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Real time dynamics of gating-related conformational changes in CorA.

Rangl M, Schmandt N, Perozo E, Scheuring S.

Elife. 2019 Nov 27;8. pii: e47322. doi: 10.7554/eLife.47322. [Epub ahead of print]


Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor.

Zhao R, Kennedy K, De Blas GA, Orta G, Pavarotti MA, Arias RJ, de la Vega-Beltrán JL, Li Q, Dai H, Perozo E, Mayorga LS, Darszon A, Goldstein SAN.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11847-E11856. doi: 10.1073/pnas.1816189115. Epub 2018 Nov 26.


Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel.

Li J, Ostmeyer J, Cuello LG, Perozo E, Roux B.

J Gen Physiol. 2018 Oct 1;150(10):1408-1420. doi: 10.1085/jgp.201812082. Epub 2018 Aug 2.


Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.

Lau C, Hunter MJ, Stewart A, Perozo E, Vandenberg JI.

J Physiol. 2018 Apr 1;596(7):1107-1119. doi: 10.1113/JP274888. Epub 2018 Mar 5. Review.


Structural Dynamics of the MscL C-terminal Domain.

Bavi N, Martinac AD, Cortes DM, Bavi O, Ridone P, Nomura T, Hill AP, Martinac B, Perozo E.

Sci Rep. 2017 Dec 8;7(1):17229. doi: 10.1038/s41598-017-17396-w.


The gating cycle of a K+ channel at atomic resolution.

Cuello LG, Cortes DM, Perozo E.

Elife. 2017 Nov 22;6. pii: e28032. doi: 10.7554/eLife.28032.


Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation.

Li J, Ostmeyer J, Boulanger E, Rui H, Perozo E, Roux B.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11145-11150. doi: 10.1073/pnas.1706983114. Epub 2017 Oct 2.


Towards a Structural View of Drug Binding to hERG K+ Channels.

Vandenberg JI, Perozo E, Allen TW.

Trends Pharmacol Sci. 2017 Oct;38(10):899-907. doi: 10.1016/ Epub 2017 Jul 12. Review.


Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy.

Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT.

J Am Chem Soc. 2017 Jul 5;139(26):8837-8845. doi: 10.1021/jacs.7b01594. Epub 2017 May 12.


Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy.

Kratochvil HT, Carr JK, Matulef K, Annen AW, Li H, Maj M, Ostmeyer J, Serrano AL, Raghuraman H, Moran SD, Skinner JL, Perozo E, Roux B, Valiyaveetil FI, Zanni MT.

Science. 2016 Sep 2;353(6303):1040-1044.


From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins.

Laguerre A, Löhr F, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM, Bernhard F, Dötsch V.

Structure. 2016 Oct 4;24(10):1830-1841. doi: 10.1016/j.str.2016.07.017. Epub 2016 Sep 15.


Toward a structural blueprint for bilayer-mediated channel mechanosensitivity.

Bavi N, Cox CD, Perozo E, Martinac B.

Channels (Austin). 2017 Mar 4;11(2):91-93. doi: 10.1080/19336950.2016.1224624. Epub 2016 Aug 17. No abstract available.


The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.

Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B.

Nat Commun. 2016 Jun 22;7:11984. doi: 10.1038/ncomms11984.


Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channel.

Medovoy D, Perozo E, Roux B.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1722-32. doi: 10.1016/j.bbamem.2016.02.019. Epub 2016 Feb 16.


Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.

Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, Reddy BG, Islam S, Bartesaghi A, Perozo E, Subramaniam S.

Cell. 2016 Feb 11;164(4):747-56. doi: 10.1016/j.cell.2015.12.055.


Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.

Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA.

Structure. 2016 Feb 2;24(2):300-9. doi: 10.1016/j.str.2015.11.014. Epub 2015 Dec 31.


Resting state of the human proton channel dimer in a lipid bilayer.

Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5926-35. doi: 10.1073/pnas.1515043112. Epub 2015 Oct 6.


Biomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling.

van der Cruijsen EA, Koers EJ, Sauvée C, Hulse RE, Weingarth M, Ouari O, Perozo E, Tordo P, Baldus M.

Chemistry. 2015 Sep 7;21(37):12971-7. doi: 10.1002/chem.201501376.


xMDFF: molecular dynamics flexible fitting of low-resolution X-ray structures.

McGreevy R, Singharoy A, Li Q, Zhang J, Xu D, Perozo E, Schulten K.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2344-55. doi: 10.1107/S1399004714013856. Epub 2014 Aug 29.


Molecular mechanism of Mg2+-dependent gating in CorA.

Dalmas O, Sompornpisut P, Bezanilla F, Perozo E.

Nat Commun. 2014 Apr 2;5:3590. doi: 10.1038/ncomms4590.


Conformational dynamics at the inner gate of KcsA during activation.

Hulse RE, Sachleben JR, Wen PC, Moradi M, Tajkhorshid E, Perozo E.

Biochemistry. 2014 Apr 29;53(16):2557-9. doi: 10.1021/bi500168u. Epub 2014 Apr 18.


A repulsion mechanism explains magnesium permeation and selectivity in CorA.

Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3002-7. doi: 10.1073/pnas.1319054111. Epub 2014 Feb 10.


Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVP.

Randich AM, Cuello LG, Wanderling SS, Perozo E.

Biochemistry. 2014 Mar 18;53(10):1627-36. doi: 10.1021/bi4014243. Epub 2014 Mar 7.


Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.

Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Roux B, Schulten K, Kossiakoff A, Perozo E.

Nat Struct Mol Biol. 2014 Mar;21(3):244-52. doi: 10.1038/nsmb.2768. Epub 2014 Feb 2.


Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating.

Raghuraman H, Islam SM, Mukherjee S, Roux B, Perozo E.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1831-6. doi: 10.1073/pnas.1314875111. Epub 2014 Jan 15. Erratum in: Proc Natl Acad Sci U S A. 2014 Feb 4;111(5). doi:10.1073/pnas.1402205111. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4644.


Structural basis of lipid-driven conformational transitions in the KvAP voltage-sensing domain.

Li Q, Wanderling S, Sompornpisut P, Perozo E.

Nat Struct Mol Biol. 2014 Feb;21(2):160-6. doi: 10.1038/nsmb.2747. Epub 2014 Jan 12.


Recovery from slow inactivation in K+ channels is controlled by water molecules.

Ostmeyer J, Chakrapani S, Pan AC, Perozo E, Roux B.

Nature. 2013 Sep 5;501(7465):121-4. doi: 10.1038/nature12395. Epub 2013 Jul 28.


Importance of lipid-pore loop interface for potassium channel structure and function.

van der Cruijsen EA, Nand D, Weingarth M, Prokofyev A, Hornig S, Cukkemane AA, Bonvin AM, Becker S, Hulse RE, Perozo E, Pongs O, Baldus M.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13008-13. doi: 10.1073/pnas.1305563110. Epub 2013 Jul 23.


Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.

White EA, Raghuraman H, Perozo E, Glotzer M.

J Biol Chem. 2013 Jul 5;288(27):19785-95. doi: 10.1074/jbc.M113.463695. Epub 2013 May 17.


An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.

Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B.

J Gen Physiol. 2012 Dec;140(6):587-94. doi: 10.1085/jgp.201210873.


Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP.

Li Q, Jogini V, Wanderling S, Cortes DM, Perozo E.

Biochemistry. 2012 Oct 16;51(41):8132-42. doi: 10.1021/bi300980q. Epub 2012 Oct 5.


Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate.

Dalmas O, Hyde HC, Hulse RE, Perozo E.

J Am Chem Soc. 2012 Oct 3;134(39):16360-9. doi: 10.1021/ja3069038. Epub 2012 Sep 18.


Mechanism of Cd2+ coordination during slow inactivation in potassium channels.

