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Items: 1 to 50 of 124

1.

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization.

Perry MD, Ng CA, Mangala MM, Ng TYM, Hines AD, Liang W, Xu MJO, Hill AP, Vandenberg JI.

Cardiovasc Res. 2019 Sep 13. pii: cvz247. doi: 10.1093/cvr/cvz247. [Epub ahead of print]

PMID:
31628797
2.

Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies.

Jones R, Velasco MS, Harris LG, Morgan S, Temple M, Ruddy MC, Williams R, Perry MD, Hitchings M, Wilkinson TS, Humphrey T, Gilbert MTP, Davies AP.

Tuberculosis (Edinb). 2019 Dec;119:101865. doi: 10.1016/j.tube.2019.101865. Epub 2019 Sep 23.

PMID:
31563810
3.

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.

Ng CA, Perry MD, Liang W, Smith NJ, Foo B, Shrier A, Lukacs GL, Hill AP, Vandenberg JI.

Heart Rhythm. 2019 Sep 23. pii: S1547-5271(19)30853-7. doi: 10.1016/j.hrthm.2019.09.020. [Epub ahead of print]

PMID:
31557540
4.

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding.

Lee W, Windley MJ, Perry MD, Vandenberg JI, Hill AP.

Mol Pharmacol. 2019 May;95(5):537-550. doi: 10.1124/mol.118.115220. Epub 2019 Feb 15.

PMID:
30770456
5.

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN Jr, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY.

Cell. 2018 Oct 18;175(3):889. doi: 10.1016/j.cell.2018.10.019. No abstract available.

6.

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN Jr, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY.

Cell. 2018 Jul 26;174(3):758-769.e9. doi: 10.1016/j.cell.2018.06.039. Epub 2018 Jul 19. Erratum in: Cell. 2018 Oct 18;175(3):889.

7.

Recent advances in understanding and prevention of sudden cardiac death.

Vandenberg JI, Perry MD, Hill AP.

F1000Res. 2017 Aug 31;6:1614. doi: 10.12688/f1000research.11855.1. eCollection 2017. Review.

8.

Evaluation of the BD MAX Enteric Parasite Panel for the detection of Cryptosporidium parvum/hominis, Giardia duodenalis and Entamoeba histolytica.

Perry MD, Corden SA, Lewis White P.

J Med Microbiol. 2017 Aug;66(8):1118-1123. doi: 10.1099/jmm.0.000558. Epub 2017 Aug 10.

PMID:
28792380
9.

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels.

Phan K, Ng CA, David E, Shishmarev D, Kuchel PW, Vandenberg JI, Perry MD.

J Biol Chem. 2017 May 5;292(18):7688-7705. doi: 10.1074/jbc.M117.779298. Epub 2017 Mar 9.

10.

Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.

Perry MD, Rajendran VM, MacLennan KA, Sandle GI.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G785-G793. doi: 10.1152/ajpgi.00181.2015. Epub 2016 Sep 8.

11.

TECRL: connecting sequence to consequence for a new sudden cardiac death gene.

Perry MD, Vandenberg JI.

EMBO Mol Med. 2016 Dec 1;8(12):1364-1365. doi: 10.15252/emmm.201606967. Print 2016 Dec. No abstract available.

12.

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes.

Mann SA, Imtiaz M, Winbo A, Rydberg A, Perry MD, Couderc JP, Polonsky B, McNitt S, Zareba W, Hill AP, Vandenberg JI.

J Mol Cell Cardiol. 2016 Nov;100:25-34. doi: 10.1016/j.yjmcc.2016.09.011. Epub 2016 Sep 20.

PMID:
27663173
13.

Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.

Ng CA, Gravel AE, Perry MD, Arnold AA, Marcotte I, Vandenberg JI.

J Biol Chem. 2016 Aug 12;291(33):17293-302. doi: 10.1074/jbc.M116.729392. Epub 2016 Jun 17.

14.

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Hill AP, Perry MD, Abi-Gerges N, Couderc JP, Fermini B, Hancox JC, Knollmann BC, Mirams GR, Skinner J, Zareba W, Vandenberg JI.

J Physiol. 2016 Dec 1;594(23):6893-6908. doi: 10.1113/JP272015. Epub 2016 Jun 9.

15.

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.

Perry MD, Ng CA, Phan K, David E, Steer K, Hunter MJ, Mann SA, Imtiaz M, Hill AP, Ke Y, Vandenberg JI.

J Physiol. 2016 Jul 15;594(14):4031-49. doi: 10.1113/JP271805. Epub 2016 May 27.

16.

Getting to the heart of hERG K(+) channel gating.

Perry MD, Ng CA, Mann SA, Sadrieh A, Imtiaz M, Hill AP, Vandenberg JI.

