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Items: 43


Flow Arrest in the Plasma Membrane.

Chein M, Perlson E, Roichman Y.

Biophys J. 2019 Sep 3;117(5):810-816. doi: 10.1016/j.bpj.2019.07.001. Epub 2019 Jul 5.


Single-Particle Diffusion Characterization by Deep Learning.

Granik N, Weiss LE, Nehme E, Levin M, Chein M, Perlson E, Roichman Y, Shechtman Y.

Biophys J. 2019 Jul 23;117(2):185-192. doi: 10.1016/j.bpj.2019.06.015. Epub 2019 Jun 22.


Efficient gene transfer into primary muscle cells to analyze nerve-independent postsynaptic organization in vitro.

Mella J, Pérez V, Zelada D, Moreno N, Ionescu A, Perlson E, Henríquez JP.

Neuromuscul Disord. 2019 Jul;29(7):533-542. doi: 10.1016/j.nmd.2019.05.005. Epub 2019 May 22.


Patient-derived co-cultures for studying ALS.

Ionescu A, Perlson E.

Nat Biomed Eng. 2019 Jan;3(1):13-14. doi: 10.1038/s41551-018-0333-8. No abstract available.


Structural Principles in Robo Activation and Auto-inhibition.

Barak R, Yom-Tov G, Guez-Haddad J, Gasri-Plotnitsky L, Maimon R, Cohen-Berkman M, McCarthy AA, Perlson E, Henis-Korenblit S, Isupov MN, Opatowsky Y.

Cell. 2019 Apr 4;177(2):272-285.e16. doi: 10.1016/j.cell.2019.02.004. Epub 2019 Mar 7.


Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.

Ionescu A, Gradus T, Altman T, Maimon R, Saraf Avraham N, Geva M, Hayden M, Perlson E.

Cell Death Dis. 2019 Mar 1;10(3):210. doi: 10.1038/s41419-019-1451-2.


Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis.

Maimon R, Perlson E.

Neural Regen Res. 2019 Jun;14(6):969-970. doi: 10.4103/1673-5374.250571. No abstract available.


Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS.

Gershoni-Emek N, Altman T, Ionescu A, Costa CJ, Gradus-Pery T, Willis DE, Perlson E.

Front Mol Neurosci. 2018 Sep 5;11:311. doi: 10.3389/fnmol.2018.00311. eCollection 2018.


Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1.

Pathak A, Stanley EM, Hickman FE, Wallace N, Brewer B, Li D, Gluska S, Perlson E, Fuhrmann S, Akassoglou K, Bronfman F, Casaccia P, Burnette DT, Carter BD.

Dev Cell. 2018 Aug 6;46(3):376-387.e7. doi: 10.1016/j.devcel.2018.07.001.


miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.

Maimon R, Ionescu A, Bonnie A, Sweetat S, Wald-Altman S, Inbar S, Gradus T, Trotti D, Weil M, Behar O, Perlson E.

J Neurosci. 2018 Jun 13;38(24):5478-5494. doi: 10.1523/JNEUROSCI.3037-17.2018. Epub 2018 May 17.


The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane.

Zahavi EE, Steinberg N, Altman T, Chein M, Joshi Y, Gradus-Pery T, Perlson E.

Sci Signal. 2018 May 8;11(529). pii: eaao4006. doi: 10.1126/scisignal.aao4006.


High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria.

Yardeni T, Fine R, Joshi Y, Gradus-Pery T, Kozer N, Reichenstein I, Yanowski E, Nevo S, Weiss-Tishler H, Eisenberg-Bord M, Shalit T, Plotnikov A, Barr HM, Perlson E, Hornstein E.

Sci Rep. 2018 Jan 8;8(1):59. doi: 10.1038/s41598-017-17878-x.


Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.

Naftelberg S, Ast G, Perlson E.

Neural Regen Res. 2017 Apr;12(4):534-537. doi: 10.4103/1673-5374.205082. Review.


Spatial-specific functions in retrograde neuronal signalling.

Zahavi EE, Maimon R, Perlson E.

Traffic. 2017 Jul;18(7):415-424. doi: 10.1111/tra.12487. Epub 2017 May 18. Review.


ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Rotem N, Magen I, Ionescu A, Gershoni-Emek N, Altman T, Costa CJ, Gradus T, Pasmanik-Chor M, Willis DE, Ben-Dov IZ, Hornstein E, Perlson E.

Sci Rep. 2017 Mar 16;7:44500. doi: 10.1038/srep44500.


Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.

Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G.

PLoS Genet. 2016 Dec 20;12(12):e1006486. doi: 10.1371/journal.pgen.1006486. eCollection 2016 Dec.


Tracking Quantum-Dot labeled neurotropic factors transport along primary neuronal axons in compartmental microfluidic chambers.

Gluska S, Chein M, Rotem N, Ionescu A, Perlson E.

Methods Cell Biol. 2016;131:365-87. doi: 10.1016/bs.mcb.2015.06.016. Epub 2015 Sep 2.


Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance.

Ionescu A, Zahavi EE, Gradus T, Ben-Yaakov K, Perlson E.

Eur J Cell Biol. 2016 Feb;95(2):69-88. doi: 10.1016/j.ejcb.2015.11.004. Epub 2015 Nov 30.


Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?

Moya-Alvarado G, Gershoni-Emek N, Perlson E, Bronfman FC.

Mol Cell Proteomics. 2016 Feb;15(2):409-25. doi: 10.1074/mcp.R115.053330. Epub 2015 Dec 11. Review.


Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.

Gershoni-Emek N, Mazza A, Chein M, Gradus-Pery T, Xiang X, Li KW, Sharan R, Perlson E.

Mol Cell Proteomics. 2016 Feb;15(2):506-22. doi: 10.1074/mcp.M115.049965. Epub 2015 Nov 23.


Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling.

Bornstein B, Zahavi EE, Gelley S, Zoosman M, Yaniv SP, Fuchs O, Porat Z, Perlson E, Schuldiner O.

Neuron. 2015 Dec 2;88(5):926-940. doi: 10.1016/j.neuron.2015.10.023. Epub 2015 Nov 12.


Receptor-mediated increase in rabies virus axonal transport.

Gluska S, Finke S, Perlson E.

Neural Regen Res. 2015 Jun;10(6):883-4. doi: 10.4103/1673-5374.158337. No abstract available.


A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.

Bauer A, Nolden T, Nemitz S, Perlson E, Finke S.

J Virol. 2015 Sep;89(18):9591-600. doi: 10.1128/JVI.01298-15. Epub 2015 Jul 8.


Amyotrophic lateral sclerosis as a spatiotemporal mislocalization disease: location, location, location.

Gershoni-Emek N, Chein M, Gluska S, Perlson E.

Int Rev Cell Mol Biol. 2015;315:23-71. doi: 10.1016/bs.ircmb.2014.11.003. Epub 2015 Feb 7. Review.


A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions.

Zahavi EE, Ionescu A, Gluska S, Gradus T, Ben-Yaakov K, Perlson E.

J Cell Sci. 2015 Mar 15;128(6):1241-52. doi: 10.1242/jcs.167544. Epub 2015 Jan 27.


Transplanted modified muscle progenitor cells expressing a mixture of neurotrophic factors delay disease onset and enhance survival in the SOD1 mouse model of ALS.

Dadon-Nachum M, Ben-Yaacov K, Ben-Zur T, Barhum Y, Yaffe D, Perlson E, Offen D.

J Mol Neurosci. 2015 Mar;55(3):788-97. doi: 10.1007/s12031-014-0426-0. Epub 2014 Oct 21.


Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.

Bauer A, Nolden T, Schröter J, Römer-Oberdörfer A, Gluska S, Perlson E, Finke S.

J Virol. 2014 Dec;88(24):14172-83. doi: 10.1128/JVI.02254-14. Epub 2014 Oct 1.


Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery.

Gluska S, Zahavi EE, Chein M, Gradus T, Bauer A, Finke S, Perlson E.

PLoS Pathog. 2014 Aug 28;10(8):e1004348. doi: 10.1371/journal.ppat.1004348. eCollection 2014 Aug.


