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Items: 1 to 50 of 230

1.

Noncoding regions are the main source of targetable tumor-specific antigens.

Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C.

Sci Transl Med. 2018 Dec 5;10(470). pii: eaau5516. doi: 10.1126/scitranslmed.aau5516.

PMID:
30518613
2.

Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods.

Lanoix J, Durette C, Courcelles M, Cossette É, Comtois-Marotte S, Hardy MP, Côté C, Perreault C, Thibault P.

Proteomics. 2018 Jun;18(12):e1700251. doi: 10.1002/pmic.201700251. Epub 2018 Apr 24.

PMID:
29508533
3.

Divide and conquer: intermediate levels of population fragmentation maximize cultural accumulation.

Derex M, Perreault C, Boyd R.

Philos Trans R Soc Lond B Biol Sci. 2018 Apr 5;373(1743). pii: 20170062. doi: 10.1098/rstb.2017.0062.

PMID:
29440527
4.

Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.

Dumont-Lagacé M, Gerbe H, Daouda T, Laverdure JP, Brochu S, Lemieux S, Gagnon É, Perreault C.

Front Immunol. 2017 Dec 5;8:1717. doi: 10.3389/fimmu.2017.01717. eCollection 2017.

5.

Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.

St-Pierre C, Morgand E, Benhammadi M, Rouette A, Hardy MP, Gaboury L, Perreault C.

Cell Rep. 2017 Nov 28;21(9):2558-2570. doi: 10.1016/j.celrep.2017.10.121.

6.

Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance.

Bloy N, Garcia P, Laumont CM, Pitt JM, Sistigu A, Stoll G, Yamazaki T, Bonneil E, Buqué A, Humeau J, Drijfhout JW, Meurice G, Walter S, Fritsche J, Weinschenk T, Rammensee HG, Melief C, Thibault P, Perreault C, Pol J, Zitvogel L, Senovilla L, Kroemer G.

Immunol Rev. 2017 Nov;280(1):165-174. doi: 10.1111/imr.12582. Review.

PMID:
29027230
7.

The SysteMHC Atlas project.

Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron E.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1237-D1247. doi: 10.1093/nar/gkx664.

8.

Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy.

Laumont CM, Perreault C.

Cell Mol Life Sci. 2018 Feb;75(4):607-621. doi: 10.1007/s00018-017-2628-4. Epub 2017 Aug 19. Review.

PMID:
28823056
9.

An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.

Collin R, St-Pierre C, Guilbault L, Mullins-Dansereau V, Policheni A, Guimont-Desrochers F, Pelletier AN, Gray DH, Drobetsky E, Perreault C, Hillhouse EE, Lesage S.

J Immunol. 2017 Aug 15;199(4):1490-1504. doi: 10.4049/jimmunol.1600789. Epub 2017 Jul 14.

10.

Major vs minor histocompatibility antigens.

Roy DC, Perreault C.

Blood. 2017 Feb 9;129(6):664-666. doi: 10.1182/blood-2016-12-754515. No abstract available.

11.

MHC class I-associated peptides derive from selective regions of the human genome.

Pearson H, Daouda T, Granados DP, Durette C, Bonneil E, Courcelles M, Rodenbrock A, Laverdure JP, Côté C, Mader S, Lemieux S, Thibault P, Perreault C.

J Clin Invest. 2016 Dec 1;126(12):4690-4701. doi: 10.1172/JCI88590. Epub 2016 Nov 14.

12.

pyGeno: A Python package for precision medicine and proteogenomics.

Daouda T, Perreault C, Lemieux S.

Version 2. F1000Res. 2016 Mar 21 [revised 2016 Jan 1];5:381. eCollection 2016.

13.

Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers.

Rouette A, Trofimov A, Haberl D, Boucher G, Lavallée VP, D'Angelo G, Hébert J, Sauvageau G, Lemieux S, Perreault C.

Sci Rep. 2016 Sep 23;6:34019. doi: 10.1038/srep34019.

14.

ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.

Nagarajan NA, de Verteuil DA, Sriranganadane D, Yahyaoui W, Thibault P, Perreault C, Shastri N.

