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Items: 1 to 50 of 51

1.

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Perissinotti L, Guo J, Kudaibergenova M, Lees-Miller J, Ol'khovich M, Sharapova A, Perlovich GL, Muruve DA, Gerull B, Noskov SY, Duff HJ.

Mol Pharmacol. 2019 Aug;96(2):259-271. doi: 10.1124/mol.118.115642. Epub 2019 Jun 10.

PMID:
31182542
2.

Crystal structure of a 1:1 salt of 4-amino-benzoic acid (vitamin B10) with pyrazinoic acid.

Drozd KV, Arkhipov SG, Boldyreva EV, Perlovich GL.

Acta Crystallogr E Crystallogr Commun. 2018 Nov 30;74(Pt 12):1923-1927. doi: 10.1107/S2056989018016663. eCollection 2018 Dec 1.

3.

Sublimation thermodynamics aspects of adamantane and memantine derivatives of sulfonamide molecular crystals.

Perlovich GL, Volkova TV.

Phys Chem Chem Phys. 2018 Aug 1;20(30):19784-19791. doi: 10.1039/c8cp03716g.

PMID:
30019053
4.

Pharmaceutical salts of emoxypine with dicarboxylic acids.

Manin AN, Voronin AP, Drozd KV, Churakov AV, Perlovich GL.

Acta Crystallogr C Struct Chem. 2018 Jul 1;74(Pt 7):797-806. doi: 10.1107/S2053229618007386. Epub 2018 Jun 5.

PMID:
29973419
5.

Cocrystals of a 1,2,4-thiadiazole-based potent neuroprotector with gallic acid: solubility, thermodynamic stability relationships and formation pathways.

Surov AO, Churakov AV, Proshin AN, Dai XL, Lu T, Perlovich GL.

Phys Chem Chem Phys. 2018 May 30;20(21):14469-14481. doi: 10.1039/c8cp02532k.

PMID:
29786712
6.

Understanding of Relationship between Phospholipid Membrane Permeability and Self-Diffusion Coefficients of Some Drugs and Biologically Active Compounds in Model Solvents.

Blokhina SV, Volkova TV, Golubev VA, Perlovich GL.

Mol Pharm. 2017 Oct 2;14(10):3381-3390. doi: 10.1021/acs.molpharmaceut.7b00401. Epub 2017 Sep 8.

PMID:
28850240
7.

Cocrystal formation, crystal structure, solubility and permeability studies for novel 1,2,4-thiadiazole derivative as a potent neuroprotector.

Surov AO, Volkova TV, Churakov AV, Proshin AN, Terekhova IV, Perlovich GL.

Eur J Pharm Sci. 2017 Nov 15;109:31-39. doi: 10.1016/j.ejps.2017.07.025. Epub 2017 Jul 26.

PMID:
28756204
8.

Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies.

Drozd KV, Manin AN, Churakov AV, Perlovich GL.

Eur J Pharm Sci. 2017 Mar 1;99:228-239. doi: 10.1016/j.ejps.2016.12.016. Epub 2016 Dec 20.

PMID:
28011126
9.

Towards the rational design of novel drugs based on solubility, partitioning/distribution, biomimetic permeability and biological activity exemplified by 1,2,4-thiadiazole derivatives.

Volkova TV, Terekhova IV, Silyukov OI, Proshin AN, Bauer-Brandl A, Perlovich GL.

Medchemcomm. 2016 Oct 28;8(1):162-175. doi: 10.1039/c6md00545d. eCollection 2017 Jan 1.

10.

Solubility, lipophilicity and membrane permeability of some fluoroquinolone antimicrobials.

Blokhina SV, Sharapova AV, Ol'khovich MV, Volkova ТV, Perlovich GL.

Eur J Pharm Sci. 2016 Oct 10;93:29-37. doi: 10.1016/j.ejps.2016.07.016. Epub 2016 Jul 26.

PMID:
27473309
11.

Adamantane derivatives of sulfonamides: sublimation, solubility, solvation and transfer processes in biologically relevant solvents.

Perlovich GL, Volkova TV, Sharapova AV, Kazachenko VP, Strakhova NN, Proshin AN.

