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Items: 1 to 50 of 165

1.

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.

Pachis ST, Hiruma Y, Tromer EC, Perrakis A, Kops GJPL.

Cell Rep. 2019 Feb 19;26(8):2101-2112.e6. doi: 10.1016/j.celrep.2019.01.017.

2.

Cross-species hybridization and the origin of North African date palms.

Flowers JM, Hazzouri KM, Gros-Balthazard M, Mo Z, Koutroumpa K, Perrakis A, Ferrand S, Khierallah HSM, Fuller DQ, Aberlenc F, Fournaraki C, Purugganan MD.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1651-1658. doi: 10.1073/pnas.1817453116. Epub 2019 Jan 14.

3.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1.

Hayashi A, Giakoumakis NN, Heidebrecht T, Ishii T, Panagopoulos A, Caillat C, Takahara M, Hibbert RG, Suenaga N, Stadnik-Spiewak M, Takahashi T, Shiomi Y, Taraviras S, von Castelmur E, Lygerou Z, Perrakis A, Nishitani H.

Life Sci Alliance. 2018 Dec 31;1(6):e201800238. doi: 10.26508/lsa.201800238. eCollection 2018 Dec.

4.

A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.

Roorda JC, Joosten RP, Perrakis A, Hiruma Y.

Proteins. 2019 Apr;87(4):348-352. doi: 10.1002/prot.25651. Epub 2019 Jan 8.

PMID:
30582207
5.

Mesothelial cyst of the round ligament.

Apostolakis S, Ioannidis A, Koutserimpas C, Patrikakos P, Perrakis A, Velimezis G.

G Chir. 2018 Sep-Oct;34(5):323-325.

PMID:
30444483
6.

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

van Beusekom B, Heidebrecht T, Adamopoulos A, Fish A, Pardon E, Steyaert J, Joosten RP, Perrakis A.

Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):690-695. doi: 10.1107/S2053230X18010282. Epub 2018 Oct 16.

PMID:
30387773
7.

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

Argenzio E, Klarenbeek J, Kedziora KM, Nahidiazar L, Isogai T, Perrakis A, Jalink K, Moolenaar WH, Innocenti M.

J Biol Chem. 2018 Dec 14;293(50):19161-19176. doi: 10.1074/jbc.RA118.002779. Epub 2018 Oct 31.

8.

Mesothelial cyst of the round ligament.

Apostolakis S, Ioannidis A, Koutserimpas C, Patrikakos P, Perrakis A, Velimezis G.

G Chir. 2018 Sep-Oct;39(5):323-325.

PMID:
30368273
9.

Homology-based loop modeling yields more complete crystallographic protein structures.

van Beusekom B, Joosten K, Hekkelman ML, Joosten RP, Perrakis A.

IUCrJ. 2018 Aug 8;5(Pt 5):585-594. doi: 10.1107/S2052252518010552. eCollection 2018 Sep 1.

10.

Gastrointestinal schwannomas: a rare but important differential diagnosis of mesenchymal tumors of gastrointestinal tract.

Mekras A, Krenn V, Perrakis A, Croner RS, Kalles V, Atamer C, Grützmann R, Vassos N.

BMC Surg. 2018 Jul 25;18(1):47. doi: 10.1186/s12893-018-0379-2.

11.

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

Salgado-Polo F, Fish A, Matsoukas MT, Heidebrecht T, Keune WJ, Perrakis A.

J Biol Chem. 2018 Sep 14;293(37):14312-14327. doi: 10.1074/jbc.RA118.004450. Epub 2018 Jul 19.

PMID:
30026231
12.

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ.

Nat Cell Biol. 2018 Jul;20(7):800-810. doi: 10.1038/s41556-018-0130-3. Epub 2018 Jun 18.

PMID:
29915359
13.

Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.

van Veen M, Mans LA, Matas-Rico E, van Pelt J, Perrakis A, Moolenaar WH, Haramis AG.

Int J Biochem Cell Biol. 2018 Jan;94:71-78. doi: 10.1016/j.biocel.2017.11.015. Epub 2017 Dec 22.

14.

Homology-based hydrogen bond information improves crystallographic structures in the PDB.

van Beusekom B, Touw WG, Tatineni M, Somani S, Rajagopal G, Luo J, Gilliland GL, Perrakis A, Joosten RP.

