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Items: 1 to 50 of 261

1.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

PMID:
30726761
2.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2018 Dec 15. doi: 10.1164/rccm.201712-2410OC. [Epub ahead of print]

PMID:
30554520
3.

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.

PMID:
30530483
4.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
5.

Hexokinase 2 is dispensable for T cell-dependent immunity.

Mehta MM, Weinberg SE, Steinert EM, Chhiba K, Martinez CA, Gao P, Perlman HR, Bryce P, Hay N, Chandel NS.

Cancer Metab. 2018 Aug 17;6:10. doi: 10.1186/s40170-018-0184-5. eCollection 2018.

6.

Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.

Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM.

J Immunol. 2018 Apr 1;200(7):2391-2404. doi: 10.4049/jimmunol.1701543. Epub 2018 Feb 14.

PMID:
29445006
7.

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis.

Mandelin AM 2nd, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges SL Jr, Bathon JM, Atkinson JP, Fox DA, Matteson EL, Buckley CD, Pitzalis C, Parks D, Hughes LB, Geraldino-Pardilla L, Ike R, Phillips K, Wright K, Filer A, Kelly S, Ruderman EM, Morgan V, Abdala-Valencia H, Misharin AV, Budinger GS, Bartom ET, Pope RM, Perlman H, Winter DR.

Arthritis Rheumatol. 2018 Jun;70(6):841-854. doi: 10.1002/art.40453. Epub 2018 May 3.

PMID:
29439295
8.

The new aims and scope of Arthritis Research & Therapy.

Buckley CD, Perlman H.

Arthritis Res Ther. 2018 Feb 7;20(1):19. doi: 10.1186/s13075-018-1518-y. No abstract available.

9.

Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus.

Chalmers SA, Wen J, Doerner J, Stock A, Cuda CM, Makinde HM, Perlman H, Bosanac T, Webb D, Nabozny G, Fine JS, Klein E, Ramanujam M, Putterman C.

Arthritis Res Ther. 2018 Jan 25;20(1):10. doi: 10.1186/s13075-017-1500-0.

10.

Effect of Granulocyte-Macrophage Colony-Stimulating Factor With or Without Supervised Exercise on Walking Performance in Patients With Peripheral Artery Disease: The PROPEL Randomized Clinical Trial.

McDermott MM, Ferrucci L, Tian L, Guralnik JM, Lloyd-Jones D, Kibbe MR, Polonsky TS, Domanchuk K, Stein JH, Zhao L, Taylor D, Skelly C, Pearce W, Perlman H, McCarthy W, Li L, Gao Y, Sufit R, Bloomfield CL, Criqui MH.

JAMA. 2017 Dec 5;318(21):2089-2098. doi: 10.1001/jama.2017.17437.

11.

Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H.

J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7.

12.

Nonclassical Monocytes Mediate Secondary Injury, Neurocognitive Outcome, and Neutrophil Infiltration after Traumatic Brain Injury.

Makinde HM, Cuda CM, Just TB, Perlman HR, Schwulst SJ.

J Immunol. 2017 Nov 15;199(10):3583-3591. doi: 10.4049/jimmunol.1700896. Epub 2017 Oct 9.

13.

Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis.

MacLauchlan S, Zuriaga MA, Fuster JJ, Cuda CM, Jonason J, Behzadi F, Duffen JP, Haines GK 3rd, Aprahamian T, Perlman H, Walsh K.

Arthritis Res Ther. 2017 Jul 19;19(1):166. doi: 10.1186/s13075-017-1375-0.

14.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

15.

FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury.

Brazee PL, Soni PN, Tokhtaeva E, Magnani N, Yemelyanov A, Perlman HR, Ridge KM, Sznajder JI, Vagin O, Dada LA.

Front Immunol. 2017 Jun 1;8:623. doi: 10.3389/fimmu.2017.00623. eCollection 2017.

16.

Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction.

