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Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.

Song W, Kir S, Hong S, Hu Y, Wang X, Binari R, Tang HW, Chung V, Banks AS, Spiegelman B, Perrimon N.

Dev Cell. 2019 Jan 2. pii: S1534-5807(18)31071-2. doi: 10.1016/j.devcel.2018.12.003. [Epub ahead of print]


Mechanosensitive channels and their functions in stem cell differentiation.

He L, Ahmad M, Perrimon N.

Exp Cell Res. 2019 Jan 15;374(2):259-265. doi: 10.1016/j.yexcr.2018.11.016. Epub 2018 Nov 28. Review.


Intestinal Stem Cells Exhibit Conditional Circadian Clock Function.

Parasram K, Bernardon N, Hammoud M, Chang H, He L, Perrimon N, Karpowicz P.

Stem Cell Reports. 2018 Nov 13;11(5):1287-1301. doi: 10.1016/j.stemcr.2018.10.010.


Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

Doupé DP, Marshall OJ, Dayton H, Brand AH, Perrimon N.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12218-12223. doi: 10.1073/pnas.1719169115. Epub 2018 Nov 7.


iProteinDB: An Integrative Database of Drosophila Post-translational Modifications.

Hu Y, Sopko R, Chung V, Foos M, Studer RA, Landry SD, Liu D, Rabinow L, Gnad F, Beltrao P, Perrimon N.

G3 (Bethesda). 2019 Jan 9;9(1):1-11. doi: 10.1534/g3.118.200637.


A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila.

Okamoto N, Viswanatha R, Bittar R, Li Z, Haga-Yamanaka S, Perrimon N, Yamanaka N.

Dev Cell. 2018 Nov 5;47(3):294-305.e7. doi: 10.1016/j.devcel.2018.09.012. Epub 2018 Oct 4.


Endocrine Regulation of Energy Balance by Drosophila TGF-β/Activins.

Song W, Ghosh AC, Cheng D, Perrimon N.

Bioessays. 2018 Nov;40(11):e1800044. doi: 10.1002/bies.201800044. Epub 2018 Sep 28. Review.


Efficient proximity labeling in living cells and organisms with TurboID.

Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY.

Nat Biotechnol. 2018 Oct;36(9):880-887. doi: 10.1038/nbt.4201. Epub 2018 Aug 20.


Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells.

Viswanatha R, Li Z, Hu Y, Perrimon N.

Elife. 2018 Jul 27;7. pii: e36333. doi: 10.7554/eLife.36333.


ovoD Co-selection: A Method for Enriching CRISPR/Cas9-Edited Alleles in Drosophila.

Ewen-Campen B, Perrimon N.

G3 (Bethesda). 2018 Jul 31;8(8):2749-2756. doi: 10.1534/g3.118.200498.


Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.

Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL.

J Clin Invest. 2018 Jul 2;128(7):3008-3023. doi: 10.1172/JCI95231. Epub 2018 Jun 11.


Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM.

Jia Y, Xu RG, Ren X, Ewen-Campen B, Rajakumar R, Zirin J, Yang-Zhou D, Zhu R, Wang F, Mao D, Peng P, Qiao HH, Wang X, Liu LP, Xu B, Ji JY, Liu Q, Sun J, Perrimon N, Ni JQ.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4719-4724. doi: 10.1073/pnas.1800677115. Epub 2018 Apr 16.


Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.

Hong S, Song W, Zushin PH, Liu B, Jedrychowski MP, Mina AI, Deng Z, Cabarkapa D, Hall JA, Palmer CJ, Aliakbarian H, Szpyt J, Gygi SP, Tavakkoli A, Lynch L, Perrimon N, Banks AS.

Mol Metab. 2018 Jun;12:25-38. doi: 10.1016/j.molmet.2018.03.012. Epub 2018 Mar 29.


The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.

Tang HW, Hu Y, Chen CL, Xia B, Zirin J, Yuan M, Asara JM, Rabinow L, Perrimon N.

