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Items: 1 to 50 of 1998

1.

Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy.

Mohammed AD, Khan MAW, Chatzistamou I, Chamseddine D, Williams-Kang K, Perry M, Enos R, Murphy A, Gomez G, Aladhami A, Oskeritzian CA, Jolly A, Chang Y, He S, Pan Z, Kubinak JL.

Front Immunol. 2019 Oct 23;10:2484. doi: 10.3389/fimmu.2019.02484. eCollection 2019.

2.

Effects of Physical Activity on Neurophysiologic and Gene Expression Profiles in Chronic Back Pain: Study Protocol.

Kim K, Ramesh D, Perry M, Bernier KM, Young EE, Walsh S, Starkweather A.

Nurs Res. 2019 Nov 5. doi: 10.1097/NNR.0000000000000400. [Epub ahead of print]

PMID:
31702701
3.

Inequalities in vaccination coverage and differences in follow-up procedures for asylum-seeking children arriving in Wales, UK.

Perry M, Townson M, Cottrell S, Fagan L, Edwards J, Saunders J, O'Hare R, Richardson G.

Eur J Pediatr. 2019 Nov 7. doi: 10.1007/s00431-019-03485-7. [Epub ahead of print]

PMID:
31701239
4.

Brucella Exposure Risk Events in Ten Clinical Laboratories, New York City, 2015 - 2017.

Ackelsberg J, Liddicoat A, Burke T, Szymczak WA, Levi MH, Ostrowsky B, Hamula C, Patel G, Kopetz V, Saverimuttu J, Sordillo EM, D'Souza D, Mitchell EA, Lowe W, Khare R, Tang YW, Bianchi AL, Egan C, Perry MJ, Hughes S, Rakeman JL, Adams E, Kharod GA, Tiller R, Saile E, Lee S, Gonzalez E, Hoppe B, Leviton IM, Hacker S, Ni KF, Orsini RL, Jhaveri S, Mazariegos I, Dingle T, Koll B, Stoddard RA, Galloway R, Hoffmaster A, Fine A, Lee E, Dentinger C, Harrison E, Layton M.

J Clin Microbiol. 2019 Nov 6. pii: JCM.01096-19. doi: 10.1128/JCM.01096-19. [Epub ahead of print]

PMID:
31694974
5.

Modifying the secondary school environment to reduce bullying and aggression: the INCLUSIVE cluster RCT.

Bonell C, Allen E, Warren E, McGowan J, Bevilacqua L, Jamal F, Sadique Z, Legood R, Wiggins M, Opondo C, Mathiot A, Sturgess J, Paparini S, Fletcher A, Perry M, West G, Tancred T, Scott S, Elbourne D, Christie D, Bond L, Viner RM.

Southampton (UK): NIHR Journals Library; 2019 Oct.

6.

A diagnostic time-out to improve differential diagnosis in pediatric abdominal pain.

Kasick RT, Melvin JE, Perera ST, Perry MF, Black JD, Bode RS, Groner JI, Kersey KE, Klamer BG, Bai S, McClead RE.

Diagnosis (Berl). 2019 Nov 2. pii: /j/dx.ahead-of-print/dx-2019-0054/dx-2019-0054.xml. doi: 10.1515/dx-2019-0054. [Epub ahead of print]

PMID:
31677376
7.

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization.

Perry MD, Ng CA, Mangala MM, Ng TYM, Hines AD, Liang W, Xu MJO, Hill AP, Vandenberg JI.

Cardiovasc Res. 2019 Sep 13. pii: cvz247. doi: 10.1093/cvr/cvz247. [Epub ahead of print]

PMID:
31628797
8.

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Sazonovs A, Kennedy NA, Moutsianas L, Heap GA, Rice DL, Reppell M, Bewshea CM, Chanchlani N, Walker GJ, Perry MH, McDonald TJ, Lees CW, Cummings JRF, Parkes M, Mansfield JC, Barrett JC, McGovern D, Goodhand JR, Anderson CA, Ahmad T; PANTS Consortium.

Gastroenterology. 2019 Oct 7. pii: S0016-5085(19)41414-5. doi: 10.1053/j.gastro.2019.09.041. [Epub ahead of print]

PMID:
31600487
9.

Increasing Vegetable Intake by Emphasizing Tasty and Enjoyable Attributes: A Randomized Controlled Multisite Intervention for Taste-Focused Labeling.

Turnwald BP, Bertoldo JD, Perry MA, Policastro P, Timmons M, Bosso C, Connors P, Valgenti RT, Pine L, Challamel G, Gardner CD, Crum AJ.

