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Cell Wall-Modifying Antifungal Drugs.

Perlin DS.

Curr Top Microbiol Immunol. 2019 Dec 25. doi: 10.1007/82_2019_188. [Epub ahead of print]


Penetration of Ibrexafungerp (formerly SCY-078) at the site of infection in an Intra-abdominal candidiasis mouse model.

Lee A, Prideaux B, Zimmerman M, Carter C, Barat S, Angulo D, Dartois V, Perlin DS, Zhao Y.

Antimicrob Agents Chemother. 2019 Dec 23. pii: AAC.02268-19. doi: 10.1128/AAC.02268-19. [Epub ahead of print]


Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata.

Hou X, Healey KR, Shor E, Kordalewska M, Ortigosa CJ, Paderu P, Xiao M, Wang H, Zhao Y, Lin LY, Zhang YH, Li YZ, Xu YC, Perlin DS, Zhao Y.

Emerg Microbes Infect. 2019;8(1):1619-1625. doi: 10.1080/22221751.2019.1684209.


Detection of Candida auris antifungal drug resistance markers directly from clinical skin swabs.

Kordalewska M, Lee A, Zhao Y, Perlin DS.

Antimicrob Agents Chemother. 2019 Oct 7. pii: AAC.01754-19. doi: 10.1128/AAC.01754-19. [Epub ahead of print]


Identification of Drug Resistant Candida auris.

Kordalewska M, Perlin DS.

Front Microbiol. 2019 Aug 20;10:1918. doi: 10.3389/fmicb.2019.01918. eCollection 2019. Review.


Molecular Diagnostics in the Times of Surveillance for Candida auris.

Kordalewska M, Perlin DS.

J Fungi (Basel). 2019 Aug 20;5(3). pii: E77. doi: 10.3390/jof5030077. Review.


Efficacy of humanized single large doses of caspofungin on the lethality and fungal tissue burden in a deeply neutropenic murine model against Candida albicans and Candida dubliniensis.

Prépost E, Tóth Z, Perlin DS, Gesztelyi R, Kardos G, Kovács R, Nagy F, Forgács L, Majoros L.

Infect Drug Resist. 2019 Jul 1;12:1805-1814. doi: 10.2147/IDR.S198764. eCollection 2019.


Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.

Satish S, Jiménez-Ortigosa C, Zhao Y, Lee MH, Dolgov E, Krüger T, Park S, Denning DW, Kniemeyer O, Brakhage AA, Perlin DS.

mBio. 2019 Jun 4;10(3). pii: e00779-19. doi: 10.1128/mBio.00779-19.


Development and multicentre validation of an agar-based screening method for echinocandin susceptibility testing of Aspergillus species.

Meletiadis J, Siopi M, Kanioura L, Jørgensen KM, Perlin DS, Mouton JW, Arendrup MC.

J Antimicrob Chemother. 2019 Aug 1;74(8):2247-2254. doi: 10.1093/jac/dkz154.


Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa.

Papp-Wallace KM, Zeiser ET, Becka SA, Park S, Wilson BM, Winkler ML, D'Souza R, Singh I, Sutton G, Fouts DE, Chen L, Kreiswirth BN, Ellis-Grosse EJ, Drusano GL, Perlin DS, Bonomo RA.

J Infect Dis. 2019 Jul 19;220(4):666-676. doi: 10.1093/infdis/jiz149.


Adipose Tissue Regulates Pulmonary Pathology during TB Infection.

Ayyappan JP, Ganapathi U, Lizardo K, Vinnard C, Subbian S, Perlin DS, Nagajyothi JF.

mBio. 2019 Apr 16;10(2). pii: e02771-18. doi: 10.1128/mBio.02771-18.


Tissue Distribution and Penetration of Isavuconazole at the Site of Infection in Experimental Invasive Aspergillosis in Mice with Underlying Chronic Granulomatous Disease.

Lee A, Prideaux B, Lee MH, Zimmerman M, Dolgov E, Perlin DS, Zhao Y.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00524-19. doi: 10.1128/AAC.00524-19. Print 2019 Jun.


