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Items: 11


Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.

Treviño JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP.

Mol Cancer Ther. 2013 Dec;12(12):2722-34. doi: 10.1158/1535-7163.MCT-12-0719. Epub 2013 Oct 9.


Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2.

Win-Piazza H, Schneeberger VE, Chen L, Pernazza D, Lawrence HR, Sebti SM, Lawrence NJ, Wu J.

Cancer Lett. 2012 Jul 1;320(1):81-5. doi: 10.1016/j.canlet.2012.01.034. Epub 2012 Feb 1.


Abnormal MDMX degradation in tumor cells due to ARF deficiency.

Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J.

Oncogene. 2012 Aug 9;31(32):3721-32. doi: 10.1038/onc.2011.534. Epub 2011 Nov 28.


Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.

Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP.

Cancer Res. 2012 Jan 15;72(2):516-26. doi: 10.1158/0008-5472.CAN-11-2647. Epub 2011 Nov 15. Erratum in: Cancer Res. 2012 Mar 1;72(5):1317.


Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine.

Singh S, Davis R, Alamanda V, Pireddu R, Pernazza D, Sebti S, Lawrence N, Chellappan S.

Mol Cancer Ther. 2010 Dec;9(12):3330-41. doi: 10.1158/1535-7163.MCT-10-0442. Epub 2010 Dec 7.


Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.

Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J.

Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25.


Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells.

Zhong B, Sallman DA, Gilvary DL, Pernazza D, Sahakian E, Fritz D, Cheng JQ, Trougakos I, Wei S, Djeu JY.

Mol Cancer Ther. 2010 Jun;9(6):1831-41. doi: 10.1158/1535-7163.MCT-09-0880. Epub 2010 May 25.


A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.

Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, Lawrence N, Sebti SM, Chellappan S.

Cancer Res. 2008 May 15;68(10):3810-8. doi: 10.1158/0008-5472.CAN-07-6672.


New Lewis-basic N-oxides as chiral organocatalysts in asymmetric allylation of aldehydes.

Malkov AV, Bell M, Orsini M, Pernazza D, Massa A, Herrmann P, Meghani P, Kocovský P.

J Org Chem. 2003 Dec 12;68(25):9659-68.


Synthesis of new chiral 2,2'-bipyridine ligands and their application in copper-catalyzed asymmetric allylic oxidation and cyclopropanation.

Malkov AV, Pernazza D, Bell M, Bella M, Massa A, Teplý F, Meghani P, Kocovský P.

J Org Chem. 2003 Jun 13;68(12):4727-42.


Chiral 2,2'-bipyridine-type N-monoxides as organocatalysts in the enantioselective allylation of aldehydes with allyltrichlorosilane.

Malkov AV, Orsini M, Pernazza D, Muir KW, Langer V, Meghani P, Kocovský P.

Org Lett. 2002 Mar 21;4(6):1047-9.


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