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Items: 1 to 50 of 469


Gene Knock-Ins in Drosophila Using Homology-Independent Insertion of Universal Donor Plasmids.

Bosch JA, Colbeth R, Zirin J, Perrimon N.

Genetics. 2019 Nov 4. pii: genetics.302819.2019. doi: 10.1534/genetics.119.302819. [Epub ahead of print]


An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms.

Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung H, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ.

Elife. 2019 Nov 1;8. pii: e51539. doi: 10.7554/eLife.51539. [Epub ahead of print]


Understanding cellular signaling and systems biology with precision: A perspective from ultrastructure and organelle studies in the Drosophila midgut.

Xu C, Ericsson M, Perrimon N.

Curr Opin Syst Biol. 2018 Oct;11:24-31. doi: 10.1016/j.coisb.2018.07.003. Epub 2018 Jul 20.


HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.

Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr.

Sci Signal. 2019 Oct 1;12(601). pii: eaay0482. doi: 10.1126/scisignal.aay0482.


Drosophila melanogaster: a simple system for understanding complexity.

Mohr SE, Perrimon N.

Dis Model Mech. 2019 Sep 27;12(10). pii: dmm041871. doi: 10.1242/dmm.041871.


Drosophila as a Model for Tumor-Induced Organ Wasting.

Saavedra P, Perrimon N.

Adv Exp Med Biol. 2019;1167:191-205. doi: 10.1007/978-3-030-23629-8_11. Review.


Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species.

Parkhitko AA, Jouandin P, Mohr SE, Perrimon N.

Aging Cell. 2019 Dec;18(6):e13034. doi: 10.1111/acel.13034. Epub 2019 Aug 28. Review.


The Multidimensional Organization of Interorgan Communication Networks.

Droujinine IA, Perrimon N.

Dev Cell. 2019 Aug 19;50(4):395-396. doi: 10.1016/j.devcel.2019.07.029.


Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.

Silver JT, Wirtz-Peitz F, Simões S, Pellikka M, Yan D, Binari R, Nishimura T, Li Y, Harris TJC, Perrimon N, Tepass U.

J Cell Biol. 2019 Oct 7;218(10):3397-3414. doi: 10.1083/jcb.201807106. Epub 2019 Aug 13.


Regulation of insulin and adipokinetic hormone/glucagon production in flies.

Ahmad M, He L, Perrimon N.

Wiley Interdiscip Rev Dev Biol. 2019 Aug 4:e360. doi: 10.1002/wdev.360. [Epub ahead of print] Review.


Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.

Zirin J, Ni X, Sack LM, Yang-Zhou D, Hu Y, Brathwaite R, Bulyk ML, Elledge SJ, Perrimon N.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14614-14619. doi: 10.1073/pnas.1821863116. Epub 2019 Jul 1. Erratum in: Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17128.


In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer.

He L, Binari R, Huang J, Falo-Sanjuan J, Perrimon N.

Elife. 2019 May 29;8. pii: e46181. doi: 10.7554/eLife.46181.


An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM.

Cell Metab. 2019 Jul 2;30(1):190-200.e6. doi: 10.1016/j.cmet.2019.04.013. Epub 2019 May 16.


Conserved phosphorylation hotspots in eukaryotic protein domain families.

Strumillo MJ, Oplová M, Viéitez C, Ochoa D, Shahraz M, Busby BP, Sopko R, Studer RA, Perrimon N, Panse VG, Beltrao P.

Nat Commun. 2019 Apr 29;10(1):1977. doi: 10.1038/s41467-019-09952-x.


A role for actomyosin contractility in Notch signaling.

Hunter GL, He L, Perrimon N, Charras G, Giniger E, Baum B.

BMC Biol. 2019 Feb 11;17(1):12. doi: 10.1186/s12915-019-0625-9.


The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling.

Xu C, Tang HW, Hung RJ, Hu Y, Ni X, Housden BE, Perrimon N.

Cell Rep. 2019 Jan 15;26(3):670-688.e6. doi: 10.1016/j.celrep.2018.12.079.


Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.

Song W, Kir S, Hong S, Hu Y, Wang X, Binari R, Tang HW, Chung V, Banks AS, Spiegelman B, Perrimon N.