Isavuconazole prophylaxis in patients with hematologic malignancies and hematopoietic-cell transplant recipients.

Fontana L, Perlin DS, Zhao Y, Noble BN, Lewis JS, Strasfeld L, Hakki M.

Clin Infect Dis. 2019 Apr 8. pii: ciz282. doi: 10.1093/cid/ciz282. [Epub ahead of print]


Beyond tissue concentrations: antifungal penetration at the site of infection.

Zhao Y, Prideaux B, Baistrocchi S, Sheppard DC, Perlin DS.

Med Mycol. 2019 Apr 1;57(Supplement_2):S161-S167. doi: 10.1093/mmy/myy067. Review.


A Novel, Drug Resistance-Independent, Fluorescence-Based Approach To Measure Mutation Rates in Microbial Pathogens.

Shor E, Schuyler J, Perlin DS.

mBio. 2019 Feb 26;10(1). pii: e00120-19. doi: 10.1128/mBio.00120-19.


[Left-sided renal cell cacrinoma with vena cava inferior thrombus: totally laparoscopic removal].

Perlin DV, Vorobiev AA, Zippunnikov VP, Dymkov IN.

Urologiia. 2018 Dec;(6):122-127. Russian.


A Novel, Rapid, and Low-Volume Assay for Therapeutic Drug Monitoring of Posaconazole and Other Long-Chain Azole-Class Antifungal Drugs.

Wiedman GR, Zhao Y, Perlin DS.

mSphere. 2018 Dec 19;3(6). pii: e00623-18. doi: 10.1128/mSphere.00623-18.


Rapid Detection of ERG11-Associated Azole Resistance and FKS-Associated Echinocandin Resistance in Candida auris.

Hou X, Lee A, Jiménez-Ortigosa C, Kordalewska M, Perlin DS, Zhao Y.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01811-18. doi: 10.1128/AAC.01811-18. Print 2019 Jan.


Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata.

Shields RK, Kline EG, Healey KR, Kordalewska M, Perlin DS, Nguyen MH, Clancy CJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01692-18. doi: 10.1128/AAC.01692-18. Print 2019 Jan.


Direct Detection of Emergent Fungal Pathogen Candida auris in Clinical Skin Swabs by SYBR Green-Based Quantitative PCR Assay.

Sexton DJ, Kordalewska M, Bentz ML, Welsh RM, Perlin DS, Litvintseva AP.

J Clin Microbiol. 2018 Nov 27;56(12). pii: e01337-18. doi: 10.1128/JCM.01337-18. Print 2018 Dec.


Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata.

Healey KR, Perlin DS.

J Fungi (Basel). 2018 Sep 1;4(3). pii: E105. doi: 10.3390/jof4030105. Review.


Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.

Vickers CF, Silva APG, Chakraborty A, Fernandez P, Kurepina N, Saville C, Naranjo Y, Pons M, Schnettger LS, Gutierrez MG, Park S, Kreiswith BN, Perlin DS, Thomas EJ, Cavet JS, Tabernero L.

J Med Chem. 2018 Sep 27;61(18):8337-8352. doi: 10.1021/acs.jmedchem.8b00832. Epub 2018 Sep 10.


Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility.

Healey KR, Kordalewska M, Jiménez Ortigosa C, Singh A, Berrío I, Chowdhary A, Perlin DS.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01427-18. doi: 10.1128/AAC.01427-18. Print 2018 Oct.


Multilocus Sequence Typing (MLST) Genotypes of Candida glabrata Bloodstream Isolates in Korea: Association With Antifungal Resistance, Mutations in Mismatch Repair Gene (Msh2), and Clinical Outcomes.

Byun SA, Won EJ, Kim MN, Lee WG, Lee K, Lee HS, Uh Y, Healey KR, Perlin DS, Choi MJ, Kim SH, Shin JH.

Front Microbiol. 2018 Jul 13;9:1523. doi: 10.3389/fmicb.2018.01523. eCollection 2018.


Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis.