Psychol Sci. 2019 Nov;30(11):1603-1615. doi: 10.1177/0956797619872191. Epub 2019 Oct 2.

PMID:
31577177
10.

Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies.

Jones R, Velasco MS, Harris LG, Morgan S, Temple M, Ruddy MC, Williams R, Perry MD, Hitchings M, Wilkinson TS, Humphrey T, Gilbert MTP, Davies AP.

Tuberculosis (Edinb). 2019 Sep 23;119:101865. doi: 10.1016/j.tube.2019.101865. [Epub ahead of print]

PMID:
31563810
11.

One-step pentaplex real-time polymerase chain reaction assay for detection of zika, dengue, chikungunya, West nile viruses and a human housekeeping gene.

Mishra N, Ng J, Rakeman JL, Perry MJ, Centurioni DA, Dean AB, Price A, Thakkar R, Angus AG, Williamson P, Delwart E, Carrington C, Sahadeo N, Che X, Briese T, Tokarz R, Lipkin WI.

J Clin Virol. 2019 Nov;120:44-50. doi: 10.1016/j.jcv.2019.08.011. Epub 2019 Sep 16.

PMID:
31557664
12.

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.

Ng CA, Perry MD, Liang W, Smith NJ, Foo B, Shrier A, Lukacs GL, Hill AP, Vandenberg JI.

Heart Rhythm. 2019 Sep 23. pii: S1547-5271(19)30853-7. doi: 10.1016/j.hrthm.2019.09.020. [Epub ahead of print]

PMID:
31557540
13.

A 50-Year Journey from Phosphate to Autonomous Underwater Vehicles.

Perry MJ.

Ann Rev Mar Sci. 2019 Sep 16. doi: 10.1146/annurev-marine-010419-010945. [Epub ahead of print]

PMID:
31525127
14.

Current practices of health care providers in recommending online resources for chronic pain self-management.

Devan H, Godfrey HK, Perry MA, Hempel D, Saipe B, Hale L, Grainger R.

J Pain Res. 2019 Aug 12;12:2457-2472. doi: 10.2147/JPR.S206539. eCollection 2019.

15.

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.

Johnson BV, Kumar R, Oishi S, Alexander S, Kasherman M, Vega MS, Ivancevic A, Gardner A, Domingo D, Corbett M, Parnell E, Yoon S, Oh T, Lines M, Lefroy H, Kini U, Van Allen M, Grønborg S, Mercier S, Küry S, Bézieau S, Pasquier L, Raynaud M, Afenjar A, Billette de Villemeur T, Keren B, Désir J, Van Maldergem L, Marangoni M, Dikow N, Koolen DA, VanHasselt PM, Weiss M, Zwijnenburg P, Sa J, Reis CF, López-Otín C, Santiago-Fernández O, Fernández-Jaén A, Rauch A, Steindl K, Joset P, Goldstein A, Madan-Khetarpal S, Infante E, Zackai E, Mcdougall C, Narayanan V, Ramsey K, Mercimek-Andrews S, Pena L, Shashi V; Undiagnosed Diseases Network, Schoch K, Sullivan JA, Pinto E Vairo F, Pichurin PN, Ewing SA, Barnett SS, Klee EW, Perry MS, Koenig MK, Keegan CE, Schuette JL, Asher S, Perilla-Young Y, Smith LD, Rosenfeld JA, Bhoj E, Kaplan P, Li D, Oegema R, van Binsbergen E, van der Zwaag B, Smeland MF, Cutcutache I, Page M, Armstrong M, Lin AE, Steeves MA, Hollander ND, Hoffer MJV, Reijnders MRF, Demirdas S, Koboldt DC, Bartholomew D, Mosher TM, Hickey SE, Shieh C, Sanchez-Lara PA, Graham JM Jr, Tezcan K, Schaefer GB, Danylchuk NR, Asamoah A, Jackson KE, Yachelevich N, Au M, Pérez-Jurado LA, Kleefstra T, Penzes P, Wood SA, Burne T, Pierson TM, Piper M, Gécz J, Jolly LA.

Biol Psychiatry. 2019 Jun 29. pii: S0006-3223(19)31479-9. doi: 10.1016/j.biopsych.2019.05.028. [Epub ahead of print]

PMID:
31443933
16.

Mapping and enumerating houses and households to support malaria control interventions on Bioko Island.

García GA, Hergott DEB, Phiri WP, Perry M, Smith J, Osa Nfumu JO, Nzamio J, Fuseini G, Stabler T, Rivas MR, Kleinschmidt I, Schwabe C, Guerra CA.