Dev Cell. 2019 Jan 28;48(2):277-286.e6. doi: 10.1016/j.devcel.2018.12.003. Epub 2019 Jan 10.


Mechanosensitive channels and their functions in stem cell differentiation.

He L, Ahmad M, Perrimon N.

Exp Cell Res. 2019 Jan 15;374(2):259-265. doi: 10.1016/j.yexcr.2018.11.016. Epub 2018 Nov 28. Review.


Intestinal Stem Cells Exhibit Conditional Circadian Clock Function.

Parasram K, Bernardon N, Hammoud M, Chang H, He L, Perrimon N, Karpowicz P.

Stem Cell Reports. 2018 Nov 13;11(5):1287-1301. doi: 10.1016/j.stemcr.2018.10.010.


Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

Doupé DP, Marshall OJ, Dayton H, Brand AH, Perrimon N.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12218-12223. doi: 10.1073/pnas.1719169115. Epub 2018 Nov 7.


iProteinDB: An Integrative Database of Drosophila Post-translational Modifications.

Hu Y, Sopko R, Chung V, Foos M, Studer RA, Landry SD, Liu D, Rabinow L, Gnad F, Beltrao P, Perrimon N.

G3 (Bethesda). 2019 Jan 9;9(1):1-11. doi: 10.1534/g3.118.200637.


A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila.

Okamoto N, Viswanatha R, Bittar R, Li Z, Haga-Yamanaka S, Perrimon N, Yamanaka N.

Dev Cell. 2018 Nov 5;47(3):294-305.e7. doi: 10.1016/j.devcel.2018.09.012. Epub 2018 Oct 4.


Endocrine Regulation of Energy Balance by Drosophila TGF-β/Activins.

Song W, Ghosh AC, Cheng D, Perrimon N.

Bioessays. 2018 Nov;40(11):e1800044. doi: 10.1002/bies.201800044. Epub 2018 Sep 28. Review.


Efficient proximity labeling in living cells and organisms with TurboID.

Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY.

Nat Biotechnol. 2018 Oct;36(9):880-887. doi: 10.1038/nbt.4201. Epub 2018 Aug 20.


Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells.

Viswanatha R, Li Z, Hu Y, Perrimon N.

Elife. 2018 Jul 27;7. pii: e36333. doi: 10.7554/eLife.36333.


ovoD Co-selection: A Method for Enriching CRISPR/Cas9-Edited Alleles in Drosophila.

Ewen-Campen B, Perrimon N.

G3 (Bethesda). 2018 Jul 31;8(8):2749-2756. doi: 10.1534/g3.118.200498.


Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.

Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL.

J Clin Invest. 2018 Jul 2;128(7):3008-3023. doi: 10.1172/JCI95231. Epub 2018 Jun 11.


Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM.

Jia Y, Xu RG, Ren X, Ewen-Campen B, Rajakumar R, Zirin J, Yang-Zhou D, Zhu R, Wang F, Mao D, Peng P, Qiao HH, Wang X, Liu LP, Xu B, Ji JY, Liu Q, Sun J, Perrimon N, Ni JQ.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4719-4724. doi: 10.1073/pnas.1800677115. Epub 2018 Apr 16.


Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.

Hong S, Song W, Zushin PH, Liu B, Jedrychowski MP, Mina AI, Deng Z, Cabarkapa D, Hall JA, Palmer CJ, Aliakbarian H, Szpyt J, Gygi SP, Tavakkoli A, Lynch L, Perrimon N, Banks AS.

Mol Metab. 2018 Jun;12:25-38. doi: 10.1016/j.molmet.2018.03.012. Epub 2018 Mar 29.


The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.

Tang HW, Hu Y, Chen CL, Xia B, Zirin J, Yuan M, Asara JM, Rabinow L, Perrimon N.

Cell Metab. 2018 May 1;27(5):1040-1054.e8. doi: 10.1016/j.cmet.2018.02.023. Epub 2018 Mar 29.


Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.

Zhang T, Song W, Li Z, Qian W, Wei L, Yang Y, Wang W, Zhou X, Meng M, Peng J, Xia Q, Perrimon N, Cheng D.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3960-3965. doi: 10.1073/pnas.1800435115. Epub 2018 Mar 22.


