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Items: 37


Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.


Regulation of age-associated B cells by IRF5 in systemic autoimmunity.

Manni M, Gupta S, Ricker E, Chinenov Y, Park SH, Shi M, Pannellini T, Jessberger R, Ivashkiv LB, Pernis AB.

Nat Immunol. 2018 Apr;19(4):407-419. doi: 10.1038/s41590-018-0056-8. Epub 2018 Feb 26.


Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, Bykerk VP, Goodman SM, Donlin LT.

Arthritis Rheumatol. 2018 May;70(5):690-701. doi: 10.1002/art.40428. Epub 2018 Apr 2.


The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.

Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, Molina H, Pernis AB.

Nat Commun. 2017 Aug 15;8(1):254. doi: 10.1038/s41467-017-00348-3.


Regulation of systemic autoimmunity and CD11c+ Tbet+ B cells by SWEF proteins.

Manni M, Ricker E, Pernis AB.

Cell Immunol. 2017 Nov;321:46-51. doi: 10.1016/j.cellimm.2017.05.010. Epub 2017 Jul 11. Review.


Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE.

Rozo C, Chinenov Y, Maharaj RK, Gupta S, Leuenberger L, Kirou KA, Bykerk VP, Goodman SM, Salmon JE, Pernis AB.

Ann Rheum Dis. 2017 Apr;76(4):740-747. doi: 10.1136/annrheumdis-2016-209850. Epub 2016 Nov 9.


Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB.

Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810.


The RhoA-ROCK pathway in the regulation of T and B cell responses.

Ricker E, Chowdhury L, Yi W, Pernis AB.

F1000Res. 2016 Sep 12;5. pii: F1000 Faculty Rev-2295. eCollection 2016. Review.


Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production.

Weng CH, Gupta S, Geraghty P, Foronjy R, Pernis AB.

Mol Immunol. 2016 Mar;71:115-122. doi: 10.1016/j.molimm.2016.01.013. Epub 2016 Feb 13.


Regulation of Effector Treg Cells in Murine Lupus.

Chandrasekaran U, Yi W, Gupta S, Weng CH, Giannopoulou E, Chinenov Y, Jessberger R, Weaver CT, Bhagat G, Pernis AB.

Arthritis Rheumatol. 2016 Jun;68(6):1454-66. doi: 10.1002/art.39599.


Rho Kinases in Autoimmune Diseases.

Pernis AB, Ricker E, Weng CH, Rozo C, Yi W.

Annu Rev Med. 2016;67:355-74. doi: 10.1146/annurev-med-051914-022120. Review.


IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus.

Manni M, Gupta S, Nixon BG, Weaver CT, Jessberger R, Pernis AB.

PLoS One. 2015 Nov 6;10(11):e0141927. doi: 10.1371/journal.pone.0141927. eCollection 2015.


Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity.

Rogatsky I, Chandrasekaran U, Manni M, Yi W, Pernis AB.

Autoimmunity. 2014 Jun;47(4):242-55. doi: 10.3109/08916934.2013.853050. Epub 2013 Nov 11. Review.


Enhanced rho-associated protein kinase activation in patients with systemic lupus erythematosus.

Isgro J, Gupta S, Jacek E, Pavri T, Duculan R, Kim M, Kirou KA, Salmon JE, Pernis AB.

Arthritis Rheum. 2013 Jun;65(6):1592-602. doi: 10.1002/art.37934.


A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21.

Biswas PS, Kang K, Gupta S, Bhagat G, Pernis AB.

Methods Mol Biol. 2012;900:233-51. doi: 10.1007/978-1-60761-720-4_11.


Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity.

Biswas PS, Gupta S, Stirzaker RA, Kumar V, Jessberger R, Lu TT, Bhagat G, Pernis AB.

J Exp Med. 2012 Mar 12;209(3):581-96. doi: 10.1084/jem.20111195. Epub 2012 Feb 27.


Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.