J Physiol. 2015 Jun 15;593(12):2575-85. doi: 10.1113/JP270095. Review.

17.

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B.

Brignell JL, Perry MD, Nelson CP, Willets JM, Challiss RA, Davies NW.

PLoS One. 2015 Mar 20;10(3):e0121285. doi: 10.1371/journal.pone.0121285. eCollection 2015.

18.

Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations.

Levy JW, Hartman JH, Perry MD Jr, Miller GP.

J Mol Graph Model. 2015 Mar;56:43-52. doi: 10.1016/j.jmgm.2014.11.013. Epub 2014 Dec 6.

19.

Can many subunits make light work of ion channel inactivation?

Vandenberg JI, Perry MD.

J Physiol. 2014 Oct 15;592(20):4411-2. doi: 10.1113/jphysiol.2014.281568. No abstract available.

20.

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

Sadrieh A, Domanski L, Pitt-Francis J, Mann SA, Hodkinson EC, Ng CA, Perry MD, Taylor JA, Gavaghan D, Subbiah RN, Vandenberg JI, Hill AP.

Nat Commun. 2014 Sep 25;5:5069. doi: 10.1038/ncomms6069.

PMID:
25254353
21.

Evaluation of the Luminex xTAG Gastrointestinal Pathogen Panel and the Savyon Diagnostics Gastrointestinal Infection Panel for the detection of enteric pathogens in clinical samples.

Perry MD, Corden SA, Howe RA.

J Med Microbiol. 2014 Nov;63(Pt 11):1419-26. doi: 10.1099/jmm.0.074773-0. Epub 2014 Aug 7.

PMID:
25102908
22.

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.

Ng CA, Phan K, Hill AP, Vandenberg JI, Perry MD.

J Biol Chem. 2014 Sep 12;289(37):25822-32. doi: 10.1074/jbc.M114.558379. Epub 2014 Jul 29.

23.

Evaluation of a commercially developed semiautomated PCR-surface-enhanced raman scattering assay for diagnosis of invasive fungal disease.

White PL, Hibbitts SJ, Perry MD, Green J, Stirling E, Woodford L, McNay G, Stevenson R, Barnes RA.

J Clin Microbiol. 2014 Oct;52(10):3536-43. doi: 10.1128/JCM.01135-14. Epub 2014 Jul 16.

24.

Comparison of four automated nucleic acid extraction platforms for the recovery of DNA from Aspergillus fumigatus.

Perry MD, White PL, Barnes RA.

J Med Microbiol. 2014 Sep;63(Pt 9):1160-6. doi: 10.1099/jmm.0.076315-0. Epub 2014 Jul 1.

PMID:
24987100
25.

Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.

Ke Y, Hunter MJ, Ng CA, Perry MD, Vandenberg JI.

J Biol Chem. 2014 May 16;289(20):13782-91. doi: 10.1074/jbc.M113.531277. Epub 2014 Apr 2.

26.
27.

Potential for use of the Seegene Anyplex MTB/NTM real-time detection assay in a regional reference laboratory.

Perry MD, White PL, Ruddy M.

J Clin Microbiol. 2014 May;52(5):1708-10. doi: 10.1128/JCM.03585-13. Epub 2014 Feb 19.

28.

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.

Ng CA, Ke Y, Perry MD, Tan PS, Hill AP, Vandenberg JI.

PLoS One. 2013 Oct 25;8(10):e77032. doi: 10.1371/journal.pone.0077032. eCollection 2013.

29.

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.

Perry MD, Wong S, Ng CA, Vandenberg JI.

J Gen Physiol. 2013 Sep;142(3):275-88. doi: 10.1085/jgp.201310975.

30.

Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE.

Trinh QM, Jen FY, Zhou Z, Chu KM, Perry MD, Kephart ET, Contrino S, Ruzanov P, Stein LD.

BMC Genomics. 2013 Jul 22;14:494. doi: 10.1186/1471-2164-14-494.

31.

Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes.

Hartman JH, Bradley AM, Laddusaw RM, Perry MD Jr, Miller GP.

Arch Biochem Biophys. 2013 Sep 1;537(1):12-20. doi: 10.1016/j.abb.2013.06.011. Epub 2013 Jun 27.

32.

Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating.

Perry MD, Ng CA, Vandenberg JI.

J Biol Chem. 2013 Apr 19;288(16):11482-91. doi: 10.1074/jbc.M113.461442. Epub 2013 Mar 7.

33.

hERG K(+) channels: structure, function, and clinical significance.

Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP.

Physiol Rev. 2012 Jul;92(3):1393-478. Review.

34.

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M.

Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111.

35.

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels.