Phys Chem Chem Phys. 2016 Apr 7;18(13):9281-94. doi: 10.1039/c6cp00379f. Epub 2016 Mar 15.

PMID:
26976747
12.

New Solid Forms of the Antiviral Drug Arbidol: Crystal Structures, Thermodynamic Stability, and Solubility.

Surov AO, Manin AN, Churakov AV, Perlovich GL.

Mol Pharm. 2015 Nov 2;12(11):4154-65. doi: 10.1021/acs.molpharmaceut.5b00629. Epub 2015 Oct 19.

PMID:
26479207
13.

Influence of Secondary Interactions on the Structure, Sublimation Thermodynamics, and Solubility of Salicylate:4-Hydroxybenzamide Cocrystals. Combined Experimental and Theoretical Study.

Manin AN, Voronin AP, Shishkina AV, Vener MV, Churakov AV, Perlovich GL.

J Phys Chem B. 2015 Aug 20;119(33):10466-77. doi: 10.1021/acs.jpcb.5b05082. Epub 2015 Aug 10.

PMID:
26258951
14.

The impact of structural modification of 1,2,4-thiadiazole derivatives on thermodynamics of solubility and hydration processes.

Surov AO, Bui CT, Volkova TV, Proshin AN, Perlovich GL.

Phys Chem Chem Phys. 2015 Aug 28;17(32):20889-96. doi: 10.1039/c5cp03263f. Epub 2015 Jul 27.

PMID:
26214375
15.

Pharmaceutical salts of ciprofloxacin with dicarboxylic acids.

Surov AO, Manin AN, Voronin AP, Drozd KV, Simagina AA, Churakov AV, Perlovich GL.

Eur J Pharm Sci. 2015 Sep 18;77:112-21. doi: 10.1016/j.ejps.2015.06.004. Epub 2015 Jun 9.

PMID:
26066411
16.

Cocrystal screening of hydroxybenzamides with benzoic acid derivatives: a comparative study of thermal and solution-based methods.

Manin AN, Voronin AP, Drozd KV, Manin NG, Bauer-Brandl A, Perlovich GL.

Eur J Pharm Sci. 2014 Dec 18;65:56-64. doi: 10.1016/j.ejps.2014.09.003. Epub 2014 Sep 16.

PMID:
25218047
17.

Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline.

Surov AO, Voronin AP, Manin AN, Manin NG, Kuzmina LG, Churakov AV, Perlovich GL.

Mol Pharm. 2014 Oct 6;11(10):3707-15. doi: 10.1021/mp5004652. Epub 2014 Sep 11.

PMID:
25184906
18.

Salicylamide cocrystals: screening, crystal structure, sublimation thermodynamics, dissolution, and solid-state DFT calculations.

Manin AN, Voronin AP, Manin NG, Vener MV, Shishkina AV, Lermontov AS, Perlovich GL.

J Phys Chem B. 2014 Jun 19;118(24):6803-14. doi: 10.1021/jp5032898. Epub 2014 Jun 5.

PMID:
24861612
19.

Synthesis, biological activity, distribution and membrane permeability of novel spiro-thiazines as potent neuroprotectors.

Blokhina SV, Volkova TV, Ol'khovich MV, Sharapova AV, Proshin AN, Bachurin SO, Perlovich GL.

Eur J Med Chem. 2014 Apr 22;77:8-17. doi: 10.1016/j.ejmech.2014.02.052. Epub 2014 Feb 21.

PMID:
24607585
20.

Crystal structure analysis and sublimation thermodynamics of bicyclo derivatives of a neuroprotector family.

Surov AO, Proshin AN, Perlovich GL.

Acta Crystallogr B Struct Sci Cryst Eng Mater. 2014 Feb;70(Pt 1):47-53. doi: 10.1107/S2052520613024384. Epub 2013 Dec 10.

PMID:
24441127
21.

Thermodynamic approaches to the challenges of solubility in drug discovery and development.

Perlovich GL.

Mol Pharm. 2014 Jan 6;11(1):1-11. doi: 10.1021/mp400460r. Epub 2013 Dec 9.

PMID:
24313553
22.