Stirzaker RA, Biswas PS, Gupta S, Song L, Bhagat G, Pernis AB.

Lupus. 2012 May;21(6):656-61. doi: 10.1177/0961203312436862. Epub 2012 Feb 16.


Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.

Biswas PS, Gupta S, Chang E, Bhagat G, Pernis AB.

Cell Immunol. 2011;266(2):111-5. doi: 10.1016/j.cellimm.2010.10.009. Epub 2010 Nov 6.


Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

Biswas PS, Gupta S, Chang E, Song L, Stirzaker RA, Liao JK, Bhagat G, Pernis AB.

J Clin Invest. 2010 Sep;120(9):3280-95. doi: 10.1172/JCI42856. Epub 2010 Aug 9.


IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

Biswas PS, Bhagat G, Pernis AB.

Immunol Rev. 2010 Jan;233(1):79-96. doi: 10.1111/j.0105-2896.2009.00864.x. Review.


Th17 cells in rheumatoid arthritis and systemic lupus erythematosus.

Pernis AB.

J Intern Med. 2009 Jun;265(6):644-52. doi: 10.1111/j.1365-2796.2009.02099.x. Review.


Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases.

Chen Q, Gupta S, Pernis AB.

J Leukoc Biol. 2009 Mar;85(3):539-43. doi: 10.1189/jlb.0308219. Epub 2008 Dec 12.


IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor.

Chen Q, Yang W, Gupta S, Biswas P, Smith P, Bhagat G, Pernis AB.

Immunity. 2008 Dec 19;29(6):899-911. doi: 10.1016/j.immuni.2008.10.011. Epub 2008 Dec 8.


Rho GTPase-mediated pathways in mature CD4+ T cells.

Pernis AB.

Autoimmun Rev. 2009 Jan;8(3):199-203. doi: 10.1016/j.autrev.2008.07.044. Epub 2008 Aug 22. Review.


Estrogen and CD4+ T cells.

Pernis AB.

Curr Opin Rheumatol. 2007 Sep;19(5):414-20. Review.


Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity.

Fanzo JC, Yang W, Jang SY, Gupta S, Chen Q, Siddiq A, Greenberg S, Pernis AB.

J Clin Invest. 2006 Mar;116(3):703-14. Epub 2006 Feb 9.


CD95 rapidly clusters in cells of diverse origins.

Fanzo JC, Lynch MP, Phee H, Hyer M, Cremesti A, Grassme H, Norris JS, Coggeshall KM, Rueda BR, Pernis AB, Kolesnick R, Gulbins E.

Cancer Biol Ther. 2003 Jul-Aug;2(4):392-5.


T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.

Gupta S, Fanzo JC, Hu C, Cox D, Jang SY, Lee AE, Greenberg S, Pernis AB.

J Biol Chem. 2003 Oct 31;278(44):43541-9. Epub 2003 Aug 15.


Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.

Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G, Pernis AB.

Hum Immunol. 2003 Apr;64(4):389-401.


Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).

Fanzo JC, Hu CM, Jang SY, Pernis AB.

J Exp Med. 2003 Feb 3;197(3):303-14.


Modulation of T cell cytokine production by interferon regulatory factor-4.

Hu CM, Jang SY, Fanzo JC, Pernis AB.

J Biol Chem. 2002 Dec 20;277(51):49238-46. Epub 2002 Oct 8.


JAK-STAT signaling in asthma.

Pernis AB, Rothman PB.

J Clin Invest. 2002 May;109(10):1279-83. Review. No abstract available.


The role of IRF-4 in B and T cell activation and differentiation.

Pernis AB.

J Interferon Cytokine Res. 2002 Jan;22(1):111-20. Review.


Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.

Gupta S, Jiang M, Anthony A, Pernis AB.

J Exp Med. 1999 Dec 20;190(12):1837-48.


IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.

Gupta S, Jiang M, Pernis AB.

J Immunol. 1999 Oct 1;163(7):3834-41.


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