Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 93

1.

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM.

Nat Commun. 2019 Aug 14;10(1):3669. doi: 10.1038/s41467-019-11558-2.

2.

A serum protein signature of APOE genotypes in centenarians.

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT.

Aging Cell. 2019 Aug 5:e13023. doi: 10.1111/acel.13023. [Epub ahead of print]

3.

PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects.

Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P.

Bioinformatics. 2019 Sep 1;35(17):3046-3054. doi: 10.1093/bioinformatics/btz017.

PMID:
30624692
4.

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE.

Am J Hum Genet. 2019 Jan 3;104(1):112-138. doi: 10.1016/j.ajhg.2018.12.001. Epub 2018 Dec 27.

5.

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1472-1481. doi: 10.1093/gerona/gly057.

6.

APOE Alleles and Extreme Human Longevity.

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. doi: 10.1093/gerona/gly174.

7.

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):108-113. doi: 10.1093/gerona/gly141.

8.

Assortative Mating by Ethnicity in Longevous Families.

Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT.

Front Genet. 2017 Nov 21;8:186. doi: 10.3389/fgene.2017.00186. eCollection 2017.

9.

Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.

Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1439-1447. doi: 10.1093/gerona/glx124.

10.

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, McDaid AF, Porteous D, Winkler TW, Salvi E, Shrine N, Liu X, Ang WQ, Zhang W, Feitosa MF, Venturini C, van der Most PJ, Rosengren A, Wood AR, Beaumont RN, Jones SE, Ruth KS, Yaghootkar H, Tyrrell J, Havulinna AS, Boers H, Mägi R, Kriebel J, Müller-Nurasyid M, Perola M, Nieminen M, Lokki ML, Kähönen M, Viikari JS, Geller F, Lahti J, Palotie A, Koponen P, Lundqvist A, Rissanen H, Bottinger EP, Afaq S, Wojczynski MK, Lenzini P, Nolte IM, Sparsø T, Schupf N, Christensen K, Perls TT, Newman AB, Werge T, Snieder H, Spector TD, Chambers JC, Koskinen S, Melbye M, Raitakari OT, Lehtimäki T, Tobin MD, Wain LV, Sinisalo J, Peters A, Meitinger T, Martin NG, Wray NR, Montgomery GW, Medland SE, Swertz MA, Vartiainen E, Borodulin K, Männistö S, Murray A, Bochud M, Jacquemont S, Rivadeneira F, Hansen TF, Oldehinkel AJ, Mangino M, Province MA, Deloukas P, Kooner JS, Freathy RM, Pennell C, Feenstra B, Strachan DP, Lettre G, Hirschhorn J, Cusi D, Heid IM, Hayward C, Männik K, Beckmann JS, Loos RJF, Nyholt DR, Metspalu A, Eriksson JG, Weedon MN, Salomaa V, Franke L, Reymond A, Frayling TM, Kutalik Z.

Nat Commun. 2017 Sep 29;8(1):744. doi: 10.1038/s41467-017-00556-x.

11.

Male Centenarians: How and Why Are They Different from Their Female Counterparts?

Perls TT.

J Am Geriatr Soc. 2017 Sep;65(9):1904-1906. doi: 10.1111/jgs.14978. Epub 2017 Jun 6. No abstract available.

12.

Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1453-1464. doi: 10.1093/gerona/glx027.

13.

Limitations and risks of meta-analyses of longevity studies.

Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT.

Mech Ageing Dev. 2017 Jul;165(Pt B):139-146. doi: 10.1016/j.mad.2017.01.008. Epub 2017 Jan 28. Review.

14.

Biomarker signatures of aging.

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT.

Aging Cell. 2017 Apr;16(2):329-338. doi: 10.1111/acel.12557. Epub 2017 Jan 6.

15.

Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT.

J Am Geriatr Soc. 2016 Nov;64(11):e189-e194. doi: 10.1111/jgs.14522. Epub 2016 Oct 26.

16.

Detection of Significant Groups in Hierarchical Clustering by Resampling.

Sebastiani P, Perls TT.

Front Genet. 2016 Aug 8;7:144. doi: 10.3389/fgene.2016.00144. eCollection 2016.