Novel 1,2,4-thiadiazole derivatives: crystal structure, conformational analysis, hydrogen bond networks, calculations, and thermodynamic characteristics of crystal lattices.

Surov AO, Bui CT, Proshin AN, Roussel P, Idrissi A, Perlovich GL.

J Phys Chem B. 2013 Sep 12;117(36):10414-29. doi: 10.1021/jp405624e. Epub 2013 Aug 30.

PMID:
23957723
23.

Felodipine-diazabicyclo[2.2.2]octane-water (1/1/1).

Solanko KA, Surov AO, Perlovich GL, Bauer-Brandl A, Bond AD.

Acta Crystallogr C. 2012 Nov;68(Pt 11):o456-8. doi: 10.1107/S0108270112043405. Epub 2012 Oct 31.

PMID:
23124462
24.

Novel 1,2,4-thiadiazole derivatives as potent neuroprotectors: approach to creation of bioavailable drugs.

Perlovich GL, Proshin AN, Volkova TV, Petrova LN, Bachurin SO.

Mol Pharm. 2012 Aug 6;9(8):2156-67. doi: 10.1021/mp300011r. Epub 2012 Mar 6.

PMID:
22352779
25.

Thermodynamic and structural aspects of novel 1,2,4-thiadiazoles in solid and biological mediums.

Perlovich GL, Proshin AN, Volkova TV, Bui CT, Bachurin SO.

Mol Pharm. 2011 Oct 3;8(5):1807-20. doi: 10.1021/mp2003237. Epub 2011 Aug 10.

PMID:
21800877
26.

Thermodynamic aspects of solubility process of some sulfonamides.

Perlovich GL, Ryzhakov AM, Strakhova NN, Kazachenko VP, Schaper KJ, Raevsky OA.

J Pharm Biomed Anal. 2011 Jan 5;54(1):222-4. doi: 10.1016/j.jpba.2010.07.039. Epub 2010 Aug 6.

PMID:
20801596
27.

Synthesis, pharmacology, crystal properties, and quantitative solvation studies from a drug transport perspective for three new 1,2,4-thiadiazoles.

Perlovich GL, Volkova TV, Proshin AN, Sergeev DY, Bui CT, Petrova LN, Bachurin SO.

J Pharm Sci. 2010 Sep;99(9):3754-68. doi: 10.1002/jps.22143.

PMID:
20665841
28.

Thermodynamic and structural study of tolfenamic acid polymorphs.

Surov AO, Szterner P, Zielenkiewicz W, Perlovich GL.

J Pharm Biomed Anal. 2009 Dec 5;50(5):831-40. doi: 10.1016/j.jpba.2009.06.045. Epub 2009 Jul 2.

PMID:
19632801
29.

Thermodynamic and structural aspects of sulfonamide crystals and solutions.

Perlovich GL, Tkachev VV, Strakhova NN, Kazachenko VP, Volkova TV, Surov OV, Schaper KJ, Raevsky OA.

J Pharm Sci. 2009 Dec;98(12):4738-55. doi: 10.1002/jps.21784.

PMID:
19408296
30.

Novel isothiourea derivatives as potent neuroprotectors and cognition enhancers: synthesis, biological and physicochemical properties.

Perlovich GL, Proshin AN, Volkova TV, Kurkov SV, Grigoriev VV, Petrova LN, Bachurin SO.

J Med Chem. 2009 Apr 9;52(7):1845-52. doi: 10.1021/jm8012882.

PMID:
19338354
31.

Influence of position and size of substituents on the mechanism of partitioning: a thermodynamic study on acetaminophens, hydroxybenzoic acids, and parabens.

Perlovich GL, Volkova TV, Manin AN, Bauer-Brandl A.

AAPS PharmSciTech. 2008;9(1):205-16. doi: 10.1208/s12249-008-9033-0. Epub 2008 Feb 5.

32.

Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: sublimation, solution and solvation of biphenyl substituted drugs.

Kurkov SV, Perlovich GL.

Int J Pharm. 2008 Jun 5;357(1-2):100-7. doi: 10.1016/j.ijpharm.2008.01.059. Epub 2008 Feb 9.

PMID:
18343061
33.

Extent and mechanism of solvation and partitioning of isomers of substituted benzoic acids: a thermodynamic study in the solid state and in solution.