J Immunol. 2016 Aug 15;197(4):1035-43. doi: 10.4049/jimmunol.1500654. Epub 2016 Jul 1.

15.

Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile.

Patenaude J, Perreault C.

J Immunol. 2016 Jun 1;196(11):4760-70. doi: 10.4049/jimmunol.1502499. Epub 2016 Apr 29.

16.

Cultural history, not ecological environment, is the main determinant of human behaviour.

Mathew S, Perreault C.

Proc Biol Sci. 2016 Mar 16;283(1826):20160177. doi: 10.1098/rspb.2016.0177. No abstract available.

17.

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.

Granados DP, Rodenbrock A, Laverdure JP, Côté C, Caron-Lizotte O, Carli C, Pearson H, Janelle V, Durette C, Bonneil E, Roy DC, Delisle JS, Lemieux S, Thibault P, Perreault C.

Leukemia. 2016 Jun;30(6):1344-54. doi: 10.1038/leu.2016.22. Epub 2016 Feb 9.

PMID:
26857467
18.

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.

Laumont CM, Daouda T, Laverdure JP, Bonneil É, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S, Thibault P, Perreault C.

Nat Commun. 2016 Jan 5;7:10238. doi: 10.1038/ncomms10238.

19.

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection.

Dieudé M, Bell C, Turgeon J, Beillevaire D, Pomerleau L, Yang B, Hamelin K, Qi S, Pallet N, Béland C, Dhahri W, Cailhier JF, Rousseau M, Duchez AC, Lévesque T, Lau A, Rondeau C, Gingras D, Muruve D, Rivard A, Cardinal H, Perreault C, Desjardins M, Boilard É, Thibault P, Hébert MJ.

Sci Transl Med. 2015 Dec 16;7(318):318ra200. doi: 10.1126/scitranslmed.aac9816.

PMID:
26676607
20.

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

Huard K, Londregan AT, Tesz G, Bahnck KB, Magee TV, Hepworth D, Polivkova J, Coffey SB, Pabst BA, Gosset JR, Nigam A, Kou K, Sun H, Lee K, Herr M, Boehm M, Carpino PA, Goodwin B, Perreault C, Li Q, Jorgensen CC, Tkalcevic GT, Subashi TA, Ahn K.

J Med Chem. 2015 Sep 24;58(18):7164-72. doi: 10.1021/acs.jmedchem.5b01008. Epub 2015 Sep 8.

PMID:
26258602
21.

Sex hormones have pervasive effects on thymic epithelial cells.

Dumont-Lagacé M, St-Pierre C, Perreault C.

Sci Rep. 2015 Aug 7;5:12895. doi: 10.1038/srep12895.

22.

Behavioural variation in 172 small-scale societies indicates that social learning is the main mode of human adaptation.

Mathew S, Perreault C.

Proc Biol Sci. 2015 Jul 7;282(1810). pii: 20150061. doi: 10.1098/rspb.2015.0061.

23.

Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells.

St-Pierre C, Trofimov A, Brochu S, Lemieux S, Perreault C.

J Immunol. 2015 Jul 15;195(2):498-506. doi: 10.4049/jimmunol.1500558. Epub 2015 Jun 1.

24.

The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection.

Pilon EA, Dieudé M, Qi S, Hamelin K, Pomerleau L, Beillevaire D, Durocher Y, Zutter M, Coutu D, Perreault C, Hébert MJ.

Am J Transplant. 2015 May;15(5):1205-18. doi: 10.1111/ajt.13119. Epub 2015 Mar 23.

25.

Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate.

Ding H, DeRoy PL, Perreault C, Larivée A, Siddiqui A, Caldwell CG, Harran S, Harran PG.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4818-22. doi: 10.1002/anie.201411663. Epub 2015 Feb 26.

PMID:
25729008
26.

The nature of self for T cells-a systems-level perspective.

Granados DP, Laumont CM, Thibault P, Perreault C.

Curr Opin Immunol. 2015 Jun;34:1-8. doi: 10.1016/j.coi.2014.10.012. Epub 2014 Nov 15. Review.

PMID:
25466393
27.

