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Items: 15


A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies.

Liu SH, Gu Y, Pascual B, Yan Z, Hallin M, Zhang C, Fan C, Wang W, Lam J, Spilker ME, Yafawi R, Blasi E, Simmons B, Huser N, Ho WH, Lindquist K, Tran TT, Kudaravalli J, Ma JT, Jimenez G, Barman I, Brown C, Chin SM, Costa MJ, Shelton D, Smeal T, Fantin VR, Pernasetti F.

Blood Adv. 2017 Jun 21;1(15):1088-1100. doi: 10.1182/bloodadvances.2016003921. eCollection 2017 Jun 27.


Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143).

Zhang Y, Saavedra E, Tang R, Gu Y, Lappin P, Trajkovic D, Liu SH, Smeal T, Fantin V, De Botton S, Legrand O, Delhommeau F, Pernasetti F, Louache F.

Sci Rep. 2017 Aug 4;7(1):7305. doi: 10.1038/s41598-017-07848-8.


Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia.

Kashyap MK, Amaya-Chanaga CI, Kumar D, Simmons B, Huser N, Gu Y, Hallin M, Lindquist K, Yafawi R, Choi MY, Amine AA, Rassenti LZ, Zhang C, Liu SH, Smeal T, Fantin VR, Kipps TJ, Pernasetti F, Castro JE.

J Hematol Oncol. 2017 May 19;10(1):112. doi: 10.1186/s13045-017-0435-x.


Targeting of humanized antibody D93 to sites of angiogenesis and tumor growth by binding to multiple epitopes on denatured collagens.

Freimark B, Clark D, Pernasetti F, Nickel J, Myszka D, Baeuerle PA, Van Epps D.

Mol Immunol. 2007 Jul;44(15):3741-50. Epub 2007 May 15.


Novel anti-denatured collagen humanized antibody D93 inhibits angiogenesis and tumor growth: An extracellular matrix-based therapeutic approach.

Pernasetti F, Nickel J, Clark D, Baeuerle PA, Van Epps D, Freimark B.

Int J Oncol. 2006 Dec;29(6):1371-9.


Expression of functional Anopheles merus alpha-amylase in the baculovirus/Spodoptera frugiperda system.

Chimoy Effio P, Folgueras-Flatschart AV, Montor WR, Pernasetti FM, Pueyo MT, Sogayar MC.

Insect Mol Biol. 2003 Oct;12(5):415-25. Erratum in: Insect Mol Biol. 2003 Dec;12(6):659. Effio, P C [corrected to Chimoy Effio, P].


Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice.

Pernasetti F, Spady TJ, Hall SB, Rosenberg SB, Givens ML, Anderson S, Paulus M, Miller WL, Mellon PL.

Mol Cell Endocrinol. 2003 May 30;203(1-2):169-83.


A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty.

Arroyo A, Pernasetti F, Vasilyev VV, Amato P, Yen SS, Mellon PL.

Clin Endocrinol (Oxf). 2002 Aug;57(2):283-91.


Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways.

Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL.

Endocrinology. 2002 May;143(5):1651-9.


Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model.

Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL.

Endocrinology. 2001 Jun;142(6):2284-95.


Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene.

Pernasetti F, Toledo SP, Vasilyev VV, Hayashida CY, Cogan JD, Ferrari C, Louren├žo DM Jr, Mellon PL.

J Clin Endocrinol Metab. 2000 Jan;85(1):390-7.


Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency.

Pernasetti F, Milner RD, al Ashwal AA, de Zegher F, Chavez VM, Muller M, Martial JA.

J Clin Endocrinol Metab. 1998 Jun;83(6):2079-83.


Thyroid hormone inhibits the human prolactin gene promoter by interfering with activating protein-1 and estrogen stimulations.

Pernasetti F, Caccavelli L, Van de Weerdt C, Martial JA, Muller M.

Mol Endocrinol. 1997 Jun;11(7):986-96.


The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.

de Zegher F, Pernasetti F, Vanhole C, Devlieger H, Van den Berghe G, Martial JA.

J Clin Endocrinol Metab. 1995 Nov;80(11):3127-30.


Cloning of a human GHF-1/Pit-1 cDNA variant.

Pernasetti F, Wera S, Belayew A, Martial JA.

Nucleic Acids Res. 1993 Jul 25;21(15):3584. No abstract available.

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