Zhao Y, Lee MH, Paderu P, Lee A, Jimenez-Ortigosa C, Park S, Mansbach RS, Shaw KJ, Perlin DS.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00425-18. doi: 10.1128/AAC.00425-18. Print 2018 Oct.


Molecular Analysis of Resistance and Detection of Non-Wild-Type Strains Using Etest Epidemiological Cutoff Values for Amphotericin B and Echinocandins for Bloodstream Candida Infections from a Tertiary Hospital in Qatar.

Taj-Aldeen SJ, Salah H, Perez WB, Almaslamani M, Motyl M, AbdulWahab A, Healey KR, Perlin DS.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00214-18. doi: 10.1128/AAC.00214-18. Print 2018 Sep.


VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.

Break TJ, Desai JV, Healey KR, Natarajan M, Ferre EMN, Henderson C, Zelazny A, Siebenlist U, Yates CM, Cohen OJ, Schotzinger RJ, Perlin DS, Garvey EP, Lionakis MS.

J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094. doi: 10.1093/jac/dky170.


Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris.

Kordalewska M, Lee A, Park S, Berrio I, Chowdhary A, Zhao Y, Perlin DS.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00238-18. doi: 10.1128/AAC.00238-18. Print 2018 Jun.


Absence of Azole or Echinocandin Resistance in Candida glabrata Isolates in India despite Background Prevalence of Strains with Defects in the DNA Mismatch Repair Pathway.

Singh A, Healey KR, Yadav P, Upadhyaya G, Sachdeva N, Sarma S, Kumar A, Tarai B, Perlin DS, Chowdhary A.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00195-18. doi: 10.1128/AAC.00195-18. Print 2018 Jun.


Correction for Yang et al., "Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling".

Yang F, Zhang L, Wakabayashi H, Myers J, Jiang Y, Cao Y, Jimenez-Ortigosa C, Perlin DS, Rustchenko E.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e00386-18. doi: 10.1128/AAC.00386-18. Print 2018 Apr. No abstract available.


Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.

Hover BM, Kim SH, Katz M, Charlop-Powers Z, Owen JG, Ternei MA, Maniko J, Estrela AB, Molina H, Park S, Perlin DS, Brady SF.

Nat Microbiol. 2018 Apr;3(4):415-422. doi: 10.1038/s41564-018-0110-1. Epub 2018 Feb 12.


An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds.

Vila-Farres X, Chu J, Ternei MA, Lemetre C, Park S, Perlin DS, Brady SF.

mSphere. 2018 Jan 24;3(1). pii: e00528-17. doi: 10.1128/mSphere.00528-17. eCollection 2018 Jan-Feb.


Applying host disease status biomarkers to therapeutic response monitoring in invasive aspergillosis patients.

Zhao Y, Nagasaki Y, Paderu P, Sugrue MW, Leather HL, Wingard JR, Perlin DS.

Med Mycol. 2019 Jan 1;57(1):38-44. doi: 10.1093/mmy/myx164.


FKS2 and FKS3 Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility.

Suwunnakorn S, Wakabayashi H, Kordalewska M, Perlin DS, Rustchenko E.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02299-17. doi: 10.1128/AAC.02299-17. Print 2018 Apr.


A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.

Chowdhary A, Prakash A, Sharma C, Kordalewska M, Kumar A, Sarma S, Tarai B, Singh A, Upadhyaya G, Upadhyay S, Yadav P, Singh PK, Khillan V, Sachdeva N, Perlin DS, Meis JF.

J Antimicrob Chemother. 2018 Apr 1;73(4):891-899. doi: 10.1093/jac/dkx480.


A novel, tomographic imaging probe for rapid diagnosis of fungal keratitis.

Lee MH, Wiedman G, Park S, Mustaev A, Zhao Y, Perlin DS.

Med Mycol. 2018 Oct 1;56(7):796-802. doi: 10.1093/mmy/myx125.


Comparative study of Candida spp. isolates: Identification and echinocandin susceptibility in isolates obtained from blood cultures in 15 hospitals in Medellín, Colombia.