Real-time sensing of enteropathogenic E. coli-induced effects on epithelial host cell height, cell-substrate interactions, and endocytic processes by infrared surface plasmon spectroscopy.

Yashunsky V, Kharilker L, Zlotkin-Rivkin E, Rund D, Melamed-Book N, Zahavi EE, Perlson E, Mercone S, Golosovsky M, Davidov D, Aroeti B.

PLoS One. 2013 Oct 23;8(10):e78431. doi: 10.1371/journal.pone.0078431. eCollection 2013.


Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.

Castle MJ, Perlson E, Holzbaur EL, Wolfe JH.

Mol Ther. 2014 Mar;22(3):554-566. doi: 10.1038/mt.2013.237. Epub 2013 Oct 8.


Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.

Perlson E, Hendricks AG, Lazarus JE, Ben-Yaakov K, Gradus T, Tokito M, Holzbaur EL.

J Biol Chem. 2013 Sep 27;288(39):27812-24. doi: 10.1074/jbc.M113.465088. Epub 2013 Aug 19.


Characterization of human sporadic ALS biomarkers in the familial ALS transgenic mSOD1(G93A) mouse model.

Lilo E, Wald-Altman S, Solmesky LJ, Ben Yaakov K, Gershoni-Emek N, Bulvik S, Kassis I, Karussis D, Perlson E, Weil M.

Hum Mol Genet. 2013 Dec 1;22(23):4720-5. doi: 10.1093/hmg/ddt325. Epub 2013 Jul 7.


Dynein tethers and stabilizes dynamic microtubule plus ends.

Hendricks AG, Lazarus JE, Perlson E, Gardner MK, Odde DJ, Goldman YE, Holzbaur EL.

Curr Biol. 2012 Apr 10;22(7):632-7. doi: 10.1016/j.cub.2012.02.023. Epub 2012 Mar 22.


Retrograde axonal transport: pathways to cell death?

Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL.

Trends Neurosci. 2010 Jul;33(7):335-44. doi: 10.1016/j.tins.2010.03.006. Epub 2010 Apr 29. Review.


Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport.

Hendricks AG, Perlson E, Ross JL, Schroeder HW 3rd, Tokito M, Holzbaur EL.

Curr Biol. 2010 Apr 27;20(8):697-702. doi: 10.1016/j.cub.2010.02.058. Epub 2010 Apr 15.


A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration.

Perlson E, Jeong GB, Ross JL, Dixit R, Wallace KE, Kalb RG, Holzbaur EL.

J Neurosci. 2009 Aug 5;29(31):9903-17. doi: 10.1523/JNEUROSCI.0813-09.2009.


Myosin learns to recruit AMPA receptors.

Perlson E, Holzbaur EL.

Cell. 2008 Oct 31;135(3):414-5. doi: 10.1016/j.cell.2008.10.013.


Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase.

Perlson E, Michaelevski I, Kowalsman N, Ben-Yaakov K, Shaked M, Seger R, Eisenstein M, Fainzilber M.

J Mol Biol. 2006 Dec 15;364(5):938-44. Epub 2006 Sep 27.


Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve.

Perlson E, Hanz S, Ben-Yaakov K, Segal-Ruder Y, Seger R, Fainzilber M.

Neuron. 2005 Mar 3;45(5):715-26.


Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury.

Perlson E, Medzihradszky KF, Darula Z, Munno DW, Syed NI, Burlingame AL, Fainzilber M.

Mol Cell Proteomics. 2004 May;3(5):510-20. Epub 2004 Feb 18.


O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes.

Medzihradszky KF, Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL.

Mol Cell Proteomics. 2004 May;3(5):429-40. Epub 2004 Jan 29.


From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons.

Perlson E, Hanz S, Medzihradszky KF, Burlingame AL, Fainzilber M.

J Neurobiol. 2004 Feb 5;58(2):287-94.


Axoplasmic importins enable retrograde injury signaling in lesioned nerve.

Hanz S, Perlson E, Willis D, Zheng JQ, Massarwa R, Huerta JJ, Koltzenburg M, Kohler M, van-Minnen J, Twiss JL, Fainzilber M.

Neuron. 2003 Dec 18;40(6):1095-104.

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