Cell Metab. 2018 May 1;27(5):1040-1054.e8. doi: 10.1016/j.cmet.2018.02.023. Epub 2018 Mar 29.


Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.

Zhang T, Song W, Li Z, Qian W, Wei L, Yang Y, Wang W, Zhou X, Meng M, Peng J, Xia Q, Perrimon N, Cheng D.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3960-3965. doi: 10.1073/pnas.1800435115. Epub 2018 Mar 22.


A gene-specific T2A-GAL4 library for Drosophila.

Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ.

Elife. 2018 Mar 22;7. pii: e35574. doi: 10.7554/eLife.35574.


Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex.

Guo J, Tang HW, Li J, Perrimon N, Yan D.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3674-3679. doi: 10.1073/pnas.1720945115. Epub 2018 Mar 19.


Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.

He L, Si G, Huang J, Samuel ADT, Perrimon N.

Nature. 2018 Mar 1;555(7694):103-106. doi: 10.1038/nature25744. Epub 2018 Feb 7.


Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells.

Mohr SE, Rudd K, Hu Y, Song WR, Gilly Q, Buckner M, Housden BE, Kelley C, Zirin J, Tao R, Amador G, Sierzputowska K, Comjean A, Perrimon N.

G3 (Bethesda). 2018 Feb 2;8(2):631-641. doi: 10.1534/g3.117.300447.


Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Housden BE, Li Z, Kelley C, Wang Y, Hu Y, Valvezan AJ, Manning BD, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10755-E10762. doi: 10.1073/pnas.1713362114. Epub 2017 Nov 28.


Molecular Interaction Search Tool (MIST): an integrated resource for mining gene and protein interaction data.

Hu Y, Vinayagam A, Nand A, Comjean A, Chung V, Hao T, Mohr SE, Perrimon N.

Nucleic Acids Res. 2018 Jan 4;46(D1):D567-D574. doi: 10.1093/nar/gkx1116.


mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD.

Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19.


A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.

Rajan A, Housden BE, Wirtz-Peitz F, Holderbaum L, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):83-98.e6. doi: 10.1016/j.devcel.2017.09.007.


Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR.

Ewen-Campen B, Mohr SE, Hu Y, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):6-9. doi: 10.1016/j.devcel.2017.09.020. Review.


Optimized strategy for in vivo Cas9-activation in Drosophila.

Ewen-Campen B, Yang-Zhou D, Fernandes VR, González DP, Liu LP, Tao R, Ren X, Sun J, Hu Y, Zirin J, Mohr SE, Ni JQ, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9409-9414. doi: 10.1073/pnas.1707635114. Epub 2017 Aug 14.


Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model.

Song W, Owusu-Ansah E, Hu Y, Cheng D, Ni X, Zirin J, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708037. doi: 10.1073/pnas.1708037114. [Epub ahead of print]


Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.

Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW.

Cell Rep. 2017 Jul 18;20(3):721-736. doi: 10.1016/j.celrep.2017.06.074.


Gene2Function: An Integrated Online Resource for Gene Function Discovery.

Hu Y, Comjean A, Mohr SE; FlyBase Consortium, Perrimon N.

G3 (Bethesda). 2017 Aug 7;7(8):2855-2858. doi: 10.1534/g3.117.043885.


Open questions: completing the parts list and finding the integrating signals.

Teleman AA, Perrimon N.

BMC Biol. 2017 Jun 8;15(1):47. doi: 10.1186/s12915-017-0388-0.


Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut.

Xu C, Luo J, He L, Montell C, Perrimon N.

Elife. 2017 May 31;6. pii: e22441. doi: 10.7554/eLife.22441.


Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells.

Housden BE, Nicholson HE, Perrimon N.

Bio Protoc. 2017 Feb 5;7(3). pii: e2119. doi: 10.21769/BioProtoc.2119.


MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.

Wang J, Al-Ouran R, Hu Y, Kim SY, Wan YW, Wangler MF, Yamamoto S, Chao HT, Comjean A, Mohr SE; UDN, Perrimon N, Liu Z, Bellen HJ.