Berrio I, Maldonado N, De Bedout C, Arango K, Cano LE, Valencia Y, Jiménez-Ortigosa C, Perlin DS, Gómez BL, Robledo C, Robledo J; Grupo GERMEN.

J Glob Antimicrob Resist. 2018 Jun;13:254-260. doi: 10.1016/j.jgar.2017.11.010. Epub 2017 Nov 26.


[Laparoscopic radical cystectomy: innovations and classics].

Perlin DV, Aleksandrov IV, Zipunnikov VP, Popova M.

Urologiia. 2017 Oct;(5):26-30. Russian.


The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.

Healey KR, Nagasaki Y, Zimmerman M, Kordalewska M, Park S, Zhao Y, Perlin DS.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01412-17. doi: 10.1128/AAC.01412-17. Print 2017 Dec.


Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis.

Jiménez-Ortigosa C, Moore C, Denning DW, Perlin DS.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01277-17. doi: 10.1128/AAC.01277-17. Print 2017 Dec.


Culture-Independent Molecular Methods for Detection of Antifungal Resistance Mechanisms and Fungal Identification.

Perlin DS, Wiederhold NP.

J Infect Dis. 2017 Aug 15;216(suppl_3):S458-S465. doi: 10.1093/infdis/jix121.


An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs.

Wiedman GR, Zhao Y, Mustaev A, Ping J, Vishnubhotla R, Johnson ATC, Perlin DS.

mSphere. 2017 Aug 23;2(4). pii: e00274-17. doi: 10.1128/mSphere.00274-17. eCollection 2017 Jul-Aug.


Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata.

Vella A, De Carolis E, Mello E, Perlin DS, Sanglard D, Sanguinetti M, Posteraro B.

Sci Rep. 2017 Aug 22;7(1):9099. doi: 10.1038/s41598-017-09329-4.


The global problem of antifungal resistance: prevalence, mechanisms, and management.

Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A.

Lancet Infect Dis. 2017 Dec;17(12):e383-e392. doi: 10.1016/S1473-3099(17)30316-X. Epub 2017 Jul 31. Review.


Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-abdominal Abscess Model.

Zhao Y, Prideaux B, Nagasaki Y, Lee MH, Chen PY, Blanc L, Ho H, Clancy CJ, Nguyen MH, Dartois V, Perlin DS.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01009-17. doi: 10.1128/AAC.01009-17. Print 2017 Oct.


De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance.

Jiménez-Ortigosa C, Perez WB, Angulo D, Borroto-Esoda K, Perlin DS.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00833-17. doi: 10.1128/AAC.00833-17. Print 2017 Sep.


Rapid and Accurate Molecular Identification of the Emerging Multidrug-Resistant Pathogen Candida auris.

Kordalewska M, Zhao Y, Lockhart SR, Chowdhary A, Berrio I, Perlin DS.

J Clin Microbiol. 2017 Aug;55(8):2445-2452. doi: 10.1128/JCM.00630-17. Epub 2017 May 24.


Expression Dynamics of Innate Immunity in Influenza Virus-Infected Swine.

Montoya M, Foni E, Solórzano A, Razzuoli E, Baratelli M, Bilato D, Córdoba L, Del Burgo MAM, Martinez J, Martinez-Orellana P, Chiapponi C, Perlin DS, Del Real G, Amadori M.

Front Vet Sci. 2017 Apr 21;4:48. doi: 10.3389/fvets.2017.00048. eCollection 2017.


Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.

Heo ST, Tatara AM, Jiménez-Ortigosa C, Jiang Y, Lewis RE, Tarrand J, Tverdek F, Albert ND, Verweij PE, Meis JF, Mikos AG, Perlin DS, Kontoyiannis DP.

Clin Infect Dis. 2017 Jul 15;65(2):216-225. doi: 10.1093/cid/cix297.


Cryptococcus flips its lid - membrane phospholipid asymmetry modulates antifungal drug resistance and virulence.

Shor E, Wang Y, Perlin DS, Xue C.

Microb Cell. 2016 Aug 1;3(8):358-360. doi: 10.15698/mic2016.08.521.

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