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Items: 1 to 50 of 108

1.

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.

Tiklová K, Björklund ÅK, Lahti L, Fiorenzano A, Nolbrant S, Gillberg L, Volakakis N, Yokota C, Hilscher MM, Hauling T, Holmström F, Joodmardi E, Nilsson M, Parmar M, Perlmann T.

Nat Commun. 2019 Feb 4;10(1):581. doi: 10.1038/s41467-019-08453-1.

2.

Author Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E, Toskas K, Rraklli V, Tiklova K, Björklund ÅK, Ringnér M, Perlmann T, Holmberg J.

Nat Commun. 2018 Nov 2;9(1):4639. doi: 10.1038/s41467-018-07154-5.

3.

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E, Toskas K, Rraklli V, Tiklova K, Björklund ÅK, Ringnér M, Perlmann T, Holmberg J.

Nat Commun. 2018 Mar 26;9(1):1226. doi: 10.1038/s41467-018-03538-9. Erratum in: Nat Commun. 2018 Nov 2;9(1):4639.

4.

Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.

Green H, Zhang X, Tiklova K, Volakakis N, Brodin L, Berg L, Greengard P, Perlmann T, Svenningsson P.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2735-2740. doi: 10.1073/pnas.1621218114. Epub 2017 Jan 30.

5.

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

Kee N, Volakakis N, Kirkeby A, Dahl L, Storvall H, Nolbrant S, Lahti L, Björklund ÅK, Gillberg L, Joodmardi E, Sandberg R, Parmar M, Perlmann T.

Cell Stem Cell. 2017 Jan 5;20(1):29-40. doi: 10.1016/j.stem.2016.10.003. Epub 2016 Oct 27.

6.

Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Ottosson DR, Lelos MJ, Rifes P, Dunnett SB, Grealish S, Perlmann T, Parmar M.

Cell Stem Cell. 2017 Jan 5;20(1):135-148. doi: 10.1016/j.stem.2016.09.004. Epub 2016 Oct 27.

7.

The stem cell niche finds its true north.

Kirkeby A, Perlmann T, Pereira CF.

Development. 2016 Aug 15;143(16):2877-81. doi: 10.1242/dev.140095. Review.

8.

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.

Doucet-Beaupré H, Gilbert C, Profes MS, Chabrat A, Pacelli C, Giguère N, Rioux V, Charest J, Deng Q, Laguna A, Ericson J, Perlmann T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Lévesque M.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96. doi: 10.1073/pnas.1520387113. Epub 2016 Jul 12.

9.

The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.

Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L.

Development. 2016 Jul 15;143(14):2616-28. doi: 10.1242/dev.130682. Epub 2016 Jun 10.

10.

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T, Simon A.

Sci Rep. 2016 Jun 1;6:26448. doi: 10.1038/srep26448.

11.

Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression.

Volakakis N, Tiklova K, Decressac M, Papathanou M, Mattsson B, Gillberg L, Nobre A, Björklund A, Perlmann T.

J Neurosci. 2015 Oct 21;35(42):14370-85. doi: 10.1523/JNEUROSCI.1155-15.2015.

12.

Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission.

Alvarsson A, Zhang X, Stan TL, Schintu N, Kadkhodaei B, Millan MJ, Perlmann T, Svenningsson P.

J Neurosci. 2015 Oct 14;35(41):14057-69. doi: 10.1523/JNEUROSCI.1312-15.2015.

13.

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gómez-Galán M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T.

Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27.

PMID:
25915474
14.

Function of transcription factors at DNA lesions in DNA repair.

Malewicz M, Perlmann T.

Exp Cell Res. 2014 Nov 15;329(1):94-100. doi: 10.1016/j.yexcr.2014.08.032. Epub 2014 Aug 28. Review.

15.

Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Panman L, Papathanou M, Laguna A, Oosterveen T, Volakakis N, Acampora D, Kurtsdotter I, Yoshitake T, Kehr J, Joodmardi E, Muhr J, Simeone A, Ericson J, Perlmann T.

Cell Rep. 2014 Aug 21;8(4):1018-25. doi: 10.1016/j.celrep.2014.07.016. Epub 2014 Aug 7.

16.

Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells.

Mong J, Panman L, Alekseenko Z, Kee N, Stanton LW, Ericson J, Perlmann T.

