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Items: 17

1.

Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues.

Jain R, Singh J, Perlman JH, Gershengorn MC.

Bioorg Med Chem. 2002 Jan;10(1):189-94.

PMID:
11738621
2.

Thyrotropin releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics.

Chu W, Perlman JH, Gershengorn MC, Moeller KD.

Bioorg Med Chem Lett. 1998 Nov 3;8(21):3093-6.

PMID:
9873682
3.

A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation.

Colson AO, Perlman JH, Jinsi-Parimoo A, Nussenzveig DR, Osman R, Gershengorn MC.

Mol Pharmacol. 1998 Dec;54(6):968-78.

PMID:
9855624
5.

Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone.

Perlman JH, Colson AO, Jain R, Czyzewski B, Cohen LA, Osman R, Gershengorn MC.

Biochemistry. 1997 Dec 16;36(50):15670-6.

PMID:
9398295
6.

Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor.

Perlman JH, Colson AO, Wang W, Bence K, Osman R, Gershengorn MC.

J Biol Chem. 1997 May 2;272(18):11937-42.

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Restricted analogues provide evidence of a biologically active conformation of thyrotropin-releasing hormone.

Laakkonen L, Li W, Perlman JH, Guarnieri F, Osman R, Moeller KD, Gershengorn MC.

Mol Pharmacol. 1996 Jun;49(6):1092-6.

PMID:
8649348
10.

Conformationally restricted TRH analogs: a probe for the pyroglutamate region.

Rutledge LD, Perlman JH, Gershengorn MC, Marshall GR, Moeller KD.

J Med Chem. 1996 Apr 12;39(8):1571-4. No abstract available.

PMID:
8648595
11.

A disulfide bond between conserved extracellular cysteines in the thyrotropin-releasing hormone receptor is critical for binding.

Perlman JH, Wang W, Nussenzveig DR, Gershengorn MC.

J Biol Chem. 1995 Oct 20;270(42):24682-5.

12.

Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotropin-releasing hormone receptor.

Perlman JH, Laakkonen L, Osman R, Gershengorn MC.

Mol Pharmacol. 1995 Mar;47(3):480-4.

PMID:
7700246
13.
14.

Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor.

Perlman JH, Thaw CN, Laakkonen L, Bowers CY, Osman R, Gershengorn MC.

J Biol Chem. 1994 Jan 21;269(3):1610-3.

15.

Analysis of the role of transmembrane helix three of the thyrotropin-releasing hormone (TRH) receptor in directly binding TRH.

Perlman JH, Laakkonen L, Thaw CN, Osman R, Gershengorn MC.

Trans Assoc Am Physicians. 1993;106:162-7. No abstract available.

PMID:
8036739

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