Zheng Z, Chiu S, Akbarpour M, Sun H, Reyfman PA, Anekalla KR, Abdala-Valencia H, Edgren D, Li W, Kreisel D, Korobova FV, Fernandez R, McQuattie-Pimentel A, Zhang ZJ, Perlman H, Misharin AV, Scott Budinger GR, Bharat A.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaal4508. doi: 10.1126/scitranslmed.aal4508.

17.

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C.

Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556.

18.

Association of Increased F4/80high Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells.

Huang QQ, Birkett R, Doyle RE, Haines GK, Perlman H, Shi B, Homan P, Xing L, Pope RM.

Arthritis Rheumatol. 2017 Sep;69(9):1762-1771. doi: 10.1002/art.40151. Epub 2017 Aug 1.

19.

The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy.

Makinde HM, Just TB, Cuda CM, Perlman H, Schwulst SJ.

Shock. 2017 Sep;48(3):276-283. doi: 10.1097/SHK.0000000000000859. Review.

20.

Willie Sutton Was Right: It's Time to Turn to the Synovium to Drive Rheumatoid Arthritis Therapy.

Ruderman EM, Mandelin AM, Perlman HR.

J Rheumatol. 2016 Dec;43(12):2089-2091. No abstract available.

21.

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

Li KP, Fähnrich A, Roy E, Cuda CM, Grimes HL, Perlman HR, Kalies K, Hildeman DA.

J Immunol. 2017 Jan 1;198(1):257-269. Epub 2016 Nov 16.

22.

The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis.

Tsai F, Perlman H, Cuda CM.

Clin Immunol. 2017 Dec;185:74-85. doi: 10.1016/j.clim.2016.10.007. Epub 2016 Oct 22. Review.

23.

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies.

Zheng F, Perlman H, Matthys P, Wen Y, Lahoutte T, Muyldermans S, Lu S, De Baetselier P, Schoonooghe S, Devoogdt N, Raes G.

Sci Rep. 2016 Oct 25;6:35966. doi: 10.1038/srep35966.

24.

Humoral Human Lung Allograft Rejection by Tissue-Restricted Non-HLA Antibodies.

Fernandez R, Chiu S, Raparia K, Garcha P, Farver C, Budev M, Tambur AR, DeCamp MM, Budinger S, Perlman H, Mohanakumar T, Bharat A.

Ann Thorac Surg. 2016 Oct;102(4):e339-41. doi: 10.1016/j.athoracsur.2016.03.042.

25.

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL, Clark AR.

Ann Rheum Dis. 2017 Mar;76(3):612-619. doi: 10.1136/annrheumdis-2016-209424. Epub 2016 Sep 5.

26.

The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases.

Cuda CM, Pope RM, Perlman H.

Nat Rev Rheumatol. 2016 Aug 23;12(9):543-58. doi: 10.1038/nrrheum.2016.132. Review.

27.

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model.

Archer AM, Saber R, Rose S, Shaffer A, Misharin AV, Tsai F, Haines Iii GK, Dominguez S, Eren M, Vaughan DE, Cuda CM, Perlman H.

J Transl Med. 2016 Jun 10;14(1):170. doi: 10.1186/s12967-016-0912-y.

28.

Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity.

Chiu S, Fernandez R, Subramanian V, Sun H, DeCamp MM, Kreisel D, Perlman H, Budinger GR, Mohanakumar T, Bharat A.

J Immunol. 2016 Jul 1;197(1):51-7. doi: 10.4049/jimmunol.1502539. Epub 2016 May 18.

29.

Lung-Restricted Antibodies Mediate Primary Graft Dysfunction and Prevent Allotolerance after Murine Lung Transplantation.

Bharat A, Chiu S, Zheng Z, Sun H, Yeldandi A, DeCamp MM, Perlman H, Budinger GR, Mohanakumar T.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):532-541.

30.

Celebrating the past, concentrating on the future: the next decade for AR&T.

Buckley CD, Perlman H.

Arthritis Res Ther. 2015 Oct 15;17:290. doi: 10.1186/s13075-015-0812-1. No abstract available.

31.

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H.

Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z.

32.

The heterogeneity of lung macrophages in the susceptibility to disease.

Morales-Nebreda L, Misharin AV, Perlman H, Budinger GR.