Malar J. 2019 Aug 22;18(1):283. doi: 10.1186/s12936-019-2920-x.

17.

The Adolescent Vaping Epidemic in the United States-How It Happened and Where We Go From Here.

Farzal Z, Perry MF, Yarbrough WG, Kimple AJ.

JAMA Otolaryngol Head Neck Surg. 2019 Aug 22. doi: 10.1001/jamaoto.2019.2410. [Epub ahead of print] No abstract available.

PMID:
31436792
18.

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance.

Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Nøhr MK, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA.

Nat Commun. 2019 Aug 13;10(1):3650. doi: 10.1038/s41467-019-11370-y.

19.

Impact of an electronic medium delivery of warfarin education in a low income, minority outpatient population: a pilot intervention study.

Heinrich K, Sanchez K, Hui C, Talabi K, Perry M, Qin H, Nguyen H, Tatachar A.

BMC Public Health. 2019 Aug 5;19(1):1050. doi: 10.1186/s12889-019-7370-4.

20.

Replication and generalization in applied neuroimaging.

Lerma-Usabiaga G, Mukherjee P, Ren Z, Perry ML, Wandell BA.

Neuroimage. 2019 Nov 15;202:116048. doi: 10.1016/j.neuroimage.2019.116048. Epub 2019 Jul 26.

PMID:
31356879
21.

Using body neutrality to inform eating disorder management in a gender diverse world.

Perry M, Watson L, Hayden L, Inwards-Breland D.

Lancet Child Adolesc Health. 2019 Sep;3(9):597-598. doi: 10.1016/S2352-4642(19)30237-8. Epub 2019 Jul 22. No abstract available.

PMID:
31345735
22.

Pesticide interactions and risks of sperm chromosomal abnormalities.

Figueroa ZI, Young HA, Mumford SL, Meeker JD, Barr DB, Gray GM, Perry MJ.

Int J Hyg Environ Health. 2019 Aug;222(7):1021-1029. doi: 10.1016/j.ijheh.2019.07.001. Epub 2019 Jul 13. Review.

PMID:
31311690
23.

Regulated Endocrine-Specific Protein-18, an Emerging Endocrine Protein in Physiology: A Literature Review.

Atari E, Perry MC, Jose PA, Kumarasamy S.

Endocrinology. 2019 Sep 1;160(9):2093-2100. doi: 10.1210/en.2019-00397.

PMID:
31294787
24.

Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing.

Evans DG, Hartley CL, Smith PT, King AT, Bowers NL, Tobi S, Wallace AJ, Perry M, Anup R, Lloyd SKW, Rutherford SA, Hammerbeck-Ward C, Pathmanaban ON, Stapleton E, Freeman SR, Kellett M, Halliday D, Parry A, Gair JJ, Axon P, Laitt R, Thomas O, Afridi SK, Obholzer R; English Specialist NF research group, Duff C, Stivaros SM, Vassallo G, Harkness EF, Smith MJ.

Genet Med. 2019 Jul 5. doi: 10.1038/s41436-019-0598-7. [Epub ahead of print]

PMID:
31273341
25.

Anticancer Triazenes: from Bioprecursors to Hybrid Molecules.

Francisco AP, Mendes E, Santos AR, Perry MJ.

Curr Pharm Des. 2019;25(14):1623-1642. doi: 10.2174/1381612825666190617155749.

PMID:
31244412
26.

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.

Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW; IMI DIRECT Consortium.

Diabetologia. 2019 Sep;62(9):1601-1615. doi: 10.1007/s00125-019-4906-1. Epub 2019 Jun 15.

27.

Successful reintroduction of tumour necrosis factor-alpha inhibition after treatment of disseminated Lyme borreliosis.

Bulteel NS, Russell CD, Perry MR, Koch O.

J R Coll Physicians Edinb. 2019 Jun;49(2):122-124. doi: 10.4997/JRCPE.2019.207.

PMID:
31188340
28.

Comparing measures of free-living sleep in school-aged children.

Brazendale K, Beets MW, Weaver RG, Perry MW, Tyler EB, Hunt ET, Decker L, Chaput JP.

Sleep Med. 2019 Aug;60:197-201. doi: 10.1016/j.sleep.2019.04.006. Epub 2019 Apr 18.

PMID:
31186212
29.

Traumatic orbital third nerve palsy.

Nagendran ST, Lee V, Perry M.

Br J Oral Maxillofac Surg. 2019 Jul;57(6):578-581. doi: 10.1016/j.bjoms.2019.01.029. Epub 2019 May 31.

PMID:
31155398
30.

