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Metabolic control analysis of hepatic glycogen synthesis in vivo.

Nozaki Y, Petersen MC, Zhang D, Vatner DF, Perry RJ, Abulizi A, Haedersdal S, Zhang XM, Butrico GM, Samuel VT, Mason GF, Cline GW, Petersen KF, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2020 Mar 18. pii: 201921694. doi: 10.1073/pnas.1921694117. [Epub ahead of print]


Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk.

Perry RJ, Lyu K, Rabin-Court A, Dong J, Li X, Yang Y, Qing H, Wang A, Yang X, Shulman GI.

J Clin Invest. 2020 Mar 9. pii: 134699. doi: 10.1172/JCI134699. [Epub ahead of print]


Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.

Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, Cline GW, Petersen KF, Nathanson MH, Ehrlich BE, Shulman GI.

Nature. 2020 Mar;579(7798):279-283. doi: 10.1038/s41586-020-2074-6. Epub 2020 Mar 4.


Mechanistic Links between Obesity, Insulin, and Cancer.

Perry RJ, Shulman GI.

Trends Cancer. 2020 Feb;6(2):75-78. doi: 10.1016/j.trecan.2019.12.003. Epub 2020 Jan 14.


Regulation of adipose tissue inflammation by interleukin 6.

Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ.

Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24.


Use of an abdominal reapproximation anchor system in the closure of large, open myelomeningoceles.

Jowdy PK, Perry RJ, Reynolds RM.

J Neurosurg Pediatr. 2020 Jan 24:1-5. doi: 10.3171/2019.11.PEDS19225. [Epub ahead of print]


SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia.

Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ.

Cancer Metab. 2019 Dec 11;7:10. doi: 10.1186/s40170-019-0203-1. eCollection 2019.


Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.

Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC.

Nat Med. 2019 Nov;25(11):1739-1747. doi: 10.1038/s41591-019-0610-4. Epub 2019 Nov 7.


Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.

Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaay0284. doi: 10.1126/scitranslmed.aay0284.


Novel Strategies to Treat Hepatic Steatosis and Steatohepatitis.

Perry RJ.

Obesity (Silver Spring). 2019 Sep;27(9):1385-1387. doi: 10.1002/oby.22559. Epub 2019 Jul 25.


Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents.

Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13670-13679. doi: 10.1073/pnas.1901795116. Epub 2019 Jun 18.


Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation.

Rabin-Court A, Rodrigues MR, Zhang XM, Perry RJ.

PLoS One. 2019 Jun 12;14(6):e0218126. doi: 10.1371/journal.pone.0218126. eCollection 2019.


Quantitative evaluation of beta-amyloid brain PET imaging in dementia: a comparison between two commercial software packages and the clinical report.

Curry S, Patel N, Fakhry-Darian D, Khan S, Perry RJ, Malhotra PA, Nijran KS, Win Z.

Br J Radiol. 2019 Sep;92(1101):20181025. doi: 10.1259/bjr.20181025. Epub 2019 May 8.


Optimisation and usefulness of quantitative analysis of 18F-florbetapir PET.

Fakhry-Darian D, Patel NH, Khan S, Barwick T, Svensson W, Khan S, Perry RJ, Malhotra P, Carswell CJ, Nijran KS, Win Z.

Br J Radiol. 2019 Sep;92(1101):20181020. doi: 10.1259/bjr.20181020. Epub 2019 May 14.


Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.

Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA.

J Biol Chem. 2019 May 31;294(22):8819-8833. doi: 10.1074/jbc.RA118.006790. Epub 2019 Apr 11.


Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2019 Mar;25(3):526-528. doi: 10.1038/s41591-018-0220-6.


Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI.

Nat Commun. 2019 Feb 1;10(1):548. doi: 10.1038/s41467-019-08466-w.


Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.

Goedeke L, Perry RJ, Shulman GI.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:65-87. doi: 10.1146/annurev-pharmtox-010716-104727.


Care Continuity in a Patient-Centered Medical Home Setting [Internet].

Perry RJ, McCall N, Wensky SG, Haber SG.

Research Triangle Park (NC): RTI Press; 2016 Feb.


Leptin revisited: The role of leptin in starvation.

Perry RJ.

Mol Cell Oncol. 2018 May 29;5(5):e1435185. doi: 10.1080/23723556.2018.1435185. eCollection 2018.


Satisfaction with Financial Incentives for Chronic Disease Prevention.

Perry RJ, Treiman K, Teixeira-Poit SM, Kish-Doto J, Hoerger TJ, Tardif-Douglin M.