Stem Cells. 2014 Mar;32(3):609-22. doi: 10.1002/stem.1585.

17.

NURR1 in Parkinson disease--from pathogenesis to therapeutic potential.

Decressac M, Volakakis N, Björklund A, Perlmann T.

Nat Rev Neurol. 2013 Nov;9(11):629-36. doi: 10.1038/nrneurol.2013.209. Epub 2013 Oct 15. Review.

PMID:
24126627
18.

Detailed expression analysis of regulatory genes in the early developing human neural tube.

Marklund U, Alekseenko Z, Andersson E, Falci S, Westgren M, Perlmann T, Graham A, Sundström E, Ericson J.

Stem Cells Dev. 2014 Jan 1;23(1):5-15. doi: 10.1089/scd.2013.0309. Epub 2013 Oct 8.

19.

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.

Kadkhodaei B, Alvarsson A, Schintu N, Ramsköld D, Volakakis N, Joodmardi E, Yoshitake T, Kehr J, Decressac M, Björklund A, Sandberg R, Svenningsson P, Perlmann T.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2360-5. doi: 10.1073/pnas.1221077110. Epub 2013 Jan 22.

20.

α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.

Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Björklund A.

Sci Transl Med. 2012 Dec 5;4(163):163ra156. doi: 10.1126/scitranslmed.3004676. Erratum in: Sci Transl Med. 2016 Apr 20;8(335):335er4.

21.

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.

Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL.

Development. 2012 Jul;139(14):2625-34. doi: 10.1242/dev.081034. Epub 2012 Jun 13.

22.

Maintaining differentiated cellular identity.

Holmberg J, Perlmann T.

Nat Rev Genet. 2012 May 18;13(6):429-39. doi: 10.1038/nrg3209. Review.

PMID:
22596319
23.

Prenatal immune activation interacts with genetic Nurr1 deficiency in the development of attentional impairments.

Vuillermot S, Joodmardi E, Perlmann T, Ögren SO, Feldon J, Meyer U.

J Neurosci. 2012 Jan 11;32(2):436-51. doi: 10.1523/JNEUROSCI.4831-11.2012.

24.

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.

Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, Leung CY, Chen B, Lewensohn R, van Gent DC, Chen DJ, Perlmann T.

Genes Dev. 2011 Oct 1;25(19):2031-40. doi: 10.1101/gad.16872411.

25.

Tracing lineages to uncover neuronal identity.

Panman L, Perlmann T.

BMC Biol. 2011 Jul 19;9:51. doi: 10.1186/1741-7007-9-51.

26.

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.

Deng Q, Andersson E, Hedlund E, Alekseenko Z, Coppola E, Panman L, Millonig JH, Brunet JF, Ericson J, Perlmann T.

Development. 2011 Aug;138(16):3399-408. doi: 10.1242/dev.065482. Epub 2011 Jul 13.

27.

Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells.

Panman L, Andersson E, Alekseenko Z, Hedlund E, Kee N, Mong J, Uhde CW, Deng Q, Sandberg R, Stanton LW, Ericson J, Perlmann T.

Cell Stem Cell. 2011 Jun 3;8(6):663-75. doi: 10.1016/j.stem.2011.04.001.

28.

Schizophrenia-relevant behaviors in a genetic mouse model of constitutive Nurr1 deficiency.

Vuillermot S, Joodmardi E, Perlmann T, Ove Ögren S, Feldon J, Meyer U.

Genes Brain Behav. 2011 Jul;10(5):589-603. doi: 10.1111/j.1601-183X.2011.00698.x. Epub 2011 May 30.

29.

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.

Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12317-22. doi: 10.1073/pnas.1007088107. Epub 2010 Jun 21.

30.

Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice.

Rojas P, Joodmardi E, Perlmann T, Ogren SO.

J Neurosci Res. 2010 Aug 1;88(10):2284-93. doi: 10.1002/jnr.22377.

PMID:
20175204
31.

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.

Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Björklund A, Ichinose H, Perlmann T.

J Neurosci. 2009 Dec 16;29(50):15923-32. doi: 10.1523/JNEUROSCI.3910-09.2009.

32.

NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.

Volakakis N, Joodmardi E, Perlmann T.

Biochem Biophys Res Commun. 2009 Dec 25;390(4):1186-91. doi: 10.1016/j.bbrc.2009.10.116. Epub 2009 Oct 25.

