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The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B.

Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099.


Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease.

Sri S, Pegasiou CM, Cave CA, Hough K, Wood N, Gomez-Nicola D, Deinhardt K, Bannerman D, Perry VH, Vargas-Caballero M.

Acta Neuropathol Commun. 2019 Feb 22;7(1):25. doi: 10.1186/s40478-019-0670-1.


Microglia and major depression: not yet a clear picture.

Perry VH.

Lancet Psychiatry. 2018 Apr;5(4):292-294. doi: 10.1016/S2215-0366(18)30087-7. Epub 2018 Feb 26. No abstract available.


Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study.

Manoharan A, Rayner PJ, Iali W, Burns MJ, Perry VH, Duckett SB.

ChemMedChem. 2018 Feb 20;13(4):352-359. doi: 10.1002/cmdc.201700725. Epub 2018 Jan 18.


The blood-brain interface: a culture change.

Galea I, Perry VH.

Brain Behav Immun. 2018 Feb;68:11-16. doi: 10.1016/j.bbi.2017.10.014. Epub 2017 Oct 26. Review.


Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder.

Leday GGR, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC, Pariante CM, Harrison NA; MRC Immunopsychiatry Consortium, Perry VH, Drevets WC, Wittenberg GM, Bullmore ET.

Biol Psychiatry. 2018 Jan 1;83(1):70-80. doi: 10.1016/j.biopsych.2017.01.021. Epub 2017 Jul 6.


Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain.

Askew K, Li K, Olmos-Alonso A, Garcia-Moreno F, Liang Y, Richardson P, Tipton T, Chapman MA, Riecken K, Beccari S, Sierra A, Molnár Z, Cragg MS, Garaschuk O, Perry VH, Gomez-Nicola D.

Cell Rep. 2017 Jan 10;18(2):391-405. doi: 10.1016/j.celrep.2016.12.041.


Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration.

Alibhai J, Blanco RA, Barria MA, Piccardo P, Caughey B, Perry VH, Freeman TC, Manson JC.

PLoS Biol. 2016 Nov 23;14(11):e1002579. doi: 10.1371/journal.pbio.1002579. eCollection 2016 Nov.



Perry VH.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0003-2015. Review.


CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves.

Martínez-Muriana A, Mancuso R, Francos-Quijorna I, Olmos-Alonso A, Osta R, Perry VH, Navarro X, Gomez-Nicola D, López-Vales R.

Sci Rep. 2016 May 13;6:25663. doi: 10.1038/srep25663.


The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation.

Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, Perry VH, Bozzi Y, Caleo M.

J Neurosci. 2016 Mar 30;36(13):3777-88. doi: 10.1523/JNEUROSCI.0451-15.2016.


Periodontitis and Cognitive Decline in Alzheimer's Disease.

Ide M, Harris M, Stevens A, Sussams R, Hopkins V, Culliford D, Fuller J, Ibbett P, Raybould R, Thomas R, Puenter U, Teeling J, Perry VH, Holmes C.

PLoS One. 2016 Mar 10;11(3):e0151081. doi: 10.1371/journal.pone.0151081. eCollection 2016.


The use of human neurons for novel drug discovery in dementia research.

Vargas-Caballero M, Willaime-Morawek S, Gomez-Nicola D, Perry VH, Bulters D, Mudher A.

Expert Opin Drug Discov. 2016;11(4):355-67. doi: 10.1517/17460441.2016.1154528. Epub 2016 Mar 1. Review.


Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.

Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D.

Brain. 2016 Mar;139(Pt 3):891-907. doi: 10.1093/brain/awv379. Epub 2016 Jan 8.


Selective and compartmentalized myelin expression of HspB5.

Quraishe S, Wyttenbach A, Matinyarare N, Perry VH, Fern R, O'Connor V.

Neuroscience. 2016 Mar 1;316:130-42. doi: 10.1016/j.neuroscience.2015.12.035. Epub 2015 Dec 21.


Microglia regulate hippocampal neurogenesis during chronic neurodegeneration.

De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry VH, Gomez-Nicola D.

Brain Behav Immun. 2016 Jul;55:179-190. doi: 10.1016/j.bbi.2015.11.001. Epub 2015 Nov 2.


Analysis of Microglial Proliferation in Alzheimer's Disease.

Gomez-Nicola D, Perry VH.

Methods Mol Biol. 2016;1303:185-93. doi: 10.1007/978-1-4939-2627-5_10.


Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial.