Systematic Review of the Effects of Cognitive and Behavioural Interventions on Fall-Related Psychological Concerns in Older Adults.

Papadimitriou A, Perry M.

J Aging Phys Act. 2019 May 29:1-43. doi: 10.1123/japa.2017-0408. [Epub ahead of print]

PMID:
31141434
31.

Spatially explicit network analysis reveals multi-species annual cycle movement patterns of sea ducks.

Lamb JS, Paton PWC, Osenkowski JE, Badzinski SS, Berlin AM, Bowman T, Dwyer C, Fara LJ, Gilliland SG, Kenow K, Lepage C, Mallory ML, Olsen GH, Perry MC, Petrie SA, Savard JL, Savoy L, Schummer M, Spiegel CS, McWilliams SR.

Ecol Appl. 2019 Jul;29(5):e01919. doi: 10.1002/eap.1919. Epub 2019 May 29.

PMID:
31141283
32.

Human mobility patterns and malaria importation on Bioko Island.

Guerra CA, Kang SY, Citron DT, Hergott DEB, Perry M, Smith J, Phiri WP, Osá Nfumu JO, Mba Eyono JN, Battle KE, Gibson HS, García GA, Smith DL.

Nat Commun. 2019 May 27;10(1):2332. doi: 10.1038/s41467-019-10339-1.

33.

Do orbital floor plates adequately protect against serious secondary injury?

Zaggut A, Perry M.

Br J Oral Maxillofac Surg. 2019 Jul;57(6):539-542. doi: 10.1016/j.bjoms.2018.12.022. Epub 2019 May 16.

PMID:
31104920
34.

Shape of (101955) Bennu indicative of a rubble pile with internal stiffness.

Barnouin OS, Daly MG, Palmer EE, Gaskell RW, Weirich JR, Johnson CL, Asad MMA, Roberts JH, Perry ME, Susorney HCM, Daly RT, Bierhaus EB, Seabrook JA, Espiritu RC, Nair AH, Nguyen L, Neumann GA, Ernst CM, Boynton WV, Nolan MC, Adam CD, Moreau MC, Risk B, D'Aubigny CD, Jawin ER, Walsh KJ, Michel P, Schwartz SR, Ballouz RL, Mazarico EM, Scheeres DJ, McMahon J, Bottke W, Sugita S, Hirata N, Hirata N, Watanabe S, Burke KN, DellaGuistina DN, Bennett CA, Lauretta DS; OSIRIS-REx Team.

Nat Geosci. 2019 Apr;12(4):247-252. doi: 10.1038/s41561-019-0330-x. Epub 2019 Mar 19.

35.

The Influence of Race, Ethnicity and Genetic Variants on Postoperative Pain Intensity: An Integrative Literature Review.

Perry M, Baumbauer K, Young EE, Dorsey SG, Taylor JY, Starkweather AR.

Pain Manag Nurs. 2019 Jun;20(3):198-206. doi: 10.1016/j.pmn.2018.11.002. Epub 2019 May 10. Review.

PMID:
31080143
36.

Mono, bis, and tris(phosphoramidate) titanium complexes: synthesis, structure, and reactivity investigations.

Perry MR, Gilmour DJ, Schafer LL.

Dalton Trans. 2019 Jul 2;48(26):9782-9790. doi: 10.1039/c9dt00911f.

PMID:
31070221
37.

Historical evidence of glyphosate exposure from a US agricultural cohort.

Perry MJ, Mandrioli D, Belpoggi F, Manservisi F, Panzacchi S, Irwin C.

Environ Health. 2019 May 7;18(1):42. doi: 10.1186/s12940-019-0474-6.

38.

Do pain management websites foster self-management support for people with persistent pain? A scoping review.

Devan H, Perry MA, van Hattem A, Thurlow G, Shepherd S, Muchemwa C, Grainger R.

Patient Educ Couns. 2019 Sep;102(9):1590-1601. doi: 10.1016/j.pec.2019.04.009. Epub 2019 Apr 8. Review.

PMID:
30981410
39.

Don't Fear the Reefer-Evidence Mounts for Plant-Based Cannabidiol as Treatment for Epilepsy.

Perry MS.

Epilepsy Curr. 2019 Mar-Apr;19(2):93-95. doi: 10.1177/1535759719835671.

40.

Phylogenetic Analysis of Mycobacterium tuberculosis Strains in Wales by Use of Core Genome Multilocus Sequence Typing To Analyze Whole-Genome Sequencing Data.

Jones RC, Harris LG, Morgan S, Ruddy MC, Perry M, Williams R, Humphrey T, Temple M, Davies AP.