Explaining group-level traits requires distinguishing process from product.

Panchanathan K, Mathew S, Perreault C.

Behav Brain Sci. 2014 Jun;37(3):269-70. doi: 10.1017/S0140525X13002975.

PMID:
24970416
28.

Immunoproteasomes shape the transcriptome and regulate the function of dendritic cells.

de Verteuil DA, Rouette A, Hardy MP, Lavallée S, Trofimov A, Gaucher É, Perreault C.

J Immunol. 2014 Aug 1;193(3):1121-32. doi: 10.4049/jimmunol.1400871. Epub 2014 Jun 23.

29.

Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.

Granados DP, Sriranganadane D, Daouda T, Zieger A, Laumont CM, Caron-Lizotte O, Boucher G, Hardy MP, Gendron P, Côté C, Lemieux S, Thibault P, Perreault C.

Nat Commun. 2014 Apr 9;5:3600. doi: 10.1038/ncomms4600.

30.

Adult thymic epithelium contains nonsenescent label-retaining cells.

Dumont-Lagacé M, Brochu S, St-Pierre C, Perreault C.

J Immunol. 2014 Mar 1;192(5):2219-26. doi: 10.4049/jimmunol.1302961. Epub 2014 Jan 29.

31.

Identification of a novel conformationally constrained glucagon receptor antagonist.

Lee EC, Tu M, Stevens BD, Bian J, Aspnes G, Perreault C, Sammons MF, Wright SW, Litchfield J, Kalgutkar AS, Sharma R, Didiuk MT, Ebner DC, Filipski KJ, Brown J, Atkinson K, Pfefferkorn JA, Guzman-Perez A.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):839-44. doi: 10.1016/j.bmcl.2013.12.090. Epub 2013 Dec 28.

PMID:
24418771
32.

Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle.

Prunskaite-Hyyryläinen R, Shan J, Railo A, Heinonen KM, Miinalainen I, Yan W, Shen B, Perreault C, Vainio SJ.

FASEB J. 2014 Apr;28(4):1568-81. doi: 10.1096/fj.13-233247. Epub 2013 Dec 26.

PMID:
24371124
33.

Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides.

Rocke BN, Bahnck KB, Herr M, Lavergne S, Mascitti V, Perreault C, Polivkova J, Shavnya A.

Org Lett. 2014 Jan 3;16(1):154-7. doi: 10.1021/ol4031233. Epub 2013 Dec 5.

PMID:
24308287
34.

Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.

Stevens BD, Litchfield J, Pfefferkorn JA, Atkinson K, Perreault C, Amor P, Bahnck K, Berliner MA, Calloway J, Carlo A, Derksen DR, Filipski KJ, Gumkowski M, Jassal C, MacDougall M, Murphy B, Nkansah P, Pettersen J, Rotter C, Zhang Y.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6588-92. doi: 10.1016/j.bmcl.2013.10.057. Epub 2013 Nov 4.

PMID:
24239482
35.

Rejection of leukemic cells requires antigen-specific T cells with high functional avidity.

Vincent K, Hardy MP, Trofimov A, Laumont CM, Sriranganadane D, Hadj-Mimoune S, Salem Fourati I, Soudeyns H, Thibault P, Perreault C.

Biol Blood Marrow Transplant. 2014 Jan;20(1):37-45. doi: 10.1016/j.bbmt.2013.10.020. Epub 2013 Oct 23.

36.

Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy.

Rafei M, Dumont-Lagacé M, Rouette A, Perreault C.

PLoS One. 2013 Sep 2;8(9):e72801. doi: 10.1371/journal.pone.0072801. eCollection 2013.

37.

Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.

Dow RL, Andrews MP, Li JC, Michael Gibbs E, Guzman-Perez A, Laperle JL, Li Q, Mather D, Munchhof MJ, Niosi M, Patel L, Perreault C, Tapley S, Zavadoski WJ.

Bioorg Med Chem. 2013 Sep 1;21(17):5081-97. doi: 10.1016/j.bmc.2013.06.045. Epub 2013 Jul 1.

PMID:
23871442
38.

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.