Butchart J, Brook L, Hopkins V, Teeling J, Püntener U, Culliford D, Sharples R, Sharif S, McFarlane B, Raybould R, Thomas R, Passmore P, Perry VH, Holmes C.

Neurology. 2015 May 26;84(21):2161-8. doi: 10.1212/WNL.0000000000001617. Epub 2015 May 1. Erratum in: Neurology. 2015 Dec 8;85(23):2084.


Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level.

Gomez-Nicola D, Riecken K, Perry VH, Fehse B.

Hum Gene Ther. 2015 Jun;26(6):332-3. doi: 10.1089/hum.2015.010. Epub 2015 Apr 20.


Neuroinflammation in Alzheimer's disease.

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Review.


Reduced expression of the presynaptic co-chaperone cysteine string protein alpha (CSPα) does not exacerbate experimentally-induced ME7 prion disease.

Davies MJ, Cooper M, Perry VH, O'Connor V.

Neurosci Lett. 2015 Mar 4;589:138-43. doi: 10.1016/j.neulet.2015.01.053. Epub 2015 Jan 23.


In-vivo RGB marking and multicolour single-cell tracking in the adult brain.

Gomez-Nicola D, Riecken K, Fehse B, Perry VH.

Sci Rep. 2014 Dec 22;4:7520. doi: 10.1038/srep07520.


Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration.

Gomez-Nicola D, Suzzi S, Vargas-Caballero M, Fransen NL, Al-Malki H, Cebrian-Silla A, Garcia-Verdugo JM, Riecken K, Fehse B, Perry VH.

Brain. 2014 Aug;137(Pt 8):2312-28. doi: 10.1093/brain/awu155. Epub 2014 Jun 18.


Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity.

Gomez-Nicola D, Perry VH.

Neuroscientist. 2015 Apr;21(2):169-84. doi: 10.1177/1073858414530512. Epub 2014 Apr 10. Review.


Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease.

Gómez-Nicola D, Schetters ST, Perry VH.

Glia. 2014 Jul;62(7):1041-52. doi: 10.1002/glia.22660. Epub 2014 Mar 19.


Microglial priming in neurodegenerative disease.

Perry VH, Holmes C.

Nat Rev Neurol. 2014 Apr;10(4):217-24. doi: 10.1038/nrneurol.2014.38. Epub 2014 Mar 18. Review.


Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration.

Asuni AA, Gray B, Bailey J, Skipp P, Perry VH, O'Connor V.

J Biol Chem. 2014 Feb 14;289(7):4532-45. doi: 10.1074/jbc.M113.502690. Epub 2013 Dec 23.


Fcγ receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration.

Murinello S, Mullins RF, Lotery AJ, Perry VH, Teeling JL.

Invest Ophthalmol Vis Sci. 2014 Jan 13;55(1):247-58. doi: 10.1167/iovs.13-11821.


Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer's disease.

Carare RO, Teeling JL, Hawkes CA, Püntener U, Weller RO, Nicoll JA, Perry VH.

Acta Neuropathol Commun. 2013 Aug 9;1:48. doi: 10.1186/2051-5960-1-48.


Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.

Hilton KJ, Cunningham C, Reynolds RA, Perry VH.

PLoS One. 2013 Jun 26;8(6):e68062. doi: 10.1371/journal.pone.0068062. Print 2013.


Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice.

Mendes Fde C, de Almeida MN, Felício AP, Fadel AC, Silva Dde J, Borralho TG, da Silva RP, Bento-Torres J, Vasconcelos PF, Perry VH, Ramos EM, Picanço-Diniz CW, Sosthenes MC.

BMC Neurosci. 2013 Jun 28;14:63. doi: 10.1186/1471-2202-14-63.


Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration.

Perry VH, Teeling J.

Semin Immunopathol. 2013 Sep;35(5):601-12. doi: 10.1007/s00281-013-0382-8. Epub 2013 Jun 4. Review.


Regulation of microglial proliferation during chronic neurodegeneration.

Gómez-Nicola D, Fransen NL, Suzzi S, Perry VH.

J Neurosci. 2013 Feb 6;33(6):2481-93. doi: 10.1523/JNEUROSCI.4440-12.2013.


Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease.

Šišková Z, Reynolds RA, O'Connor V, Perry VH.

PLoS One. 2013;8(1):e55004. doi: 10.1371/journal.pone.0055004. Epub 2013 Jan 30.


Silencing synapses: a route to understanding synapse degeneration in chronic neurodegenerative disease.

Caleo M, Restani L, Perry VH.