Tan PS, Perry MD, Ng CA, Vandenberg JI, Hill AP.

J Gen Physiol. 2012 Sep;140(3):293-306. doi: 10.1085/jgp.201110761. Epub 2012 Aug 13.

36.

Reconstruction of the foot after leg or foot compartment syndrome.

Perry MD, Manoli A 2nd.

Crit Care Nurs Clin North Am. 2012 Jun;24(2):311-22. doi: 10.1016/j.ccell.2012.03.005. No abstract available.

PMID:
22548865
37.

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

Ng CA, Perry MD, Tan PS, Hill AP, Kuchel PW, Vandenberg JI.

PLoS One. 2012;7(2):e31640. doi: 10.1371/journal.pone.0031640. Epub 2012 Feb 16.

38.

modMine: flexible access to modENCODE data.

Contrino S, Smith RN, Butano D, Carr A, Hu F, Lyne R, Rutherford K, Kalderimis A, Sullivan J, Carbon S, Kephart ET, Lloyd P, Stinson EO, Washington NL, Perry MD, Ruzanov P, Zha Z, Lewis SE, Stein LD, Micklem G.

Nucleic Acids Res. 2012 Jan;40(Database issue):D1082-8. doi: 10.1093/nar/gkr921. Epub 2011 Nov 12.

39.

The modENCODE Data Coordination Center: lessons in harvesting comprehensive experimental details.

Washington NL, Stinson EO, Perry MD, Ruzanov P, Contrino S, Smith R, Zha Z, Lyne R, Carr A, Lloyd P, Kephart E, McKay SJ, Micklem G, Stein LD, Lewis SE.

Database (Oxford). 2011 Aug 19;2011:bar023. doi: 10.1093/database/bar023. Print 2011.

40.

Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.

Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets JM, Davies NW, Standen NB, Challiss RA.

Cardiovasc Res. 2011 Sep 1;91(4):694-702. doi: 10.1093/cvr/cvr137. Epub 2011 May 23.

41.

Evaluation of analytical and preliminary clinical performance of Myconostica MycAssay Aspergillus when testing serum specimens for diagnosis of invasive Aspergillosis.

White PL, Perry MD, Moody A, Follett SA, Morgan G, Barnes RA.

J Clin Microbiol. 2011 Jun;49(6):2169-74. doi: 10.1128/JCM.00101-11. Epub 2011 Mar 30.

42.

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

Ng CA, Hunter MJ, Perry MD, Mobli M, Ke Y, Kuchel PW, King GF, Stock D, Vandenberg JI.

PLoS One. 2011 Jan 13;6(1):e16191. doi: 10.1371/journal.pone.0016191.

43.

Critical stages of extracting DNA from Aspergillus fumigatus in whole-blood specimens.

White PL, Perry MD, Loeffler J, Melchers W, Klingspor L, Bretagne S, McCulloch E, Cuenca-Estrella M, Finnstrom N, Donnelly JP, Barnes RA; European Aspergillus PCR Initiative.

J Clin Microbiol. 2010 Oct;48(10):3753-5. doi: 10.1128/JCM.01466-10. Epub 2010 Aug 18.

44.

An update on the molecular diagnosis of invasive fungal disease.

White PL, Perry MD, Barnes RA.

FEMS Microbiol Lett. 2009 Jul;296(1):1-10. doi: 10.1111/j.1574-6968.2009.01575.x. Epub 2009 Apr 9. Review.

45.

Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.

Perry MD, Sandle GI.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G159-67. doi: 10.1152/ajpgi.00132.2009. Epub 2009 Apr 30.

46.

Fabrication of large-aperture lightweight diffractive lenses for use in space.

Barton IM, Britten JA, Dixit SN, Summers LJ, Thomas IM, Rushford MC, Lu K, Hyde RA, Perry MD.

Appl Opt. 2001 Feb 1;40(4):447-51.

PMID:
18357017
47.

Petawatt laser pulses.

Perry MD, Pennington D, Stuart BC, Tietbohl G, Britten JA, Brown C, Herman S, Golick B, Kartz M, Miller J, Powell HT, Vergino M, Yanovsky V.

Opt Lett. 1999 Feb 1;24(3):160-2.

PMID:
18071440
48.
49.

CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds.

Collom SL, Laddusaw RM, Burch AM, Kuzmic P, Perry MD Jr, Miller GP.

J Biol Chem. 2008 Feb 8;283(6):3487-96. Epub 2007 Dec 4. Erratum in: J Biol Chem. 2013 Nov 8;288(45):32640.

50.

Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis.

Sandle GI, Perry MD, Mathialahan T, Linley JE, Robinson P, Hunter M, MacLennan KA.

J Pathol. 2007 May;212(1):66-73.

PMID:
17405186

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