Eur Respir Rev. 2015 Sep;24(137):505-9. doi: 10.1183/16000617.0031-2015. Review.

33.

Ischemia-related changes in circulating stem and progenitor cells and associated clinical characteristics in peripheral artery disease.

Saber R, Liu K, Ferrucci L, Criqui MH, Zhao L, Tian L, Guralnik JM, Liao Y, Domanchuk K, Kibbe MR, Green D, Perlman H, McDermott MM.

Vasc Med. 2015 Dec;20(6):534-43. doi: 10.1177/1358863X15600255. Epub 2015 Aug 31.

34.

Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model.

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G 3rd, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR.

Arthritis Rheumatol. 2015 Dec;67(12):3146-57. doi: 10.1002/art.39321.

35.

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.

36.

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice.

Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GR, Misharin AV.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):147-9. doi: 10.1165/rcmb.2015-0147LE. No abstract available.

37.

Differential Activation of Infiltrating Monocyte-Derived Cells After Mild and Severe Traumatic Brain Injury.

Trahanas DM, Cuda CM, Perlman H, Schwulst SJ.

Shock. 2015 Mar;43(3):255-60. doi: 10.1097/SHK.0000000000000291.

38.

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.

Huang QQ, Perlman H, Birkett R, Doyle R, Fang D, Haines GK, Robinson W, Datta S, Huang Z, Li QZ, Phee H, Pope RM.

Nat Commun. 2015 May 12;6:7086. doi: 10.1038/ncomms8086.

39.

Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF-1.

Belmadani A, Ren D, Bhattacharyya BJ, Rothwangl KB, Hope TJ, Perlman H, Miller RJ.

Hippocampus. 2015 Nov;25(11):1224-41. doi: 10.1002/hipo.22428. Epub 2015 Mar 27.

40.

Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.

Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK 3rd, Berdnikovs S, Filer A, Clark AR, Buckley CD, Mutlu GM, Budinger GR, Perlman H.

Cell Rep. 2014 Oct 23;9(2):591-604. doi: 10.1016/j.celrep.2014.09.032. Epub 2014 Oct 16.

41.

Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.

Xia Y, Herlitz LC, Gindea S, Wen J, Pawar RD, Misharin A, Perlman H, Wu L, Wu P, Michaelson JS, Burkly LC, Putterman C.

J Am Soc Nephrol. 2015 May;26(5):1053-70. doi: 10.1681/ASN.2014030233. Epub 2014 Sep 30.

42.

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM.

PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014.

43.

Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC.

44.

β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.

Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM.

J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27.

45.

Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H.

J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7.

46.

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.

Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.

47.

Fas signaling in macrophages promotes chronicity in K/BxN serum-induced arthritis.

Huang QQ, Birkett R, Koessler RE, Cuda CM, Haines GK 3rd, Jin JP, Perlman H, Pope RM.

Arthritis Rheumatol. 2014 Jan;66(1):68-77. doi: 10.1002/art.38198.

48.

Reply: Moving forward in sepsis research.

Perlman H, Budinger GR, Ward PA.

Am J Respir Crit Care Med. 2013 Nov 15;188(10):1265-6. doi: 10.1164/rccm.201305-0997LE. No abstract available.

PMID:
24236593
49.

Traumatic brain injury-induced alterations in peripheral immunity.

Schwulst SJ, Trahanas DM, Saber R, Perlman H.

J Trauma Acute Care Surg. 2013 Nov;75(5):780-8. doi: 10.1097/TA.0b013e318299616a.

50.

Progenitor cell release plus exercise to improve functional performance in peripheral artery disease: the PROPEL Study.

Domanchuk K, Ferrucci L, Guralnik JM, Criqui MH, Tian L, Liu K, Losordo D, Stein J, Green D, Kibbe M, Zhao L, Annex B, Perlman H, Lloyd-Jones D, Pearce W, Taylor D, McDermott MM.

Contemp Clin Trials. 2013 Nov;36(2):502-9. doi: 10.1016/j.cct.2013.09.011. Epub 2013 Sep 27.

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