Am J Hum Genet. 2017 Jun 1;100(6):843-853. doi: 10.1016/j.ajhg.2017.04.010. Epub 2017 May 11.


An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.

Kang J, Shin S, Perrimon N, Shen J.

Genetics. 2017 Jul;206(3):1479-1493. doi: 10.1534/genetics.116.196881. Epub 2017 May 11.


Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor.

He L, Huang J, Perrimon N.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5467-5472. doi: 10.1073/pnas.1703205114. Epub 2017 May 10.


Thermogenesis by THADA.

Chatterjee N, Perrimon N.

Dev Cell. 2017 Apr 10;41(1):1-2. doi: 10.1016/j.devcel.2017.03.021.


Proximity-dependent labeling methods for proteomic profiling in living cells.

Chen CL, Perrimon N.

Wiley Interdiscip Rev Dev Biol. 2017 Jul;6(4). doi: 10.1002/wdev.272. Epub 2017 Apr 7. Review.


The Drosophila Gene Expression Tool (DGET) for expression analyses.

Hu Y, Comjean A, Perrimon N, Mohr SE.

BMC Bioinformatics. 2017 Feb 10;18(1):98. doi: 10.1186/s12859-017-1509-z.


Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.

Song W, Cheng D, Hong S, Sappe B, Hu Y, Wei N, Zhu C, O'Connor MB, Pissios P, Perrimon N.

Cell Metab. 2017 Feb 7;25(2):386-399. doi: 10.1016/j.cmet.2017.01.002.


eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells.

Yeh JT, Nam K, Yeh JT, Perrimon N.

Sci Rep. 2017 Feb 8;7:41619. doi: 10.1038/srep41619.


miR-263a Regulates ENaC to Maintain Osmotic and Intestinal Stem Cell Homeostasis in Drosophila.

Kim K, Hung RJ, Perrimon N.

Dev Cell. 2017 Jan 9;40(1):23-36. doi: 10.1016/j.devcel.2016.11.023. Epub 2016 Dec 22.

41. database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update.

Hu Y, Comjean A, Roesel C, Vinayagam A, Flockhart I, Zirin J, Perkins L, Perrimon N, Mohr SE.

Nucleic Acids Res. 2017 Jan 4;45(D1):D672-D678. doi: 10.1093/nar/gkw977. Epub 2016 Oct 23.


Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Housden BE, Muhar M, Gemberling M, Gersbach CA, Stainier DY, Seydoux G, Mohr SE, Zuber J, Perrimon N.

Nat Rev Genet. 2017 Jan;18(1):24-40. doi: 10.1038/nrg.2016.118. Epub 2016 Oct 31. Review.


Interorgan Communication Pathways in Physiology: Focus on Drosophila.

Droujinine IA, Perrimon N.

Annu Rev Genet. 2016 Nov 23;50:539-570. Epub 2016 Oct 10. Review.


An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling.

Vinayagam A, Kulkarni MM, Sopko R, Sun X, Hu Y, Nand A, Villalta C, Moghimi A, Yang X, Mohr SE, Hong P, Asara JM, Perrimon N.

Cell Rep. 2016 Sep 13;16(11):3062-3074. doi: 10.1016/j.celrep.2016.08.029.


Cas9-Mediated Genome Engineering in Drosophila melanogaster.

Housden BE, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top086843.


Detection of Indel Mutations in Drosophila by High-Resolution Melt Analysis (HRMA).

Housden BE, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot090795.


Design and Generation of Donor Constructs for Genome Engineering in Drosophila.

Housden BE, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot090787.


Design and Generation of Drosophila Single Guide RNA Expression Constructs.

Housden BE, Hu Y, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot090779.


Seipin is required for converting nascent to mature lipid droplets.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.

Elife. 2016 Aug 26;5. pii: e16582. doi: 10.7554/eLife.16582.


Mapping signaling pathway cross-talk in Drosophila cells.

Ammeux N, Housden BE, Georgiadis A, Hu Y, Perrimon N.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9940-5. doi: 10.1073/pnas.1610432113. Epub 2016 Aug 15.

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