17.

The Survival of Spouses Marrying Into Longevity-Enriched Families.

Pedersen JK, Elo IT, Schupf N, Perls TT, Stallard E, Yashin AI, Christensen K.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):109-114. Epub 2016 Aug 18.

18.

Testosterone Treatment in Older Men.

Perls TT.

N Engl J Med. 2016 Jul 7;375(1):88. doi: 10.1056/NEJMc1603665. No abstract available.

PMID:
27406355
19.

Learning Bayesian Networks from Correlated Data.

Bae H, Monti S, Montano M, Steinberg MH, Perls TT, Sebastiani P.

Sci Rep. 2016 May 5;6:25156. doi: 10.1038/srep25156.

20.

Familial Risk for Exceptional Longevity.

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT.

N Am Actuar J. 2016 Jan 1;20(1):57-64. Epub 2015 Oct 7.

21.

Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity".

Sebastiani P, Nussbaum L, Andersen SL, Black MJ, Perls TT.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):340-6. doi: 10.1093/gerona/glv020. Epub 2015 Mar 26.

22.

Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.

Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):1003-8. doi: 10.1093/gerona/glv006. Epub 2015 Mar 10.

23.

Are Members of Long-Lived Families Healthier Than Their Equally Long-Lived Peers? Evidence From the Long Life Family Study.

Ash AS, Kroll-Desrosiers AR, Hoaglin DC, Christensen K, Fang H, Perls TT.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):971-6. doi: 10.1093/gerona/glv015. Epub 2015 Mar 5.

24.

An efficient technique for Bayesian modeling of family data using the BUGS software.

Bae HT, Perls TT, Sebastiani P.

Front Genet. 2014 Nov 18;5:390. doi: 10.3389/fgene.2014.00390. eCollection 2014.

25.

Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly.

Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R; Long Life Family Study.

JAMA Neurol. 2014 Dec;71(12):1514-9. doi: 10.1001/jamaneurol.2014.1663.

26.

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SL, Kiel DP, Oostra BA, Orwoll ES, Parimi N, Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM.

J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):110-8. doi: 10.1093/gerona/glu166. Epub 2014 Sep 8.

27.

Extended maternal age at birth of last child and women's longevity in the Long Life Family Study.

Sun F, Sebastiani P, Schupf N, Bae H, Andersen SL, McIntosh A, Abel H, Elo IT, Perls TT.

Menopause. 2015 Jan;22(1):26-31. doi: 10.1097/GME.0000000000000276.

28.

An oral health study of centenarians and children of centenarians.

Kaufman LB, Setiono TK, Doros G, Andersen S, Silliman RA, Friedman PK, Perls TT.

J Am Geriatr Soc. 2014 Jun;62(6):1168-73. doi: 10.1111/jgs.12842. Epub 2014 Jun 2.

29.

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).

An P, Miljkovic I, Thyagarajan B, Kraja AT, Daw EW, Pankow JS, Selvin E, Kao WH, Maruthur NM, Nalls MA, Liu Y, Harris TB, Lee JH, Borecki IB, Christensen K, Eckfeldt JH, Mayeux R, Perls TT, Newman AB, Province MA.

Metabolism. 2014 Apr;63(4):461-8. doi: 10.1016/j.metabol.2013.11.018. Epub 2013 Dec 4.

30.

Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study.

Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT.

Front Public Health. 2013 Sep 30;1:38. doi: 10.3389/fpubh.2013.00038. eCollection 2013.

31.

Meta‐analysis of genetic variants associated with human exceptional longevity.

Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT.

Aging (Albany NY). 2013 Sep;5(9):653-61.

32.

Exceptional memory performance in the Long Life Family Study.

Barral S, Cosentino S, Costa R, Andersen SL, Christensen K, Eckfeldt JH, Newman AB, Perls TT, Province MA, Hadley EC, Rossi WK, Mayeux R; Long Life Family Study.

Neurobiol Aging. 2013 Nov;34(11):2445-8. doi: 10.1016/j.neurobiolaging.2013.05.002. Epub 2013 Jun 4.

33.

Genome-wide association study of personality traits in the long life family study.

Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT.

Front Genet. 2013 May 8;4:65. doi: 10.3389/fgene.2013.00065. eCollection 2013.

34.

Personality factors in the Long Life Family Study.

Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT.

J Gerontol B Psychol Sci Soc Sci. 2013 Sep;68(5):739-49. doi: 10.1093/geronb/gbs117. Epub 2012 Dec 28.

35.

The genetics of extreme longevity: lessons from the new England centenarian study.

Sebastiani P, Perls TT.

Front Genet. 2012 Nov 30;3:277. doi: 10.3389/fgene.2012.00277. eCollection 2012.

36.

Human longevity and common variations in the LMNA gene: a meta-analysis.

Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS.

Aging Cell. 2012 Jun;11(3):475-81. doi: 10.1111/j.1474-9726.2012.00808.x. Epub 2012 Mar 27.

37.

Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.

Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls TT.

Front Genet. 2012 Jan 3;2:90. doi: 10.3389/fgene.2011.00090. eCollection 2011.

38.

Genetic signatures of exceptional longevity in humans.

Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT.

PLoS One. 2012;7(1):e29848. doi: 10.1371/journal.pone.0029848. Epub 2012 Jan 18.

39.

Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span.

Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT.

J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):395-405. doi: 10.1093/gerona/glr223. Epub 2012 Jan 4.

40.

Retraction.

Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT.

Science. 2011 Jul 22;333(6041):404. doi: 10.1126/science.333.6041.404-a. No abstract available.

PMID:
21778381
41.

Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits.

Kulminski AM, Arbeev KG, Christensen K, Mayeux R, Newman AB, Province MA, Hadley EC, Rossi W, Perls TT, Elo IT, Yashin AI.

Mech Ageing Dev. 2011 Apr;132(4):195-201. doi: 10.1016/j.mad.2011.03.006. Epub 2011 Apr 2.

42.

Health and function of participants in the Long Life Family Study: A comparison with other cohorts.

Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E.

Aging (Albany NY). 2011 Jan;3(1):63-76.

43.

Clustering by genetic ancestry using genome-wide SNP data.

Solovieff N, Hartley SW, Baldwin CT, Perls TT, Steinberg MH, Sebastiani P.

BMC Genet. 2010 Dec 9;11:108. doi: 10.1186/1471-2156-11-108.

44.

Genetic signatures of exceptional longevity in humans.

Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT.

Science. 2010 Jul 1;2010. doi: 10.1126/science.1190532. Epub 2010 Jul 1. Retraction in: Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Science. 2011 Jul 22;333(6041):404.

PMID:
20595579
45.

Growth hormone and anabolic steroids: athletes are the tip of the iceberg.

Perls TT.

Drug Test Anal. 2009 Sep;1(9-10):419-25. doi: 10.1002/dta.87.

PMID:
20355224
46.

Prediction models that include genetic data.

Sebastiani P, Perls TT.

Circ Cardiovasc Genet. 2010 Feb;3(1):1-2. doi: 10.1161/CIRCGENETICS.110.937862. No abstract available.

47.

Typologies of extreme longevity myths.

Young RD, Desjardins B, McLaughlin K, Poulain M, Perls TT.

Curr Gerontol Geriatr Res. 2010;2010:423087. doi: 10.1155/2010/423087. Epub 2011 Mar 15.

48.

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT.

PLoS One. 2009 Dec 14;4(12):e8210. doi: 10.1371/journal.pone.0008210. Erratum in: PLoS One. 2009;4(12) doi: 10.1371/annotation/387f8074-5f80-4bdd-bb0b-b36d49a16ac0.

49.

A family longevity selection score: ranking sibships by their longevity, size, and availability for study.

Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS.

Am J Epidemiol. 2009 Dec 15;170(12):1555-62. doi: 10.1093/aje/kwp309. Epub 2009 Nov 12.

50.

Genome-wide association studies and the genetic dissection of complex traits.

Sebastiani P, Timofeev N, Dworkis DA, Perls TT, Steinberg MH.

Am J Hematol. 2009 Aug;84(8):504-15. doi: 10.1002/ajh.21440. Review.

Supplemental Content

Loading ...
Support Center