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Items: 1 to 50 of 150

1.

Biobanking and cryopreservation of human lung explants for omic analysis.

Chu SG, Poli De Frias S, Sakairi Y, Kelly RS, Chase R, Konishi K, Blau A, Tsai E, Tsoyi K, Padera RF, Sholl LM, Goldberg HJ, Mallidi HR, Camp PC, El-Chemaly SY, Perrella MA, Choi AMK, Washko GR, Raby BA, Rosas IO.

Eur Respir J. 2020 Jan 23;55(1). pii: 1801635. doi: 10.1183/13993003.01635-2018. Print 2020 Jan. No abstract available.

PMID:
31699836
2.

Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways.

Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S.

PLoS One. 2019 Apr 9;14(4):e0213831. doi: 10.1371/journal.pone.0213831. eCollection 2019.

3.

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.

Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):659-666. doi: 10.1165/rcmb.2018-0118OC.

PMID:
30562054
4.

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM.

JCI Insight. 2018 Dec 6;3(23). pii: 124039. doi: 10.1172/jci.insight.124039.

5.

Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure.

Shu C, Huang H, Xu Y, Rota M, Sorrentino A, Peng Y, Padera RF Jr, Huntoon V, Agrawal PB, Liu X, Perrella MA.

Front Physiol. 2018 Jul 10;9:863. doi: 10.3389/fphys.2018.00863. eCollection 2018.

6.

Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis.

Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA.

J Leukoc Biol. 2018 Oct;104(4):677-689. doi: 10.1002/JLB.4HI0817-333RR. Epub 2018 Jul 5.

7.

NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation.

Kwon MY, Hwang N, Park YJ, Perrella MA, Chung SW.

Oncotarget. 2018 Jan 3;9(16):12671-12681. doi: 10.18632/oncotarget.23912. eCollection 2018 Feb 27.

8.

SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling.

Huntoon V, Widrick JJ, Sanchez C, Rosen SM, Kutchukian C, Cao S, Pierson CR, Liu X, Perrella MA, Beggs AH, Jacquemond V, Agrawal PB.

Hum Mol Genet. 2018 May 1;27(9):1608-1617. doi: 10.1093/hmg/ddy068.

9.

Mesenchymal Stromal Cell Therapy: Does the Source Matter?

Ghanta S, Kwon MY, Rosas IO, Liu X, Perrella MA.

Crit Care Med. 2018 Feb;46(2):343-345. doi: 10.1097/CCM.0000000000002894. No abstract available.

10.

Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148.

Tsoyi K, Chu SG, Patino-Jaramillo NG, Wilder J, Villalba J, Doyle-Eisele M, McDonald J, Liu X, El-Chemaly S, Perrella MA, Rosas IO.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):208-215. doi: 10.1165/rcmb.2017-0088OC.

11.

Evidence for a retinal progenitor cell in the postnatal and adult mouse.

Chen X, Wang S, Xu H, Pereira JD, Hatzistergos KE, Saur D, Seidler B, Hare JM, Perrella MA, Yin ZQ, Liu X.

Stem Cell Res. 2017 Aug;23:20-32. doi: 10.1016/j.scr.2017.06.010. Epub 2017 Jun 24.

12.

Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.

Ghatak S, Markwald RR, Hascall VC, Dowling W, Lottes RG, Baatz JE, Beeson G, Beeson CC, Perrella MA, Thannickal VJ, Misra S.

J Biol Chem. 2017 Jun 23;292(25):10465-10489. doi: 10.1074/jbc.M116.752451. Epub 2017 Apr 7.

13.

Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.

Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):47-58. doi: 10.1165/rcmb.2016-0328OC.

14.

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.

Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, Fredenburgh LE, Englert JA, Piantadosi CA, Choi AM, Perrella MA.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):300-309. doi: 10.1165/rcmb.2016-0061OC.

15.

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.

Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA.

Crit Care Med. 2016 Dec;44(12):e1236-e1245.

16.

Hhip haploinsufficiency sensitizes mice to age-related emphysema.

Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21.

17.

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC.

18.

Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.

Liu X, Hall SRR, Wang Z, Huang H, Ghanta S, Di Sante M, Leri A, Anversa P, Perrella MA.

Nat Commun. 2015 Nov 23;6:8825. doi: 10.1038/ncomms9825.

19.

Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection.

Cui Y, Liu K, Monzon-Medina ME, Padera RF, Wang H, George G, Toprak D, Abdelnour E, D'Agostino E, Goldberg HJ, Perrella MA, Forteza RM, Rosas IO, Visner G, El-Chemaly S.

J Clin Invest. 2015 Nov 2;125(11):4255-68. doi: 10.1172/JCI79693. Epub 2015 Oct 20.

20.

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY.

EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511.

21.

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X.

Genome Med. 2015 Feb 14;7(1):12. doi: 10.1186/s13073-015-0137-3. eCollection 2015.

22.

Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.

Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA.

J Leukoc Biol. 2015 Jan;97(1):171-80. doi: 10.1189/jlb.4A0214-087R. Epub 2014 Oct 28.

23.

SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.

Agrawal PB, Pierson CR, Joshi M, Liu X, Ravenscroft G, Moghadaszadeh B, Talabere T, Viola M, Swanson LC, Haliloğlu G, Talim B, Yau KS, Allcock RJ, Laing NG, Perrella MA, Beggs AH.

Am J Hum Genet. 2014 Aug 7;95(2):218-26. doi: 10.1016/j.ajhg.2014.07.004. Epub 2014 Jul 31.

24.

Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.

Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC.

25.

c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.