Filipski KJ, Guzman-Perez A, Bian J, Perreault C, Aspnes GE, Didiuk MT, Dow RL, Hank RF, Jones CS, Maguire RJ, Tu M, Zeng D, Liu S, Knafels JD, Litchfield J, Atkinson K, Derksen DR, Bourbonais F, Gajiwala KS, Hickey M, Johnson TO, Humphries PS, Pfefferkorn JA.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4571-8. doi: 10.1016/j.bmcl.2013.06.036. Epub 2013 Jun 20.

PMID:
23831135
39.

Transcriptome sequencing of neonatal thymic epithelial cells.

St-Pierre C, Brochu S, Vanegas JR, Dumont-Lagacé M, Lemieux S, Perreault C.

Sci Rep. 2013;3:1860. doi: 10.1038/srep01860.

40.

The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.

Guzman-Perez A, Pfefferkorn JA, Lee EC, Stevens BD, Aspnes GE, Bian J, Didiuk MT, Filipski KJ, Moore D, Perreault C, Sammons MF, Tu M, Brown J, Atkinson K, Litchfield J, Tan B, Samas B, Zavadoski WJ, Salatto CT, Treadway J.

Bioorg Med Chem Lett. 2013 May 15;23(10):3051-8. doi: 10.1016/j.bmcl.2013.03.014. Epub 2013 Mar 13.

PMID:
23562063
41.

Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial, vascular smooth muscle, and vascular endothelial cells.

Ahmarani L, Avedanian L, Al-Khoury J, Perreault C, Jacques D, Bkaily G.

Can J Physiol Pharmacol. 2013 Jan;91(1):71-9. doi: 10.1139/cjpp-2012-0265. Epub 2013 Jan 1.

PMID:
23368419
42.

The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.

Delisle JS, Giroux M, Boucher G, Landry JR, Hardy MP, Lemieux S, Jones RG, Wilhelm BT, Perreault C.

Genes Immun. 2013 Mar;14(2):115-26. doi: 10.1038/gene.2012.63. Epub 2013 Jan 17. Erratum in: Genes Immun. 2013 Mar;14(2):132.

PMID:
23328844
43.

In search of immunodominant minor histocompatibility antigens.

Perreault C.

Biol Blood Marrow Transplant. 2013 Feb;19(2):171-2. doi: 10.1016/j.bbmt.2012.11.003. Epub 2012 Nov 11. No abstract available.

44.

Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells.

Abdel-Samad D, Perreault C, Ahmarani L, Avedanian L, Bkaily G, Magder S, D'Orléans-Juste P, Jacques D.

Neuropeptides. 2012 Dec;46(6):373-82. doi: 10.1016/j.npep.2012.09.003. Epub 2012 Oct 26.

PMID:
23107364
45.

Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.

Rafei M, Rouette A, Brochu S, Vanegas JR, Perreault C.

Blood. 2013 Jan 3;121(1):107-17. doi: 10.1182/blood-2012-05-433508. Epub 2012 Oct 4.

46.

The pace of cultural evolution.

Perreault C.

PLoS One. 2012;7(9):e45150. Epub 2012 Sep 14.

47.

Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions.

Bkaily G, Avedanian L, Al-Khoury J, Ahmarani L, Perreault C, Jacques D.

Can J Physiol Pharmacol. 2012 Aug;90(8):953-65. doi: 10.1139/y2012-077. Epub 2012 Jul 11. Review.

PMID:
22783834
48.

Sensing tissue damage.

Perreault C.

Blood. 2012 May 10;119(19):4346-7. doi: 10.1182/blood-2012-02-406777. No abstract available.

49.

Dating the origin of language using phonemic diversity.

Perreault C, Mathew S.

PLoS One. 2012;7(4):e35289. doi: 10.1371/journal.pone.0035289. Epub 2012 Apr 27.

50.

MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements.

Granados DP, Yahyaoui W, Laumont CM, Daouda T, Muratore-Schroeder TL, Côté C, Laverdure JP, Lemieux S, Thibault P, Perreault C.

Blood. 2012 Jun 28;119(26):e181-91. doi: 10.1182/blood-2012-02-412593. Epub 2012 Mar 21.

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