Am J Health Behav. 2018 Nov 1;42(6):46-59. doi: 10.5993/AJHB.42.6.5.


Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23. Erratum in: Nat Med. 2019 Mar;25(3):526-528.


Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.

Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ.

Cell Rep. 2018 Jul 3;24(1):47-55. doi: 10.1016/j.celrep.2018.06.008.


How are States Measuring It?: National Survey Findings on State Access Monitoring Efforts for Fee-for-Service Medicaid Enrollees.

Perry RJ, Karon S.

J Health Care Poor Underserved. 2018;29(2):767-781. doi: 10.1353/hpu.2018.0057.


Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI.

Hepatology. 2018 Dec;68(6):2197-2211. doi: 10.1002/hep.30097.


The Role of Leptin in Maintaining Plasma Glucose During Starvation.

Perry RJ, Shulman GI.

Postdoc J. 2018 Mar;6(3):3-19. doi: 10.14304/surya.jpr.v6n3.2.


In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF.

Biochem J. 2018 Mar 20;475(6):1063-1074. doi: 10.1042/BCJ20180063.


Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.


Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI.

Cell. 2018 Jan 11;172(1-2):234-248.e17. doi: 10.1016/j.cell.2017.12.001. Epub 2018 Jan 4.


Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.

Kim Y, Park SJ, Manson SR, Molina CA, Kidd K, Thiessen-Philbrook H, Perry RJ, Liapis H, Kmoch S, Parikh CR, Bleyer AJ, Chen YM.

JCI Insight. 2017 Dec 7;2(23). pii: 92896. doi: 10.1172/jci.insight.92896.


Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ.

Diabetes. 2018 Feb;67(2):208-221. doi: 10.2337/db17-0524. Epub 2017 Dec 4.


Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. Epub 2017 Nov 9.


Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9172-E9180. doi: 10.1073/pnas.1707797114. Epub 2017 Oct 10.


Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.


Clinical utility of amyloid PET imaging with (18)F-florbetapir: a retrospective study of 100 patients.

Carswell CJ, Win Z, Muckle K, Kennedy A, Waldman A, Dawe G, Barwick TD, Khan S, Malhotra PA, Perry RJ.

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):294-299. doi: 10.1136/jnnp-2017-316194. Epub 2017 Oct 10.


Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.


Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P.

Cell. 2017 Mar 23;169(1):148-160.e15. doi: 10.1016/j.cell.2017.03.001.


A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI.

FASEB J. 2017 Jul;31(7):2916-2924. doi: 10.1096/fj.201700001R. Epub 2017 Mar 22.


Care continuity's critical yet elusive role in healthcare.

Perry RJ.

BMJ. 2017 Mar 2;356:j1068. doi: 10.1136/bmj.j1068. No abstract available.


Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance.

Corbit KC, Camporez JPG, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ.

JCI Insight. 2017 Feb 9;2(3):e91001. doi: 10.1172/jci.insight.91001.


Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis.

Perry RJ, Peng L, Abulizi A, Kennedy L, Cline GW, Shulman GI.

J Clin Invest. 2017 Feb 1;127(2):657-669. doi: 10.1172/JCI88477. Epub 2017 Jan 23.


A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI.

Cell Metab. 2017 Mar 7;25(3):749-756. doi: 10.1016/j.cmet.2016.12.017. Epub 2017 Jan 19.


Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1189-1194. doi: 10.1073/pnas.1620506114. Epub 2017 Jan 17.


Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E461-70. doi: 10.1152/ajpendo.00009.2016. Epub 2016 Jul 12.


Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI.

Nature. 2016 Jun 9;534(7606):213-7. doi: 10.1038/nature18309.


Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI.

J Biol Chem. 2016 Jun 3;291(23):12161-70. doi: 10.1074/jbc.M116.720631. Epub 2016 Mar 21.


Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis.

Perry RJ, Petersen KF, Shulman GI.

Diabetologia. 2016 May;59(5):933-7. doi: 10.1007/s00125-016-3909-4. Epub 2016 Mar 10. Review.


Inferior Vena Cava Reconstruction with Tubularized Bovine Pericardium.

Mehaffey JH, Perry RJ, Pope NH, Upchurch GR Jr.

J Vasc Surg Cases. 2016 Mar 1;2(1):28-30.


A Woman With Right Hand and Leg Discoordination.

Perry RJ, Upchurch GR Jr.

JAMA Surg. 2016 Apr;151(4):387-8. doi: 10.1001/jamasurg.2015.4727. No abstract available.


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