Protein Sci. 2018 Mar;27(3):798-808. doi: 10.1002/pro.3353. Epub 2017 Dec 8.

15.

Vasohibins encode tubulin detyrosinating activity.

Nieuwenhuis J, Adamopoulos A, Bleijerveld OB, Mazouzi A, Stickel E, Celie P, Altelaar M, Knipscheer P, Perrakis A, Blomen VA, Brummelkamp TR.

Science. 2017 Dec 15;358(6369):1453-1456. doi: 10.1126/science.aao5676. Epub 2017 Nov 16.

PMID:
29146869
16.

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora KM, De Lorenzi V, Stijf-Bultsma Y, van den Broek B, Jalink K, Sidenius N, Perrakis A, Moolenaar WH.

Elife. 2017 Aug 29;6. pii: e23649. doi: 10.7554/eLife.23649.

17.

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

Hiruma Y, Koch A, Hazraty N, Tsakou F, Medema RH, Joosten RP, Perrakis A.

J Biol Chem. 2017 Sep 1;292(35):14496-14504. doi: 10.1074/jbc.M117.783555. Epub 2017 Jul 18.

18.

Incarcerated recurrent inguinal hernia containing an acute appendicitis (Amyand hernia): an extremely rare surgical situation.

Velimezis G, Vassos N, Kapogiannatos G, Koronakis D, Perrakis E, Perrakis A.

Arch Med Sci. 2017 Apr 1;13(3):702-704. doi: 10.5114/aoms.2016.60403. Epub 2016 Jun 7. No abstract available.

19.

What is Changing in Indications and Treatment of Focal Nodular Hyperplasia of the Liver. Is There Any Place for Surgery?

Perrakis A, Vassos N, Grützmann R, Croner RS.

Ann Hepatol. 2017 May - Jun;16(3):333-341. doi: 10.5604/16652681.1235475. Review.

20.

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.

Keune WJ, Potjewyd F, Heidebrecht T, Salgado-Polo F, Macdonald SJ, Chelvarajan L, Abdel Latif A, Soman S, Morris AJ, Watson AJ, Jamieson C, Perrakis A.

J Med Chem. 2017 Mar 9;60(5):2006-2017. doi: 10.1021/acs.jmedchem.6b01743. Epub 2017 Feb 16.

21.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR.

Nature. 2017 Jan 19;541(7637):412-416. doi: 10.1038/nature21032. Epub 2017 Jan 11.

PMID:
28077878
22.

Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.

Miller LM, Keune WJ, Castagna D, Young LC, Duffy EL, Potjewyd F, Salgado-Polo F, Engel García P, Semaan D, Pritchard JM, Perrakis A, Macdonald SJ, Jamieson C, Watson AJ.

J Med Chem. 2017 Jan 26;60(2):722-748. doi: 10.1021/acs.jmedchem.6b01597. Epub 2017 Jan 5.

23.

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJA, de Rink I, Medema RH, Giepmans BNG, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Dec 12;30(6):986. doi: 10.1016/j.ccell.2016.11.008. No abstract available.

24.

Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.

Hiruma Y, Koch A, Dharadhar S, Joosten RP, Perrakis A.

Proteins. 2016 Dec;84(12):1761-1766. doi: 10.1002/prot.25174. Epub 2016 Oct 11.

PMID:
27699881
25.

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Oct 10;30(4):548-562. doi: 10.1016/j.ccell.2016.08.016. Epub 2016 Sep 29. Erratum in: Cancer Cell. 2016 Dec 12;30(6):986.

26.

In silico Transcriptional Regulatory Networks Involved in Tomato Fruit Ripening.

Arhondakis S, Bita CE, Perrakis A, Manioudaki ME, Krokida A, Kaloudas D, Kalaitzis P.

Front Plant Sci. 2016 Aug 30;7:1234. doi: 10.3389/fpls.2016.01234. eCollection 2016.

27.

Editorial overview: New constructs and expression of proteins.

Meijers R, Perrakis A.

Curr Opin Struct Biol. 2016 Jun;38:v-vi. doi: 10.1016/j.sbi.2016.07.013. Epub 2016 Aug 9. No abstract available.

PMID:
27520611
28.

Surgery along the embryological planes for colon cancer: a systematic review of complete mesocolic excision.