PMID:
19861119
33.

Neuronal cell replacement in Parkinson's disease.

Hedlund E, Perlmann T.

J Intern Med. 2009 Oct;266(4):358-71. doi: 10.1111/j.1365-2796.2009.02155.x. Review.

34.

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells.

Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, Alekseenko Z, Marklund U, Kjellander S, Volakakis N, Hovatta O, El Manira A, Björklund A, Perlmann T, Ericson J.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7613-8. doi: 10.1073/pnas.0902396106. Epub 2009 Apr 21. Erratum in: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21229.

35.

Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus.

Aberg E, Perlmann T, Olson L, Brené S.

Hippocampus. 2008;18(8):785-92. doi: 10.1002/hipo.20438.

PMID:
18493951
36.

SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation.

Holmberg J, Hansson E, Malewicz M, Sandberg M, Perlmann T, Lendahl U, Muhr J.

Development. 2008 May;135(10):1843-51. doi: 10.1242/dev.020180. Epub 2008 Apr 16.

37.

Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers.

Lammi J, Perlmann T, Aarnisalo P.

Arch Biochem Biophys. 2008 Apr 15;472(2):105-14. doi: 10.1016/j.abb.2008.02.003. Epub 2008 Feb 8.

PMID:
18282463
38.

Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development.

Kiss I, Rühl R, Szegezdi E, Fritzsche B, Tóth B, Pongrácz J, Perlmann T, Fésüs L, Szondy Z.

Eur J Immunol. 2008 Jan;38(1):147-55.

39.

Adult mice with reduced Nurr1 expression: an animal model for schizophrenia.

Rojas P, Joodmardi E, Hong Y, Perlmann T, Ogren SO.

Mol Psychiatry. 2007 Aug;12(8):756-66. Epub 2007 Apr 24.

PMID:
17457314
40.

The establishment of neuronal properties is controlled by Sox4 and Sox11.

Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J.

Genes Dev. 2006 Dec 15;20(24):3475-86.

41.

International Union of Pharmacology. LXVI. Orphan nuclear receptors.

Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V.

Pharmacol Rev. 2006 Dec;58(4):798-836. Review.

PMID:
17132856
42.

Characterization of the Nurr1 ligand-binding domain co-activator interaction surface.

Volakakis N, Malewicz M, Kadkhodai B, Perlmann T, Benoit G.

J Mol Endocrinol. 2006 Oct;37(2):317-26.

PMID:
17032747
43.

Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem.

Hermanson E, Borgius L, Bergsland M, Joodmardi E, Perlmann T.

J Neurochem. 2006 Jun;97(5):1403-11. Epub 2006 Apr 21.

44.

Identification of intrinsic determinants of midbrain dopamine neurons.

Andersson E, Tryggvason U, Deng Q, Friling S, Alekseenko Z, Robert B, Perlmann T, Ericson J.

Cell. 2006 Jan 27;124(2):393-405.

45.
46.

Full-length p73alpha represses drug-induced apoptosis in small cell lung carcinoma cells.

Nyman U, Sobczak-Pluta A, Vlachos P, Perlmann T, Zhivotovsky B, Joseph B.

J Biol Chem. 2005 Oct 7;280(40):34159-69. Epub 2005 Aug 8.

47.

Electrospray mass spectrometry for the direct accurate mass measurement of ligands in complex with the retinoid X receptor alpha ligand binding domain.

Lengqvist J, Alvélius G, Jörnvall H, Sjövall J, Perlmann T, Griffiths WJ.

J Am Soc Mass Spectrom. 2005 Oct;16(10):1631-40.

48.

Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.

Codina A, Benoit G, Gooch JT, Neuhaus D, Perlmann T, Schwabe JW.

J Biol Chem. 2004 Dec 17;279(51):53338-45. Epub 2004 Sep 28.

49.

Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells.

Perlmann T, Wallén-Mackenzie A.

Cell Tissue Res. 2004 Oct;318(1):45-52. Epub 2004 Sep 1. Review.

PMID:
15340833
50.

Digging deep into the pockets of orphan nuclear receptors: insights from structural studies.

Benoit G, Malewicz M, Perlmann T.

Trends Cell Biol. 2004 Jul;14(7):369-76. Review.

PMID:
15246430

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