J Clin Microbiol. 2019 May 24;57(6). pii: e02025-18. doi: 10.1128/JCM.02025-18. Print 2019 Jun.

PMID:
30944195
41.

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines.

Ni S, Padial NM, Kingston C, Vantourout JC, Schmitt DC, Edwards JT, Kruszyk MM, Merchant RR, Mykhailiuk PK, Sanchez BB, Yang S, Perry MA, Gallego GM, Mousseau JJ, Collins MR, Cherney RJ, Lebed PS, Chen JS, Qin T, Baran PS.

J Am Chem Soc. 2019 Apr 24;141(16):6726-6739. doi: 10.1021/jacs.9b02238. Epub 2019 Apr 16.

PMID:
30943023
42.

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability.

Braga C, Vaz AR, Oliveira MC, Matilde Marques M, Moreira R, Brites D, Perry MJ.

Eur J Med Chem. 2019 Jun 15;172:16-25. doi: 10.1016/j.ejmech.2019.03.048. Epub 2019 Mar 22.

PMID:
30939350
43.

Molecular Characterization of Clostridium botulinum Harboring the bont/B7 Gene.

Halpin JL, Dykes JK, Katz L, Centurioni DA, Perry MJ, Egan CT, Lúquez C.

Foodborne Pathog Dis. 2019 Jun;16(6):428-433. doi: 10.1089/fpd.2018.2600. Epub 2019 Mar 30.

44.

Validity and Wearability of Consumer-based Fitness Trackers in Free-living Children.

Brazendale K, Decker L, Hunt ET, Perry MW, Brazendale AB, Weaver RG, Beets MW.

Int J Exerc Sci. 2019 Mar 1;12(5):471-482. eCollection 2019.

45.

Ambient Cured Fly Ash Geopolymer Coatings for Concrete.

Biondi L, Perry M, Vlachakis C, Wu Z, Hamilton A, McAlorum J.

Materials (Basel). 2019 Mar 20;12(6). pii: E923. doi: 10.3390/ma12060923.

46.

Notes from the Field: Botulism Outbreak Associated with Home-Canned Peas - New York City, 2018.

Bergeron G, Latash J, Da Costa-Carter CA, Egan C, Stavinsky F, Kileci JA, Winstead A, Zhao B, Perry MJ, Chatham-Stephens K, Sarpel D, Hughes S, Conlon MA, Edmunds S, Mohanraj M, Rakeman JL, Centurioni DA, Lúquez C, Chiefari AK, Harper S.

MMWR Morb Mortal Wkly Rep. 2019 Mar 15;68(10):251-252. doi: 10.15585/mmwr.mm6810a5. No abstract available.

47.

The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system.

Manservisi F, Lesseur C, Panzacchi S, Mandrioli D, Falcioni L, Bua L, Manservigi M, Spinaci M, Galeati G, Mantovani A, Lorenzetti S, Miglio R, Andrade AM, Kristensen DM, Perry MJ, Swan SH, Chen J, Belpoggi F.

Environ Health. 2019 Mar 12;18(1):15. doi: 10.1186/s12940-019-0453-y.

48.

A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles).

Bernier UR, Kline DL, Vazquez-Abad A, Perry M, Cohnstaedt LW, Gurman P, D'hers S, Elman NM.

PLoS Negl Trop Dis. 2019 Mar 11;13(3):e0007188. doi: 10.1371/journal.pntd.0007188. eCollection 2019 Mar.

49.

Promoting self-management of breast and nipple pain in breastfeeding women: Protocol of a pilot randomized controlled trial.

Lucas R, Bernier K, Perry M, Evans H, Ramesh D, Young E, Walsh S, Starkweather A.

Res Nurs Health. 2019 Jun;42(3):176-188. doi: 10.1002/nur.21938. Epub 2019 Mar 5.

PMID:
30835887
50.

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.

Kennedy NA, Heap GA, Green HD, Hamilton B, Bewshea C, Walker GJ, Thomas A, Nice R, Perry MH, Bouri S, Chanchlani N, Heerasing NM, Hendy P, Lin S, Gaya DR, Cummings JRF, Selinger CP, Lees CW, Hart AL, Parkes M, Sebastian S, Mansfield JC, Irving PM, Lindsay J, Russell RK, McDonald TJ, McGovern D, Goodhand JR, Ahmad T; UK Inflammatory Bowel Disease Pharmacogenetics Study Group.

Lancet Gastroenterol Hepatol. 2019 May;4(5):341-353. doi: 10.1016/S2468-1253(19)30012-3. Epub 2019 Feb 27.

PMID:
30824404

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