Sanada F, Kim J, Czarna A, Chan NY, Signore S, Ogórek B, Isobe K, Wybieralska E, Borghetti G, Pesapane A, Sorrentino A, Mangano E, Cappetta D, Mangiaracina C, Ricciardi M, Cimini M, Ifedigbo E, Perrella MA, Goichberg P, Choi AM, Kajstura J, Hosoda T, Rota M, Anversa P, Leri A.

Circ Res. 2014 Jan 3;114(1):41-55. doi: 10.1161/CIRCRESAHA.114.302500. Epub 2013 Oct 29. Erratum in: Circ Res. 2015 Jul 31;117(4):e54.

26.

Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.

Lee S, Lee SJ, Coronata AA, Fredenburgh LE, Chung SW, Perrella MA, Nakahira K, Ryter SW, Choi AM.

Antioxid Redox Signal. 2014 Jan 20;20(3):432-42. doi: 10.1089/ars.2013.5368. Epub 2013 Oct 5.

27.

Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.

Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J, Silverman EK.

Genomics. 2013 May;101(5):263-72. doi: 10.1016/j.ygeno.2013.02.010. Epub 2013 Mar 1.

28.

Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.

Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD.

Sci Transl Med. 2013 Feb 27;5(174):174ra26. doi: 10.1126/scitranslmed.3004812.

29.

Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils.

Hall SR, Tsoyi K, Ith B, Padera RF Jr, Lederer JA, Wang Z, Liu X, Perrella MA.

Stem Cells. 2013 Feb;31(2):397-407. doi: 10.1002/stem.1270.

30.

Cardiomyogenesis in the aging and failing human heart.

Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D'Alessandro DA, Michler RE, del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P.

Circulation. 2012 Oct 9;126(15):1869-81. doi: 10.1161/CIRCULATIONAHA.112.118380. Epub 2012 Sep 6. Retraction in: Circulation. 2014 Apr 22;129(16):e466.

31.

Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.

Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J.

Eur J Clin Invest. 2012 Aug;42(8):900-13. doi: 10.1111/j.1365-2362.2012.02667.x. Epub 2012 Mar 21. Review.

32.

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.

Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK.

Hum Mol Genet. 2012 Mar 15;21(6):1325-35. doi: 10.1093/hmg/ddr569. Epub 2011 Dec 2.

33.

Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.

Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA.

J Immunol. 2011 Nov 15;187(10):5255-67. doi: 10.4049/jimmunol.1101186. Epub 2011 Oct 3.

34.

Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury.

Kwon MY, Liu X, Lee SJ, Kang YH, Choi AM, Lee KU, Perrella MA, Chung SW.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2441-7. doi: 10.1161/ATVBAHA.111.235135.

35.

Evidence for human lung stem cells.

Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P.

N Engl J Med. 2011 May 12;364(19):1795-806. doi: 10.1056/NEJMoa1101324. Retraction in: N Engl J Med. 2018 Nov 8;379(19):1870.

36.

Transforming growth factor-β1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2.

Chung SW, Kwon MY, Kang YH, Chung HT, Lee SJ, Kim HP, Perrella MA.

J Cell Physiol. 2012 Jan;227(1):351-60. doi: 10.1002/jcp.22741.

37.

Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA.

PLoS One. 2010 May 14;5(5):e10656. doi: 10.1371/journal.pone.0010656.

38.

Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression.

Hung CC, Liu X, Kwon MY, Kang YH, Chung SW, Perrella MA.

Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L870-9. doi: 10.1152/ajplung.00382.2009. Epub 2010 Mar 26.

39.

Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility.

Fredenburgh LE, Ma J, Perrella MA.

Trends Cardiovasc Med. 2009 Feb;19(2):31-7. doi: 10.1016/j.tcm.2009.04.003.

40.

Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.

Schissel SL, Dunsmore SE, Liu X, Shine RW, Perrella MA, Layne MD.

Am J Pathol. 2009 Mar;174(3):818-28. doi: 10.2353/ajpath.2009.080856. Epub 2009 Jan 29.

41.

Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.

Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF Jr, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA.

Circulation. 2009 Jan 20;119(2):261-8. doi: 10.1161/CIRCULATIONAHA.108.799536. Epub 2008 Dec 31.

42.

High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.

Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA.

Am J Respir Cell Mol Biol. 2009 Aug;41(2):129-35. doi: 10.1165/rcmb.2008-0331OC. Epub 2008 Dec 18.

43.

Role of haem oxygenase-1 in microbial host defence.

Chung SW, Hall SR, Perrella MA.

Cell Microbiol. 2009 Feb;11(2):199-207. doi: 10.1111/j.1462-5822.2008.01261.x. Epub 2008 Nov 3. Review.

44.

Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.

Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC.

Biochem J. 2009 Feb 15;418(1):103-12. doi: 10.1042/BJ20081427.

45.

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.

Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL.

J Biol Chem. 2008 Dec 5;283(49):34327-36. doi: 10.1074/jbc.M807036200. Epub 2008 Oct 14.

46.

Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.

Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA.

Circulation. 2008 Apr 22;117(16):2114-22. doi: 10.1161/CIRCULATIONAHA.107.716241. Epub 2008 Apr 7.

47.

High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.

Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA.

FEBS Lett. 2008 Mar 5;582(5):810-4. doi: 10.1016/j.febslet.2008.02.008. Epub 2008 Feb 13.

48.

Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.

Chung SW, Liu X, Macias AA, Baron RM, Perrella MA.

J Clin Invest. 2008 Jan;118(1):239-47.

49.

Heme oxygenase-1: a multifaceted triple-threat molecule.

Perrella MA.

Am J Respir Cell Mol Biol. 2007 Feb;36(2):137. No abstract available.

PMID:
17227881
50.

Plasma gelsolin is a marker and therapeutic agent in animal sepsis.

Lee PS, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP.

Crit Care Med. 2007 Mar;35(3):849-55.

PMID:
17205019

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