Gouvas N, Agalianos C, Papaparaskeva K, Perrakis A, Hohenberger W, Xynos E.

Int J Colorectal Dis. 2016 Sep;31(9):1577-94. doi: 10.1007/s00384-016-2626-2. Epub 2016 Jul 28. Review.

PMID:
27469525
29.

Recombinant cloning strategies for protein expression.

Celie PH, Parret AH, Perrakis A.

Curr Opin Struct Biol. 2016 Jun;38:145-54. doi: 10.1016/j.sbi.2016.06.010. Epub 2016 Jul 5. Review.

PMID:
27391134
30.

Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.

Hausmann J, Keune WJ, Hipgrave Ederveen AL, van Zeijl L, Joosten RP, Perrakis A.

J Struct Biol. 2016 Aug;195(2):199-206. doi: 10.1016/j.jsb.2016.06.002. Epub 2016 Jun 4.

PMID:
27268273
31.

Robotic liver surgery for minor hepatic resections: a comparison with laparoscopic and open standard procedures.

Croner RS, Perrakis A, Hohenberger W, Brunner M.

Langenbecks Arch Surg. 2016 Aug;401(5):707-14. doi: 10.1007/s00423-016-1440-1. Epub 2016 May 20.

PMID:
27207697
32.

Strangulation and necrosis of right hemicolon as an extremely rare complication of Spigelian hernia.

Velimezis G, Vassos N, Kapogiannatos G, Koronakis D, Salpiggidis C, Perrakis E, Perrakis A.

Arch Med Sci. 2016 Apr 1;12(2):469-72. doi: 10.5114/aoms.2016.59273. Epub 2016 Apr 12. No abstract available.

33.

Prognostic and diagnostic value of procalcitonin in the post-transplant setting after liver transplantation.

Perrakis A, Stirkat F, Croner RS, Vassos N, Raptis D, Yedibela S, Hohenberger W, Müller V.

Arch Med Sci. 2016 Apr 1;12(2):372-9. doi: 10.5114/aoms.2016.59264. Epub 2016 Apr 12.

34.

Data Mining of Macromolecular Structures.

van Beusekom B, Perrakis A, Joosten RP.

Methods Mol Biol. 2016;1415:107-38. doi: 10.1007/978-1-4939-3572-7_6.

PMID:
27115630
35.

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.

Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A.

Nat Commun. 2016 Apr 14;7:11248. doi: 10.1038/ncomms11248.

36.

[Robotic-Assisted Liver Surgery].

Croner R, Perrakis A, Grützmann R, Hohenberger W, Brunner M.

Zentralbl Chir. 2016 Apr;141(2):154-9. doi: 10.1055/s-0042-104067. Epub 2016 Apr 13. German.

PMID:
27074212
37.

Intra-abdominal localized hyaline-vascular Castleman disease: imaging characteristics and management of a rare condition.

Vassos N, Raptis D, Lell M, Klein P, Perrakis A, Köhler J, Croner RS, Hohenberger W, Agaimy A.

Arch Med Sci. 2016 Feb 1;12(1):227-32. doi: 10.5114/aoms.2016.57600. Epub 2016 Feb 2. No abstract available.

38.

[Surgery for metastases, anatomical and ethical limits. Special aspect: oligometastases].

Perrakis A, Juratli TA, Hohenberger W, Croner RS, Schackert G.

Chirurg. 2016 Mar;87(3):208-15. doi: 10.1007/s00104-015-0147-0. Review. German.

PMID:
26857002
39.

Left-sided Gallbladder in the Era of Laparoscopic Cholecystectomy: A Single-center Experience.

Velimezis G, Vassos N, Kapogiannatos G, Koronakis D, Salpiggidis C, Perrakis E, Perrakis A.

Am Surg. 2015 Dec;81(12):1249-52.

PMID:
26736163
40.

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.

Caillat C, Fish A, Pefani DE, Taraviras S, Lygerou Z, Perrakis A.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2278-86. doi: 10.1107/S1399004715016892. Epub 2015 Oct 31.

41.

Incisional Hernia: Difficult Cases 2.

