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Items: 32


PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.

Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB.

J Clin Invest. 2019 Oct 1;129(10):4138-4150. doi: 10.1172/JCI127092.


Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell Metab. 2018 Oct 2;28(4):543-546. doi: 10.1016/j.cmet.2018.09.007. Epub 2018 Sep 20.


Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB.

Cell Metab. 2018 Feb 6;27(2):419-427.e4. doi: 10.1016/j.cmet.2018.01.001.


Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.


Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A.

Biochemistry. 2016 Aug 23;55(33):4636-41. doi: 10.1021/acs.biochem.6b00565. Epub 2016 Aug 10.


Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.

Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB.

Diabetes. 2016 May;65(5):1317-27. doi: 10.2337/db15-1696. Epub 2016 Mar 2.


Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.

Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB.

Diabetes. 2015 May;64(5):1603-14. doi: 10.2337/db14-0970. Epub 2014 Dec 18.


Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035.


Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.

Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB.

J Clin Invest. 2014 Sep;124(9):3781-92. doi: 10.1172/JCI68585. Epub 2014 Aug 1.


Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.

Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.


Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.

Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB.

Mol Cell Biol. 2014 Mar;34(6):1170-86. doi: 10.1128/MCB.01106-13. Epub 2014 Jan 13.


Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.

Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB.

PLoS One. 2012;7(5):e36335. doi: 10.1371/journal.pone.0036335. Epub 2012 May 10.


A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.

Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB.

Nature. 2012 Apr 19;484(7394):333-8. doi: 10.1038/nature10986.


Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.

Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB.

J Biol Chem. 2011 Mar 18;286(11):8798-809. doi: 10.1074/jbc.M111.218719. Epub 2011 Jan 5.


Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.

Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB.

J Biol Chem. 2010 Apr 9;285(15):11348-56. doi: 10.1074/jbc.M109.075184. Epub 2010 Jan 21.


Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis.

Preitner F, Mody N, Graham TE, Peroni OD, Kahn BB.

Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1420-9. doi: 10.1152/ajpendo.00362.2009. Epub 2009 Oct 13.


Cathepsin L activity controls adipogenesis and glucose tolerance.

Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP.

Nat Cell Biol. 2007 Aug;9(8):970-7. Epub 2007 Jul 22.


Regulation of gluconeogenesis by Krüppel-like factor 15.

Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK.

Cell Metab. 2007 Apr;5(4):305-12.


Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.

Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB.

Mol Cell Biol. 2005 Nov;25(21):9713-23.


Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.

Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB.

Nature. 2005 Jul 21;436(7049):356-62.


Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.

Carvalho E, Kotani K, Peroni OD, Kahn BB.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E551-61. Epub 2005 May 31.


GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB.

J Clin Invest. 2004 Dec;114(11):1666-75.


Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.

Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC.

Mol Cell Biol. 2004 Jun;24(11):5080-7.


GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase.

Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, Kahn BB.

J Biol Chem. 2004 May 14;279(20):21598-605. Epub 2004 Feb 24.


Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.

Blüher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR.

Dev Cell. 2002 Jul;3(1):25-38.


Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.

Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB.

Nature. 2002 Jan 17;415(6869):339-43.


Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.

Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI.

J Clin Invest. 2001 Jul;108(1):153-60.


Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.

Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5187-92. Epub 2001 Apr 17.


Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB.

Nat Med. 2000 Aug;6(8):924-8.


Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

Kim YB, Peroni OD, Franke TF, Kahn BB.

Diabetes. 2000 May;49(5):847-56.


Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.

Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB.

Mol Cell Biol. 2000 Aug;20(15):5479-89.


Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.

Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI.

J Clin Invest. 2000 Jun;105(12):1791-7.

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