Raghuraman H, Cordero-Morales JF, Jogini V, Pan AC, Kollewe A, Roux B, Perozo E.

Structure. 2012 Aug 8;20(8):1332-42. doi: 10.1016/j.str.2012.03.027. Epub 2012 Jul 5.


Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.

Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20982-7. doi: 10.1073/pnas.1111202108. Epub 2011 Dec 8.


Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations.

Pan AC, Cuello LG, Perozo E, Roux B.

J Gen Physiol. 2011 Dec;138(6):571-80. doi: 10.1085/jgp.201110670.


Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.

Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M.

J Biol Chem. 2011 Nov 11;286(45):39091-9. doi: 10.1074/jbc.M111.292060. Epub 2011 Sep 9.


Mechanism of activation gating in the full-length KcsA K+ channel.

Uysal S, Cuello LG, Cortes DM, Koide S, Kossiakoff AA, Perozo E.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11896-9. doi: 10.1073/pnas.1105112108. Epub 2011 Jul 5.


A multipoint hydrogen-bond network underlying KcsA C-type inactivation.

Cordero-Morales JF, Jogini V, Chakrapani S, Perozo E.

Biophys J. 2011 May 18;100(10):2387-93. doi: 10.1016/j.bpj.2011.01.073.


On the structural basis of modal gating behavior in K(+) channels.

Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Roux B, Perozo E.

Nat Struct Mol Biol. 2011 Jan;18(1):67-74. doi: 10.1038/nsmb.1968. Epub 2010 Dec 26.


Up a hydrophobic creek with a short paddle.

Hulse RE, Li Q, Perozo E.

Cell. 2010 Aug 20;142(4):515-6. doi: 10.1016/j.cell.2010.08.005.


Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer.

Dalmas O, Cuello LG, Jogini V, Cortes DM, Roux B, Perozo E.

Structure. 2010 Jul 14;18(7):868-78. doi: 10.1016/j.str.2010.04.009.


Structural basis for the coupling between activation and inactivation gates in K(+) channels.

Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E.

Nature. 2010 Jul 8;466(7303):272-5. doi: 10.1038/nature09136.


Structural mechanism of C-type inactivation in K(+) channels.

Cuello LG, Jogini V, Cortes DM, Perozo E.

Nature. 2010 Jul 8;466(7303):203-8. doi: 10.1038/nature09153.


The activated state of a sodium channel voltage sensor in a membrane environment.

Chakrapani S, Sompornpisut P, Intharathep P, Roux B, Perozo E.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5435-40. doi: 10.1073/pnas.0914109107. Epub 2010 Mar 5.


Design and characterization of a constitutively open KcsA.

Cuello LG, Jogini V, Cortes DM, Sompornpisut A, Purdy MD, Wiener MC, Perozo E.

FEBS Lett. 2010 Mar 19;584(6):1133-8. doi: 10.1016/j.febslet.2010.02.015. Epub 2010 Feb 12.


A molecular mechanism for proton-dependent gating in KcsA.

Cuello LG, Cortes DM, Jogini V, Sompornpisut A, Perozo E.

FEBS Lett. 2010 Mar 19;584(6):1126-32. doi: 10.1016/j.febslet.2010.02.003. Epub 2010 Feb 6.


A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.

Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22211-6. doi: 10.1073/pnas.0910123106. Epub 2009 Dec 10.


Structural biology: A channel with a twist.

Vásquez V, Perozo E.

Nature. 2009 Sep 3;461(7260):47-9. doi: 10.1038/461047a. No abstract available.


Crystal structure of full-length KcsA in its closed conformation.

Uysal S, Vásquez V, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6644-9. doi: 10.1073/pnas.0810663106. Epub 2009 Apr 3.


Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy.

Torbeev VY, Raghuraman H, Mandal K, Senapati S, Perozo E, Kent SB.

J Am Chem Soc. 2009 Jan 28;131(3):884-5. doi: 10.1021/ja806526z.


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