PMID:
9435482
38.

Trypanosoma cruzi: resistance to the pore forming protein of cytotoxic lymphocytes--perforin.

Bisaggio Rda C, de Castro SL, Barbosa HS, Brandão Cde A, Persechini PM.

Exp Parasitol. 1997 Jun;86(2):144-54.

PMID:
9207744
39.

Are there functional gap junctions or junctional hemichannels in macrophages?

Alves LA, Coutinho-Silva R, Persechini PM, Spray DC, Savino W, Campos de Carvalho AC.

Blood. 1996 Jul 1;88(1):328-34.

PMID:
8704191
40.

The P2Z purinoceptor: an open question in the immune system.

Persechini PM, Coutinho-Silva R, Alves LA, Campos-de-Carvalho AC, Savino W.

Immunol Today. 1996 Jun;17(6):292-4. No abstract available.

PMID:
8962635
41.

Expression and characterization of functionally active recombinant perforin produced in insect cells.

Liu CC, Persechini PM, Young JD.

J Immunol. 1996 May 1;156(9):3292-300.

PMID:
8617952
42.

Characterization of P2Z purinergic receptors on phagocytic cells of the thymic reticulum in culture.

Coutinho-Silva R, Alves LA, de Carvalho AC, Savino W, Persechini PM.

Biochim Biophys Acta. 1996 Apr 26;1280(2):217-22.

43.

A cation non-selective channel induced by extracellular ATP in macrophages and phagocytic cells of the thymic reticulum.

Coutinho-Silva R, Alves LA, Savino W, Persechini PM.

Biochim Biophys Acta. 1996 Jan 12;1278(1):125-30.

44.

Perforin and lymphocyte-mediated cytolysis.

Liu CC, Persechini PM, Young JD.

Immunol Rev. 1995 Aug;146:145-75. Review.

PMID:
7493752
45.

Characterization of recombinant mouse perforin expressed in insect cells using the baculovirus system.

Liu CC, Persechini PM, Young JD.

Biochem Biophys Res Commun. 1994 May 30;201(1):318-25.

PMID:
8198590
46.

ATP- and UTP-induced currents in macrophages and macrophage polykaryons.

Albuquerque C, Oliveira SM, Coutinho-Silva R, Oliveira-Castro GM, Persechini PM.

Am J Physiol. 1993 Dec;265(6 Pt 1):C1663-73.

PMID:
7904123
47.

Channel-forming activity of the perforin N-terminus and a putative alpha-helical region homologous with complement C9.

Persechini PM, Ojcius DM, Adeodato SC, Notaroberto PC, Daniel CB, Young JD.

Biochemistry. 1992 Jun 2;31(21):5017-21.

PMID:
1599928
48.

Cytoplasts from cytotoxic T lymphocytes are resistant to perforin-mediated lysis.

Ojcius DM, Jiang SB, Persechini PM, Detmers PA, Young JD.

Mol Immunol. 1991 Sep;28(9):1011-8.

PMID:
1922107
49.

Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.

Ojcius DM, Persechini PM, Zheng LM, Notaroberto PC, Adeodato SC, Young JD.

Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4621-5.

50.

Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase.

Murta AC, Persechini PM, Padron Tde S, de Souza W, Guimarães JA, Scharfstein J.

Mol Biochem Parasitol. 1990 Nov;43(1):27-38.

PMID:
1705310

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