Prion. 2013 Mar-Apr;7(2):147-50. doi: 10.4161/pri.23327. Epub 2013 Jan 28.


Environmental influences on antibody-enhanced dengue disease outcomes.

Diniz DG, Fôro CA, Turiel MC, Sosthenes MC, Demachki S, Gomes GF, Rego CM, Magalhães MC, Pinho BG, Ramos JP, Casseb SM, Brito Mde V, da Silva EV, Nunes MR, Diniz JA, Cunningham C, Perry VH, Vasconcelos PF, Diniz CW.

Mem Inst Oswaldo Cruz. 2012 Dec;107(8):1021-9.


Review: activation patterns of microglia and their identification in the human brain.

Boche D, Perry VH, Nicoll JA.

Neuropathol Appl Neurobiol. 2013 Feb;39(1):3-18. doi: 10.1111/nan.12011. Review.


Impact of stroke-associated infection on long-term survival: a cohort study.

Kwan J, Pickering RM, Kunkel D, Fitton C, Jenkinson D, Perry VH, Ashburn AM; Stroke Association Rehabilitation Research Centre.

J Neurol Neurosurg Psychiatry. 2013 Mar;84(3):297-304. doi: 10.1136/jnnp-2012-302552. Epub 2012 Nov 17.


Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton.

Garland P, Broom LJ, Quraishe S, Dalton PD, Skipp P, Newman TA, Perry VH.

PLoS One. 2012;7(10):e47552. doi: 10.1371/journal.pone.0047552. Epub 2012 Oct 24.


Innate inflammation in Parkinson's disease.

Perry VH.

Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a009373. doi: 10.1101/cshperspect.a009373. Review.


The role of activity in synaptic degeneration in a protein misfolding disease, prion disease.

Caleo M, Restani L, Vannini E, Siskova Z, Al-Malki H, Morgan R, O'Connor V, Perry VH.

PLoS One. 2012;7(7):e41182. doi: 10.1371/journal.pone.0041182. Epub 2012 Jul 16.


Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia.

Püntener U, Booth SG, Perry VH, Teeling JL.

J Neuroinflammation. 2012 Jun 27;9:146. doi: 10.1186/1742-2094-9-146.


Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction.

Teeling JL, Carare RO, Glennie MJ, Perry VH.

Acta Neuropathol. 2012 Oct;124(4):479-90. doi: 10.1007/s00401-012-0995-3. Epub 2012 May 18.


Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat.

Hall JC, Priestley JV, Perry VH, Michael-Titus AT.

J Neurochem. 2012 Jun;121(5):738-50. doi: 10.1111/j.1471-4159.2012.07726.x. Epub 2012 Apr 12.


The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage.

Galea J, Cruickshank G, Teeling JL, Boche D, Garland P, Perry VH, Galea I.

J Neurochem. 2012 Jun;121(5):785-92. doi: 10.1111/j.1471-4159.2012.07716.x. Epub 2012 Mar 30.


Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes.

Frota de Almeida MN, de Siqueira Mendes Fde C, Gurgel Felício AP, Falsoni M, Ferreira de Andrade ML, Bento-Torres J, da Costa Vasconcelos PF, Perry VH, Picanço-Diniz CW, Kronka Sosthenes MC.

BMC Neurosci. 2012 Feb 29;13:23. doi: 10.1186/1471-2202-13-23.


Systemic inflammation induces axon injury during brain inflammation.

Moreno B, Jukes JP, Vergara-Irigaray N, Errea O, Villoslada P, Perry VH, Newman TA.

Ann Neurol. 2011 Dec;70(6):932-42. doi: 10.1002/ana.22550.


Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences.

Hart AD, Wyttenbach A, Perry VH, Teeling JL.

Brain Behav Immun. 2012 Jul;26(5):754-65. doi: 10.1016/j.bbi.2011.11.006. Epub 2011 Dec 2.


Early behavioral changes and quantitative analysis of neuropathological features in murine prion disease: stereological analysis in the albino Swiss mice model.

Borner R, Bento-Torres J, Souza DR, Sadala DB, Trevia N, Farias JA, Lins N, Passos A, Quintairos A, Diniz JA, Perry VH, Vasconcelos PF, Cunningham C, Picanço-Diniz CW.

Prion. 2011 Jul-Sep;5(3):215-27. doi: 10.4161/pri.5.3.16936. Epub 2011 Jul 1.


Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process.

Arundell M, Perry VH, Newman TA.

Lab Chip. 2011 Sep 7;11(17):3001-5. doi: 10.1039/c1lc20120d. Epub 2011 Jul 20.


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