A gene-specific T2A-GAL4 library for Drosophila.

Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ.

Elife. 2018 Mar 22;7. pii: e35574. doi: 10.7554/eLife.35574.


Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex.

Guo J, Tang HW, Li J, Perrimon N, Yan D.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3674-3679. doi: 10.1073/pnas.1720945115. Epub 2018 Mar 19.


Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.

He L, Si G, Huang J, Samuel ADT, Perrimon N.

Nature. 2018 Mar 1;555(7694):103-106. doi: 10.1038/nature25744. Epub 2018 Feb 7.


Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells.

Mohr SE, Rudd K, Hu Y, Song WR, Gilly Q, Buckner M, Housden BE, Kelley C, Zirin J, Tao R, Amador G, Sierzputowska K, Comjean A, Perrimon N.

G3 (Bethesda). 2018 Feb 2;8(2):631-641. doi: 10.1534/g3.117.300447.


Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Housden BE, Li Z, Kelley C, Wang Y, Hu Y, Valvezan AJ, Manning BD, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10755-E10762. doi: 10.1073/pnas.1713362114. Epub 2017 Nov 28.


Molecular Interaction Search Tool (MIST): an integrated resource for mining gene and protein interaction data.

Hu Y, Vinayagam A, Nand A, Comjean A, Chung V, Hao T, Mohr SE, Perrimon N.

Nucleic Acids Res. 2018 Jan 4;46(D1):D567-D574. doi: 10.1093/nar/gkx1116.


mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD.

Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19.


A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.

Rajan A, Housden BE, Wirtz-Peitz F, Holderbaum L, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):83-98.e6. doi: 10.1016/j.devcel.2017.09.007.


Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR.

Ewen-Campen B, Mohr SE, Hu Y, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):6-9. doi: 10.1016/j.devcel.2017.09.020. Review.


Optimized strategy for in vivo Cas9-activation in Drosophila.

Ewen-Campen B, Yang-Zhou D, Fernandes VR, González DP, Liu LP, Tao R, Ren X, Sun J, Hu Y, Zirin J, Mohr SE, Ni JQ, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9409-9414. doi: 10.1073/pnas.1707635114. Epub 2017 Aug 14.


Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model.

Song W, Owusu-Ansah E, Hu Y, Cheng D, Ni X, Zirin J, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8596-8601. doi: 10.1073/pnas.1708037114. Epub 2017 Jul 24.


Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.

Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW.

Cell Rep. 2017 Jul 18;20(3):721-736. doi: 10.1016/j.celrep.2017.06.074.


Gene2Function: An Integrated Online Resource for Gene Function Discovery.

Hu Y, Comjean A, Mohr SE; FlyBase Consortium, Perrimon N.

G3 (Bethesda). 2017 Aug 7;7(8):2855-2858. doi: 10.1534/g3.117.043885.


Open questions: completing the parts list and finding the integrating signals.

Teleman AA, Perrimon N.

BMC Biol. 2017 Jun 8;15(1):47. doi: 10.1186/s12915-017-0388-0.


Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut.

Xu C, Luo J, He L, Montell C, Perrimon N.

Elife. 2017 May 31;6. pii: e22441. doi: 10.7554/eLife.22441.


Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells.

Housden BE, Nicholson HE, Perrimon N.

Bio Protoc. 2017 Feb 5;7(3). pii: e2119. doi: 10.21769/BioProtoc.2119.


MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.

Wang J, Al-Ouran R, Hu Y, Kim SY, Wan YW, Wangler MF, Yamamoto S, Chao HT, Comjean A, Mohr SE; UDN, Perrimon N, Liu Z, Bellen HJ.

Am J Hum Genet. 2017 Jun 1;100(6):843-853. doi: 10.1016/j.ajhg.2017.04.010. Epub 2017 May 11.


An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.

Kang J, Shin S, Perrimon N, Shen J.

Genetics. 2017 Jul;206(3):1479-1493. doi: 10.1534/genetics.116.196881. Epub 2017 May 11.


Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor.

He L, Huang J, Perrimon N.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5467-5472. doi: 10.1073/pnas.1703205114. Epub 2017 May 10.

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