Perlovich GL, Volkova TV, Manin AN, Bauer-Brandl A.

J Pharm Sci. 2008 Sep;97(9):3883-96. doi: 10.1002/jps.21260.

PMID:
18200548
34.

Thermodynamic study of sublimation, solubility, solvation, and distribution processes of atenolol and pindolol.

Perlovich GL, Volkova TV, Bauer-Brandl A.

Mol Pharm. 2007 Nov-Dec;4(6):929-35. Epub 2007 Oct 11.

PMID:
17927262
35.

Sulfonamides as a subject to study molecular interactions in crystals and solutions: sublimation, solubility, solvation, distribution and crystal structure.

Perlovich GL, Strakhova NN, Kazachenko VP, Volkova TV, Tkachev VV, Schaper KJ, Raevsky OA.

Int J Pharm. 2008 Feb 12;349(1-2):300-13. Epub 2007 Aug 2.

PMID:
17913412
36.
37.

Energetic aspects of diclofenac acid in crystal modifications and in solutions--mechanism of solvation, partitioning and distribution.

Perlovich GL, Surov AO, Hansen LK, Bauer-Brandl A.

J Pharm Sci. 2007 May;96(5):1031-42.

PMID:
17455325
38.
39.

Studying thermodynamic aspects of sublimation, solubility and solvation processes and crystal structure analysis of some sulfonamides.

Perlovich GL, Strakhova NN, Kazachenko VP, Volkova TV, Tkachev VV, Schaper KJ, Raevsky OA.

Int J Pharm. 2007 Apr 4;334(1-2):115-24. Epub 2006 Oct 28.

PMID:
17126506
42.

Solvation of drugs as a key for understanding partitioning and passive transport exemplified by NSAIDs.

Perlovich GL, Bauer-Brandl A.

Curr Drug Deliv. 2004 Jul;1(3):213-26. Review.

PMID:
16305385
43.

The difference between partitioning and distribution from a thermodynamic point of view: NSAIDs as an example.

Perlovich GL, Kurkov SV, Bauer-Brandl A.

Eur J Pharm Sci. 2006 Feb;27(2-3):150-7. Epub 2005 Oct 25.

PMID:
16253486
44.

Thermodynamics of solubility, sublimation and solvation processes of parabens.

Perlovich GL, Rodionov SV, Bauer-Brandl A.

Eur J Pharm Sci. 2005 Jan;24(1):25-33.

PMID:
15626575
45.

Solvation and hydration characteristics of ibuprofen and acetylsalicylic acid.

Perlovich GL, Kurkov SV, Kinchin AN, Bauer-Brandl A.

AAPS PharmSci. 2004 Jan 26;6(1):E3.

46.

Thermodynamics of solutions III: comparison of the solvation of (+)-naproxen with other NSAIDs.

Perlovich GL, Kurkov SV, Kinchin AN, Bauer-Brandl A.

Eur J Pharm Biopharm. 2004 Mar;57(2):411-20.

PMID:
15019002
47.

Thermodynamics of sublimation, crystal lattice energies, and crystal structures of racemates and enantiomers: (+)- and (+/-)-ibuprofen.

Perlovich GL, Kurkov SV, Hansen LK, Bauer-Brandl A.

J Pharm Sci. 2004 Mar;93(3):654-66.

PMID:
14762904
48.

Thermodynamics of solutions IV: Solvation of ketoprofen in comparison with other NSAIDs.

Perlovich GL, Kurkov SV, Kinchin AN, Bauer-Brandl A.

J Pharm Sci. 2003 Dec;92(12):2502-11.

PMID:
14603496
49.

Driving forces and the influence of the buffer composition on the complexation reaction between ibuprofen and HPCD.

Perlovich GL, Skar M, Bauer-Brandl A.

Eur J Pharm Sci. 2003 Oct;20(2):197-200.

PMID:
14550885
50.

Thermodynamics of solutions. II. Flurbiprofen and diflunisal as models for studying solvation of drug substances.

Perlovich GL, Kurkov SV, Bauer-Brandl A.

Eur J Pharm Sci. 2003 Aug;19(5):423-32.

PMID:
12907293

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