Novitsky Y, Fayezizadeh M, Majumder A, Yee S, Petro C, Orenstein S, Woeste G, Reinisch A, Bechstein WO, Rosen M, Carbonell A, Cobb W, Bauer J, Selzer D, Chao J, Harmaty M, Poulose B, Matthews B, Goldblatt M, Jacobsen G, Rosman C, Hansson B, Prabhu A, Fathi A, Skipworth J, Younis I, Floyd D, Shankar A, Olmi S, Cesana G, Ciccarese F, Uccelli M, Carrieri D, Castello G, Legnani G, Lyo V, Irwin C, Xu X, Harris H, Zuvela M, Galun D, Petrovic J, Palibrk I, Koncar I, Basaric D, Tian W, Fei Y, Pittman M, Jones E, Schwartz J, Mikami D, Perrakis A, Knüttel D, Klein P, Croner RS, Hohenberger W, Perrakis E, Müller V, Grande M, Villa M, Lisi G, Esser A, De Sanctis F, Petrella G, Birolini C, Miranda JS, Tanaka EY, Utiyama EM, Rasslan S, Shi Y, Guo XB, Zhuo HQ, Li LP, Liu HJ, Bauder A, Gerety P, Epps G, Pannucci C, Fischer J, Kovach S.

Hernia. 2015 Apr;19 Suppl 1:S105-11. doi: 10.1007/BF03355335. No abstract available.

PMID:
26518784
42.

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

Hiruma Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, von Castelmur E, Perrakis A, Kops GJ.

Science. 2015 Jun 12;348(6240):1264-7. doi: 10.1126/science.aaa4055. Epub 2015 Jun 11.

43.

Pioneering Robotic Liver Surgery in Germany: First Experiences with Liver Malignancies.

Croner RS, Perrakis A, Brunner M, Matzel KE, Hohenberger W.

Front Surg. 2015 May 20;2:18. doi: 10.3389/fsurg.2015.00018. eCollection 2015.

44.

The first step of peptide selection in antigen presentation by MHC class I molecules.

Garstka MA, Fish A, Celie PH, Joosten RP, Janssen GM, Berlin I, Hoppes R, Stadnik M, Janssen L, Ovaa H, van Veelen PA, Perrakis A, Neefjes J.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1505-10. doi: 10.1073/pnas.1416543112. Epub 2015 Jan 20.

45.

The PDB_REDO server for macromolecular structure model optimization.

Joosten RP, Long F, Murshudov GN, Perrakis A.

IUCrJ. 2014 May 30;1(Pt 4):213-20. doi: 10.1107/S2052252514009324. eCollection 2014 Jul 1.

46.

Lymph node metastasis of carcinomas of transverse colon including flexures. Consideration of the extramesocolic lymph node stations.

Perrakis A, Weber K, Merkel S, Matzel K, Agaimy A, Gebbert C, Hohenberger W.

Int J Colorectal Dis. 2014 Oct;29(10):1223-9. doi: 10.1007/s00384-014-1971-2. Epub 2014 Jul 25.

PMID:
25060216
47.

Quality of surgery for stage III colon cancer: comparison between England, Germany, and Japan.

Kobayashi H, West NP, Takahashi K, Perrakis A, Weber K, Hohenberger W, Quirke P, Sugihara K.

Ann Surg Oncol. 2014 Jun;21 Suppl 3:S398-404. doi: 10.1245/s10434-014-3578-9. Epub 2014 Feb 25.

PMID:
24566862
48.

Autotaxin: structure-function and signaling.

Perrakis A, Moolenaar WH.

J Lipid Res. 2014 Jun;55(6):1010-8. doi: 10.1194/jlr.R046391. Epub 2014 Feb 18. Review.

49.

Genetic structure of Bemisia tabaci Med populations from home-range countries, inferred by nuclear and cytoplasmic markers: impact on the distribution of the insecticide resistance genes.

Gauthier N, Clouet C, Perrakis A, Kapantaidaki D, Peterschmitt M, Tsagkarakou A.

Pest Manag Sci. 2014 Oct;70(10):1477-91. doi: 10.1002/ps.3733. Epub 2014 Mar 7.

PMID:
24458589
50.

Timely deposition of macromolecular structures is necessary for peer review.

Joosten RP, Soueidan H, Wessels LF, Perrakis A.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2293-5. doi: 10.1107/S0907444913024621. Epub 2013 Nov 19.

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